PPAR signaling (Homo sapiens)

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Description

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP2316 revision 69143, with a 92.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Takada I, Kato S; ''[PPARs target genes].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
  2. Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T; ''[PPARs-mediated intracellular signal transduction].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
  3. Fujii H; ''[PPARs-mediated intracellular signal transduction].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
  4. Desvergne B, Michalik L, Wahli W; ''Transcriptional regulation of metabolism.''; Physiol Rev, 2006 PubMed Europe PMC Scholia
  5. Inoue H; ''[Endogenous ligands for PPARs].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
  6. Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W; ''From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.''; Prog Lipid Res, 2006 PubMed Europe PMC Scholia
  7. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  8. Desvergne B, Wahli W; ''Peroxisome proliferator-activated receptors: nuclear control of metabolism.''; Endocr Rev, 1999 PubMed Europe PMC Scholia
  9. Savage DB; ''PPAR gamma as a metabolic regulator: insights from genomics and pharmacology.''; Expert Rev Mol Med, 2005 PubMed Europe PMC Scholia
  10. Semple RK, Chatterjee VK, O'Rahilly S; ''PPAR gamma and human metabolic disease.''; J Clin Invest, 2006 PubMed Europe PMC Scholia
  11. Lehrke M, Lazar MA; ''The many faces of PPARgamma.''; Cell, 2005 PubMed Europe PMC Scholia
  12. Hauner H; ''The mode of action of thiazolidinediones.''; Diabetes Metab Res Rev, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137952view20:52, 10 March 2025KhanspersModified description
136348view00:45, 27 January 2025EweitzOntology Term : 'CL:0000448' removed !
136347view00:36, 27 January 2025EweitzAdd references from source KEGG pathway (hsa03320)
136346view00:26, 27 January 2025EweitzOntology Term : 'hepatocyte' added !
136345view00:25, 27 January 2025EweitzOntology Term : 'PW:0001355' removed !
136344view00:25, 27 January 2025EweitzOntology Term : 'adipocyte' added !
136343view00:11, 27 January 2025EweitzRemove HomologyMapper comment and mouse metadata; revised to directly translate human KEGG pathway
136342view00:08, 27 January 2025EweitzAdd new pathway start: VLDL, chylomicron
136341view14:14, 26 January 2025EweitzRemove genes not in source KEGG pathway (presumably inferred through broad homology mapping)
136340view14:03, 26 January 2025EweitzRefine label size and alignment
136339view13:52, 26 January 2025EweitzRefine interactions at start
136338view13:47, 26 January 2025EweitzRefine terminal interactions
136337view05:10, 26 January 2025EweitzMitigate PathVisio discrepancy with Pvjs / Kaavio
136336view05:09, 26 January 2025EweitzAlign nodes
136335view05:08, 26 January 2025EweitzEconomize layout
136334view05:07, 26 January 2025EweitzEconomize layout, align nodes
136333view05:04, 26 January 2025EweitzAlign nodes
136332view05:03, 26 January 2025EweitzUpgrade to pathway nodes
136331view04:56, 26 January 2025EweitzAdd cell membrane, nucleus membrane
136330view04:43, 26 January 2025EweitzConvert PPAR complex lines from straight to elbow, for easier discernibility
136329view04:14, 26 January 2025EweitzRefine layout
136328view04:13, 26 January 2025EweitzEconomize layout
136327view04:08, 26 January 2025EweitzEconomize layout
136326view03:20, 26 January 2025EweitzClear cached board dimensions
136325view03:19, 26 January 2025EweitzRemove label uneditable in PathVisio, via https://classic.wikipathways.org/index.php?title=Pathway:WP3942&action=edit
136324view03:13, 26 January 2025EweitzEconomize layout
136323view03:10, 26 January 2025EweitzEconomize layout
136322view03:07, 26 January 2025EweitzEconomize layout
136321view02:56, 26 January 2025EweitzEconomize layout
136320view02:55, 26 January 2025EweitzRemove large empty graphical element
136319view02:54, 26 January 2025EweitzStandardize case
136318view02:52, 26 January 2025EweitzEconomize layout
136317view02:46, 26 January 2025EweitzEconomize layout
136316view02:41, 26 January 2025EweitzEconomize layout
136315view02:35, 26 January 2025EweitzEconomize layout
136314view02:22, 26 January 2025EweitzEconomize layout
136313view02:22, 26 January 2025EweitzEconomize layout
136312view01:59, 26 January 2025EweitzRemove duplicate genes, genes not in source
136311view01:14, 26 January 2025EweitzRemove genes not in source KEGG pathway
136310view22:20, 25 January 2025EweitzStandardize node size, font size, font family
136309view21:52, 25 January 2025EweitzEconomize layout
129708view01:30, 22 May 2024EweitzModified title
106517view23:28, 5 September 2019KhanspersModified description
106205view12:10, 16 August 2019MaintBotHMDB identifier normalization
105777view19:42, 15 August 2019KhanspersModified description
104982view19:15, 27 June 2019KhanspersModified description
94205view21:11, 25 August 2017DeSlAdded ID for thiazolidine compound class from ChEBI.
