Network map of SARS-CoV-2 signaling (Homo sapiens)
From WikiPathways
Description
This pathway shows protein-protein interactions and downstream molecular events regulated by SARS-CoV-2 including molecular association, catalysis, and gene regulation. Each event is color-coded as described in the pathway legend. Information on site and residue of post-translational modification are also included.
Quality Tags
Ontology Terms
Bibliography
View all... |
- Ren Y, Shu T, Wu D, Mu J, Wang C, Huang M, Han Y, Zhang XY, Zhou W, Qiu Y, Zhou X; ''The ORF3a protein of SARS-CoV-2 induces apoptosis in cells.''; Cell Mol Immunol, 2020 PubMed Europe PMC Scholia
- Miao G, Zhao H, Li Y, Ji M, Chen Y, Shi Y, Bi Y, Wang P, Zhang H; ''ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.''; Dev Cell, 2021 PubMed Europe PMC Scholia
- Appelberg S, Gupta S, Svensson Akusjärvi S, Ambikan AT, Mikaeloff F, Saccon E, Végvári �, Benfeitas R, Sperk M, Ståhlberg M, Krishnan S, Singh K, Penninger JM, Mirazimi A, Neogi U; ''Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells.''; Emerg Microbes Infect, 2020 PubMed Europe PMC Scholia
- Shang J, Wan Y, Luo C, Ye G, Geng Q, Auerbach A, Li F; ''Cell entry mechanisms of SARS-CoV-2.''; Proc Natl Acad Sci U S A, 2020 PubMed Europe PMC Scholia
- Ouyang Y, Yin J, Wang W, Shi H, Shi Y, Xu B, Qiao L, Feng Y, Pang L, Wei F, Guo X, Jin R, Chen D; ''Downregulated Gene Expression Spectrum and Immune Responses Changed During the Disease Progression in Patients With COVID-19.''; Clin Infect Dis, 2020 PubMed Europe PMC Scholia
- Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, GarcÃÂÂa-Sastre A, Shokat KM, Shoichet BK, Krogan NJ; ''A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.''; Nature, 2020 PubMed Europe PMC Scholia
- Schmoldt A, Benthe HF, Haberland G, Jallon JM, Risler Y, Iwatsubo M; ''Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.''; Biochem Biophys Res Commun, 1975 DOI Scholia
- Shen B, Yi X, Sun Y, Bi X, Du J, Zhang C, Quan S, Zhang F, Sun R, Qian L, Ge W, Liu W, Liang S, Chen H, Zhang Y, Li J, Xu J, He Z, Chen B, Wang J, Yan H, Zheng Y, Wang D, Zhu J, Kong Z, Kang Z, Liang X, Ding X, Ruan G, Xiang N, Cai X, Gao H, Li L, Li S, Xiao Q, Lu T, Zhu Y, Liu H, Guo T; ''Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.''; Cell, 2020 PubMed Europe PMC Scholia
- Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY; ''Evasion of Type I Interferon by SARS-CoV-2.''; Cell Rep, 2020 PubMed Europe PMC Scholia
