Poly(glycerol phosphate) wall teichoic acid biosynthesis (Saccharomyces cerevisiae)
From WikiPathways
Description
Teichoic acids serve several roles in the cell. They serve as reservoirs of phosphates that can be mobilized when phosphate becomes limiting. Being anionic, they are scavengers of cations (in particular Mg²⁺), and may create a pH gradient across the wall by sequestering the protons expelled through the cytoplasmic membrane. In addition, lipoteichoic acids are the main source of the hydrophobicity of the cell envelope, and may contribute to its adhesiveness. Teichoic acids are also immunogenic, and can be considered the Gram-positive equivalent of the Gram-negative lipopolysaccharides.
Quality Tags
Ontology Terms
Saving...Bibliography
- Gale, R. T., Sewell, E. W., Garrett, T. A., Brown, E. D.; ''Reconstituting poly (glycerol phosphate) wall teichoic acid biosynthesis in vitro using authentic substrates.''; Chemical Science, 2014 DOI Scholia
History
View all... |
External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| ((2-Glc)Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenol | Metabolite | CHEBI:132356 (ChEBI)  | |
| (Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenol | Metabolite | CHEBI:132224 (ChEBI) | |
| 2 H+ | Metabolite | CHEBI:15378 (ChEBI) | |
| 2-O-D-alanyl-1-O-phosphatidylglycerol | Metabolite | Q46328873 (Wikidata) | |
| ADP | Metabolite | Q185253 (Wikidata) | |
| AMP | Metabolite | 15938965 (PubChem-compound) | |
| ATP | Metabolite | 5461108 (PubChem-compound) | |
| ATP | Metabolite | Q80863 (Wikidata) | |
| Bs-dltA | Protein | 6.2.1.M5 (Enzyme Nomenclature) | D-alanine-[D-alanyl carrier protein] ligase (Bs) |
| Bs-dltB | Protein | 2.3.1.M32 (Enzyme Nomenclature) | PG: teichoic acid D-alanyltransferase (Bs) |
| Bs-dltD | Protein | 2.3.1.M31 (Enzyme Nomenclature) | D-alanine carrier protein:PG D-alanyltransferase (Bs) |
| Bs-mnaA | Protein | 5.1.3.14 (Enzyme Nomenclature) | UDP-N-acetylglucosamine 2-epimerase (BS) |
| Bs-tagA | Protein | 2.4.1.187 (Enzyme Nomenclature) | UDP-N-acetylmannosamine transferase (Bs) |
| Bs-tagB | Protein | 2.7.8.44 (Enzyme Nomenclature) | Teichoic acid glycerol-phosphate primase (Bs) |
| Bs-tagD | Protein | 2.7.7.39 (Enzyme Nomenclature) | glycerol-3-phosphate-cytidyltransferase (Bs) |
| Bs-tagE | Protein | 2.4.1.52 (Enzyme Nomenclature) | Poly(glycerol-phosphate)alpha-glucosyltranferase (Bs) |
| Bs-tagF | Protein | 2.7.8.12 (Enzyme Nomenclature) | Teichoic acid poly(glycerol-phosphate) polymerase (Bs) |
| Bs-tagH + Bs-tagG | Protein | 3.6.3.40 (Enzyme Nomenclature) | Poly(glycerol-phosphate) teichoic acid transporter (Bs) |
| Bs-tagO | Protein | 2.7.8.33 (Enzyme Nomenclature) | UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (Bs) |
| Bs-tagV + Bs-tagU + Bs-tagT | Protein | 2.7.8.M1 (Enzyme Nomenclature) | Polyisoprenyl-major teichoic acid -- peptidoglycan teichoic acis transferase |
| CDP-glycerol | Metabolite | 90659090 (PubChem-compound) | |
| CDP-glycerol | Metabolite | Q27102700 (Wikidata) | |
| CMP (n) | Metabolite | CHEBI:60377 (ChEBI) | |
| CMP | Metabolite | CHEBI:60377 (ChEBI) | |
| CTP | Metabolite | Q409648 (Wikidata) | cytidine triphosphate |
| D-alanine | Metabolite | Q27076975 (Wikidata) | |
| D-alanyl | Metabolite | ||
| Gro-P-ManNac-GlcNAc-PP-undecaprenol | Metabolite | 122706646 (PubChem-compound) | |
| H+ | Metabolite | CHEBI:15378 (ChEBI) | |
| H2O | Metabolite | Q283 (Wikidata) | |
| ManNAc-GlcNAc-PP-undecaprenol | Metabolite | 121225527 (PubChem-compound) | |
| N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol | Metabolite | 52921677 (PubChem-compound) | |
| UDP-N-acety-alpha-D-glucosamide | Metabolite | Q312208 (Wikidata) | |
| UDP-N-acetyl-D-glucosamine biosynthesis I | Pathway | ||
| UDP-N-acetyl-alpha-D-mannosamine | Metabolite | Q27137103 (Wikidata) | |
| UDP-alpha-D-glucose (n) | Metabolite | Q27126319 (Wikidata) | |
| UDP | Metabolite | CHEBI:17659 (ChEBI) | |
| UDP | Metabolite | Q412593 (Wikidata) | |
| UMP | Metabolite | Q27074278 (Wikidata) | |
| a D-alanyl-carrier protein | Protein | ||
| a D-alanyl-carrier protein | Protein | Q24771273 (Wikidata) | |
| a peptidoglycan-major wall teichoic acid complex | Metabolite | Q46330851 (Wikidata) | |
| a polyisoprenyl-major wall techoic acid | Metabolite | Q46329416 (Wikidata) | |
| an L-1-phosphatidyl-sn-glycerol | Metabolite | Q46326783 (Wikidata) | |
| di-trans,octa-cis-undecaprenyl diphosphate | Metabolite | Q27125764 (Wikidata) | |
| di-trans,octa-cis-undecaprenyl phosphate | Metabolite | Q27127244 (Wikidata) | |
| di-trans,octa-cis-undecaprenyl phosphate | Metabolite | Q27127302 (Wikidata) | |
| diphosphate | Metabolite | Q290828 (Wikidata) | |
| ditrans,octacis-undecaprenyldiphospho-[(N-acetyl-beta-D-glucosaminyl)-
(1,4-)]-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6- diaminopimeloyl-D-alanyl-D-alanine | Metabolite | Q46330436 (Wikidata) | |
| phosphate | Metabolite | Q177811 (Wikidata) | |
| sn-glycerol-3-phosphate | Metabolite | 7048686 (PubChem-compound) |
Annotated Interactions
| View all... |
| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| CDP-glycerol | mim-conversion | 33815 (Rhea) | ||
| Gro-P-ManNac-GlcNAc-PP-undecaprenol | mim-conversion | 33815 (Rhea) | ||
| ManNAc-GlcNAc-PP-undecaprenol | mim-conversion | 16053 (Rhea) | ||
| ManNAc-GlcNAc-PP-undecaprenol | mim-conversion | 33815 (Rhea) | ||
| N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol | mim-conversion | 16053 (Rhea) | ||
| UDP-N-acety-alpha-D-glucosamide | N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol | mim-conversion | 28090 (Rhea) | |
| UDP-N-acety-alpha-D-glucosamide | UDP-N-acetyl-alpha-D-mannosamine | mim-conversion | 17213 (Rhea) | |
| UDP-N-acetyl-alpha-D-mannosamine | mim-conversion | 16053 (Rhea) | ||
| sn-glycerol-3-phosphate | CDP-glycerol | mim-conversion | 13361 (Rhea) |
