Oxidative stress in pulmonary tissue (Homo sapiens)

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1Industrial smokeKE5: Collagen production and reduced ECMAO1: Idophatic pulmonary fibrosisCarbon monoxideParticulate matterPesticidesSenescenceNRF2 pathwayAO4: AsthmaCigarette smokeChemokine signalling pathwayKE3: Cell death and cycle arrestOzoneNitrogen oxidesKE4: Mitrochondrial dysfucntionRelease of pro-inflammatory cytokinesKE1: Increased oxidative stressEmission from biomassfuel and combusitonProfibrotic pathwaySulphur oxidesROS damage pathwayKE6: ER stressPollen grainsMIE1: ROS production upregulationAO2: COPDKE2: Inflammation and pro-fibrotic stateApoptosisEndogenous ROS productionAO3: Acute respiratory distresssyndrome


Description

Test version AOP lungs oxidative stress

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Bibliography

  1. Sajal Chakraborti, Narasimham L. Parinandi, Rita Ghosh, Nirmal K. Gangul, Tapati Chakraborti; ''Oxidative Stress Mechanisms in the Pathogenesis of Environmental Lung Diseases''; Pubmed, 2019 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
129620view08:33, 21 May 2024BurritacoKey event changed
129575view09:34, 14 May 2024BurritacoNRF-2 pathway update
129574view09:27, 14 May 2024BurritacoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AO1: Idophatic pulmonary fibrosis1458 (Other)
AO2: COPD
AO3: Acute respiratory distress syndrome
AO4: Asthma
ApoptosisPathwayWP254 (WikiPathways)
Carbon monoxide
Chemokine signalling pathwayPathwayWP3929 (WikiPathways)
Cigarette smoke
Emission from biomass fuel and combusiton
Endogenous ROS productionPathwayCHEBI:26523 (ChEBI)
Industrial smoke
KE1: Increased oxidative stress1392 (Other)
KE2: Inflammation and pro-fibrotic state 1497 (Other)
KE3: Cell death and cycle arrest
KE4: Mitrochondrial dysfucntion177 (Other)
KE5: Collagen production and reduced ECM
KE6: ER stress
MIE1: ROS production upregulation
NRF2 pathwayPathwayWP20884 (WikiPathways)
Nitrogen oxides
Ozone
Particulate matter
Pesticides
Pollen grains
Profibrotic pathwayPathwayWP3624 (WikiPathways)
ROS damage pathwayPathwayWP408 (WikiPathways)
Release of pro-inflammatory cytokinesPathwayWP530 (WikiPathways)
SenescencePathwayWP2902 (WikiPathways)
Sulphur oxides

Annotated Interactions

No annotated interactions

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