IL17 signaling (Homo sapiens)
From WikiPathways
Description
Interleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL-23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as proinflammatory cytokines that responds to the invasion of the immune system by extracellular pathogens. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1.
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Ontology Terms
Bibliography
- Gu C, Wu L, Li X; ''IL-17 family: cytokines, receptors and signaling.''; Cytokine, 2013 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AKT1 | GeneProduct | 207 (Entrez Gene) | |
CEBPB | GeneProduct | 1051 (Entrez Gene) | |
CEBPD | GeneProduct | 1052 (Entrez Gene) | |
GSK3B | GeneProduct | 2932 (Entrez Gene) | |
IKBKB | GeneProduct | 3551 (Entrez Gene) | |
IKBKG | GeneProduct | 8517 (Entrez Gene) | |
IL17A | GeneProduct | 3605 (Entrez Gene) | |
IL17B | GeneProduct | 27190 (Entrez Gene) | |
IL17C | GeneProduct | 27189 (Entrez Gene) | |
IL17D | GeneProduct | 53342 (Entrez Gene) | |
IL17F | GeneProduct | 112744 (Entrez Gene) | |
IL17RA | GeneProduct | 23765 (Entrez Gene) | |
IL17RB | GeneProduct | 55540 (Entrez Gene) | |
IL17RC | GeneProduct | 84818 (Entrez Gene) | |
IL17RD | GeneProduct | 54756 (Entrez Gene) | |
IL17RE | GeneProduct | 132014 (Entrez Gene) | |
IL25 | GeneProduct | 64806 (Entrez Gene) | |
JAK1 | GeneProduct | 3716 (Entrez Gene) | |
JAK2 | GeneProduct | 3717 (Entrez Gene) | |
MAP3K14 | GeneProduct | 9020 (Entrez Gene) | NIK or p38 |
MAP3K7 | GeneProduct | 6885 (Entrez Gene) | |
MAPK | Protein | ||
MAPK1 | GeneProduct | 5594 (Entrez Gene) | |
MAPK3 | GeneProduct | 5595 (Entrez Gene) | |
NFKB1 | GeneProduct | 4790 (Entrez Gene) | |
NFKBIB | GeneProduct | 4793 (Entrez Gene) | |
PI3K | Protein | 5290 (Entrez Gene) | |
RELA | GeneProduct | 5970 (Entrez Gene) | |
SP1 | GeneProduct | 6667 (Entrez Gene) | |
STAT3 | GeneProduct | 6774 (Entrez Gene) | |
TRAF3 | GeneProduct | 7187 (Entrez Gene) | |
TRAF3IP2 | GeneProduct | 10758 (Entrez Gene) | |
TRAF6 | GeneProduct | 7189 (Entrez Gene) |
Annotated Interactions
No annotated interactions