Poly(glycerol phosphate) wall teichoic acid biosynthesis (Saccharomyces cerevisiae)

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1TransportcytosolCDP-glycerolD-alanineD-alanylsn-glycerol-3-phosphatea peptidoglycan-major wall teichoic acid complexAMPUDP-N-acetyl-D-glucosamine biosynthesis IN-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenoldi-trans,octa-cis-undecaprenyl phosphate diphosphateditrans,octacis-undecaprenyldiphospho-[(N-acetyl-beta-D-glucosaminyl)-(1,4-)]-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineH2OBs-mnaABs-tagOphosphateUDP-alpha-D-glucose (n)ManNAc-GlcNAc-PP-undecaprenolGro-P-ManNac-GlcNAc-PP-undecaprenolBs-tagBCDP-glycerola polyisoprenyl-major wall techoic aciddiphosphateCMP (n)UDPH+ATPan L-1-phosphatidyl-sn-glyceroldi-trans,octa-cis-undecaprenyl diphosphate H2OUDP-N-acetyl-alpha-D-mannosamine2 H+UDP-N-acety-alpha-D-glucosamide2-O-D-alanyl-1-O-phosphatidylglycerolH+UDPATPBs-dltABs-tagAa D-alanyl-carrier proteindi-trans,octa-cis-undecaprenyl phosphateUMPH+CMPH+CTPBs-tagD(Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenolBs-tagF((2-Glc)Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenolextracellular space((2-Glc)Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenolBs-tagEBs-tagH + Bs-tagGADPH+a D-alanyl-carrier proteinBs-dltDa D-alanyl-carrier proteinan L-1-phosphatidyl-sn-glycerolBs-dltBBs-tagV + Bs-tagU + Bs-tagT


