Endothelin pathways (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Sensory motor nerveVasocontrictionRAMP1Y1CGRPsGCSERCAGTPPKAEDHFL-ArginineACK+ channelK+COX2a adrenergic receptorcGMPK+NOCa2+ channelATPcAMPCitrullineCa2+ channelNPYArachidonic acidCRLRPGI2IP1eNOSEndothelin 1ECEIP3CapPKCGaQGbQGgQMLCBig ET1MEKEDNRAMLCKDAGERK1/2EDNRBFurin-like proteaseRAFPLCbIP3RPre-pro ET1CADCa2+CaMPIP2Pre-pro ET1Endothelin 1Ca2+PMCACa2+EDNRBGaQGbQGgQPLCbPIP2IP3DAGCa2+Ca2+Ca2+ channelIP3RNOPGI2PKCCa2+K+GaSGbSGgSGaQGbQGgQb adrenergic receptorGaSGbSGgSSympathic nerveEndothelial cellSmooth muscle cellK+CGRPCGRPGaSGbSGgSK+K+NPYNPYGaIGbIGgINONOCa2+Cellular growth and survivalName: Endothelin pathwaysLast Modified: 10/17/2013Organism: Homo sapiens


Description

Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2197)

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Quality Tags

Image:MissingXref.pngAnnotate nodes
Image:NeedsRef.pngAdd references
Image:Curated.pngApproved version
Image:Unconnected.pngFix interactions

Ontology Terms

Disease : heart disease
 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
137718
Approved
view11:54, 7 March 2025EgonwModified description
134211view19:22, 16 July 2024EgonwRemoved template comments
117710view12:27, 22 May 2021EweitzModified title
108353view09:28, 11 December 2019L DupuisConverted interaction lines in vasoconstriction to graphical lines
106403view21:33, 28 August 2019KhanspersModified description
106134view12:03, 16 August 2019MaintBotHMDB identifier normalization
105584view04:42, 10 August 2019KhanspersModified description
94181view13:41, 25 August 2017Mkutmonadded missing metabolite identifiers
74852view08:47, 1 May 2014SabinedaemenSpecify description
71380view18:39, 17 October 2013MaintBotAutomated update of data sources
69912view19:37, 11 July 2013AlexanderPicoModified title
67194view10:19, 26 June 2013Christine ChichesterOntology Term : 'endothelin signaling pathway' added !
64830view21:33, 3 June 2013MaintBotModified title
63181view20:43, 8 May 2013MaintBotUpdating gpml version
59179view18:44, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
57671view20:17, 31 January 2013KhanspersModified categories
56443view21:38, 7 January 2013EgonwAdded missing HMDB data source values.
48538view07:48, 3 June 2012MireilleSthijnsPeriodical save, work in progress
48535view10:31, 2 June 2012MireilleSthijnsPeriodical save, work in progress
48447view15:13, 24 May 2012Sabinedaemen
48446view15:10, 24 May 2012Sabinedaemen
48435view10:42, 24 May 2012Sabinedaemen
48434view10:39, 24 May 2012Sabinedaemen
48433view10:30, 24 May 2012SabinedaemenModified description
48432view10:20, 24 May 2012Sabinedaemen
48431view10:15, 24 May 2012Sabinedaemen
48430view10:13, 24 May 2012Sabinedaemen
48429view10:09, 24 May 2012SabinedaemenPeriodical save, work in progress
48428view10:01, 24 May 2012SabinedaemenSpecify description
48427view09:52, 24 May 2012SabinedaemenOntology Term : 'Ras superfamily mediated signaling pathway' added !
48426view09:51, 24 May 2012SabinedaemenOntology Term : 'calcium/calmodulin dependent signaling pathway' added !
48425view09:50, 24 May 2012SabinedaemenOntology Term : 'hypertension' added !
48424view09:49, 24 May 2012SabinedaemenOntology Term : 'smooth muscle cell' added !
48423view09:49, 24 May 2012SabinedaemenOntology Term : 'blood vessel endothelial cell' added !
48422view09:47, 24 May 2012SabinedaemenOntology Term : 'benign essential hypertension' added !
48421view09:44, 24 May 2012SabinedaemenOntology Term : 'G protein mediated signaling pathway via Galphas family' added !
48420view09:43, 24 May 2012SabinedaemenOntology Term : 'G protein mediated signaling pathway via Galphaq family' added !
48419view09:42, 24 May 2012SabinedaemenOntology Term : 'G protein mediated signaling pathway via Galphai family' added !
48418view09:40, 24 May 2012SabinedaemenSpecify description
48417view09:37, 24 May 2012MireilleSthijnsSpecify description
48416view09:34, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48415view09:29, 24 May 2012MireilleSthijnsSpecify description
48414view09:23, 24 May 2012MireilleSthijnsSpecify description
48413view09:14, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48412view09:04, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48411view08:59, 24 May 2012MireilleSthijnsSpecify description
48410view08:54, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48409view08:43, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48408view08:33, 24 May 2012MireilleSthijnsSpecify description
48407view08:31, 24 May 2012MireilleSthijnsSpecify description

