Aerobic glycolysis - augmented (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ATPATPaseADPHPATPAMPADPADPAKATPADPCRPCRCKNADHATPPMetabolitex 12.5ATPApplies to PKA and PKL; does not apply to PKMx 12.5x 12.5x 3ADPPPYRO2O2CytosolExtracellular environmentCytosolExtracellular environmentCytosolMitochondrionx 2.5x 2.5NADHADPPx 2.5ATPNADStimulationCatalysisConversionBranch pathway originatingfrom glycolysisGlycolytic metaboliteEnzyme or processMetabolite only in supplementEnzyme or process only in supplementMetabolites; color-codedfor better visualizationEffector of the reactionpointed atConversion of acatalyzing chemicalMetabolite fixed incomputer modelMetabolite only in article figureMetabolite in supplement and article figure, not modelEnzyme or processonly in article figureEnzyme or process in supplement and article figure, not modelHADPHKGLUT_2PGMALBPGPYRGAPPGKENOTriglyceride synthesisATPGPILDHG6PSerine biosynthesisGlycogen metabolismLACPEPG6PDHPKGSYNGPHOSPentose phosphate pathway_3PGHADPGLUF6PDHAPALDPFKGLUeGAPDHFBPPGMTPIATPAMPNADPNADHHATPADPATPADPLACeNADNADHOXPHOSMASF26BPSERNADNADHHPHGDHGLYGHMTGRPDHATPADPGPSALTGPTSPTPDHASPH2OO2ePathwayMetaboliteEnzymeMetaboliteMetaboliteEnzymeMetaboliteEnzymeEnzymeLegendName: Aerobic glycolysis - augmentedOrganism: Homo sapiens


Description

Glycolysis converts glucose, C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH.

This pathway shows changed glycolytic fluxes during the Warburg effect. It is an extended version of the glycolysis pathway ([WP534](https://www.wikipathways.org/index.php/Pathway:WP534)), and describes content in the computer model of the corresponding supplement, and the article of [Shestov et al., 2014](https://www.ncbi.nlm.nih.gov/pubmed/25009227). Passive transport of oxygen and lactic acid into the cell is depicted using dashed arrows, which may differ from the original computer model.

Referred article: [Shestov et al., 2014](https://www.ncbi.nlm.nih.gov/pubmed/25009227)

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

  1. Berg JM, Tymoczko JL, Stryer L; ''Biochemistry''; https://www.ncbi.nlm.nih.gov/books/NBK22395/, 2002
  2. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J; ''A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.''; Science, 2012 PubMed Europe PMC Scholia
  3. Carbonell J, Felíu JE, Marco R, Sols A; ''Pyruvate kinase. Classes of regulatory isoenzymes in mammalian tissues.''; Eur J Biochem, 1973 PubMed Europe PMC Scholia
  4. Shestov AA, Liu X, Ser Z, Cluntun AA, Hung YP, Huang L, Kim D, Le A, Yellen G, Albeck JG, Locasale JW; ''Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.''; Elife, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137871
Approved
view20:18, 9 March 2025EweitzModified description
137870view20:18, 9 March 2025EweitzModified description
137869view20:18, 9 March 2025EweitzModified description
137868view20:17, 9 March 2025EweitzModified description
137864view19:26, 8 March 2025EgonwModified description
134298view06:21, 20 July 2024EgonwAdded the reference from the description to the reference list too
134296view06:06, 20 July 2024EgonwRemoved a template comment
129607view00:46, 19 May 2024EweitzModified title
129566view15:10, 13 May 2024EweitzModified description
129565view15:09, 13 May 2024EweitzRefine legend
129564view15:08, 13 May 2024EweitzRefine legend, economize layout
129563view14:55, 13 May 2024EweitzModified title
129561view14:53, 13 May 2024EweitzRefine legend, economize layout
129408view15:57, 11 April 2024KhanspersModified description
129403view21:02, 10 April 2024KhanspersModified description
129402view20:53, 10 April 2024Khansperscompleted legend
129401view19:06, 10 April 2024Khanspersupdate legend - work in progress
129400view18:57, 10 April 2024KhanspersModified description
129399view18:53, 10 April 2024KhanspersModified description
129398view18:51, 10 April 2024Khanspersupdated legend
129397view18:50, 10 April 2024Khanspersremoved LACT and OXYT nodes (passive transport)
127024view09:56, 19 July 2023Ash iyerDatanode clickable.
127023view09:49, 19 July 2023Ash iyerDatanodes clickable.
127022view09:47, 19 July 2023Ash iyerMade datanodes clickable.
127021view09:45, 19 July 2023Ash iyerMade datanodes clickable.
127020view09:43, 19 July 2023Ash iyerMade pathway nodes clickable.
127012view09:14, 19 July 2023Ash iyerData annotation update.
127011view08:37, 19 July 2023Ash iyerOntology Term : 'cancer pathway' added !
127010view21:43, 18 July 2023Khanspersattempt at switching node fill color for edge color
125611view12:04, 4 March 2023EgonwMinor updates: fixed a HGNC identifier, removed to incorrect identifiers, and make a pathway clickable
125610view11:59, 4 March 2023EgonwRemoved duplicate reference fields
119265view07:53, 23 June 2021FinterlyAdded ISBN for book citation
117689view12:09, 22 May 2021EweitzModified title
109374view14:57, 16 March 2020L DupuisConnected line
109373view14:57, 16 March 2020L DupuisConverted interaction lines to graphical lines
107176view14:26, 17 September 2019MaintBotChEBI identifier normalization
106805view13:28, 17 September 2019MaintBotHMDB identifier normalization
105520view08:43, 8 August 2019KJanssenChanged descriptions in legend
105419view16:31, 7 August 2019DeSlRemoved licence number and last modified part.
105417view16:30, 7 August 2019DeSlRemoved reference which was not connected to anything
105416view16:28, 7 August 2019DeSlRemoved weird signs in another lit. ref
105415view16:25, 7 August 2019DeSlRemoved weird signs in lit. ref
105414view16:20, 7 August 2019DeSlConverted interactions in legend to graphical lines, to avoid unconnected lines warning
105134view11:43, 10 July 2019EgonwRemoved a few '0' identifiers.
104985view20:32, 27 June 2019KJanssenChanged colour coding and legend
104935view00:26, 26 June 2019AlexanderPicoModified title
104903view07:09, 24 June 2019KJanssenAdded PDH
104640view07:00, 7 June 2019EgonwA few more.
104636view06:02, 7 June 2019EgonwIf there is no identifier, plz leave the Xref fields empty.
104616view08:07, 4 June 2019KJanssenModified description

