Network map of SARS-CoV-2 signaling pathway (Homo sapiens)

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152082082222211261019 Viral entry into cellsCytochrome CSARS-CoV-2SACE2K702K6255, 14, 16TMPRSS217SARS-CoV-2OS9MARK2TBKBP1CLCC1FAM98ASIGMAR1ERLEC1TLE1SDF2GTF2F2UGGT2NEK9G3BP2NPTX1ATP6AP1 TLE3ATP13A3MOV10UPF1TLE5ADAM9G3BP1MIB1SRP72SRP54SRP19ATE1GGHLARP1MDN1TOMM70TRIM59nsp614, 19orf7borf3a8, 14, 198, 19nsp1014, 19M14, 19Snsp214, 19orf67, 14, 19nsp914, 19N8, 14, 19orf9b8, 14, 1914, 19nsp13nsp814, 19orf7a14, 1914, 19orf814, 19RTN4PITRM1COQ8BPMPCBINTS4CASP3BID11CASP83CASP911BIDApoptosisSTAT1S7272, 18JAK2MYD88IRAK1TRAF6144TLRs14NFKB2S222TGFBR2SMAD514S465SMAD1S463FGBSERPINE1FGGITGA3COL7A1FN1MAPK814T183Y185FOSEGR1PTGS2JUNDUSP1ITCHMAVS414TANKS222S12914TRAF2K165K27CXCL2TNFIL6TRAF3IRF3ISG56ISREInterferon signalingMX1IFIT1IRF9IFN1IFNB118MAPK1T185Y18714MAPK3T202Y204PLA2G4A10ThromboxaneproductionMAPK14Y182T18014IFI27BST2IFI6IFITM1FOSJUNDUSP1IRF27JUNBIFITM3IFI27Interferon-MAPK pathwaymediated adaptive immune responseIFIH1IFNB118ACE2CXCL8 CCL11IL6CXCL9CCR5CXCR1CXCR2TNFIL1RACCL20IL6CXCL6CD226CCR6CXCL16CXCL1IL1ACXCL2CD163CXCL16CXCR7CXCL3CXCL2IL1BCCL8CXCL5CXCL8CCL2Uncontrolled infiltration and activation of neutrophilsIL8NKRF8IL6SQSTM1T269K281 S36114S355K157S272K435MAP1LC3BTAX1BP114NBR11414Autophagy receptorsGABARAPL2K82K2414K97K46K74HOPS complexVPS16VPS11VPS41VPS18VPS36VPS33AAutophagosome and lysosome fusionRPS6KB1S238K143K149S240MLST8DEPTORRPTORRHEB14LARP114ATG13ULK114S638S479AKT1S473TSC2S1347EIF4ES209PI3K15HIF1APRAS40EIF4EBP115AutophagyMTORS2448Autophagosome/Late endosomeNeutrophilactivationMHC class II moleculesImmunoglobulin subunitsT cell receptor(TCR) subunitsTCR signaling kinases T cell surface moleculesTNFCCL8STEAP3PIAS1IL17AFGASELPIFITM3GTSE1MIP1AIL6IL6HSPA8CFPFGBJAK1GMCSFIFI27LCKCCL27IL1AC8ACCL26CAMK4SAA1RPS6IL2RCCL5IGFBP3CCL1TP53I3CRPEIF4A2ITIH4GCSFWDR74CCL4BIRC5AHRTNFSF10IL18CXCL12MIP1BIL22MCP1HRGGSNTROCCL4ACTBCCL21PF4IFNGAPOHIL1BCTSDHBBIL2BPDGFCXCL9HPIL1RAOAS2IL8LRG1C1SAPOMCXCL10FGF2APOA2ACTG1SKAP1C1QBPCTSDCPN1APOA1IL33APOL1DDIT4BTN3A1CARD11IL1R2NFATC3IL5CEBPBPARP2 CCL3CTSZCXCL10CCNB2JUNBFAM83ACXCL13IL10APOC1LCKC1RCASP5CCL2CALC1FGGA1BGFYNIL7CTSBRAC1CFHIL13ITIH3HBDTNFCD14SERPINA10PTPN6LGALS3BPMAPK8IL1BCXCL10CFICDK1CCL22LDHCRPLBPIL16VEGFACCL15PRKCQRRASTNFSAA2IL10IFNAIL9IL18RAPCCL2IL23TFIL21CFBCCL3IL4RRM2CCL2APODCTSBIGLC2APOA1IL1AIGHEHLA-DRASERPINA5CD4CD8AIL10HLA-DRB1ALBIGLL1PRG3CD8ACRPTPOMMP25NLRP3JUNBIFI6IFI44LCCNB16LBPHLA-DRB4IGHG4GP1BANTRK1IGHG26CTSL6CD2CTSL6NLRP1HLA-DRB5IL1BIGHG1CD247CD3GLCKCD3EZAP70TRBC1FYNTRACLung