- Lei X, Dong X, Ma R, Wang W, Xiao X, Tian Z, Wang C, Wang Y, Li L, Ren L, Guo F, Zhao Z, Zhou Z, Xiang Z, Wang J; ''Activation and evasion of type I interferon responses by SARS-CoV-2.''; Nat Commun, 2020 PubMed Europe PMC Scholia
- Li J, Guo M, Tian X, Wang X, Yang X, Wu P, Liu C, Xiao Z, Qu Y, Yin Y, Wang C, Zhang Y, Zhu Z, Liu Z, Peng C, Zhu T, Liang Q; ''Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.''; Med (N Y), 2021 PubMed Europe PMC Scholia
- Xiong Y, Liu Y, Cao L, Wang D, Guo M, Jiang A, Guo D, Hu W, Yang J, Tang Z, Wu H, Lin Y, Zhang M, Zhang Q, Shi M, Zhou Y, Lan K, Chen Y; ''Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.''; Emerg Microbes Infect, 2020 PubMed Europe PMC Scholia
- Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, Haas DA, Huang Y, Oubraham L, Wang A, Hamad MS, Piras A, Hansen FM, Tanzer MC, Paron I, Zinzula L, Engleitner T, Reinecke M, Lavacca TM, Ehmann R, Wölfel R, Jores J, Kuster B, Protzer U, Rad R, Ziebuhr J, Thiel V, Scaturro P, Mann M, Pichlmair A; ''Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.''; Nature, 2021 PubMed Europe PMC Scholia
- Blanco-Melo D, Nilsson-Payant BE, Liu WC, Uhl S, Hoagland D, Møller R, Jordan TX, Oishi K, Panis M, Sachs D, Wang TT, Schwartz RE, Lim JK, Albrecht RA, tenOever BR; ''Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.''; Cell, 2020 PubMed Europe PMC Scholia
- Schmoldt A, Benthe HF, Haberland G, Jallon JM, Risler Y, Iwatsubo M; ''Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.''; Biochem Biophys Res Commun, 1975 PubMed Europe PMC Scholia
- Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J, Wang Z, Li J, Feng C, Zhang Z, Wang L, Peng L, Chen L, Qin Y, Zhao D, Tan S, Yin L, Xu J, Zhou C, Jiang C, Liu L; ''Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.''; Sci China Life Sci, 2020 PubMed Europe PMC Scholia
- Li J, Guo M, Tian X, Wang X, Yang X, Wu P, Liu C, Xiao Z, Qu Y, Yin Y, Wang C, Zhang Y, Zhu Z, Liu Z, Peng C, Zhu T, Liang Q; ''Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.''; Med (N Y), 2021 PubMed Europe PMC Scholia
- Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M; ''Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection.''; Cell Syst, 2020 PubMed Europe PMC Scholia
- Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA; ''Platelet gene expression and function in patients with COVID-19.''; Blood, 2020 PubMed Europe PMC Scholia
- Schmoldt A, Benthe HF, Haberland G, Adzerikho RD, Aksentsev SL, Okun' IM, Konev SV, Durbin RP, Hendrickson WA, Ward KB, Marniemi J, Parkki MG, Lande IJ, Feldbush TL, Lubaroff DM, Bonney WW; ''Rat prostate carcinoma 11095-A: profile of organ- and tumor-specific antigens.''; Natl Cancer Inst Monogr, 1978 DOI Scholia
- Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q; ''Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.''; Science, 2020 PubMed Europe PMC Scholia
- Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, Castañeda G, DeRisi JL, Detweiler AM, Hao S, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Christenson SA, Kistler A, Langelier C; ''Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2.''; medRxiv, 2020 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
A1BG | GeneProduct | ENSG00000121410 (Ensembl) ![]() | |
ACE2 | GeneProduct | ENSG00000130234 (Ensembl) ![]() | |
ACTB | GeneProduct | ENSG00000075624 (Ensembl) ![]() | |
ACTG1 | GeneProduct | ENSG00000184009 (Ensembl) ![]() | |
ADAM9 | GeneProduct | ||
AGT | GeneProduct | AGT (HGNC) ![]() | |
AHR | GeneProduct | AHR (HGNC) ![]() | |
AKT1 | Protein | P31749 (Uniprot-TrEMBL) ![]() | |
ALB | GeneProduct | ALB (HGNC) ![]() | |
APOA1 | GeneProduct | APOA1 (HGNC) ![]() | |
APOA2 | GeneProduct | APOA2 (HGNC) ![]() | |
APOC1 | GeneProduct | APOC1 (HGNC) ![]() | |
APOD | GeneProduct | APOD (HGNC) ![]() | |
APOH | GeneProduct | APOH (HGNC) ![]() | |
APOL1 | GeneProduct | APOL1 (HGNC) ![]() | |
APOM | GeneProduct | APOM (HGNC) ![]() | |
ATE1 | GeneProduct | ||
ATG13 | Protein | 9776 (Entrez Gene) ![]() | |
ATP13A3 | GeneProduct | ||
ATP6AP1 | GeneProduct | ||
BID | Protein | 637 (Entrez Gene) ![]() | |
BIRC5 | GeneProduct | BIRC5 (HGNC) ![]() | |
BST2 | GeneProduct | BST2 (HGNC) ![]() | |
BTN3A1 | GeneProduct | BTN3A1 (HGNC) ![]() | |
C1QBP | GeneProduct | C1QBP (HGNC) ![]() | |
C1R | GeneProduct | ENSG00000159403 (Ensembl) ![]() | |
C1S | GeneProduct | ENSG00000182326 (Ensembl) ![]() | |
C8A | GeneProduct | ENSG00000157131 (Ensembl) ![]() | |
CALC1 | GeneProduct | CALC1 (HGNC) ![]() | |
CAMK4 | GeneProduct | CAMK4 (HGNC) ![]() | |
CARD11 | GeneProduct | CARD11 (HGNC) ![]() | |
CASP3 | GeneProduct | ENSG00000164305 (Ensembl) ![]() | |
CASP5 | GeneProduct | CASP5 (HGNC) ![]() | |
CASP8 | GeneProduct | CASP8 (HGNC) ![]() | |
CASP9 | GeneProduct | CASP9 (HGNC) ![]() | |
CCL11 | GeneProduct | CCL11 (HGNC) ![]() | |
CCL15 | GeneProduct | CCL15 (HGNC) ![]() | |
CCL1 | GeneProduct | CCL1 (HGNC) ![]() | |
CCL20 | GeneProduct | CCL20 (HGNC) ![]() | |
CCL21 | GeneProduct | CCL21 (HGNC) ![]() | |
CCL22 | GeneProduct | CCL22 (HGNC) ![]() | |
CCL26 | GeneProduct | CCL26 (HGNC) ![]() | |
CCL27 | GeneProduct | CCL27 (HGNC) ![]() | |
CCL2 | GeneProduct | CCL2 (HGNC) ![]() | |
CCL2 | GeneProduct | ENSG00000108691 (Ensembl) ![]() | |