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ACGeneProductENSG00000143199 (Ensembl) adenylate cyclase
ATPMetaboliteHMDB0001532 (HMDB)
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
Big ET1Protein
CADGeneProductENSG00000084774 (Ensembl) Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contraction
CGRPGeneProductENSG00000110680 (Ensembl)
COX2GeneProduct4513 (Entrez Gene)
CRLRGeneProductENSG00000064989 (Ensembl)
Ca2+ channelGeneProduct
Ca2+MetaboliteHMDB0000464 (HMDB)
CaMGeneProductENSG00000198668 (Ensembl)
CapGeneProductENSG00000130176 (Ensembl) Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle
CitrullineMetaboliteHMDB0000904 (HMDB)
DAGMetaboliteHMDB0007008 (HMDB)
ECEGeneProductENSG00000117298 (Ensembl)
EDHFProtein
EDNRAGeneProductENSG00000151617 (Ensembl)
EDNRBGeneProductENSG00000136160 (Ensembl)
ERK1/2GeneProductENSG00000100030 (Ensembl)
Endothelin 1GeneProductENSG00000078401 (Ensembl)
Furin-like proteaseProtein
GTPMetaboliteHMDB0001440 (HMDB)
GaIGeneProductENSG00000127955 (Ensembl)
GaQGeneProductENSG00000060558 (Ensembl)
GaSGeneProductENSG00000087460 (Ensembl)
GbIGeneProductENSG00000069966 (Ensembl)
GbQGeneProductENSG00000069966 (Ensembl)
GbSGeneProductENSG00000069966 (Ensembl)
GgIGeneProductENSG00000127588 (Ensembl)
GgQGeneProductENSG00000127588 (Ensembl)
GgSGeneProductENSG00000127588 (Ensembl)
IP1GeneProductENSG00000160013 (Ensembl) Prostaglandin I2 Receptor
IP3MetaboliteHMDB0001059 (HMDB)
IP3RProtein
K+ channelProtein
K+MetaboliteHMDB0000586 (HMDB)
L-ArginineMetaboliteHMDB0000517 (HMDB)
MEKGeneProductENSG00000169032 (Ensembl)
MLCGeneProductENSG00000168530 (Ensembl) myosine light chain
MLCKGeneProductENSG00000065534 (Ensembl)
NOMetaboliteHMDB0003378 (HMDB)
NPYGeneProductENSG00000122585 (Ensembl)
PGI2MetaboliteQ412050 (Wikidata)
PIP2MetaboliteHMDB0010032 (HMDB)
PKAGeneProductENSG00000178796 (Ensembl)
PKCGeneProductENSG00000154229 (Ensembl)
PLCbGeneProductENSG00000182621 (Ensembl)
PMCAProtein
Pre-pro ET1Protein
RAFGeneProductENSG00000132155 (Ensembl)
RAMP1GeneProductENSG00000132329 (Ensembl)
SERCAGeneProductENSG00000174437 (Ensembl)
Y1GeneProductENSG00000164128 (Ensembl)
a adrenergic receptorGeneProductENSG00000120907 (Ensembl)
b adrenergic receptorGeneProductENSG00000043591 (Ensembl)
cAMPMetaboliteHMDB0000058 (HMDB)
cGMPMetaboliteHMDB0001314 (HMDB)
eNOSGeneProductENSG00000164867 (Ensembl)
sGCGeneProductENSG00000123201 (Ensembl)

Annotated Interactions

No annotated interactions

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