injuryIn PlasmaSevere/critical patientsInflammasome activation and activity InterferonresponseIn Bronchoalveolar lavage fluid (BALF)AutophagyIn Peripheral blood mononuclear cells (PBMC)ApoptosisP53 pathwaySerumIn Peripheral blood mononuclear cells (PBMC)Common protein-protein interactions identified commonly bytwo or three studies (Stukalov et al, Gordon DE et al and Li et al)Mediated Negative regulation of gene/protein expression Positive regulation of gene/protein expression Phospho (S/T) siteLegend Autophagy receptors Ubiqutination (K) siteSARS-CoV-2 InhibitionThrough ACE2 activationnsp6orf3aMorf7bnsp10orf6nsp2SElevated expression ofcytokines and chemokinesCell invasion, migration, proliferation and innate immunityCommon protein-protein interactions identified commonly bytwo or three studies (Stukalov et al, Gordon DE et al and Li et al)TBK1DDX58IKBKGK285 truncatedSARS-CoV-2 protein and host protein intereactionRAP1GDS1MediatedMediatedMediatedMediatedMediatedMediatedIFNB1 MediatedProteinmRNAIn patientsin ICU TNFAGTIFNAIL17ACXCL5LDHCRPMCP1CXCL10CXCL1IL1BIL10LDHIL1AIL12ACRPIL6ALB


Description

This pathway shows protein-protein interactions and downstream molecular events regulated by SARS-CoV-2 including molecular association, catalysis, and gene regulation. Each event is color-coded as described in the pathway legend. Information on site and residue of post-translational modification are also included.

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Bibliography

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  3. Schmoldt A, Benthe HF, Haberland G, Jallon JM, Risler Y, Iwatsubo M; ''Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.''; Biochem Biophys Res Commun, 1975 PubMed Europe PMC Scholia
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  7. Li J, Guo M, Tian X, Wang X, Yang X, Wu P, Liu C, Xiao Z, Qu Y, Yin Y, Wang C, Zhang Y, Zhu Z, Liu Z, Peng C, Zhu T, Liang Q; ''Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.''; Med (N Y), 2021 PubMed Europe PMC Scholia
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  9. Blanco-Melo D, Nilsson-Payant BE, Liu WC, Uhl S, Hoagland D, Møller R, Jordan TX, Oishi K, Panis M, Sachs D, Wang TT, Schwartz RE, Lim JK, Albrecht RA, tenOever BR; ''Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.''; Cell, 2020 PubMed Europe PMC Scholia
  10. Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA; ''Platelet gene expression and function in patients with COVID-19.''; Blood, 2020 PubMed Europe PMC Scholia
