Macrophage-stimulating protein (MSP) signaling (Homo sapiens)
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10
Blood brain barrier
Cell adhesion / motility
Osteoblast
differentiation
Cell cycle regulation
Other types of cancers
Superoxide
production
Cytokine secretion from
FVB and C57Bl6 mice
peritoneal macrophages
Breast cancer
DU145 & PC-3 cells
Cancer metastasis
Molecular association
TGF-beta
pathway
In adherent cells
In T47D cells
PI3K
Downregulation
Kidney fibrosis &
Epithelial-mesenchymal transition
Upregulation
Leads to phosphorylation
Regulation of
IFN-gamma signaling
Cell
Migration
Cytoplasm
Osteoblast
differentiation
Phosphosite
Inhibitory effects on
systemic innate immunity
Cell proliferation,
invasion & metastasis
Regulation of
tumor angiogenesis
CY
Transport
Regulation of
non-alcoholic
steatohepatitis
Genetically susceptible
MSP variant (p.R703C)
to Crohn's disease and
ulcerative colitis
Cancer initiation,
progression & EMT
Ant-inflammatory response
in human monocytoid cells
Nucleus
Epithelial-mesenchymal
transition
Regulation of growth and apoptosis in
RON+ Ba/F3 and MEL cells
RON
Overexpression
Cell motility
Regulation of
hepatic
gluconegenesis
Inhibition of anoikis
Regulation of M1/M2
macrophage phenotype
Cell
Proliferation
MDM Cells
sf-RON
overexpression
Preservation of
blood brain barrier integrity
in intracerebral hemorrhage
PI3K-dependent
Cell adhesion
and motility
Epithelial-mesenchymal
transition
Cell proliferation
& anti-apoptosis
Cigarette smoke
toxicity
Cell proliferation,
migration,
invasion & EMT
Cell proliferation &
glucose metabolism
MST1
27
MAPK1
27
T185
Y187
MST1R
Y1238
27
Y1239
MAPK3
27
T202
Y204
SRC
Y419
27
PLCG1
27
Y783
AKT1
27
T308
S473
MTOR
S2448
27
RPS6KB1
27
T412
PDCD4
S457
27
RPS6KA1
T573
27
RPS6
S236
S240
27
S235
S244
COL4A1
27
Protein
mRNA
Receptor
NU
Protein/ Gene
Protein
PC
Protein/ Gene
Ligand
MST1
17, 28, 29
MST1R
17, 28, 29
PCNA
Y211
17
ABL1
17
P
17
AKT1
P
29
MBD4
29
Cancer
Metastasis
MST1R
9
MST1
9
WNT10B
9
DEK
9
FZD1
9
CTNNB1
9
WNT10B
9
CTNNB1
9
CY
NU
CLDN1
28
MST1
18
MST1R
18
sf-MST1R
4
SMAD2
S467
4
S465
SMAD3
S423
4
S425
PDPK1
4
S241
AKT1
T308
S473
4
ZEB1
4
SLUG
4
SIP1
4
CDH2
4
CDH1
4
RPS6KA3
18
CDH1
18
VIM
18
MST1R Δ 165
25
pY
PTEN
25
S380
MTOR
S2448
25
AKT1
S473
25
MAPK1
25
T185
Y187
MAPK3
T202
25
Y204
MST1R
1
Prostate cancer
sf-MST1R
6
sf-RON
overexpression
AKT1
S473
6
GSK3B
S9
6
CTNNB1
6
GLUT1
6
LDHA
6
HK2
6
Gastric cancer
MST1R
5
RON
overexpression
SMAD9
5
S465
S467
SMAD5
S465
