NOTCH1 regulation of endothelial cell calcification (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Extracellular MatrixValve endotheliumFlow / Shear stressInterstitial CellNOTCH1PAR1SOX6FGFR3ITGA1GJA5ALPLSAT1CALUMGPVEGFSecreted proteinsPLATPTHrPCalcificationDLL1DLL3DLL4JAG1JAG2Name: NOTCH1 regulation of endothelial cell calcificationOrganism: Homo sapiens


Description

Model of NOTCH1 regulation of human endothelial cell calcification.


Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3413).

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Quality Tags

Image:Curated.pngApproved version
Image:Featured.pngReview changes for Featured

Ontology Terms

Pathway Ontology : regulatory pathway
 

Bibliography

  1. White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D; ''NOTCH1 regulates matrix gla protein and calcificationgene networks in human valve endothelium.''; J Mol Cell Cardiol, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137969
Approved
view21:05, 10 March 2025KhanspersModified description
116601
Featured
view09:29, 9 May 2021EweitzModified title
106657view21:17, 12 September 2019KhanspersModified description
105658view05:15, 10 August 2019KhanspersModified description
87953view13:07, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
87385view11:05, 22 July 2016MaintBotadded missing graphids
82217view20:45, 15 September 2015Khanspersupdates
81814view06:06, 1 September 2015KhanspersModified description
81813view06:04, 1 September 2015KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ALPLGeneProductENSG00000162551 (Ensembl)
CALUGeneProductENSG00000128595 (Ensembl)
DLL1GeneProductENSG00000198719 (Ensembl)
DLL3GeneProductENSG00000090932 (Ensembl)
DLL4GeneProductENSG00000128917 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
GJA5GeneProduct2702 (Entrez Gene)
ITGA1GeneProductENSG00000213949 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
JAG2GeneProductENSG00000184916 (Ensembl)
MGPProteinENSG00000111341 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
PAR1GeneProductENSG00000198121 (Ensembl)
PLATProteinENSG00000104368 (Ensembl)
PTHrPProteinENSG00000104368 (Ensembl)
SAT1GeneProductENSG00000130066 (Ensembl)
SOX6GeneProductENSG00000110693 (Ensembl)
VEGFGeneProductENSG00000112715 (Ensembl)

Annotated Interactions

No annotated interactions

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