Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011.

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Cancer Hallmark Categories

Sustaining proliferative signaling

Hippo-Merlin signaling dysregulation (Homo sapiens)

Hippo-Merlin signaling dysregulation
Hippo-Merlin signaling dysregulation
Evading growth suppressors

Tumor suppressor activity of SMARCB1 (Homo sapiens)

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Tumor suppressor activity of SMARCB1
Activating invasion and metastasis

H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer (Homo sapiens)

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H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer
Enabling replicative immortality

Regulation of Wnt / B-catenin signaling by small molecule compounds (Homo sapiens)

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Regulation of Wnt / B-catenin signaling by small molecule compounds
Inducing angiogenesis

VEGFA-VEGFR2 signaling (Homo sapiens)

VEGFA-VEGFR2 signaling
VEGFA-VEGFR2 signaling
Resisting cell death

PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer (Homo sapiens)

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PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer
Deregulating cellular energetics

Target of rapamycin signaling (Homo sapiens)

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Target of rapamycin signaling
Genome instability and mutation

ATM signaling in development and disease (Homo sapiens)

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ATM signaling in development and disease
Tumor promoting inflammation

IL6 signaling (Homo sapiens)

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IL6 signaling
Avoiding immune destruction

Interferon type I signaling (Homo sapiens)

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Interferon type I signaling
Therapeutics

Imatinib and chronic myeloid leukemia (Homo sapiens)

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Imatinib and chronic myeloid leukemia

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Featured Pathways

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Assay Portal

CPTAC also includes an Assay Portal to widely disseminate highly characterized proteomic assays to the global research community, with access to SOPs, reagents, and assay characterization/validation data

Resources

Learn how they incorpated WikiPathways images with custom links on their site.

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links

Personal tools