5
S463
SMAD1
S463
S465
5
ZEB2
5
VIM
5
CDH1
5
Endometrial cancer
MST1
11
MST1R
11
AKT1
11
T308
S473
MTOR
11
P
RPS6KB1
T412
11
S447
T444
JUN
11
P
MAPK3
11
P
MAPK1
11
P
RPS6KA4
11
P
TP53
S15
11
S392
S46
RPS6KA5
11
P
Mesothelioma
MST1
22
MST1R
22
MAPK1
T185
22
Y187
MAPK3
22
T202
Y204
SMAD1
S465
22
S463
SMAD5
S463
S465
22
SMAD9
22
S467
S465
ALP
22
BGLAP
22
BSP
22
SP7
22
MST1 p.R703C
15
MST1R
15
AKT1
S473
15
MST1
26
MST1R
26
IL10
26
MMP9
26
IL1B
26
MMP9
26
IL1B
26
TNF
26
Differentiated
U937 Cells
MST1
14
MST1R
14
PRKAA2
10, 14
T172
P
10
14
ACACA
P
14
ACO
14
CPT1A
14
PPARGC1A
14
MST1
19
MST1R
19
PTK2
19
AKT1
19
SRC
19
MAPK3
19
CY
NU
MAPK3
19
MST1
21
MST1R
13
MAPK1
T185
Y187
13
MAPK3
13
Y204
T202
CDH1
13
ACTA2
13
RON
overexpression
MST1R
21
NFKB1
21
NFKB1
21
TNF
21
IL1B
21
IL10
21
CY
NU
MST1R
23
RON overexpression
SRC
23
Y419
SMAD2
23
S465
S467
SMAD3
S425
S423
23
MAPK1
P
23
MAPK3
P
23
MAPK8
P
23
MAPK9
23
P
MAPK14
23
P
SMAD4
23
IGF1R
23
FGFR1
23
VEGFR1
23
VEGFR2
23
PDGFRA
23
PDGFRB
23
CDH2
23
VIM
23
TGFB1
23
ACTA2
23
FN1
23
CDH1
23
MST1
20
MST1R
20
STAT3
Y705
20
STAT1
P
20
MAPK1
P
20
MAPK3
P
20
MAPK8
P
20
MAPK9
P
20
MAPK14
20
P
SOCS1
20
SOCS3
20
NR0B2
10
MST1
8
MST1R
8
PTK2
8
Y397
MST1R
24
STAT3
24
P
AKT1
24
P
MAPK1
P
24
MAPK3
24
P
MAPK14
P
24
EGR1
24
FOS
24
NR4A1
24
DUSP1
24
DUSP6
24
IL6
24
CXCL2
24
CXCL10
24
rh-MST1
12
MST1R
12
P
GAB1
12
Y627
CTNNB1
12
CTNNB1
12
CY
NU
CLDN5
12
OCLN
12
TJP1
12
MST1
16
MST1R
Y1360
16
Y1353
MAPK1
P
16
MAPK8
P
16
PLCG1
16
P
PIK3R1
16
P
SHC1
P
16
GRB2
16
P
PRKCB
S661
27
HSPB1
S82
27
RAF1
27
S338
NDRG1
27
T346
ELK1
S383
27
DUSP4
27
MST1R
Y1238
Y1239
27
PIK3R1
27
RAF1
27
S338
AKT1
T308
27
S473
RPS6
27
S235
S244
S236
S240
MAPK1
T185
27
Y187
MAPK3
T202
27
Y204
PIK3R1
27
RON
overexpression
PDCD4
27
In primary and metastatic tumors
and ER+ cells and HCC-1143 cells
MAPK1
Y187
T185
9
MAPK3
9
Y204
T202
EC
CY
17
MAPK1
T185
17
Y187
MAPK3
T202
Y204
17
CRKL
Y207
17
PIK3CA
29
MST1R
26
NFKB1
1
RELA
1
CXCL8
1
CXCL5
1
CXCL1
1
VEGFA
1
NU
SIX1
6
CTNNB1
6
CY
NU
MST1R
6
SRC
Y419
12
MAP2K1
19
MAPK1
19
MAPK1
19
MAP2K2
19
PARP1
PC
19
Leads to through indirect/multiple reactions
Indirect regulation of expression
Indirect inhibition
Protein cleavage
PI3K
ITGB1
8
IL10
CSF2
24
CCL2
24
24
CSF3
24
MST1
21
In healthy smoker
alveolar macrophages
and MDMs
Cytokine secretion
in healthy smoker
alveolar macrophages
and MDMs
IFNB1
24
28
Inflammation and innate immunity
Ligand other than MST1
Direct regulation of expression
Ovarian cancer
Pancreatic cancer