Macrophage-stimulating protein (MSP) signaling (Homo sapiens)

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10Blood brain barrierCell adhesion / motilityOsteoblast differentiationCell cycle regulationOther types of cancersSuperoxideproductionCytokine secretion fromFVB and C57Bl6 miceperitoneal macrophagesBreast cancerDU145 & PC-3 cellsCancer metastasisMolecular associationTGF-betapathway In adherent cells In T47D cellsPI3KDownregulationKidney fibrosis & Epithelial-mesenchymal transitionUpregulationLeads to phosphorylationRegulation of IFN-gamma signalingCell MigrationCytoplasmOsteoblastdifferentiationPhosphositeInhibitory effects onsystemic innate immunityCell proliferation, invasion & metastasisRegulation of tumor angiogenesisCYTransportRegulation ofnon-alcoholic steatohepatitisGenetically susceptibleMSP variant (p.R703C)to Crohn's disease andulcerative colitisCancer initiation, progression & EMTAnt-inflammatory responsein human monocytoid cellsNucleusEpithelial-mesenchymal transition Regulation of growth and apoptosis in RON+ Ba/F3 and MEL cellsRON OverexpressionCell motilityRegulation of hepatic gluconegenesisInhibition of anoikisRegulation of M1/M2 macrophage phenotypeCell ProliferationMDM Cellssf-RON overexpressionPreservation ofblood brain barrier integrityin intracerebral hemorrhagePI3K-dependentCell adhesionand motility Epithelial-mesenchymal transition Cell proliferation & anti-apoptosisCigarette smoke toxicityCell proliferation,migration,invasion & EMTCell proliferation & glucose metabolismMST127MAPK127T185Y187MST1RY123827Y1239MAPK327T202Y204SRCY41927PLCG127Y783AKT127T308S473MTORS244827RPS6KB127T412PDCD4S45727RPS6KA1T57327RPS6S236S24027S235S244COL4A127ProteinmRNAReceptorNUProtein/ GeneProteinPCProtein/ GeneLigandMST117, 28, 29MST1R17, 28, 29PCNAY21117ABL117P17AKT1P29MBD429Cancer MetastasisMST1R9MST19WNT10B9DEK9FZD19CTNNB19WNT10B9CTNNB19CYNUCLDN128MST118MST1R18sf-MST1R4SMAD2S4674S465SMAD3S4234S425PDPK14S241AKT1T308S4734ZEB14SLUG4SIP14CDH24CDH14RPS6KA318CDH118VIM18MST1R Δ 16525pYPTEN25S380MTORS244825AKT1S47325MAPK125T185Y187MAPK3T20225Y204MST1R1Prostate cancersf-MST1R6sf-RON overexpressionAKT1S4736GSK3BS96CTNNB16GLUT16LDHA6HK26Gastric cancerMST1R5RON overexpressionSMAD95S465S467SMAD5S4655S463SMAD1S463S4655ZEB25VIM5CDH15Endometrial cancerMST111MST1R11AKT111T308S473MTOR11PRPS6KB1T41211S447T444JUN11PMAPK311PMAPK111PRPS6KA411PTP53S1511S392S46RPS6KA511PMesotheliomaMST122MST1R22MAPK1T18522Y187MAPK322T202Y204SMAD1S46522S463SMAD5S463S46522SMAD922S467S465ALP22BGLAP22BSP22SP722 MST1 p.R703C15MST1R15AKT1S47315MST126MST1R26IL1026MMP926IL1B26MMP926IL1B26TNF26DifferentiatedU937 CellsMST114MST1R14PRKAA210, 14T172P1014ACACAP14ACO14CPT1A14PPARGC1A14MST119MST1R19PTK219AKT119SRC19MAPK319CYNUMAPK319MST121MST1R13MAPK1T185Y18713MAPK313Y204T202CDH113ACTA213RON overexpressionMST1R21NFKB121NFKB121TNF21IL1B21IL1021CYNUMST1R23RON overexpressionSRC23Y419SMAD223S465S467SMAD3S425S42323MAPK1P23MAPK3P23MAPK8P23MAPK923PMAPK1423PSMAD423IGF1R23FGFR123VEGFR123VEGFR223PDGFRA23PDGFRB23CDH223VIM23TGFB123ACTA223FN123CDH123MST120MST1R20STAT3Y70520STAT1P20MAPK1P20MAPK3P20MAPK8P20MAPK9P20MAPK1420PSOCS120SOCS320NR0B210MST18MST1R8PTK28Y397MST1R24STAT324PAKT124PMAPK1P24MAPK324PMAPK14P24EGR124FOS24NR4A124DUSP124DUSP624IL624CXCL224CXCL1024rh-MST112MST1R12PGAB112Y627CTNNB112CTNNB112CYNUCLDN512OCLN12TJP112MST116 MST1RY136016Y1353MAPK1P16MAPK8P16PLCG116PPIK3R116PSHC1P16GRB216PPRKCBS66127 HSPB1S8227RAF127S338NDRG127T346ELK1S38327DUSP427MST1RY1238Y123927PIK3R127RAF127S338AKT1T30827S473RPS627S235S244S236S240MAPK1T18527Y187MAPK3T20227Y204PIK3R127RONoverexpressionPDCD427In primary and metastatic tumorsand ER+ cells and HCC-1143 cellsMAPK1Y187T1859MAPK39Y204T202ECCY17MAPK1T18517Y187MAPK3T202Y20417CRKLY20717PIK3CA29MST1R26NFKB11RELA1CXCL81CXCL51CXCL11VEGFA1NUSIX16CTNNB16CYNUMST1R6SRCY41912MAP2K119MAPK119MAPK119MAP2K219PARP1PC19Leads to through indirect/multiple reactionsIndirect regulation of expressionIndirect inhibitionProtein cleavagePI3KITGB18IL10CSF224CCL22424CSF324MST121In healthy smokeralveolar macrophagesand MDMsCytokine secretion in healthy smoker alveolar macrophages and MDMs IFNB12428Inflammation and innate immunityLigand other than MST1Direct regulation of expressionOvarian cancerPancreatic cancer