CCL3 | GeneProduct | CCL3 (HGNC) ![]() | |
CCL4 | GeneProduct | CCL4 (HGNC) ![]() | |
CCL5 | GeneProduct | CCL5 (HGNC) ![]() | |
CCL8 | GeneProduct | CCL8 (HGNC) ![]() | |
CCNB1 | GeneProduct | CCNB1 (HGNC) ![]() | |
CCNB2 | GeneProduct | CCNB2 (HGNC) ![]() | |
CCR5 | GeneProduct | CCR5 (HGNC) ![]() | |
CCR6 | GeneProduct | CCR6 (HGNC) ![]() | |
CD14 | GeneProduct | ENSG00000170458 (Ensembl) ![]() | |
CD163 | GeneProduct | CD163 (HGNC) ![]() | |
CD226 | GeneProduct | CD226 (HGNC) ![]() | |
CD247 | GeneProduct | 919 (Entrez Gene) ![]() | |
CD2 | GeneProduct | 914 (Entrez Gene) ![]() | |
CD3E | GeneProduct | 916 (Entrez Gene) ![]() | |
CD3G | GeneProduct | 917 (Entrez Gene) ![]() | |
CD4 | GeneProduct | 920 (Entrez Gene) ![]() | |
CD8A | GeneProduct | 925 (Entrez Gene) ![]() | |
CD8A | GeneProduct | 926 (Entrez Gene) ![]() | |
CDK1 | GeneProduct | CDK1 (HGNC) ![]() | |
CEBPB | GeneProduct | CEBPB (HGNC) ![]() | |
CFB | GeneProduct | ENSG00000243649 (Ensembl) ![]() | |
CFH | GeneProduct | ENSG00000000971 (Ensembl) ![]() | |
CFI | GeneProduct | ENSG00000205403 (Ensembl) ![]() | |
CFP | GeneProduct | CFP (HGNC) ![]() | |
CLCC1 | GeneProduct | ||
COL7A1 | GeneProduct | COL7A1 (HGNC) ![]() | |
COQ8B | GeneProduct | ||
CPN1 | GeneProduct | CPN1 (HGNC) ![]() | |
CRP | GeneProduct | 1401 (Entrez Gene) ![]() | |
CRP | GeneProduct | CRP (HGNC) ![]() | |
CRP | GeneProduct | ENSG00000132693 (Ensembl) ![]() | |
CTSB | GeneProduct | CTSB (HGNC) ![]() | |
CTSD | GeneProduct | CTSD (HGNC) ![]() | |
CTSL | GeneProduct | CTSL (HGNC) ![]() | |
CTSZ | GeneProduct | CTSZ (HGNC) ![]() | |
CXCL10 | GeneProduct | CXCL10 (HGNC) ![]() | |
CXCL12 | GeneProduct | CXCL12 (HGNC) ![]() | |
CXCL13 | GeneProduct | CXCL13 (HGNC) ![]() | |
CXCL16 | GeneProduct | CXCL16 (HGNC) ![]() | |
CXCL1 | GeneProduct | CXCL1 (HGNC) ![]() | |
CXCL2 | GeneProduct | CXCL2 (HGNC) ![]() | |
CXCL3 | GeneProduct | CXCL3 (HGNC) ![]() | |
CXCL5 | GeneProduct | CXCL5 (HGNC) ![]() | |
CXCL6 | GeneProduct | CXCL6 (HGNC) ![]() | |
CXCL8 | GeneProduct | CXCL8 (HGNC) ![]() | |
CXCL8 | GeneProduct | CXCL8 (HGNC) ![]() | |
CXCL9 | GeneProduct | CXCL9 (HGNC) ![]() | |
CXCR1 | GeneProduct | CXCR1 (HGNC) ![]() | |
CXCR2 | GeneProduct | CXCR2 (HGNC) ![]() | |
CXCR7 | GeneProduct | CXCR7 (HGNC) ![]() | |
Cytochrome C | Metabolite | 18070 (ChEBI) ![]() | |
DDIT4 | GeneProduct | DDIT4 (HGNC) ![]() | |
DDX58 | GeneProduct | DDX58 (HGNC) ![]() | |
DEPTOR | Protein | 64798 (Entrez Gene) ![]() | |
DUSP1 | GeneProduct | DUSP1 (HGNC) ![]() | |
EGR1 | GeneProduct | EGR1 (HGNC) ![]() | |
