Sebaleic acid formation and metabolism (Homo sapiens)

From WikiPathways

Jump to: navigation, search
121113FADS1Sapienoyl-CoAFADS28Z-octadecenoyl-CoAALOX5Palmitic AcidUnidentifiedSapienic acid5S-18-DiODESebaleoyl CoA5S-HODE5-oxo-18-ODESebaleic acid5-KODECYP4F3Palmitoyl CoAACSL1et al


Description

Formation of sebaleic acid and its related octadecanoids

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Cossette C, Patel P, Anumolu JR, Sivendran S, Lee GJ, Gravel S, Graham FD, Lesimple A, Mamer OA, Rokach J, Powell WS; ''Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  2. Küçüksayan E, Sansone A, Chatgilialoglu C, Ozben T, Tekeli D, Talibova G, Ferreri C; ''Sapienic Acid Metabolism Influences Membrane Plasticity and Protein Signaling in Breast Cancer Cell Lines.''; Cells, 2022 PubMed Europe PMC Scholia
  3. Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM; ''Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity.''; J Invest Dermatol, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134474view00:52, 22 July 2024EweitzFix graphical truncation in node, improve node alignment
125120view10:08, 24 January 2023Conroy lipidsadd ECs
125089view22:47, 20 January 2023AlexanderPicofixed uniprot ref
125051view12:19, 17 January 2023Conroy lipidsOntology Term : 'classic metabolic pathway' added !
125050view12:18, 17 January 2023Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
125049view12:18, 17 January 2023Conroy lipidsOntology Term : 'fatty acid biosynthetic pathway' added !
125045view12:06, 17 January 2023Conroy lipidsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
5-KODEMetaboliteLMFA02000395 (LIPID MAPS)
5-oxo-18-ODEMetaboliteLMFA02000396 (LIPID MAPS)
5S-18-DiODEMetaboliteLMFA02000397 (LIPID MAPS)
5S-HODEMetaboliteLMFA02000394 (LIPID MAPS)
8Z-octadecenoyl-CoAMetaboliteLMFA07050489 (LIPID MAPS)
ACSL1 et alGeneProductP33121 (Uniprot-TrEMBL)
ALOX5GeneProductP09917 (Uniprot-TrEMBL)
CYP4F3GeneProductQ08477 (Uniprot-TrEMBL)
FADS1GeneProductO60427 (Uniprot-TrEMBL) EC:1.14.19.44
FADS2GeneProductO95864 (Uniprot-TrEMBL) EC:1.14.19.3
Palmitic AcidMetaboliteLMFA01010001 (LIPID MAPS)
Palmitoyl CoAMetaboliteLMFA07050360 (LIPID MAPS)
Sapienic acidMetaboliteLMFA01030267 (LIPID MAPS)
Sapienoyl-CoAMetaboliteLMFA07050488 (LIPID MAPS)
Sebaleic acidMetaboliteLMFA01030323 (LIPID MAPS)
Sebaleoyl CoAMetaboliteLMFA07050490 (LIPID MAPS)
UnidentifiedGeneProduct

Annotated Interactions

SourceTargetTypeDatabase referenceComment
Palmitic AcidPalmitoyl CoAmim-conversion30752 (Rhea)
Palmitoyl CoASapienoyl-CoAmim-conversion37024 (Rhea)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5315"
Personal tools