  11. Ren Y, Shu T, Wu D, Mu J, Wang C, Huang M, Han Y, Zhang XY, Zhou W, Qiu Y, Zhou X; ''The ORF3a protein of SARS-CoV-2 induces apoptosis in cells.''; Cell Mol Immunol, 2020 PubMed Europe PMC Scholia
  12. Miao G, Zhao H, Li Y, Ji M, Chen Y, Shi Y, Bi Y, Wang P, Zhang H; ''ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.''; Dev Cell, 2021 PubMed Europe PMC Scholia
  13. Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J, Wang Z, Li J, Feng C, Zhang Z, Wang L, Peng L, Chen L, Qin Y, Zhao D, Tan S, Yin L, Xu J, Zhou C, Jiang C, Liu L; ''Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.''; Sci China Life Sci, 2020 PubMed Europe PMC Scholia
  14. Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, Haas DA, Huang Y, Oubraham L, Wang A, Hamad MS, Piras A, Hansen FM, Tanzer MC, Paron I, Zinzula L, Engleitner T, Reinecke M, Lavacca TM, Ehmann R, Wölfel R, Jores J, Kuster B, Protzer U, Rad R, Ziebuhr J, Thiel V, Scaturro P, Mann M, Pichlmair A; ''Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.''; Nature, 2021 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
126845view06:56, 27 June 2023Honoremove duplicate "CXCL9"
125317view21:47, 31 January 2023LarsgwFix reference bp:DB
124648view13:07, 18 November 2022JfigueirahasbunUpdated viral protein labels and identifiers
124550view12:12, 8 November 2022EweitzModified description
123443view08:56, 27 July 2022MvdGardeChanged IP10 to CXCL10 in the 'In patients in ICU' column
120811view14:54, 11 January 2022SusanOntology Term : 'respiratory system disease pathway' added !
120597view21:29, 17 December 2021EweitzModified description
120279view13:52, 23 November 2021EgonwRemoved a period from a pubmed identifier
120269view12:05, 23 November 2021EgonwReplaced a DOI with the respective PMID
119638view06:30, 27 July 2021EgonwRemoved NCBI gene annotations where the ID were not numbers
119635view06:20, 27 July 2021Egonwinteraction between NFKB2 and TRAF2
119516view09:23, 8 July 2021EweitzModified title
119501view12:19, 5 July 2021FehrhartOntology Term : 'disease pathway' added !
119500view12:18, 5 July 2021FehrhartOntology Term : 'severe acute respiratory syndrome' added !
119496view15:10, 4 July 2021Keshav
118993view13:29, 7 June 2021KeshavModified description
118984view05:12, 7 June 2021KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A1BGGeneProductENSG00000121410 (Ensembl)
ACE2GeneProductENSG00000130234 (Ensembl)
ACTBGeneProductENSG00000075624 (Ensembl)
