Network map of SARS-CoV-2 signaling (Homo sapiens)

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3181718172222821219514 Viral entry into cellsCytochrome CSARS-CoV-2SACE2K702K6254, 13, 21TMPRSS220SARS-CoV-2OS9MARK2TBKBP1CLCC1FAM98ASIGMAR1ERLEC1TLE1SDF2GTF2F2UGGT2NEK9G3BP2NPTX1ATP6AP1 TLE3ATP13A3MOV10UPF1TLE5ADAM9G3BP1MIB1SRP72SRP54SRP19ATE1GGHLARP1MDN1TOMM70TRIM59nsp66, 13orf7borf3a6, 13, 176, 17nsp106, 13M6, 13Snsp26, 13orf66, 11, 13nsp96, 13N6, 13, 17orf9b6, 13, 176, 13nsp13nsp86, 13orf7a6, 136, 13orf86, 13RTN4PITRM1COQ8BPMPCBINTS4CASP3BID1CASP815CASP91BIDApoptosisSTAT1S7279, 10JAK2MYD88IRAK1TRAF6137TLRs13NFKB2S222TGFBR2SMAD513S465SMAD1S463FGBSERPINE1FGGITGA3COL7A1FN1MAPK813T183Y185FOSEGR1PTGS2JUNDUSP1ITCHMAVS713TANKS222S12913TRAF2K165K27CXCL2TNFIL6TRAF3IRF3ISG56ISREInterferon signalingMX1IFIT1IRF9IFN1IFNB19MAPK1T185Y18713MAPK3T202Y204PLA2G4A19ThromboxaneproductionMAPK14Y182T18013IFI27BST2IFI6IFITM1FOSJUNDUSP1IRF27JUNBIFITM3IFI27Interferon-MAPK pathwaymediated adaptive immune responseIFIH1IFNB19ACE2CXCL8 CCL11IL6CXCL9CCR5CXCR1CXCR2TNFIL1RACCL20IL6CXCL6CD226CCR6CXCL16CXCL1IL1ACXCL2CD163CXCL16CXCR7CXCL3CXCL2IL1BCCL8CXCL5CXCL8CCL2Uncontrolled infiltration and activation of neutrophilsIL8NKRF17IL6SQSTM1T269K281 S36113S355K157S272K435MAP1LC3BTAX1BP113NBR11313Autophagy receptorsGABARAPL2K82K2413K97K46K74HOPS complexVPS16VPS11VPS41VPS18VPS36VPS33AAutophagosome and lysosome fusionRPS6KB1S238K143K149S240MLST8DEPTORRPTORRHEB13LARP113ATG13ULK113S638S479AKT1S473TSC2S1347EIF4ES209PI3K3HIF1APRAS40EIF4EBP13AutophagyMTORS2448Autophagosome/Late endosomeNeutrophilactivationMHC class II moleculesImmunoglobulin subunitsT cell receptor(TCR) subunitsTCR signaling kinases T cell surface moleculesTNFCCL8STEAP3PIAS1IL17AFGASELPIFITM3GTSE1MIP1AIL6IL6HSPA8CFPFGBJAK1GMCSFIFI27LCKCCL27IL1AC8ACCL26CAMK4SAA1RPS6IL2RCCL5IGFBP3CCL1TP53I3CRPEIF4A2ITIH4GCSFWDR74CCL4BIRC5AHRTNFSF10IL18CXCL12MIP1BIL22MCP1HRGGSNTROCCL4ACTBCCL21PF4IFNGAPOHIL1BCTSDHBBIL2BPDGFCXCL9HPIL1RAOAS2IL8LRG1C1SAPOMCXCL10FGF2APOA2ACTG1SKAP1C1QBPCTSDCPN1APOA1IL33APOL1DDIT4BTN3A1CARD11IL1R2NFATC3IL5CEBPBPARP2 CCL3CTSZCXCL10CCNB2JUNBFAM83ACXCL13IL10APOC1LCKC1RCASP5CCL2CALC1FGGA1BGFYNIL7CTSBRAC1CFHIL13ITIH3HBDTNFCD14SERPINA10PTPN6LGALS3BPMAPK8IL1BCXCL10CFICDK1CCL22LDHCRPLBPIL16VEGFACCL15PRKCQRRASTNFSAA2IL10IFNAIL9IL18RAPCCL2IL23TFIL21CFBCCL3IL4RRM2CCL2APODCTSBIGLC2APOA1IL1AIGHEHLA-DRASERPINA5CD4CD8AIL10HLA-DRB1ALBIGLL1PRG3CD8ACRPTPOMMP25NLRP3JUNBIFI6IFI44LCCNB112LBPHLA-DRB4IGHG4GP1BANTRK1IGHG212CTSL12CD2CTSL12NLRP1HLA-DRB5IL1BIGHG1CD247CD3GLCKCD3EZAP70TRBC1FYNTRACLung injuryIn PlasmaSevere/critical patientsInflammasome activation and activity InterferonresponseIn Bronchoalveolar lavage fluid (BALF)AutophagyIn Peripheral blood mononuclear cells (PBMC)ApoptosisP53 pathwaySerumIn Peripheral blood mononuclear cells (PBMC)Common protein-protein interactions identified commonly bytwo or three studies (Stukalov et al, Gordon DE et al and Li et al)Mediated Negative regulation of gene/protein expression Positive regulation of gene/protein expression Phospho (S/T) siteLegend