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ADPMetaboliteCHEBI:16761 (ChEBI)
AKGeneProduct2.7.4.3 (Enzyme Nomenclature)
ALDGeneProduct226 (Entrez Gene)
ALTGeneProduct
AMPMetabolite16027 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
ASPMetabolite
ATPMetabolite15422 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
ATPaseGeneProduct
BPGMetaboliteHMDB0001270 (HMDB)
CKGeneProduct2.7.3.2 (Enzyme Nomenclature)
CRMetaboliteHMDB0000064 (HMDB)
DHAPMetaboliteHMDB0001473 (HMDB)
ENOGeneProduct2023 (Entrez Gene)
F26BPMetaboliteHMDB0001047 (HMDB)
F6PMetaboliteCHEBI:61527 (ChEBI)
FBPMetaboliteHMDB0001058 (HMDB)
G6PMetaboliteCHEBI:75052 (ChEBI) Glucose-6-Phosphate (2-)
G6PDHGeneProduct4057 (HGNC Accession number)
GAPDHGeneProductENSG00000111640 (Ensembl)
GAPMetaboliteHMDB0001112 (HMDB)
GHMTGeneProduct2.1.2.1 (Enzyme Nomenclature)
GLUMetaboliteHMDB0000122 (HMDB)
GLUTGeneProduct6513 (Entrez Gene)
GLUeMetaboliteHMDB0000122 (HMDB)
GLYMetaboliteHMDB0000187 (HMDB)
GPHOSGeneProduct
GPIGeneProduct2821 (Entrez Gene) glucose-6-phosphate isomerase
GPSGeneProduct
GPTGeneProduct2875 (Entrez Gene)
GRPDHGeneProduct
GSYNGeneProduct
Glycogen metabolismPathwayWP500 (WikiPathways)
H2OMetaboliteCHEBI:26689 (ChEBI)
HMetaboliteCHEBI:49637 (ChEBI)
HKGeneProduct3098 (Entrez Gene)
LACMetaboliteHMDB0000190 (HMDB)
LACeMetaboliteHMDB0000190 (HMDB)
LDH GeneProduct3939 (Entrez Gene)
MALMetabolite
MAS
NADMetaboliteCHEBI:15846 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
O2MetaboliteCHEBI:26689 (ChEBI)
O2eMetaboliteCHEBI:26689 (ChEBI)
OXPHOS
PMetaboliteCHEBI:28659 (ChEBI)
PCRMetaboliteHMDB0001511 (HMDB)
PDHGeneProduct
PEPMetaboliteHMDB0000263 (HMDB)
PFKGeneProduct5213 (Entrez Gene)
PGK GeneProduct5230 (Entrez Gene)
PGM GeneProduct5224 (Entrez Gene)
PHGDHGeneProduct
PKGeneProduct5315 (Entrez Gene)
PYRMetaboliteHMDB0000243 (HMDB)
Pentose phosphate pathwayPathwayWP134 (WikiPathways)
SERMetaboliteHMDB0000187 (HMDB)
SPTGeneProduct
Serine biosynthesisPathway
TPIGeneProduct7167 (Entrez Gene)
Triglyceride synthesisPathwayWP325 (WikiPathways)
_2PGMetaboliteHMDB0000362 (HMDB)
_3PGMetaboliteHMDB0000807 (HMDB)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4628"
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