ACTG1GeneProductENSG00000184009 (Ensembl)
ADAM9GeneProductADAM9
AGTGeneProductAGT (HGNC)
AHRGeneProductAHR (HGNC)
AKT1ProteinP31749 (Uniprot-TrEMBL)
ALBGeneProductALB (HGNC)
APOA1GeneProductAPOA1 (HGNC)
APOA2GeneProductAPOA2 (HGNC)
APOC1GeneProductAPOC1 (HGNC)
APODGeneProductAPOD (HGNC)
APOHGeneProductAPOH (HGNC)
APOL1GeneProductAPOL1 (HGNC)
APOMGeneProductAPOM (HGNC)
ATE1GeneProductATE1
ATG13Protein9776 (Entrez Gene)
ATP13A3GeneProductATP13A3
ATP6AP1 GeneProductATP6AP1
BIDProtein637 (Entrez Gene)
BIRC5GeneProductBIRC5 (HGNC)
BST2GeneProductBST2 (HGNC)
BTN3A1GeneProductBTN3A1 (HGNC)
C1QBPGeneProductC1QBP (HGNC)
C1RGeneProductENSG00000159403 (Ensembl)
C1SGeneProductENSG00000182326 (Ensembl)
C8AGeneProductENSG00000157131 (Ensembl)
CALC1GeneProductCALC1 (HGNC)
CAMK4GeneProductCAMK4 (HGNC)
CARD11GeneProductCARD11 (HGNC)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP5GeneProductCASP5 (HGNC)
CASP8GeneProductCASP8 (HGNC)
CASP9GeneProductCASP9 (HGNC)
CCL11GeneProductCCL11 (HGNC)
CCL15GeneProductCCL15 (HGNC)
CCL1GeneProductCCL1 (HGNC)
CCL20GeneProductCCL20 (HGNC)
CCL21GeneProductCCL21 (HGNC)
CCL22GeneProductCCL22 (HGNC)
CCL26GeneProductCCL26 (HGNC)
CCL27GeneProductCCL27 (HGNC)
CCL2GeneProductCCL2 (HGNC)
CCL2GeneProductENSG00000108691 (Ensembl)
CCL3GeneProductCCL3 (HGNC)
CCL4GeneProductCCL4 (HGNC)
CCL5GeneProductCCL5 (HGNC)
CCL8GeneProductCCL8 (HGNC)
CCNB1GeneProductCCNB1 (HGNC)
CCNB2GeneProductCCNB2 (HGNC)
CCR5GeneProductCCR5 (HGNC)
CCR6GeneProductCCR6 (HGNC)
CD14GeneProductENSG00000170458 (Ensembl)
CD163GeneProductCD163 (HGNC)
CD226GeneProductCD226 (HGNC)
CD247GeneProduct919 (Entrez Gene)
CD2GeneProduct914 (Entrez Gene)
CD3EGeneProduct916 (Entrez Gene)
CD3G GeneProduct917 (Entrez Gene)
CD4GeneProduct920 (Entrez Gene)
CD8AGeneProduct925 (Entrez Gene)
CD8AGeneProduct926 (Entrez Gene)
CDK1GeneProductCDK1 (HGNC)
CEBPBGeneProductCEBPB (HGNC)
CFBGeneProductENSG00000243649 (Ensembl)
CFHGeneProductENSG00000000971 (Ensembl)
CFIGeneProductENSG00000205403 (Ensembl)
CFPGeneProductCFP (HGNC)
CLCC1GeneProduct
COL7A1GeneProductCOL7A1 (HGNC)
COQ8BGeneProductCOQ8B
CPN1GeneProductCPN1 (HGNC)
CRPGeneProduct1401 (Entrez Gene)
CRPGeneProductCRP (HGNC)
CRPGeneProductENSG00000132693 (Ensembl)
CTSBGeneProductCTSB (HGNC)
CTSDGeneProductCTSD (HGNC)
CTSLGeneProductCTSL (HGNC)
CTSZGeneProductCTSZ (HGNC)
CXCL10GeneProductCXCL10 (HGNC)
CXCL12GeneProductCXCL12 (HGNC)
CXCL13GeneProductCXCL13 (HGNC)
CXCL16GeneProductCXCL16 (HGNC)
CXCL1GeneProductCXCL1 (HGNC)
CXCL2GeneProductCXCL2 (HGNC)
