Nodal signaling pathway (Danio rerio)

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Description

Pathway describing the activation of the transcription of the NODAL genes and genes that respond to that.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Krens SF, Corredor-Adamez M, He S, Snaar-Jagalska BE, Spaink HP; ''ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis.''; BMC Genomics, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141499view08:26, 16 November 2025EgonwModified description
118480view05:45, 28 May 2021EgonwReplaced UniGene with Ensembl IDs
116893view11:20, 15 May 2021EweitzModified title
95702view19:56, 18 January 2018AlexanderPicofixed xref
95700view19:55, 18 January 2018AlexanderPicofixed xref
95699view19:54, 18 January 2018AlexanderPicofixed xref
95698view19:53, 18 January 2018AlexanderPicoupdated retired unigene id
95697view19:51, 18 January 2018AlexanderPicofixed xref
95696view19:49, 18 January 2018AlexanderPicofixed xref
95692view19:48, 18 January 2018AlexanderPicofixed xref
95691view19:47, 18 January 2018AlexanderPicofixed xref
95690view19:45, 18 January 2018AlexanderPicofixed xref
95689view19:43, 18 January 2018AlexanderPicofixed xref
95688view19:41, 18 January 2018AlexanderPicofixed xref
95687view19:38, 18 January 2018AlexanderPicoRemoved stray characters and updated xref
95686view19:31, 18 January 2018AlexanderPicoupdated retired entrez id
95685view19:26, 18 January 2018AlexanderPicoupdated retired unigene ids
71978view00:27, 24 October 2013MaintBotremoved data source from nodes without identifier
70244view21:32, 15 July 2013MaintBotupated to 2013 schema
70193view01:59, 13 July 2013AlexanderPicoModified title
67512view11:19, 26 June 2013DdiglesOntology Term : 'Nodal signaling pathway' added !
58800view22:53, 20 February 2013MaintBotUpdated Ensembl data source
52980view11:41, 25 October 2012Fredpadded lft1/antivin with correct mapping
40857view22:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
34975view09:01, 9 February 2010Danio368correct ectoderm to endoderm
29185view18:26, 9 April 2009KhanspersChanges pathway name: removed "zebrafish"
21395view11:31, 14 November 2008MaintBot[[Pathway:Danio rerio:Nodal Signaling]] moved to [[Pathway:WP341]]: Moved to stable identifier
16296view20:44, 17 June 2008Khanspers[[Pathway:Danio rerio:Dr Nodal-signaling]] moved to [[Pathway:Danio rerio:Nodal Signaling]]: Removed species code prefix from pathway name
14278view07:48, 22 May 2008SFGKrensModified categories
14047view08:24, 21 May 2008SFGKrensNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BAMBIGeneProduct83496 (Entrez Gene)
CBP / crebbpGeneProductGENE-050208-439 (Other)
ERK1 / mapk3GeneProduct399480 (Entrez Gene)
ERK2 / mapk1GeneProduct360144 (Entrez Gene)
Foxh1 / surGeneProduct327135 (Entrez Gene) FAST1 (fast1) (foxh1)
Foxh1 / surGeneProduct337369 (Entrez Gene) Forkhead box H1, mRNA (cDNA clone MGC:55221 IMAGE:2639305) (foxh1)
Foxh1 / surGeneProductENSDARG00000023527 (Ensembl) Forkhead box H1 (foxh1), mRNA (foxh1) - forkhead box H1 / schmalspur (sur)
MITFaGeneProduct30080 (Entrez Gene)
NFkB1GeneProduct565756 (Entrez Gene)
NFkB2GeneProduct415100 (Entrez Gene)
RasGeneProduct
TGIFGeneProduct321756 (Entrez Gene)
acvr1b / TARAMAGeneProduct30183 (Entrez Gene)
acvr2aGeneProduct338214 (Entrez Gene) Activin receptor IIA (acvr2a)
acvr2bGeneProduct80357 (Entrez Gene) ctivin receptor IIb (acvr2b), mRNA (acvr2b)
axial / FOXA2GeneProduct30126 (Entrez Gene)
bhikGeneProduct64281 (Entrez Gene) Bhikhari (bhik), mRNA (bhik)
bon / mixerGeneProduct336263 (Entrez Gene) Homeodomain transcription factor Mixer (mix) (bon)
bon / mixerGeneProduct492490 (Entrez Gene) Homeodomain transcription factor Mixer (mix) (bon)
bon / mixerGeneProductENSDARG00000069252 (Ensembl)
catGeneProduct368234 (Entrez Gene) Catalase (cat)
cdx4GeneProduct30330 (Entrez Gene)
cldndGeneProduct286779 (Entrez Gene) Claudin-like gene, clone ZF-A89 (cldnd) - anosmin1 precursor
cyc / foxa / ndr2GeneProduct195823 (Entrez Gene)
cyc / foxa / ndr2GeneProduct30292 (Entrez Gene)
cyc / foxa / ndr2GeneProduct492721 (Entrez Gene)
cyc / foxa /ndr2GeneProduct30292 (Entrez Gene)
cyc / foxa /ndr2GeneProduct564119 (Entrez Gene)
dharma / bozGeneProduct30170 (Entrez Gene)
