IL17 signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none INFLAMMATORYFACTORSERK1/2MAPK1MAPK1NFkBRELANFKB1JAK2JAK1TRAF6IL17RDIKBKGPI3KGSK3BSP1IL17REIL17AAKT1IL17FTRAF3IP2IKBKBIL17DSTAT3NFKBIBIL17CIL25IL17RCMAP3K7CEBPBIL17RAIL17RBMAP3K14IL17BCEBPDTRAF3TRAF3IP2MAP3K7TRAF6TRAF3IP2MAPKHOST DEFENSE GENESmRNA STABILITYTH2 CYTOKINESNFkBNFKB1RELAMAPK3Name: IL17 signalingOrganism: Homo sapiens


Description

Interleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL-23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as proinflammatory cytokines that responds to the invasion of the immune system by extracellular pathogens. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1.


Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2112)

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : flavonoid biosynthetic pathway
 

Bibliography

  1. Gu C, Wu L, Li X; ''IL-17 family: cytokines, receptors and signaling.''; Cytokine, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137374
Approved
view22:47, 1 March 2025EweitzRefine node positions, node shapes
137373view22:42, 1 March 2025EweitzTailor node width
137372view22:39, 1 March 2025EweitzEconomize layout
137371view22:37, 1 March 2025EweitzModified description
137370view22:36, 1 March 2025EweitzOntology Term : 'interleukin-17 family mediated signaling pathway' added !
137369view22:35, 1 March 2025EweitzModified description
137368view22:35, 1 March 2025EweitzModified description
137367view22:35, 1 March 2025EweitzIncrease font size
129719view01:33, 22 May 2024EweitzModified title
117960view10:52, 23 May 2021EweitzModified title
106599view19:38, 10 September 2019KhanspersModified description
105622view04:59, 10 August 2019KhanspersModified description
103728view20:34, 31 March 2019AndraAdded bibliographic reference
103639view23:27, 22 March 2019AlexanderPicoFixed Entrez ID for PI3K
103638view23:23, 22 March 2019AlexanderPicoadded ID for PI3K
94745view15:14, 5 October 2017Ryanmillerconnected lines
89838view12:11, 6 October 2016MkutmonModified description
63216view20:59, 8 May 2013MaintBotUpdating gpml version
47070view23:57, 14 March 2012KhanspersModified categories
46943view13:20, 7 March 2012Sham.ukOntology Term : 'cytokine mediated signaling pathway' added !
46937view16:00, 6 March 2012Sham.ukupdate
46936view15:50, 6 March 2012Sham.ukPeriodical save, work in progress
46935view15:45, 6 March 2012Sham.ukSpecify description
46934view15:40, 6 March 2012Sham.ukPeriodical save, work in progress
46933view15:29, 6 March 2012Sham.ukPeriodical save, work in progress
46930view13:18, 6 March 2012Sham.ukModified description
46929view13:10, 6 March 2012Sham.ukNEW PATHWAY
46928view13:05, 6 March 2012Sham.ukPeriodical save, work in progress
46927view12:55, 6 March 2012Sham.ukPeriodical save, work in progress
46926view12:44, 6 March 2012Sham.ukPeriodical save, work in progress
46925view12:34, 6 March 2012Sham.ukPeriodical save, work in progress
46924view12:24, 6 March 2012Sham.ukPeriodical save, work in progress
46923view12:14, 6 March 2012Sham.ukPeriodical save, work in progress
46922view12:04, 6 March 2012Sham.ukPeriodical save, work in progress
46919view04:07, 6 March 2012Sham.ukSpecify description
46918view04:05, 6 March 2012Sham.ukPeriodical save, work in progress
46917view03:55, 6 March 2012Sham.ukNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProduct207 (Entrez Gene)
CEBPBGeneProduct1051 (Entrez Gene)
CEBPDGeneProduct1052 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
IKBKGGeneProduct8517 (Entrez Gene)
IL17AGeneProduct3605 (Entrez Gene)
IL17BGeneProduct27190 (Entrez Gene)
IL17CGeneProduct27189 (Entrez Gene)
IL17DGeneProduct53342 (Entrez Gene)
IL17FGeneProduct112744 (Entrez Gene)
IL17RAGeneProduct23765 (Entrez Gene)
IL17RBGeneProduct55540 (Entrez Gene)
IL17RCGeneProduct84818 (Entrez Gene)
IL17RDGeneProduct54756 (Entrez Gene)
IL17REGeneProduct132014 (Entrez Gene)
IL25GeneProduct64806 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
MAP3K14GeneProduct9020 (Entrez Gene) NIK or p38
MAP3K7GeneProduct6885 (Entrez Gene)
MAPKProtein
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NFKBIBGeneProduct4793 (Entrez Gene)
PI3KProtein5290 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TRAF3GeneProduct7187 (Entrez Gene)
TRAF3IP2GeneProduct10758 (Entrez Gene)
TRAF6GeneProduct7189 (Entrez Gene)

Annotated Interactions

No annotated interactions

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