Effect of mutated HTT on cholesterol synthesis in brain (Homo sapiens)

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1NeuronAstrocyteOligodendrocyteHMGCS2PGC1aHMGCRHMGCS1DHCR7MBPmHTTABCG1CYP46A1LXRCholesterolSREBF2HMGCR24S-HCABCG4BDNFAPOECYP51A1ABCA1SREBF2LXRCholesterolmHTTABCA1ABCG1Cholesterol24S-HCCholesterolPGC1a


Description

The influence of the mutated huntingtin (HTT) gene on cholesterol pathways in the brain.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Leoni V, Caccia C; ''Study of cholesterol metabolism in Huntington's disease.''; Biochem Biophys Res Commun, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129616view01:17, 19 May 2024EweitzRefine interaction anchors, pluralization
129615view01:13, 19 May 2024EweitzColor focal mutated gene, HTT
129614view01:11, 19 May 2024EweitzRefine node dimensions
129613view01:08, 19 May 2024EweitzModified description
129612view01:07, 19 May 2024EweitzModified title
129611view01:05, 19 May 2024EweitzOntology Term : 'oligodendrocyte' added !
129610view01:05, 19 May 2024EweitzOntology Term : 'neuron' added !
129609view01:04, 19 May 2024EweitzOntology Term : 'astrocyte' added !
129608view01:04, 19 May 2024EweitzModified title
129557view12:22, 13 May 2024KimberleyBijlModified title
129556view12:21, 13 May 2024KimberleyBijlOntology Term : 'cholesterol metabolic pathway' added !
129555view12:21, 13 May 2024KimberleyBijlOntology Term : 'disease pathway' added !
129554view12:21, 13 May 2024KimberleyBijlOntology Term : 'Huntington's disease pathway' added !
129553view12:20, 13 May 2024KimberleyBijlOntology Term : 'Huntington's disease' added !
129552view12:12, 13 May 2024KimberleyBijlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
24S-HC Metabolite34310 (ChEBI)
ABCA1GeneProductENSG00000165029 (Ensembl)
ABCG1GeneProductENSG00000160179 (Ensembl)
ABCG4GeneProductENSG00000172350 (Ensembl)
APOEGeneProductENSG00000130203 (Ensembl)
BDNFGeneProductENSG00000176697 (Ensembl)
CYP46A1GeneProductENSG00000036530 (Ensembl)
CYP51A1GeneProductENSG00000001630 (Ensembl)
CholesterolMetabolite16113 (ChEBI)
DHCR7GeneProductENSG00000172893 (Ensembl)
HMGCRGeneProductENSG00000113161 (Ensembl)
HMGCS1GeneProductENSG00000112972 (Ensembl)
HMGCS2GeneProductENSG00000134240 (Ensembl)
LXR ProteinP55055 (Uniprot-TrEMBL)
MBPGeneProductENSG00000197971 (Ensembl)
PGC1aProteinENSG00000109819 (Ensembl)
SREBF2GeneProductENSG00000198911 (Ensembl)
mHTTGeneProductENSG00000197386 (Ensembl)

Annotated Interactions

No annotated interactions

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