Autophagy receptors Ubiqutination (K) siteSARS-CoV-2 InhibitionThrough ACE2 activationnsp6orf3aMorf7bnsp10orf6nsp2SElevated expression ofcytokines and chemokinesCell invasion, migration, proliferation and innate immunityCommon protein-protein interactions identified commonly bytwo or three studies (Stukalov et al, Gordon DE et al and Li et al)TBK1DDX58IKBKGK285 truncatedSARS-CoV-2 protein and host protein intereactionRAP1GDS1MediatedMediatedMediatedMediatedMediatedMediatedIFNB1 MediatedProteinmRNAIn patientsin ICU TNFAGTIFNAIL17ACXCL5LDHCRPMCP1CXCL10CXCL1IL1BIL10LDHIL1AIL12ACRPIL6ALB


Description

This pathway shows protein-protein interactions and downstream molecular events regulated by SARS-CoV-2 including molecular association, catalysis, and gene regulation. Each event is color-coded as described in the pathway legend. Information on site and residue of post-translational modification are also included.

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Bibliography

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  2. Miao G, Zhao H, Li Y, Ji M, Chen Y, Shi Y, Bi Y, Wang P, Zhang H; ''ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.''; Dev Cell, 2021 PubMed Europe PMC Scholia
  3. Appelberg S, Gupta S, Svensson Akusjärvi S, Ambikan AT, Mikaeloff F, Saccon E, Végvári �, Benfeitas R, Sperk M, Ståhlberg M, Krishnan S, Singh K, Penninger JM, Mirazimi A, Neogi U; ''Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells.''; Emerg Microbes Infect, 2020 PubMed Europe PMC Scholia
  4. Shang J, Wan Y, Luo C, Ye G, Geng Q, Auerbach A, Li F; ''Cell entry mechanisms of SARS-CoV-2.''; Proc Natl Acad Sci U S A, 2020 PubMed Europe PMC Scholia
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  6. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ; ''A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.''; Nature, 2020 PubMed Europe PMC Scholia
  7. Schmoldt A, Benthe HF, Haberland G, Jallon JM, Risler Y, Iwatsubo M; ''Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.''; Biochem Biophys Res Commun, 1975 DOI Scholia
  8. Shen B, Yi X, Sun Y, Bi X, Du J, Zhang C, Quan S, Zhang F, Sun R, Qian L, Ge W, Liu W, Liang S, Chen H, Zhang Y, Li J, Xu J, He Z, Chen B, Wang J, Yan H, Zheng Y, Wang D, Zhu J, Kong Z, Kang Z, Liang X, Ding X, Ruan G, Xiang N, Cai X, Gao H, Li L, Li S, Xiao Q, Lu T, Zhu Y, Liu H, Guo T; ''Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.''; Cell, 2020 PubMed Europe PMC Scholia
  9. Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY; ''Evasion of Type I Interferon by SARS-CoV-2.''; Cell Rep, 2020 PubMed Europe PMC Scholia
  10. Lei X, Dong X, Ma R, Wang W, Xiao X, Tian Z, Wang C, Wang Y, Li L, Ren L, Guo F, Zhao Z, Zhou Z, Xiang Z, Wang J; ''Activation and evasion of type I interferon responses by SARS-CoV-2.''; Nat Commun, 2020 PubMed Europe PMC Scholia
  11. Li J, Guo M, Tian X, Wang X, Yang X, Wu P, Liu C, Xiao Z, Qu Y, Yin Y, Wang C, Zhang Y, Zhu Z, Liu Z, Peng C, Zhu T, Liang Q; ''Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.''; Med (N Y), 2021 PubMed Europe PMC Scholia
