ACE inhibitor pathway (Danio rerio)
From WikiPathways
Description
The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists.
Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)
Quality Tags
Ontology Terms
Bibliography
- Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ACE Inhibitor | Metabolite | CHEBI:35457 (ChEBI) | |
Aldosterone | Metabolite | C01780 (KEGG Compound) | |
Angiotensin I | Metabolite | 3081372 (PubChem-compound) | |
Angiotensin II | Metabolite | HMDB0001035 (HMDB) | |
Bradykinin | Metabolite | HMDB0004246 (HMDB) | |
ace2 | GeneProduct | 492331 (Entrez Gene) | |
agt | GeneProduct | 322485 (Entrez Gene) | |
agtr1 | GeneProduct | 561935 (Entrez Gene) | |
agtr2 | GeneProduct | 503772 (Entrez Gene) | |
bdkrb2 | GeneProduct | 368199 (Entrez Gene) | |
kng1 | GeneProduct | 449808 (Entrez Gene) | |
nos3 | GeneProduct | ||
ren | GeneProduct | 405786 (Entrez Gene) |
Annotated Interactions
No annotated interactions