Acetate mediated promotion of metabolic syndrome (Rattus norvegicus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Microbial cellHigh fat dietparasympatheticnervous systemPlasmafatty acidintermediatemetabolite(s)gastrininsulinacetateglucosefatty acidacetateName: Acetate mediated promotion of metabolic syndromeOrganism: Rattus norvegicus


Description

Acetates produced by gut microbes stimulates the parasympathetic nervous system which causes in an increase in the release of the gastrin hormone which triggers insulin release from beta-cells. Prolonged exposure to high acetate levels promote a state of metabolic syndrome.

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Quality Tags

Image:MissingXref.pngAnnotate nodes
Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : Notch signaling pathway
 

Bibliography

  1. Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI; ''Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome.''; Nature, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
110699
Approved
view14:06, 28 May 2020EgonwBetter semantic annotation
93052view12:27, 27 July 2017DeSlChanged glucose ID to D-glucose ID.
89051view22:46, 18 August 2016AriuttaOntology Term : 'disease pathway' added !
85964view23:32, 21 June 2016KhanspersOntology Term : 'parasympathetic neuron' added !
85963view23:32, 21 June 2016KhanspersOntology Term : 'B cell' added !
85962view23:30, 21 June 2016KhanspersOntology Term : 'acquired metabolic disease' added !
85763view14:24, 11 June 2016EgonwNow has the rat IDs.
85762view14:15, 11 June 2016EgonwModified description
85761view14:13, 11 June 2016EgonwModified title
85760view14:12, 11 June 2016EgonwNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
acetateMetaboliteCHEBI:30089 (ChEBI)
fatty acidMetaboliteCHEBI:35366 (ChEBI)
gastrinProteinP04563 (Uniprot-TrEMBL)
glucoseMetaboliteCHEBI:17634 (ChEBI)
insulinProteinP01323 (Uniprot-TrEMBL)
intermediate metabolite(s)Metabolite

Annotated Interactions

No annotated interactions

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