  12. Xiong Y, Liu Y, Cao L, Wang D, Guo M, Jiang A, Guo D, Hu W, Yang J, Tang Z, Wu H, Lin Y, Zhang M, Zhang Q, Shi M, Zhou Y, Lan K, Chen Y; ''Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.''; Emerg Microbes Infect, 2020 PubMed Europe PMC Scholia
  13. Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, Haas DA, Huang Y, Oubraham L, Wang A, Hamad MS, Piras A, Hansen FM, Tanzer MC, Paron I, Zinzula L, Engleitner T, Reinecke M, Lavacca TM, Ehmann R, Wölfel R, Jores J, Kuster B, Protzer U, Rad R, Ziebuhr J, Thiel V, Scaturro P, Mann M, Pichlmair A; ''Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.''; Nature, 2021 PubMed Europe PMC Scholia
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  15. Schmoldt A, Benthe HF, Haberland G, Jallon JM, Risler Y, Iwatsubo M; ''Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.''; Biochem Biophys Res Commun, 1975 PubMed Europe PMC Scholia
  16. Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J, Wang Z, Li J, Feng C, Zhang Z, Wang L, Peng L, Chen L, Qin Y, Zhao D, Tan S, Yin L, Xu J, Zhou C, Jiang C, Liu L; ''Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.''; Sci China Life Sci, 2020 PubMed Europe PMC Scholia
  17. Li J, Guo M, Tian X, Wang X, Yang X, Wu P, Liu C, Xiao Z, Qu Y, Yin Y, Wang C, Zhang Y, Zhu Z, Liu Z, Peng C, Zhu T, Liang Q; ''Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.''; Med (N Y), 2021 PubMed Europe PMC Scholia
  18. Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M; ''Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection.''; Cell Syst, 2020 PubMed Europe PMC Scholia
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  20. Schmoldt A, Benthe HF, Haberland G, Adzerikho RD, Aksentsev SL, Okun' IM, Konev SV, Durbin RP, Hendrickson WA, Ward KB, Marniemi J, Parkki MG, Lande IJ, Feldbush TL, Lubaroff DM, Bonney WW; ''Rat prostate carcinoma 11095-A: profile of organ- and tumor-specific antigens.''; Natl Cancer Inst Monogr, 1978 DOI Scholia
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  22. Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, Castañeda G, DeRisi JL, Detweiler AM, Hao S, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Christenson SA, Kistler A, Langelier C; ''Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2.''; medRxiv, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134657view10:12, 25 July 2024Ash iyerAdding annotation for datanodes
134648view09:01, 24 July 2024EgonwRemoved labels that were listed as identifier without datasource
129746view01:55, 22 May 2024EweitzModified title
126845view06:56, 27 June 2023Honoremove duplicate "CXCL9"
125317view21:47, 31 January 2023LarsgwFix reference bp:DB
124648view13:07, 18 November 2022JfigueirahasbunUpdated viral protein labels and identifiers
124550view12:12, 8 November 2022EweitzModified description
123443view08:56, 27 July 2022MvdGardeChanged IP10 to CXCL10 in the 'In patients in ICU' column
120811view14:54, 11 January 2022SusanOntology Term : 'respiratory system disease pathway' added !
