Sebaleic acid formation and metabolism (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Palmitic AcidACSL1et alFADS2Sebaleic acid5-oxo-18-ODESebaleoyl CoAALOX5Palmitoyl CoASapienic acid5-KODEUnidentifiedFADS1Sapienoyl-CoACYP4F35S-HODE8Z-octadecenoyl-CoA5S-18-DiODEName: Sebaleic acid formation and metabolismOrganism: Homo sapiens


Description

Formation of sebaleic acid and its related octadecanoids

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Quality Tags

Image:Curated.pngApproved version
Image:Unconnected.pngFix interactions
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Bibliography

  1. Cossette C, Patel P, Anumolu JR, Sivendran S, Lee GJ, Gravel S, Graham FD, Lesimple A, Mamer OA, Rokach J, Powell WS; ''Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  2. Küçüksayan E, Sansone A, Chatgilialoglu C, Ozben T, Tekeli D, Talibova G, Ferreri C; ''Sapienic Acid Metabolism Influences Membrane Plasticity and Protein Signaling in Breast Cancer Cell Lines.''; Cells, 2022 PubMed Europe PMC Scholia
  3. Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM; ''Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity.''; J Invest Dermatol, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134474
Approved
view00:52, 22 July 2024EweitzFix graphical truncation in node, improve node alignment
125120view10:08, 24 January 2023Conroy lipidsadd ECs
125089view22:47, 20 January 2023AlexanderPicofixed uniprot ref
125051view12:19, 17 January 2023Conroy lipidsOntology Term : 'classic metabolic pathway' added !
125050view12:18, 17 January 2023Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
125049view12:18, 17 January 2023Conroy lipidsOntology Term : 'fatty acid biosynthetic pathway' added !
125045view12:06, 17 January 2023Conroy lipidsNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
5-KODEMetaboliteLMFA02000395 (LIPID MAPS)
5-oxo-18-ODEMetaboliteLMFA02000396 (LIPID MAPS)
5S-18-DiODEMetaboliteLMFA02000397 (LIPID MAPS)
5S-HODEMetaboliteLMFA02000394 (LIPID MAPS)
8Z-octadecenoyl-CoAMetaboliteLMFA07050489 (LIPID MAPS)
ACSL1 et alGeneProductP33121 (Uniprot-TrEMBL)
ALOX5GeneProductP09917 (Uniprot-TrEMBL)
CYP4F3GeneProductQ08477 (Uniprot-TrEMBL)
FADS1GeneProductO60427 (Uniprot-TrEMBL) EC:1.14.19.44
FADS2GeneProductO95864 (Uniprot-TrEMBL) EC:1.14.19.3
Palmitic AcidMetaboliteLMFA01010001 (LIPID MAPS)
Palmitoyl CoAMetaboliteLMFA07050360 (LIPID MAPS)
Sapienic acidMetaboliteLMFA01030267 (LIPID MAPS)
Sapienoyl-CoAMetaboliteLMFA07050488 (LIPID MAPS)
Sebaleic acidMetaboliteLMFA01030323 (LIPID MAPS)
Sebaleoyl CoAMetaboliteLMFA07050490 (LIPID MAPS)
UnidentifiedGeneProduct

Annotated Interactions

Source  ↓Target  ↓Type  ↓Database reference  ↓Comment  ↓
Palmitic AcidPalmitoyl CoAmim-conversion30752 (Rhea)
Palmitoyl CoASapienoyl-CoAmim-conversion37024 (Rhea)
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