91095view01:11, 4 January 2017Khanspersfixed unconnected interactions, updated missing xrefs, added lit ref
90815view18:40, 14 December 2016KhanspersOntology Term : 'cell of skeletal muscle' added !
90814view18:39, 14 December 2016KhanspersOntology Term : 'white fat cell' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment
9-cis-Retinoic acidMetaboliteHMDB0002369 (HMDB)
ACAA1GeneProductENSG00000060971 (Ensembl)
  • Original kegg element: gene;21;mmu:113868 mmu:235674
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235674
ACOX1GeneProductENSG00000161533 (Ensembl)
  • Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430
ACSL1GeneProductENSG00000151726 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081
ADIPOQGeneProductENSG00000181092 (Ensembl)
  • Original kegg element: gene;53;mmu:11450
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11450
ANGPTL4GeneProductENSG00000167772 (Ensembl)
  • Original kegg element: gene;41;mmu:57875
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57875
APOA1GeneProductENSG00000118137 (Ensembl)
  • Original kegg element: gene;61;mmu:11806
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11806
APOA2GeneProductENSG00000158874 (Ensembl)
  • Original kegg element: gene;46;mmu:11807
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11807
APOA5GeneProductENSG00000110243 (Ensembl)
  • Original kegg element: gene;64;mmu:66113
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66113
APOC3GeneProductENSG00000110245 (Ensembl)
  • Original kegg element: gene;57;mmu:11814
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11814
AQP7GeneProductENSG00000165269 (Ensembl)
  • Original kegg element: gene;7;mmu:11832
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11832
Adipocytokine signalingPathwayOriginal kegg element: map;34;path:mmu04920
CD36GeneProductENSG00000135218 (Ensembl)
  • Original kegg element: gene;11;mmu:12491
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491
CPT1CGeneProductENSG00000169169 (Ensembl)
  • Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78070
CPT2GeneProductENSG00000157184 (Ensembl)
  • Original kegg element: gene;26;mmu:12896
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12896
CYP27A1GeneProductENSG00000135929 (Ensembl)
  • Original kegg element: gene;60;mmu:104086
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086
CYP4A11GeneProductENSG00000187048 (Ensembl)
  • Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:666168
CYP7A1GeneProductENSG00000167910 (Ensembl)
  • Original kegg element: gene;33;mmu:13122
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13122
CYP8B1GeneProductENSG00000180432 (Ensembl)
  • Original kegg element: gene;58;mmu:13124
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13124
CiprofibrateMetaboliteCHEBI:50867 (ChEBI)
DBIGeneProductENSG00000155368 (Ensembl)
  • Original kegg element: gene;63;mmu:13167
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13167
EHHADHGeneProductENSG00000113790 (Ensembl)
  • Original kegg element: gene;25;mmu:74147
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147
EicosanoidMetaboliteCHEBI:23899 (ChEBI)
FABP1GeneProductENSG00000163586 (Ensembl)
  • Original kegg element: gene;44;mmu:14080
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080
FABP2GeneProductENSG00000145384 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14079
FABP3GeneProductENSG00000121769 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077
FABP4GeneProductENSG00000170323 (Ensembl)
  • Original kegg element: gene;40;mmu:11770
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770
FABP5GeneProductENSG00000164687 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16592
FABP6GeneProductENSG00000170231 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16204
FABP7GeneProductENSG00000164434 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12140
FADS2GeneProductENSG00000134824 (Ensembl)
  • Original kegg element: gene;56;mmu:56473
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473
Fatty acid metabolismGeneProductOriginal kegg element: map;35;path:mmu00071
GKGeneProductENSG00000198814 (Ensembl)
  • Original kegg element: gene;8;mmu:14626 mmu:14933
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14626