120597view21:29, 17 December 2021EweitzModified description
120279view13:52, 23 November 2021EgonwRemoved a period from a pubmed identifier
120269view12:05, 23 November 2021EgonwReplaced a DOI with the respective PMID
119638view06:30, 27 July 2021EgonwRemoved NCBI gene annotations where the ID were not numbers
119635view06:20, 27 July 2021Egonwinteraction between NFKB2 and TRAF2
119516view09:23, 8 July 2021EweitzModified title
119501view12:19, 5 July 2021FehrhartOntology Term : 'disease pathway' added !
119500view12:18, 5 July 2021FehrhartOntology Term : 'severe acute respiratory syndrome' added !
119496view15:10, 4 July 2021Keshav
118993view13:29, 7 June 2021KeshavModified description
118984view05:12, 7 June 2021KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A1BGGeneProductENSG00000121410 (Ensembl)
ACE2GeneProductENSG00000130234 (Ensembl)
ACTBGeneProductENSG00000075624 (Ensembl)
ACTG1GeneProductENSG00000184009 (Ensembl)
ADAM9GeneProduct8754 (Entrez Gene)
AGTGeneProductAGT (HGNC)
AHRGeneProductAHR (HGNC)
AKT1ProteinP31749 (Uniprot-TrEMBL)
ALBGeneProductALB (HGNC)
APOA1GeneProductAPOA1 (HGNC)
APOA2GeneProductAPOA2 (HGNC)
APOC1GeneProductAPOC1 (HGNC)
APODGeneProductAPOD (HGNC)
APOHGeneProductAPOH (HGNC)
APOL1GeneProductAPOL1 (HGNC)
APOMGeneProductAPOM (HGNC)
ATE1GeneProduct11101 (Entrez Gene)
ATG13Protein9776 (Entrez Gene)
ATP13A3GeneProduct79572 (Entrez Gene)
ATP6AP1 GeneProduct537 (Entrez Gene)
BIDProtein637 (Entrez Gene)
BIRC5GeneProductBIRC5 (HGNC)
BST2GeneProductBST2 (HGNC)
BTN3A1GeneProductBTN3A1 (HGNC)
C1QBPGeneProductC1QBP (HGNC)
C1RGeneProductENSG00000159403 (Ensembl)
C1SGeneProductENSG00000182326 (Ensembl)
C8AGeneProductENSG00000157131 (Ensembl)
CALC1GeneProductCALC1 (HGNC)
CAMK4GeneProductCAMK4 (HGNC)
CARD11GeneProductCARD11 (HGNC)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP5GeneProductCASP5 (HGNC)
CASP8GeneProductCASP8 (HGNC)
CASP9GeneProductCASP9 (HGNC)
CCL11GeneProductCCL11 (HGNC)
CCL15GeneProductCCL15 (HGNC)
CCL1GeneProductCCL1 (HGNC)
CCL20GeneProductCCL20 (HGNC)
CCL21GeneProductCCL21 (HGNC)
CCL22GeneProductCCL22 (HGNC)
CCL26GeneProductCCL26 (HGNC)
CCL27GeneProductCCL27 (HGNC)
CCL2GeneProductCCL2 (HGNC)
CCL2GeneProductENSG00000108691 (Ensembl)
CCL3GeneProductCCL3 (HGNC)
CCL4GeneProductCCL4 (HGNC)