CXCL3GeneProductCXCL3 (HGNC)
CXCL5GeneProductCXCL5 (HGNC)
CXCL6GeneProductCXCL6 (HGNC)
CXCL8 GeneProductCXCL8 (HGNC)
CXCL8GeneProductCXCL8 (HGNC)
CXCL9GeneProductCXCL9 (HGNC)
CXCR1GeneProductCXCR1 (HGNC)
CXCR2GeneProductCXCR2 (HGNC)
CXCR7GeneProductCXCR7 (HGNC)
Cytochrome CMetabolite18070 (ChEBI)
DDIT4GeneProductDDIT4 (HGNC)
DDX58GeneProductDDX58 (HGNC)
DEPTORProtein64798 (Entrez Gene)
DUSP1GeneProductDUSP1 (HGNC)
EGR1GeneProductEGR1 (HGNC)
EIF4A2GeneProductEIF4A2 (HGNC)
EIF4EBP1GeneProduct1978 (Entrez Gene)
EIF4EProteinEIF4E (HGNC)
ERLEC1GeneProductERLEC1
FAM83AGeneProductFAM83A (HGNC)
FAM98AGeneProductFAM98A
FGAGeneProductENSG00000171560 (Ensembl)
FGBGeneProductENSG00000171564 (Ensembl)
FGBGeneProductFGB (HGNC)
FGF2GeneProductFGF2 (HGNC)
FGGGeneProductENSG00000171557 (Ensembl)
FGGGeneProductFGG (HGNC)
FN1GeneProductFN1 (HGNC)
FOSGeneProductFOS (HGNC)
FYNGeneProduct2534 (Entrez Gene)
FYNGeneProductFYN (HGNC)
G3BP1GeneProductG3BP1
G3BP2GeneProductG3BP2
GABARAPL2Protein11345 (Entrez Gene)
GCSFGeneProductGCSF (HGNC)
GGHGeneProductGGH
GMCSFGeneProductGMCSF (HGNC)
GP1BAGeneProductGP1BA (HGNC)
GSNGeneProductGSN (HGNC)
GTF2F2GeneProductGTF2F2
GTSE1GeneProductGTSE1 (HGNC)
HBBGeneProductHBB (HGNC)
HBDGeneProductHBD (HGNC)
GeneProduct
HIF1AGeneProduct3091 (Entrez Gene)
HLA-DRAGeneProduct3122 (Entrez Gene)
HLA-DRB1GeneProduct3123 (Entrez Gene)
HLA-DRB4GeneProduct3126 (Entrez Gene)
HLA-DRB5GeneProduct3127 (Entrez Gene)
HPGeneProductENSG00000257017 (Ensembl)
HRGGeneProductHRG (HGNC)
HSPA8GeneProductHSPA8 (HGNC)
IFI27GeneProductIFI27 (HGNC)
IFI44LGeneProductIFI44L (HGNC)
IFI6GeneProductIFI6 (HGNC)
IFIH1GeneProductIFIH1 (HGNC)
IFIT1GeneProductIFIT1 (HGNC)
IFITM1GeneProductIFITM1 (HGNC)
IFITM3GeneProductENSG00000142089 (Ensembl)
IFITM3GeneProductIFITM3 (HGNC)
IFN1ProteinIFN1 (Uniprot-TrEMBL)
IFNAGeneProductIFNA (HGNC)
IFNB1ProteinP01574 (Uniprot-TrEMBL)
IFNGGeneProductIFNG (HGNC)
IGFBP3GeneProductIGFBP3 (HGNC)
IGHEGeneProduct3497 (Entrez Gene)
IGHG1GeneProduct3500 (Entrez Gene)
IGHG2GeneProduct3501 (Entrez Gene)
IGHG4GeneProduct3503 (Entrez Gene)
IGLC2GeneProduct3538 (Entrez Gene)
IGLL1GeneProduct3543 (Entrez Gene)
IKBKGProtein8517 (Entrez Gene)
IL10GeneProductIL10 (HGNC)
IL12AGeneProductIL12A (HGNC)
IL13GeneProductIL13 (HGNC)
IL16GeneProductIL16 (HGNC)
IL17AGeneProductIL17A (HGNC)
IL18GeneProductIL18 (HGNC)
IL18RAPGeneProductIL18RAP (HGNC)
IL1AGeneProductIL1A (HGNC)
IL1BGeneProductENSG00000125538 (Ensembl)
IL1BGeneProductIL1B (HGNC)
IL1R2GeneProductIL1R2 (HGNC)
IL1RAGeneProductIL1RA (HGNC)