dlx1aGeneProduct30216 (Entrez Gene) Dlx1 (dlx1a)
flhGeneProduct30260 (Entrez Gene) flh: Floating head (flh), mRNA
foxg1GeneProductENSDARG00000070769 (Ensembl) foxg1 / BF1
foxh1 / surGeneProduct57930 (Entrez Gene)
gata5 / fauGeneProduct30482 (Entrez Gene)
junGeneProductENSDARG00000043531 (Ensembl)
junbGeneProduct407086 (Entrez Gene)
junblGeneProduct336038 (Entrez Gene)
lef1GeneProductENSDARG00000031894 (Ensembl)
lft1 / antivinGeneProduct114417 (Entrez Gene)
lft1 / antivinGeneProduct327065 (Entrez Gene)
lft1 / antivinGeneProductENSDARG00000019920 (Ensembl)
lft2GeneProduct30146 (Entrez Gene) Lefty2 (lft2), mRNA (lft2)
lft2GeneProduct336233 (Entrez Gene) Signaling molecule lefty2 (lft2) (lft2)
lft2GeneProduct393724 (Entrez Gene) Lefty2 (lft2), mRNA (lft2)
lim1 / lhx1aGeneProduct30463 (Entrez Gene)
men1GeneProduct321622 (Entrez Gene) Menin (men1 gene) (men1)
myoDGeneProduct30513 (Entrez Gene)
myoDGeneProduct664740 (Entrez Gene)
neurog1GeneProduct30269 (Entrez Gene) Neurogenin 1, mRNA (cDNA clone MGC:76812 IMAGE:6963393) (neurog1)
neurog1GeneProduct30475 (Entrez Gene) Neurogenin 1, mRNA (cDNA clone MGC:76812 IMAGE:6963393) (neurog1)
neurog1GeneProduct393697 (Entrez Gene) Neurogenin 1 (neurog1), mRNA (neurog1)
neurog1GeneProduct58121 (Entrez Gene) Neurogenin (neurog1)
ntlGeneProduct30399 (Entrez Gene) ntl: No tail (ntl), mRNA
oepGeneProduct30346 (Entrez Gene) One-eyed pinhead long form protein (oep)
oepGeneProduct30406 (Entrez Gene) One-eyed pinhead short form protein (oep)
oepGeneProduct386614 (Entrez Gene) One-eyed pinhead (oep), mRNA (oep)
p300GeneProduct
p300 - Dr.161135GeneProductENSDARG00000076430 (Ensembl)
p300 - pred.GeneProduct327385 (Entrez Gene)
p300 - similarGeneProduct337477 (Entrez Gene)
p300 - similarGeneProduct337578 (Entrez Gene)
p300a - Dr.67573GeneProduct
p300b - Dr.162298GeneProductENSDARG00000061108 (Ensembl)
pax6aGeneProduct30567 (Entrez Gene)
pcdh8 / papcGeneProduct30456 (Entrez Gene)
runx2a/cbfa1GeneProduct405784 (Entrez Gene)
runx2b/cbfa1GeneProductENSDARG00000059233 (Ensembl)
runx2b/cbfa3GeneProductENSDARG00000059233 (Ensembl)
skiBGeneProduct30113 (Entrez Gene)
smad1GeneProduct30628 (Entrez Gene)
smad2GeneProduct30639 (Entrez Gene)
smad2GeneProduct323832 (Entrez Gene) Transcription factor Smad2 (smad2)
smad2GeneProduct324790 (Entrez Gene) Smad2 protein (smad2) (smad2)
smad2GeneProduct326879 (Entrez Gene) MAD homolog 2 (Drosophila), mRNA (cDNA clone MGC:113963 IMAGE:7395088) (smad2)
smad2GeneProduct393344 (Entrez Gene) MAD homolog 2 (Drosophila) (smad2), mRNA (smad2)
smad3aGeneProduct58092 (Entrez Gene)
smad3bGeneProduct326283 (Entrez Gene)
smad4GeneProduct559111 (Entrez Gene)
smad4GeneProductENSDARG00000023527 (Ensembl)
smad5GeneProduct30641 (Entrez Gene)
smad5GeneProduct393459 (Entrez Gene) MAD homolog 5 (Drosophila), mRNA
smad5GeneProduct415211 (Entrez Gene) Mad-related protein Smad5 (smad5) (smad5)
smad5GeneProduct553171 (Entrez Gene) MAD homolog 5 (Drosophila) (smad5), mRNA (smad5)
smad5GeneProduct58093 (Entrez Gene) MAD homolog 5 (Drosophila), mRNA
smad6aGeneProduct116992 (Entrez Gene)
smad7GeneProduct326282 (Entrez Gene)
smurf1GeneProduct
snip1GeneProduct474374 (Entrez Gene)
sox17GeneProduct30544 (Entrez Gene) sox17: SRY-box containing gene 17, mRNA (cDNA clone MGC:91776
sox32 / casGeneProduct116990 (Entrez Gene) sox32: SRY-box containing gene 32, mRNA (cDNA clone MGC:114019
sox32 / casGeneProduct322641 (Entrez Gene) Sox transcription factor 226D7 (sox32)
sox32 / casGeneProduct664758 (Entrez Gene) SRY-box containing gene 32, mRNA (cDNA clone MGC:114019 IMAGE:7450460) (sox32)
sqt / foxa3 / ndr1GeneProduct
sqt / foxa3 / ndr1GeneProduct336281 (Entrez Gene)
sqt / foxa3 / ndr1GeneProductENSDARG00000043673 (Ensembl)
stat1GeneProduct30768 (Entrez Gene)
stat3GeneProduct30767 (Entrez Gene)
taf5lGeneProduct334055 (Entrez Gene)
tbx16 / sptGeneProduct30264 (Entrez Gene)
tcf7/tcf1GeneProduct497649 (Entrez Gene)
tcfl1aGeneProductENSDARG00000038159 (Ensembl)
tcfl1bGeneProduct30556 (Entrez Gene)
ube2d1GeneProduct324015 (Entrez Gene)
vedGeneProduct368201 (Entrez Gene)
ventGeneProduct64810 (Entrez Gene)
voxGeneProduct64807 (Entrez Gene)

Annotated Interactions

No annotated interactions

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