CCL5GeneProductCCL5 (HGNC)
CCL8GeneProductCCL8 (HGNC)
CCNB1GeneProductCCNB1 (HGNC)
CCNB2GeneProductCCNB2 (HGNC)
CCR5GeneProductCCR5 (HGNC)
CCR6GeneProductCCR6 (HGNC)
CD14GeneProductENSG00000170458 (Ensembl)
CD163GeneProductCD163 (HGNC)
CD226GeneProductCD226 (HGNC)
CD247GeneProduct919 (Entrez Gene)
CD2GeneProduct914 (Entrez Gene)
CD3EGeneProduct916 (Entrez Gene)
CD3G GeneProduct917 (Entrez Gene)
CD4GeneProduct920 (Entrez Gene)
CD8AGeneProduct925 (Entrez Gene)
CD8AGeneProduct926 (Entrez Gene)
CDK1GeneProductCDK1 (HGNC)
CEBPBGeneProductCEBPB (HGNC)
CFBGeneProductENSG00000243649 (Ensembl)
CFHGeneProductENSG00000000971 (Ensembl)
CFIGeneProductENSG00000205403 (Ensembl)
CFPGeneProductCFP (HGNC)
CLCC1GeneProduct23155 (Entrez Gene)
COL7A1GeneProductCOL7A1 (HGNC)
COQ8BProtein79934 (Entrez Gene)
CPN1GeneProductCPN1 (HGNC)
CRPGeneProduct1401 (Entrez Gene)
CRPGeneProductCRP (HGNC)
CRPGeneProductENSG00000132693 (Ensembl)
CTSBGeneProductCTSB (HGNC)
CTSDGeneProductCTSD (HGNC)
CTSLGeneProductCTSL (HGNC)
CTSZGeneProductCTSZ (HGNC)
CXCL10GeneProductCXCL10 (HGNC)
CXCL12GeneProductCXCL12 (HGNC)
CXCL13GeneProductCXCL13 (HGNC)
CXCL16GeneProductCXCL16 (HGNC)
CXCL1GeneProductCXCL1 (HGNC)
CXCL2GeneProductCXCL2 (HGNC)
CXCL3GeneProductCXCL3 (HGNC)
CXCL5GeneProductCXCL5 (HGNC)
CXCL6GeneProductCXCL6 (HGNC)
CXCL8 GeneProductCXCL8 (HGNC)
CXCL8GeneProductCXCL8 (HGNC)
CXCL9GeneProductCXCL9 (HGNC)
CXCR1GeneProductCXCR1 (HGNC)
CXCR2GeneProductCXCR2 (HGNC)
CXCR7GeneProductCXCR7 (HGNC)
Cytochrome CMetabolite18070 (ChEBI)
DDIT4GeneProductDDIT4 (HGNC)
DDX58GeneProductDDX58 (HGNC)
DEPTORProtein64798 (Entrez Gene)
DUSP1GeneProductDUSP1 (HGNC)
EGR1GeneProductEGR1 (HGNC)
EIF4A2GeneProductEIF4A2 (HGNC)
EIF4EBP1GeneProduct1978 (Entrez Gene)
EIF4EProteinEIF4E (HGNC)
ERLEC1GeneProduct27248 (Entrez Gene)
FAM83AGeneProductFAM83A (HGNC)
FAM98AProtein25940 (Entrez Gene)
FGAGeneProductENSG00000171560 (Ensembl)
FGBGeneProductENSG00000171564 (Ensembl)
FGBGeneProductFGB (HGNC)
FGF2GeneProductFGF2 (HGNC)
FGGGeneProductENSG00000171557 (Ensembl)
FGGGeneProductFGG (HGNC)
FN1GeneProductFN1 (HGNC)
FOSGeneProductFOS (HGNC)
FYNGeneProduct2534 (Entrez Gene)
FYNGeneProductFYN (HGNC)
G3BP1Protein10146 (Entrez Gene)
G3BP2Protein9908 (Entrez Gene)
GABARAPL2Protein11345 (Entrez Gene)
GCSFGeneProductGCSF (HGNC)
