Portal:Disease

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Disease Pathways at WikiPathways


Welcome to the Disease Portal

This portal highlights WikiPathways content related to human disease, and is designed as a central organizing point for exploring, curating and expanding the collection of disease pathways.

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Get information

Exploring Pathways

  • On the right, you'll find a curated set of Featured Pathways, representing all human disease-related pathways at WikiPathways.
  • On the left, you'll find a Search box to help find pathways by keywords or gene names.
  • Below, you'll find information on how to get involved with pathway curation, to help improve and expand the WikiPathways collection of disease pathways.

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Get involved

Create new pathways

Improve existing pathways

Integrated Cancer Pathway Nifedipine Activity
Pilocytic astrocytoma Prostate Cancer
Influenza A virus infection Pathogenic Escherichia coli infection
Ovarian Infertility Genes Polycystic kidney disease
Type II diabetes mellitus Physiological and Pathological Hypertrophy of the Heart

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How to add a pathway to the portal

The list of Featured Pathways is not static and can be updated at any time. If you know of a pathway that should be added, please contact the administrator.

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Pathways from Blau et al.


Alternative pathway of fetal androgen synthesis (Homo sapiens)

Alternative pathway of fetal androgen synthesis
Alternative pathway of fetal androgen synthesis

View all digitized Pathways from the Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases by Blau et al.


How to add a pathway to the portal

The list of Featured Pathways is not static and can be updated at any time. If you know of a pathway that should be added, please contact Denise Slenter.


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COVID-19 Pathways

Hijack of Ubiquitination by SARS-CoV-2

SARS-CoV-2 includes a novel Orf10 that interacts with muliple members of the Cullin 2 ubiquitin ligase complex.

View all COVID pathways

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Related Portal: Rare diseases

See also the Rare disease portal on WikiPathways

A rare or orphan disease is a disease which affects relatively few people. The exact definition varies between 1:1000 and 1:200.000. E.g. it can be 1:1500 (USA) , 1:2000 (EU) or 1:2500 (Japan). Rare diseases are mostly caused by genetic variation making them chronic and hard to cure. The severity depends on the affected gene and its physiological implications. Rare disease pathways on WikiPathways:

Database for rare diseases (ORPHANET)


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