IL21GeneProductIL21 (HGNC)
IL22GeneProductIL22 (HGNC)
IL23GeneProductIL23 (HGNC)
IL2BGeneProductIL2B (HGNC)
IL2RGeneProductIL2R (HGNC)
IL33GeneProductIL33 (HGNC)
IL4GeneProductIL4 (HGNC)
IL5GeneProductIL5 (HGNC)
IL6GeneProduct3569 (Entrez Gene)
IL6GeneProductENSG00000136244 (Ensembl)
IL6GeneProductIL6 (HGNC)
IL7GeneProductIL7 (HGNC)
IL8GeneProduct3576 (Entrez Gene)
IL8GeneProductIL8 (HGNC)
IL9GeneProductIL9 (HGNC)
INTS4GeneProductINTS4
IRAK1GeneProduct3654 (Entrez Gene)
IRF27GeneProductIRF27 (HGNC)
IRF3GeneProductIRF3 (HGNC)
IRF9GeneProductIRF9 (HGNC)
ISG56GeneProductISG56 (HGNC)
ISREGeneProductISRE (HGNC)
ITCHGeneProductITCH (HGNC)
ITGA3GeneProductITGA3 (HGNC)
ITIH3GeneProductENSG00000162267 (Ensembl)
ITIH4GeneProductENSG00000055955 (Ensembl)
JAK1GeneProductJAK1 (HGNC)
JAK2GeneProductJAK2 (HGNC)
JUNBGeneProductJUNB (HGNC)
JUNGeneProductJUN (HGNC)
LARP1GeneProduct23367 (Entrez Gene)
LARP1GeneProductLARP1
LBPGeneProduct3929 (Entrez Gene)
LBPGeneProductENSG00000129988 (Ensembl)
LCKGeneProduct3932 (Entrez Gene)
LCKGeneProductLCK (HGNC)
LDHGeneProductLDH (HGNC)
LGALS3BPGeneProductENSG00000108679 (Ensembl)
LRG1GeneProductENSG00000171236 (Ensembl)
MAP1LC3BGeneProduct81631 (Entrez Gene)
MAPK14ProteinNP_001306.1 (NCBI Protein)
MAPK1ProteinNP_002736.3 (NCBI Protein)
MAPK3ProteinNP_002737.2 (NCBI Protein)
MAPK8GeneProductMAPK8 (HGNC)
MAPK8ProteinNP_001310259.1 (NCBI Protein)
MARK2GeneProductMARK2
MAVSGeneProductENSG00000088888 (Ensembl)
MCP1GeneProductMCP1 (HGNC)
MDN1GeneProductMDN1
MIB1GeneProductMIB1
MIP1AGeneProductMIP1A (HGNC)
MIP1BGeneProductMIP1B (HGNC)
MLST8Protein64223 (Entrez Gene)
MMP25 GeneProduct64386 (Entrez Gene)
MOV10GeneProductMOV10
MTORProtein2475 (Entrez Gene)
MX1GeneProductMX1 (HGNC)
MYD88GeneProductMYD88 (HGNC)
MProteinYP_009724393.1 (NCBI Protein)
NBR1ProteinNBR1 (NCBI Protein)
NEK9GeneProductNEK9
NFATC3GeneProductNFATC3 (HGNC)
NFKB2Protein4791 (Entrez Gene)
NKRFGeneProduct55922 (Entrez Gene)
NLRP1GeneProduct22861 (Entrez Gene)
NLRP3GeneProductNLRP3 (HGNC)
NPTX1GeneProductNPTX1
NTRK1GeneProductNTRK1 (HGNC)
NProteinYP_009724397.2 (NCBI Protein)
OAS2GeneProductOAS2 (HGNC)
OS9GeneProductOS9
PARP2 GeneProductPARP2 (HGNC)
PDGFGeneProductPDGF (HGNC)
PF4GeneProductPF4 (HGNC)
PI3KProteinP31749 (Uniprot-TrEMBL)
PIAS1GeneProductPIAS1 (HGNC)
PITRM1GeneProductPITRM1
PLA2G4AProteinNP_077734.1 (NCBI Protein)
PMPCBGeneProductPMPCB
PRAS40GeneProductENSG00000204673 (Ensembl)
PRG3GeneProduct10394 (Entrez Gene)
PRKCQGeneProductPRKCQ (HGNC)
PTGS2GeneProductPTGS2 (HGNC)