EIF4A2 | GeneProduct | EIF4A2 (HGNC) ![]() | |
EIF4EBP1 | GeneProduct | 1978 (Entrez Gene) ![]() | |
EIF4E | Protein | EIF4E (HGNC) ![]() | |
ERLEC1 | GeneProduct | ||
FAM83A | GeneProduct | FAM83A (HGNC) ![]() | |
FAM98A | GeneProduct | ||
FGA | GeneProduct | ENSG00000171560 (Ensembl) ![]() | |
FGB | GeneProduct | ENSG00000171564 (Ensembl) ![]() | |
FGB | GeneProduct | FGB (HGNC) ![]() | |
FGF2 | GeneProduct | FGF2 (HGNC) ![]() | |
FGG | GeneProduct | ENSG00000171557 (Ensembl) ![]() | |
FGG | GeneProduct | FGG (HGNC) ![]() | |
FN1 | GeneProduct | FN1 (HGNC) ![]() | |
FOS | GeneProduct | FOS (HGNC) ![]() | |
FYN | GeneProduct | 2534 (Entrez Gene) ![]() | |
FYN | GeneProduct | FYN (HGNC) ![]() | |
G3BP1 | GeneProduct | ||
G3BP2 | GeneProduct | ||
GABARAPL2 | Protein | 11345 (Entrez Gene) ![]() | |
GCSF | GeneProduct | GCSF (HGNC) ![]() | |
GGH | GeneProduct | ||
GMCSF | GeneProduct | GMCSF (HGNC) ![]() | |
GP1BA | GeneProduct | GP1BA (HGNC) ![]() | |
GSN | GeneProduct | GSN (HGNC) ![]() | |
GTF2F2 | GeneProduct | ||
GTSE1 | GeneProduct | GTSE1 (HGNC) ![]() | |
HBB | GeneProduct | HBB (HGNC) ![]() | |
HBD | GeneProduct | HBD (HGNC) ![]() | |
GeneProduct | |||
HIF1A | GeneProduct | 3091 (Entrez Gene) ![]() | |
HLA-DRA | GeneProduct | 3122 (Entrez Gene) ![]() | |
HLA-DRB1 | GeneProduct | 3123 (Entrez Gene) ![]() | |
HLA-DRB4 | GeneProduct | 3126 (Entrez Gene) ![]() | |
HLA-DRB5 | GeneProduct | 3127 (Entrez Gene) ![]() | |
HP | GeneProduct | ENSG00000257017 (Ensembl) ![]() | |
HRG | GeneProduct | HRG (HGNC) ![]() | |
HSPA8 | GeneProduct | HSPA8 (HGNC) ![]() | |
IFI27 | GeneProduct | IFI27 (HGNC) ![]() | |
IFI44L | GeneProduct | IFI44L (HGNC) ![]() | |
IFI6 | GeneProduct | IFI6 (HGNC) ![]() | |
IFIH1 | GeneProduct | IFIH1 (HGNC) ![]() | |
IFIT1 | GeneProduct | IFIT1 (HGNC) ![]() | |
IFITM1 | GeneProduct | IFITM1 (HGNC) ![]() | |
IFITM3 | GeneProduct | ENSG00000142089 (Ensembl) ![]() | |
IFITM3 | GeneProduct | IFITM3 (HGNC) ![]() | |
IFN1 | Protein | IFN1 (Uniprot-TrEMBL) ![]() | |
IFNA | GeneProduct | IFNA (HGNC) ![]() | |
IFNB1 | Protein | P01574 (Uniprot-TrEMBL) ![]() | |
IFNG | GeneProduct | IFNG (HGNC) ![]() | |
IGFBP3 | GeneProduct | IGFBP3 (HGNC) ![]() | |
IGHE | GeneProduct | 3497 (Entrez Gene) ![]() | |
IGHG1 | GeneProduct | 3500 (Entrez Gene) ![]() | |
IGHG2 | GeneProduct | 3501 (Entrez Gene) ![]() | |
IGHG4 | GeneProduct | 3503 (Entrez Gene) ![]() | |
IGLC2 | GeneProduct | 3538 (Entrez Gene) ![]() | |
IGLL1 | GeneProduct | 3543 (Entrez Gene) ![]() | |
IKBKG | Protein | 8517 (Entrez Gene) ![]() | |
IL10 | GeneProduct | IL10 (HGNC) ![]() | |
