Acetate mediated promotion of metabolic syndrome (Rattus norvegicus)
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Description
Acetates produced by gut microbes stimulates the parasympathetic nervous system which causes in an increase in the release of the gastrin hormone which triggers insulin release from beta-cells. Prolonged exposure to high acetate levels promote a state of metabolic syndrome.
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Ontology Terms
Saving...Bibliography
- Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI; ''Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome.''; Nature, 2016 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| acetate | Metabolite | CHEBI:30089 (ChEBI)  | |
| fatty acid | Metabolite | CHEBI:35366 (ChEBI) | |
| gastrin | Protein | P04563 (Uniprot-TrEMBL) | |
| glucose | Metabolite | CHEBI:17634 (ChEBI) | |
| insulin | Protein | P01323 (Uniprot-TrEMBL) | |
| intermediate metabolite(s) | Metabolite |
Annotated Interactions
No annotated interactions