Glycerophospholipid metabolismGeneProductOriginal kegg element: map;52;path:mmu00564
HMGCS2GeneProductENSG00000134240 (Ensembl)
  • Original kegg element: gene;37;mmu:15360
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360
ILKGeneProductENSG00000166333 (Ensembl)
  • Original kegg element: gene;43;mmu:16202
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16202
LPLGeneProductENSG00000175445 (Ensembl)
  • Original kegg element: gene;30;mmu:16956
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16956
ME1GeneProductENSG00000065833 (Ensembl)
  • Original kegg element: gene;65;mmu:17436
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17436
MMP1GeneProductENSG00000196611 (Ensembl)
  • Original kegg element: gene;39;mmu:83995 mmu:83996
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83996
NR1H3GeneProductENSG00000025434 (Ensembl)
  • Original kegg element: gene;59;mmu:22259
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22259
NSAIDsMetaboliteCHEBI:35475 (ChEBI)
OLR1GeneProductENSG00000173391 (Ensembl)
  • Original kegg element: gene;29;mmu:108078
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108078
PCK1GeneProductENSG00000124253 (Ensembl)
  • Original kegg element: gene;9;mmu:18534 mmu:74551
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18534
PCK2GeneProductENSG00000100889 (Ensembl)
  • Original kegg element: gene;9;mmu:18534 mmu:74551
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74551
PDPK1GeneProductENSG00000140992 (Ensembl)
  • Original kegg element: gene;45;mmu:18607
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607
PLIN1GeneProductENSG00000166819 (Ensembl)
  • Original kegg element: gene;10;mmu:103968
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:103968
PLTPGeneProductENSG00000100979 (Ensembl)
  • Original kegg element: gene;47;mmu:18830
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18830
PPARAGeneProductENSG00000186951 (Ensembl)
  • Original kegg element: gene;14;mmu:19013
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19013
PPARDGeneProductENSG00000112033 (Ensembl)
  • Original kegg element: gene;16;mmu:19015
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19015
PPARGGeneProductENSG00000132170 (Ensembl)
  • Original kegg element: gene;18;mmu:19016
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19016
Primary bile acid biosynthesisGeneProductOriginal kegg element: map;51;path:mmu00120
RXRAGeneProductENSG00000186350 (Ensembl)
  • Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181
RXRBGeneProductENSG00000204231 (Ensembl)
  • Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182
RXRGGeneProductENSG00000143171 (Ensembl)
  • Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183
SCDGeneProductENSG00000099194 (Ensembl)
  • Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:329065
SCP2GeneProductENSG00000116171 (Ensembl)
  • Original kegg element: gene;20;mmu:20280
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20280
SLC27A1GeneProductENSG00000130304 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457
SLC27A2GeneProductENSG00000140284 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26458
SLC27A4GeneProductENSG00000167114 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569
SLC27A5GeneProductENSG00000083807 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26459
SLC27A6GeneProductENSG00000113396 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:225579
SORBS1GeneProductENSG00000095637 (Ensembl)
  • Original kegg element: gene;38;mmu:20411
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20411
Saturated fatty acidsMetaboliteCHEBI:26607 (ChEBI)
Synthesis and degradation of ketone bodiesGeneProductOriginal kegg element: map;50;path:mmu00072
Thiazolidine derivativeMetaboliteCHEBI:35622 (ChEBI)
UBCGeneProductENSG00000150991 (Ensembl)
  • Original kegg element: gene;62;mmu:22190
  • No homologues found for original id L:22190
UCP1GeneProductENSG00000109424 (Ensembl)
  • Original kegg element: gene;66;mmu:22227
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22227
Unsaturated fatty acidsMetaboliteCHEBI:27208 (ChEBI)

Annotated Interactions

No annotated interactions
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