IL12A | GeneProduct | IL12A (HGNC) ![]() | |
IL13 | GeneProduct | IL13 (HGNC) ![]() | |
IL16 | GeneProduct | IL16 (HGNC) ![]() | |
IL17A | GeneProduct | IL17A (HGNC) ![]() | |
IL18 | GeneProduct | IL18 (HGNC) ![]() | |
IL18RAP | GeneProduct | IL18RAP (HGNC) ![]() | |
IL1A | GeneProduct | IL1A (HGNC) ![]() | |
IL1B | GeneProduct | ENSG00000125538 (Ensembl) ![]() | |
IL1B | GeneProduct | IL1B (HGNC) ![]() | |
IL1R2 | GeneProduct | IL1R2 (HGNC) ![]() | |
IL1RA | GeneProduct | IL1RA (HGNC) ![]() | |
IL21 | GeneProduct | IL21 (HGNC) ![]() | |
IL22 | GeneProduct | IL22 (HGNC) ![]() | |
IL23 | GeneProduct | IL23 (HGNC) ![]() | |
IL2B | GeneProduct | IL2B (HGNC) ![]() | |
IL2R | GeneProduct | IL2R (HGNC) ![]() | |
IL33 | GeneProduct | IL33 (HGNC) ![]() | |
IL4 | GeneProduct | IL4 (HGNC) ![]() | |
IL5 | GeneProduct | IL5 (HGNC) ![]() | |
IL6 | GeneProduct | 3569 (Entrez Gene) ![]() | |
IL6 | GeneProduct | ENSG00000136244 (Ensembl) ![]() | |
IL6 | GeneProduct | IL6 (HGNC) ![]() | |
IL7 | GeneProduct | IL7 (HGNC) ![]() | |
IL8 | GeneProduct | 3576 (Entrez Gene) ![]() | |
IL8 | GeneProduct | IL8 (HGNC) ![]() | |
IL9 | GeneProduct | IL9 (HGNC) ![]() | |
INTS4 | GeneProduct | ||
IRAK1 | GeneProduct | 3654 (Entrez Gene) ![]() | |
IRF27 | GeneProduct | IRF27 (HGNC) ![]() | |
IRF3 | GeneProduct | IRF3 (HGNC) ![]() | |
IRF9 | GeneProduct | IRF9 (HGNC) ![]() | |
ISG56 | GeneProduct | ISG56 (HGNC) ![]() | |
ISRE | GeneProduct | ISRE (HGNC) ![]() | |
ITCH | GeneProduct | ITCH (HGNC) ![]() | |
ITGA3 | GeneProduct | ITGA3 (HGNC) ![]() | |
ITIH3 | GeneProduct | ENSG00000162267 (Ensembl) ![]() | |
ITIH4 | GeneProduct | ENSG00000055955 (Ensembl) ![]() | |
JAK1 | GeneProduct | JAK1 (HGNC) ![]() | |
JAK2 | GeneProduct | JAK2 (HGNC) ![]() | |
JUNB | GeneProduct | JUNB (HGNC) ![]() | |
JUN | GeneProduct | JUN (HGNC) ![]() | |
LARP1 | GeneProduct | ||
LARP1 | GeneProduct | 23367 (Entrez Gene) ![]() | |
LBP | GeneProduct | 3929 (Entrez Gene) ![]() | |
LBP | GeneProduct | ENSG00000129988 (Ensembl) ![]() | |
LCK | GeneProduct | 3932 (Entrez Gene) ![]() | |
LCK | GeneProduct | LCK (HGNC) ![]() | |
LDH | GeneProduct | LDH (HGNC) ![]() | |
LGALS3BP | GeneProduct | ENSG00000108679 (Ensembl) ![]() | |
LRG1 | GeneProduct | ENSG00000171236 (Ensembl) ![]() | |
MAP1LC3B | GeneProduct | 81631 (Entrez Gene) ![]() | |
MAPK14 | Protein | NP_001306.1 (NCBI Protein) ![]() | |
MAPK1 | Protein | NP_002736.3 (NCBI Protein) ![]() | |
MAPK3 | Protein | NP_002737.2 (NCBI Protein) ![]() | |
MAPK8 | GeneProduct | MAPK8 (HGNC) ![]() | |
MAPK8 | Protein | NP_001310259.1 (NCBI Protein) ![]() | |