GGHGeneProduct8836 (Entrez Gene)
GMCSFGeneProductGMCSF (HGNC)
GP1BAGeneProductGP1BA (HGNC)
GSNGeneProductGSN (HGNC)
GTF2F2GeneProduct2963 (Entrez Gene)
GTSE1GeneProductGTSE1 (HGNC)
HBBGeneProductHBB (HGNC)
HBDGeneProductHBD (HGNC)
GeneProduct
HIF1AGeneProduct3091 (Entrez Gene)
HLA-DRAGeneProduct3122 (Entrez Gene)
HLA-DRB1GeneProduct3123 (Entrez Gene)
HLA-DRB4GeneProduct3126 (Entrez Gene)
HLA-DRB5GeneProduct3127 (Entrez Gene)
HPGeneProductENSG00000257017 (Ensembl)
HRGGeneProductHRG (HGNC)
HSPA8GeneProductHSPA8 (HGNC)
IFI27GeneProductIFI27 (HGNC)
IFI44LGeneProductIFI44L (HGNC)
IFI6GeneProductIFI6 (HGNC)
IFIH1GeneProductIFIH1 (HGNC)
IFIT1GeneProductIFIT1 (HGNC)
IFITM1GeneProductIFITM1 (HGNC)
IFITM3GeneProductENSG00000142089 (Ensembl)
IFITM3GeneProductIFITM3 (HGNC)
IFN1ProteinIFN1 (Uniprot-TrEMBL)
IFNAGeneProductIFNA (HGNC)
IFNB1ProteinP01574 (Uniprot-TrEMBL)
IFNGGeneProductIFNG (HGNC)
IGFBP3GeneProductIGFBP3 (HGNC)
IGHEGeneProduct3497 (Entrez Gene)
IGHG1GeneProduct3500 (Entrez Gene)
IGHG2GeneProduct3501 (Entrez Gene)
IGHG4GeneProduct3503 (Entrez Gene)
IGLC2GeneProduct3538 (Entrez Gene)
IGLL1GeneProduct3543 (Entrez Gene)
IKBKGProtein8517 (Entrez Gene)
IL10GeneProductIL10 (HGNC)
IL12AGeneProductIL12A (HGNC)
IL13GeneProductIL13 (HGNC)
IL16GeneProductIL16 (HGNC)
IL17AGeneProductIL17A (HGNC)
IL18GeneProductIL18 (HGNC)
IL18RAPGeneProductIL18RAP (HGNC)
IL1AGeneProductIL1A (HGNC)
IL1BGeneProductENSG00000125538 (Ensembl)
IL1BGeneProductIL1B (HGNC)
IL1R2GeneProductIL1R2 (HGNC)
IL1RAGeneProductIL1RA (HGNC)
IL21GeneProductIL21 (HGNC)
IL22GeneProductIL22 (HGNC)
IL23GeneProductIL23 (HGNC)
IL2BGeneProductIL2B (HGNC)
IL2RGeneProductIL2R (HGNC)
IL33GeneProductIL33 (HGNC)
IL4GeneProductIL4 (HGNC)
IL5GeneProductIL5 (HGNC)
IL6GeneProduct3569 (Entrez Gene)
IL6GeneProductENSG00000136244 (Ensembl)
IL6GeneProductIL6 (HGNC)
IL7GeneProductIL7 (HGNC)
IL8GeneProduct3576 (Entrez Gene)
IL8GeneProductIL8 (HGNC)
IL9GeneProductIL9 (HGNC)
INTS4Protein92105 (Entrez Gene)
IRAK1GeneProduct3654 (Entrez Gene)
IRF27GeneProductIRF27 (HGNC)
IRF3GeneProductIRF3 (HGNC)
IRF9GeneProductIRF9 (HGNC)
ISG56GeneProductISG56 (HGNC)
ISREGeneProductISRE (HGNC)
ITCHGeneProductITCH (HGNC)
ITGA3GeneProductITGA3 (HGNC)
ITIH3GeneProductENSG00000162267 (Ensembl)
ITIH4GeneProductENSG00000055955 (Ensembl)