PTPN6GeneProductPTPN6 (HGNC)
RAC1GeneProductRAC1 (HGNC)
RAP1GDS1GeneProduct
RHEBProtein6009 (Entrez Gene)
RPS6KB1ProteinNP_003152.1 (NCBI Protein)
RPS6GeneProductRPS6 (HGNC)
RPTORProtein57521 (Entrez Gene)
RRASGeneProductRRAS (HGNC)
RRM2GeneProductRRM2 (HGNC)
RTN4GeneProductRTN4
SAA1GeneProductENSG00000173432 (Ensembl)
SAA2GeneProductENSG00000134339 (Ensembl)
SARS-CoV-2PathwayWP4846 (WikiPathways)
SDF2GeneProductSDF2
SELPGeneProductENSG00000174175 (Ensembl)
SERPINA10GeneProductENSG00000140093 (Ensembl)
SERPINA5GeneProductSERPINA5 (HGNC)
SERPINE1GeneProductSERPINE1 (HGNC)
SIGMAR1GeneProductSIGMAR1
SKAP1GeneProductSKAP1 (HGNC)
SMAD1GeneProduct4086 (Entrez Gene)
SMAD5GeneProduct4090 (Entrez Gene)
SQSTM1ProteinNP_003891.1 (NCBI Protein)
SRP19GeneProductSRP19
SRP54GeneProductSRP54
SRP72GeneProductSRP72
STAT1GeneProductSTAT1 (HGNC)
STEAP3GeneProductSTEAP3 (HGNC)
SProteinYP_009724390.1 (NCBI Protein)
TANKGeneProductTANK (EMBL)
TAX1BP1ProteinTAX1BP1 (NCBI Protein)
TBK1GeneProduct29110 (Entrez Gene)
TBKBP1GeneProductTBKBP1
TFGeneProductTF (HGNC)
TGFBR2ProteinTGFBR2 (HGNC)
TLE1GeneProductTLE1
TLE3GeneProductTLE3
TLE5GeneProductTLE5
TLRsGeneProduct
TMPRSS2Protein7226 (Entrez Gene)
TNFSF10GeneProductTNFSF10 (HGNC)
TNFGeneProductTNF (HGNC)
TOMM70GeneProductTOMM70
TP53I3GeneProductTP53I3 (HGNC)
TPOGeneProductTPO (HGNC)
TRACGeneProduct28755 (Entrez Gene)
TRAF2GeneProductTRAF2 (HGNC)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF6GeneProduct7189 (Entrez Gene)
TRBC1 GeneProduct28639 (Entrez Gene)
TRIM59GeneProduct
TROGeneProductTRO (HGNC)
TSC2ProteinP31749 (Uniprot-TrEMBL)
UGGT2GeneProductUGGT2
ULK1GeneProduct8408 (Entrez Gene)
UPF1GeneProductUPF1
VEGFAGeneProduct
VPS11Protein55823 (Entrez Gene)
VPS16Protein64601 (Entrez Gene)
VPS18GeneProductVPS18 (HGNC)
VPS33AProtein65082 (Entrez Gene)
VPS36Protein51028 (Entrez Gene)
VPS41Protein27072 (Entrez Gene)
WDR74GeneProductWDR74 (HGNC)
ZAP70GeneProduct7535 (Entrez Gene)
nsp10ProteinYP_009725306 (NCBI Protein)
nsp13ProteinYP_009725308 (NCBI Protein)
nsp2ProteinYP_009725298 (NCBI Protein)
nsp6ProteinYP_009725302 (NCBI Protein)
nsp8ProteinYP_009725304 (NCBI Protein)
nsp9ProteinYP_009725305 (NCBI Protein)
orf3aProteinYP_009724391.1 (NCBI Protein)
orf6ProteinYP_009724394.1 (NCBI Protein)
orf7aProteinYP_009724395.1 (NCBI Protein)
orf7bProteinYP_009725318.1 (NCBI Protein)
orf8ProteinYP_009724396.1 (NCBI Protein)
orf9bProteinP0DTD2 (NCBI Protein)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5115"
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