MARK2 | GeneProduct | MARK2 | |
MAVS | GeneProduct | ENSG00000088888 (Ensembl) ![]() | |
MCP1 | GeneProduct | MCP1 (HGNC) ![]() | |
MDN1 | GeneProduct | ||
MIB1 | GeneProduct | ||
MIP1A | GeneProduct | MIP1A (HGNC) ![]() | |
MIP1B | GeneProduct | MIP1B (HGNC) ![]() | |
MLST8 | Protein | 64223 (Entrez Gene) ![]() | |
MMP25 | GeneProduct | 64386 (Entrez Gene) ![]() | |
MOV10 | GeneProduct | ||
MTOR | Protein | 2475 (Entrez Gene) ![]() | |
MX1 | GeneProduct | MX1 (HGNC) ![]() | |
MYD88 | GeneProduct | MYD88 (HGNC) ![]() | |
M | Protein | YP_009724393.1 (NCBI Protein) ![]() | |
NBR1 | Protein | NBR1 (NCBI Protein) ![]() | |
NEK9 | GeneProduct | ||
NFATC3 | GeneProduct | NFATC3 (HGNC) ![]() | |
NFKB2 | Protein | 4791 (Entrez Gene) ![]() | |
NKRF | GeneProduct | 55922 (Entrez Gene) ![]() | |
NLRP1 | GeneProduct | 22861 (Entrez Gene) ![]() | |
NLRP3 | GeneProduct | NLRP3 (HGNC) ![]() | |
NPTX1 | GeneProduct | ||
NTRK1 | GeneProduct | NTRK1 (HGNC) ![]() | |
N | Protein | YP_009724397.2 (NCBI Protein) ![]() | |
OAS2 | GeneProduct | OAS2 (HGNC) ![]() | |
OS9 | GeneProduct | OS9 | |
PARP2 | GeneProduct | PARP2 (HGNC) ![]() | |
PDGF | GeneProduct | PDGF (HGNC) ![]() | |
PF4 | GeneProduct | PF4 (HGNC) ![]() | |
PI3K | Protein | P31749 (Uniprot-TrEMBL) ![]() | |
PIAS1 | GeneProduct | PIAS1 (HGNC) ![]() | |
PITRM1 | GeneProduct | ||
PLA2G4A | Protein | NP_077734.1 (NCBI Protein) ![]() | |
PMPCB | GeneProduct | ||
PRAS40 | GeneProduct | ENSG00000204673 (Ensembl) ![]() | |
PRG3 | GeneProduct | 10394 (Entrez Gene) ![]() | |
PRKCQ | GeneProduct | PRKCQ (HGNC) ![]() | |
PTGS2 | GeneProduct | PTGS2 (HGNC) ![]() | |
PTPN6 | GeneProduct | PTPN6 (HGNC) ![]() | |
RAC1 | GeneProduct | RAC1 (HGNC) ![]() | |
RAP1GDS1 | GeneProduct | ||
RHEB | Protein | 6009 (Entrez Gene) ![]() | |
RPS6KB1 | Protein | NP_003152.1 (NCBI Protein) ![]() | |
RPS6 | GeneProduct | RPS6 (HGNC) ![]() | |
RPTOR | Protein | 57521 (Entrez Gene) ![]() | |
RRAS | GeneProduct | RRAS (HGNC) ![]() | |
RRM2 | GeneProduct | RRM2 (HGNC) ![]() | |
RTN4 | GeneProduct | ||
SAA1 | GeneProduct | ENSG00000173432 (Ensembl) ![]() | |
SAA2 | GeneProduct | ENSG00000134339 (Ensembl) ![]() | |
SARS-CoV-2 | Pathway | WP4846 (WikiPathways) ![]() | |
SDF2 | GeneProduct | ||
SELP | GeneProduct | ENSG00000174175 (Ensembl) ![]() | |
SERPINA10 | GeneProduct | ENSG00000140093 (Ensembl) ![]() | |
SERPINA5 | GeneProduct | SERPINA5 (HGNC) ![]() | |
SERPINE1 | GeneProduct | SERPINE1 (HGNC) ![]() | |
SIGMAR1 | GeneProduct | ||
SKAP1 | GeneProduct | SKAP1 (HGNC) ![]() | |