JAK1GeneProductJAK1 (HGNC)
JAK2GeneProductJAK2 (HGNC)
JUNBGeneProductJUNB (HGNC)
JUNGeneProductJUN (HGNC)
LARP1GeneProduct23367 (Entrez Gene)
LBPGeneProduct3929 (Entrez Gene)
LBPGeneProductENSG00000129988 (Ensembl)
LCKGeneProduct3932 (Entrez Gene)
LCKGeneProductLCK (HGNC)
LDHGeneProductLDH (HGNC)
LGALS3BPGeneProductENSG00000108679 (Ensembl)
LRG1GeneProductENSG00000171236 (Ensembl)
MAP1LC3BGeneProduct81631 (Entrez Gene)
MAPK14ProteinNP_001306.1 (NCBI Protein)
MAPK1ProteinNP_002736.3 (NCBI Protein)
MAPK3ProteinNP_002737.2 (NCBI Protein)
MAPK8GeneProductMAPK8 (HGNC)
MAPK8ProteinNP_001310259.1 (NCBI Protein)
MARK2GeneProductMARK2 (HGNC)
MAVSGeneProductENSG00000088888 (Ensembl)
MCP1GeneProductMCP1 (HGNC)
MDN1Protein23195 (Entrez Gene)
MIB1GeneProduct57534 (Entrez Gene)
MIP1AGeneProductMIP1A (HGNC)
MIP1BGeneProductMIP1B (HGNC)
MLST8Protein64223 (Entrez Gene)
MMP25 GeneProduct64386 (Entrez Gene)
MOV10Protein4343 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
MX1GeneProductMX1 (HGNC)
MYD88GeneProductMYD88 (HGNC)
MProteinYP_009724393.1 (NCBI Protein)
NBR1ProteinNBR1 (NCBI Protein)
NEK9GeneProduct91754 (Entrez Gene)
NFATC3GeneProductNFATC3 (HGNC)
NFKB2Protein4791 (Entrez Gene)
NKRFGeneProduct55922 (Entrez Gene)
NLRP1GeneProduct22861 (Entrez Gene)
NLRP3GeneProductNLRP3 (HGNC)
NPTX1GeneProduct4884 (Entrez Gene)
NTRK1GeneProductNTRK1 (HGNC)
NProteinYP_009724397.2 (NCBI Protein)
OAS2GeneProductOAS2 (HGNC)
OS9GeneProductOS9 (HGNC)
PARP2 GeneProductPARP2 (HGNC)
PDGFGeneProductPDGF (HGNC)
PF4GeneProductPF4 (HGNC)
PI3KProteinP31749 (Uniprot-TrEMBL)
PIAS1GeneProductPIAS1 (HGNC)
PITRM1Protein10531 (Entrez Gene)
PLA2G4AProteinNP_077734.1 (NCBI Protein)
PMPCBProtein9512 (Entrez Gene)
PRAS40GeneProductENSG00000204673 (Ensembl)
PRG3GeneProduct10394 (Entrez Gene)
PRKCQGeneProductPRKCQ (HGNC)
PTGS2GeneProductPTGS2 (HGNC)
PTPN6GeneProductPTPN6 (HGNC)
RAC1GeneProductRAC1 (HGNC)
RAP1GDS1GeneProduct5910 (Entrez Gene)
RHEBProtein6009 (Entrez Gene)
RPS6KB1ProteinNP_003152.1 (NCBI Protein)
RPS6GeneProductRPS6 (HGNC)
RPTORProtein57521 (Entrez Gene)
RRASGeneProductRRAS (HGNC)
RRM2GeneProductRRM2 (HGNC)
RTN4Protein57142 (Entrez Gene)
SAA1GeneProductENSG00000173432 (Ensembl)
SAA2GeneProductENSG00000134339 (Ensembl)
SARS-CoV-2PathwayWP4846 (WikiPathways)