Description

Teichoic acids serve several roles in the cell. They serve as reservoirs of phosphates that can be mobilized when phosphate becomes limiting. Being anionic, they are scavengers of cations (in particular Mg²⁺), and may create a pH gradient across the wall by sequestering the protons expelled through the cytoplasmic membrane. In addition, lipoteichoic acids are the main source of the hydrophobicity of the cell envelope, and may contribute to its adhesiveness. Teichoic acids are also immunogenic, and can be considered the Gram-positive equivalent of the Gram-negative lipopolysaccharides.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Gale, R. T., Sewell, E. W., Garrett, T. A., Brown, E. D.; ''Reconstituting poly (glycerol phosphate) wall teichoic acid biosynthesis in vitro using authentic substrates.''; Chemical Science, 2014 DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
129256view10:23, 16 March 2024EgonwOntology Term : 'classic metabolic pathway' added !
129255view10:22, 16 March 2024EgonwModified description
125299view17:33, 31 January 2023LarsgwAdd DOI to reference
124814view21:49, 11 December 2022AlexanderPicofixed citations
124783view06:38, 11 December 2022AlexanderPicofixed citations
117327view11:48, 20 May 2021EweitzModified title
107260view14:35, 17 September 2019MaintBotChEBI identifier normalization
102328view11:16, 20 December 2018EgonwReplace the identifier with that of the neutral compound.
96442view08:05, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96269view05:23, 3 March 2018EgonwCorrected the data sources.
95539view10:55, 21 December 2017DeSlAdded literature reference
95538view10:50, 21 December 2017DeSlAdded missing identifier
95537view10:41, 21 December 2017DeSlConnected lines where I could, added identifiers for metabolites+reactions
95536view09:59, 21 December 2017DeSlAdded reaction ID.
95535view09:53, 21 December 2017DeSlAnnotated additional metabolites
95534view09:22, 21 December 2017DeSlAdded several IDs
95485view10:11, 18 December 2017Andraadded missing metabolite identifiers
95384view11:06, 11 December 2017DeSlAdded IDs to several metabolites.
95061view13:02, 11 November 2017EgonwFixed the data source of three Wikidata identifiers.
94983view11:44, 23 October 2017DeSlannotated some nodes
94971view14:20, 20 October 2017DeSlModified description
94970view14:19, 20 October 2017DeSlModified description
94969view14:18, 20 October 2017DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
((2-Glc)Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenolMetaboliteCHEBI:132356 (ChEBI)
(Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenolMetaboliteCHEBI:132224 (ChEBI)
2 H+MetaboliteCHEBI:15378 (ChEBI)
2-O-D-alanyl-1-O-phosphatidylglycerolMetaboliteQ46328873 (Wikidata)
ADPMetaboliteQ185253 (Wikidata)
AMPMetabolite15938965 (PubChem-compound)
ATPMetabolite5461108 (PubChem-compound)
ATPMetaboliteQ80863 (Wikidata)
Bs-dltAProtein6.2.1.M5 (Enzyme Nomenclature) D-alanine-[D-alanyl carrier protein] ligase (Bs)
Bs-dltBProtein2.3.1.M32 (Enzyme Nomenclature) PG: teichoic acid D-alanyltransferase (Bs)
Bs-dltDProtein2.3.1.M31 (Enzyme Nomenclature) D-alanine carrier protein:PG D-alanyltransferase (Bs)
Bs-mnaAProtein5.1.3.14 (Enzyme Nomenclature) UDP-N-acetylglucosamine 2-epimerase (BS)
Bs-tagAProtein2.4.1.187 (Enzyme Nomenclature) UDP-N-acetylmannosamine transferase (Bs)
Bs-tagBProtein2.7.8.44 (Enzyme Nomenclature) Teichoic acid glycerol-phosphate primase (Bs)
Bs-tagDProtein2.7.7.39 (Enzyme Nomenclature) glycerol-3-phosphate-cytidyltransferase (Bs)
Bs-tagEProtein2.4.1.52 (Enzyme Nomenclature) Poly(glycerol-phosphate)alpha-glucosyltranferase (Bs)
Bs-tagFProtein2.7.8.12 (Enzyme Nomenclature) Teichoic acid poly(glycerol-phosphate) polymerase (Bs)
Bs-tagH + Bs-tagGProtein3.6.3.40 (Enzyme Nomenclature) Poly(glycerol-phosphate) teichoic acid transporter (Bs)
Bs-tagOProtein2.7.8.33 (Enzyme Nomenclature) UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (Bs)
Bs-tagV + Bs-tagU + Bs-tagTProtein2.7.8.M1 (Enzyme Nomenclature) Polyisoprenyl-major teichoic acid -- peptidoglycan teichoic acis transferase
CDP-glycerolMetabolite90659090 (PubChem-compound)
CDP-glycerolMetaboliteQ27102700 (Wikidata)
CMP (n)MetaboliteCHEBI:60377 (ChEBI)
CMPMetaboliteCHEBI:60377 (ChEBI)
CTPMetaboliteQ409648 (Wikidata) cytidine triphosphate
D-alanineMetaboliteQ27076975 (Wikidata)
D-alanylMetabolite
Gro-P-ManNac-GlcNAc-PP-undecaprenolMetabolite122706646 (PubChem-compound)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteQ283 (Wikidata)
ManNAc-GlcNAc-PP-undecaprenolMetabolite121225527 (PubChem-compound)
N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenolMetabolite52921677 (PubChem-compound)
UDP-N-acety-alpha-D-glucosamideMetaboliteQ312208 (Wikidata)
UDP-N-acetyl-D-glucosamine biosynthesis IPathway
UDP-N-acetyl-alpha-D-mannosamineMetaboliteQ27137103 (Wikidata)
UDP-alpha-D-glucose (n)MetaboliteQ27126319 (Wikidata)
UDPMetaboliteCHEBI:17659 (ChEBI)
UDPMetaboliteQ412593 (Wikidata)
UMPMetaboliteQ27074278 (Wikidata)
a D-alanyl-carrier proteinProtein
a D-alanyl-carrier proteinProteinQ24771273 (Wikidata)
a peptidoglycan-major wall teichoic acid complexMetaboliteQ46330851 (Wikidata)
a polyisoprenyl-major wall techoic acidMetaboliteQ46329416 (Wikidata)
an L-1-phosphatidyl-sn-glycerolMetaboliteQ46326783 (Wikidata)
di-trans,octa-cis-undecaprenyl diphosphate MetaboliteQ27125764 (Wikidata)
di-trans,octa-cis-undecaprenyl phosphate MetaboliteQ27127244 (Wikidata)
di-trans,octa-cis-undecaprenyl phosphateMetaboliteQ27127302 (Wikidata)
diphosphateMetaboliteQ290828 (Wikidata)
ditrans,octacis-undecaprenyldiphospho-[(N-acetyl-beta-D-glucosaminyl)-

(1,4-)]-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-

diaminopimeloyl-D-alanyl-D-alanine		MetaboliteQ46330436 (Wikidata)
phosphateMetaboliteQ177811 (Wikidata)
sn-glycerol-3-phosphateMetabolite7048686 (PubChem-compound)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
CDP-glycerolmim-conversion33815 (Rhea)
Gro-P-ManNac-GlcNAc-PP-undecaprenolmim-conversion33815 (Rhea)
ManNAc-GlcNAc-PP-undecaprenolmim-conversion16053 (Rhea)
ManNAc-GlcNAc-PP-undecaprenolmim-conversion33815 (Rhea)
N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenolmim-conversion16053 (Rhea)
UDP-N-acety-alpha-D-glucosamideN-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenolmim-conversion28090 (Rhea)
UDP-N-acety-alpha-D-glucosamideUDP-N-acetyl-alpha-D-mannosaminemim-conversion17213 (Rhea)
UDP-N-acetyl-alpha-D-mannosaminemim-conversion16053 (Rhea)
sn-glycerol-3-phosphateCDP-glycerolmim-conversion13361 (Rhea)
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