Endothelin pathways (Homo sapiens)
From WikiPathways
Description
Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2197)
Quality Tags
Ontology Terms
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History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| AC | GeneProduct | ENSG00000143199 (Ensembl)  | adenylate cyclase |
| ATP | Metabolite | HMDB0001532 (HMDB) | |
| Arachidonic acid | Metabolite | HMDB0001043 (HMDB) | |
| Big ET1 | Protein | ||
| CAD | GeneProduct | ENSG00000084774 (Ensembl) | Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca²⁺ dependent inhibition of smooth muscle contraction |
| CGRP | GeneProduct | ENSG00000110680 (Ensembl) | |
| COX2 | GeneProduct | 4513 (Entrez Gene) | |
| CRLR | GeneProduct | ENSG00000064989 (Ensembl) | |
| CaM | GeneProduct | ENSG00000198668 (Ensembl) | |
| Cap | GeneProduct | ENSG00000130176 (Ensembl) | Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle |
| Ca²⁺ channel | GeneProduct | ||
| Ca²⁺ | Metabolite | HMDB0000464 (HMDB) | |
| Citrulline | Metabolite | HMDB0000904 (HMDB) | |
| DAG | Metabolite | HMDB0007008 (HMDB) | |
| ECE | GeneProduct | ENSG00000117298 (Ensembl) | |
| EDHF | Protein | ||
| EDNRA | GeneProduct | ENSG00000151617 (Ensembl) | |
| EDNRB | GeneProduct | ENSG00000136160 (Ensembl) | |
| ERK1/2 | GeneProduct | ENSG00000100030 (Ensembl) | |
| Endothelin 1 | GeneProduct | ENSG00000078401 (Ensembl) | |
| Furin-like protease | Protein | ||
| GTP | Metabolite | HMDB0001440 (HMDB) | |
| GaI | GeneProduct | ENSG00000127955 (Ensembl) | |
| GaQ | GeneProduct | ENSG00000060558 (Ensembl) | |
| GaS | GeneProduct | ENSG00000087460 (Ensembl) | |
| GbI | GeneProduct | ENSG00000069966 (Ensembl) | |
| GbQ | GeneProduct | ENSG00000069966 (Ensembl) | |
| GbS | GeneProduct | ENSG00000069966 (Ensembl) | |
| GgI | GeneProduct | ENSG00000127588 (Ensembl) | |
| GgQ | GeneProduct | ENSG00000127588 (Ensembl) | |
| GgS | GeneProduct | ENSG00000127588 (Ensembl) | |
| IP1 | GeneProduct | ENSG00000160013 (Ensembl) | Prostaglandin I2 Receptor |
| IP3 | Metabolite | HMDB0001059 (HMDB) | |
| IP3R | Protein | ||
| K⁺ channel | Protein | ||
| K⁺ | Metabolite | HMDB0000586 (HMDB) | |
| L-Arginine | Metabolite | HMDB0000517 (HMDB) | |
| MEK | GeneProduct | ENSG00000169032 (Ensembl) | |
| MLC | GeneProduct | ENSG00000168530 (Ensembl) | myosine light chain |
| MLCK | GeneProduct | ENSG00000065534 (Ensembl) | |
| NO | Metabolite | HMDB0003378 (HMDB) | |
| NPY | GeneProduct | ENSG00000122585 (Ensembl) | |
| PGI2 | Metabolite | Q412050 (Wikidata) | |
| PIP2 | Metabolite | HMDB0010032 (HMDB) | |
| PKA | GeneProduct | ENSG00000178796 (Ensembl) | |
| PKC | GeneProduct | ENSG00000154229 (Ensembl) | |
| PLCb | GeneProduct | ENSG00000182621 (Ensembl) | |
| PMCA | Protein | ||
| Pre-pro ET1 | Protein | ||
| RAF | GeneProduct | ENSG00000132155 (Ensembl) | |
| RAMP1 | GeneProduct | ENSG00000132329 (Ensembl) | |
| SERCA | GeneProduct | ENSG00000174437 (Ensembl) | |
| Y1 | GeneProduct | ENSG00000164128 (Ensembl) | |
| a adrenergic receptor | GeneProduct | ENSG00000120907 (Ensembl) | |
| b adrenergic receptor | GeneProduct | ENSG00000043591 (Ensembl) | |
| cAMP | Metabolite | HMDB0000058 (HMDB) | |
| cGMP | Metabolite | HMDB0001314 (HMDB) | |
| eNOS | GeneProduct | ENSG00000164867 (Ensembl) | |
| sGC | GeneProduct | ENSG00000123201 (Ensembl) |
Annotated Interactions
No annotated interactions