SDF2GeneProduct6388 (Entrez Gene)
SELPGeneProductENSG00000174175 (Ensembl)
SERPINA10GeneProductENSG00000140093 (Ensembl)
SERPINA5GeneProductSERPINA5 (HGNC)
SERPINE1GeneProductSERPINE1 (HGNC)
SIGMAR1GeneProduct10280 (Entrez Gene)
SKAP1GeneProductSKAP1 (HGNC)
SMAD1GeneProduct4086 (Entrez Gene)
SMAD5GeneProduct4090 (Entrez Gene)
SQSTM1ProteinNP_003891.1 (NCBI Protein)
SRP19GeneProduct6728 (Entrez Gene)
SRP54GeneProduct6729 (Entrez Gene)
SRP72GeneProduct6731 (Entrez Gene)
STAT1GeneProductSTAT1 (HGNC)
STEAP3GeneProductSTEAP3 (HGNC)
SProteinYP_009724390.1 (NCBI Protein)
TANKGeneProductTANK (EMBL)
TAX1BP1ProteinTAX1BP1 (NCBI Protein)
TBK1GeneProduct29110 (Entrez Gene)
TBKBP1Protein9755 (Entrez Gene)
TFGeneProductTF (HGNC)
TGFBR2ProteinTGFBR2 (HGNC)
TLE1Protein7088 (Entrez Gene)
TLE3Protein7090 (Entrez Gene)
TLE5Protein9755 (Entrez Gene)
TLRsGeneProduct
TMPRSS2Protein7226 (Entrez Gene)
TNFSF10GeneProductTNFSF10 (HGNC)
TNFGeneProductTNF (HGNC)
TOMM70GeneProduct9868 (Entrez Gene)
TP53I3GeneProductTP53I3 (HGNC)
TPOGeneProductTPO (HGNC)
TRACGeneProduct28755 (Entrez Gene)
TRAF2GeneProductTRAF2 (HGNC)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF6GeneProduct7189 (Entrez Gene)
TRBC1 GeneProduct28639 (Entrez Gene)
TRIM59GeneProduct286827 (Entrez Gene)
TROGeneProductTRO (HGNC)
TSC2ProteinP31749 (Uniprot-TrEMBL)
UGGT2GeneProduct55757 (Entrez Gene)
ULK1GeneProduct8408 (Entrez Gene)
UPF1Protein5976 (Entrez Gene)
VEGFAGeneProduct
VPS11Protein55823 (Entrez Gene)
VPS16Protein64601 (Entrez Gene)
VPS18GeneProductVPS18 (HGNC)
VPS33AProtein65082 (Entrez Gene)
VPS36Protein51028 (Entrez Gene)
VPS41Protein27072 (Entrez Gene)
WDR74GeneProductWDR74 (HGNC)
ZAP70GeneProduct7535 (Entrez Gene)
nsp10ProteinYP_009725306 (NCBI Protein)
nsp13ProteinYP_009725308 (NCBI Protein)
nsp2ProteinYP_009725298 (NCBI Protein)
nsp6ProteinYP_009725302 (NCBI Protein)
nsp8ProteinYP_009725304 (NCBI Protein)
nsp9ProteinYP_009725305 (NCBI Protein)
orf3aProteinYP_009724391.1 (NCBI Protein)
orf6ProteinYP_009724394.1 (NCBI Protein)
orf7aProteinYP_009724395.1 (NCBI Protein)
orf7bProteinYP_009725318.1 (NCBI Protein)
orf8ProteinYP_009724396.1 (NCBI Protein)
orf9bProteinP0DTD2 (NCBI Protein)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5115"
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