SMAD1 | GeneProduct | 4086 (Entrez Gene) ![]() | |
SMAD5 | GeneProduct | 4090 (Entrez Gene) ![]() | |
SQSTM1 | Protein | NP_003891.1 (NCBI Protein) ![]() | |
SRP19 | GeneProduct | ||
SRP54 | GeneProduct | ||
SRP72 | GeneProduct | ||
STAT1 | GeneProduct | STAT1 (HGNC) ![]() | |
STEAP3 | GeneProduct | STEAP3 (HGNC) ![]() | |
S | Protein | YP_009724390.1 (NCBI Protein) ![]() | |
TANK | GeneProduct | TANK (EMBL) ![]() | |
TAX1BP1 | Protein | TAX1BP1 (NCBI Protein) ![]() | |
TBK1 | GeneProduct | 29110 (Entrez Gene) ![]() | |
TBKBP1 | GeneProduct | TBKBP1 | |
TF | GeneProduct | TF (HGNC) ![]() | |
TGFBR2 | Protein | TGFBR2 (HGNC) ![]() | |
TLE1 | GeneProduct | ||
TLE3 | GeneProduct | ||
TLE5 | GeneProduct | ||
TLRs | GeneProduct | ||
TMPRSS2 | Protein | 7226 (Entrez Gene) ![]() | |
TNFSF10 | GeneProduct | TNFSF10 (HGNC) ![]() | |
TNF | GeneProduct | TNF (HGNC) ![]() | |
TOMM70 | GeneProduct | ||
TP53I3 | GeneProduct | TP53I3 (HGNC) ![]() | |
TPO | GeneProduct | TPO (HGNC) ![]() | |
TRAC | GeneProduct | 28755 (Entrez Gene) ![]() | |
TRAF2 | GeneProduct | TRAF2 (HGNC) ![]() | |
TRAF3 | GeneProduct | ENSG00000131323 (Ensembl) ![]() | |
TRAF6 | GeneProduct | 7189 (Entrez Gene) ![]() | |
TRBC1 | GeneProduct | 28639 (Entrez Gene) ![]() | |
TRIM59 | GeneProduct | ||
TRO | GeneProduct | TRO (HGNC) ![]() | |
TSC2 | Protein | P31749 (Uniprot-TrEMBL) ![]() | |
UGGT2 | GeneProduct | ||
ULK1 | GeneProduct | 8408 (Entrez Gene) ![]() | |
UPF1 | GeneProduct | ||
VEGFA | GeneProduct | ||
VPS11 | Protein | 55823 (Entrez Gene) ![]() | |
VPS16 | Protein | 64601 (Entrez Gene) ![]() | |
VPS18 | GeneProduct | VPS18 (HGNC) ![]() | |
VPS33A | Protein | 65082 (Entrez Gene) ![]() | |
VPS36 | Protein | 51028 (Entrez Gene) ![]() | |
VPS41 | Protein | 27072 (Entrez Gene) ![]() | |
WDR74 | GeneProduct | WDR74 (HGNC) ![]() | |
ZAP70 | GeneProduct | 7535 (Entrez Gene) ![]() | |
nsp10 | Protein | YP_009725306 (NCBI Protein) ![]() | |
nsp13 | Protein | YP_009725308 (NCBI Protein) ![]() | |
nsp2 | Protein | YP_009725298 (NCBI Protein) ![]() | |
nsp6 | Protein | YP_009725302 (NCBI Protein) ![]() | |
nsp8 | Protein | YP_009725304 (NCBI Protein) ![]() | |
nsp9 | Protein | YP_009725305 (NCBI Protein) ![]() | |
orf3a | Protein | YP_009724391.1 (NCBI Protein) ![]() | |
orf6 | Protein | YP_009724394.1 (NCBI Protein) ![]() | |
orf7a | Protein | YP_009724395.1 (NCBI Protein) ![]() | |
orf7b | Protein | YP_009725318.1 (NCBI Protein) ![]() | |
orf8 | Protein | YP_009724396.1 (NCBI Protein) ![]() | |
orf9b | Protein | P0DTD2 (NCBI Protein) ![]() |
Annotated Interactions
No annotated interactions