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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Miscellaneous factors Differentiated adipocyte Preadipocyte Transcription factors / modulators RORA PPARG RARA NR2F1 MEF2D NCOR2 CEBPB NCOR1 SREBF1 MEF2A NCOA1 NRIP1 CEBPD MBNL1 PPARA CEBPA NR1H3 RXRG RXRA PPARD MEF2B MEF2C CREB1 Inhibitors of preadipocyte to adipocyte transition WNT5B WNT1 DLK1 GATA2 NDN WNT10B GATA3 GATA4 Fully differentiated adipocyte markers LPL UCP1 PLIN FAS LIPE SLC2A4 GTF3A PPARGC1A Growth factors / hormones NR3C1 IGF1 INS PRLR TGFB1 GH1 Insulin action genes IRS1 IRS2 IRS4 IRS3P Possible lipodystrophy genes LPIN2 LMNA ZMPSTE24 AGPAT2 BSCL2 LPIN3 LPIN1 Adipocyte secretory products AGT ADIPOQ SPOCK ADPN ADFP DF PBEF1 TNF LEP IL6 RETN STAT5A DDIT3 FOXO1A MIXL1 DVL1 SOCS1 KLF6 BMP4 OSM ID3 KLF7 KLF15 ASIP STAT2 SOCS3 STAT5B EBF CNTFR FOXC2 GDF10 CTNNB1 PTGIS SFRP4 TCF1 SP1 HIF1A BMP2 C10orf70 HMGA1 PCK2 MIF EGR2 RBL1 AHR WWTR1 FZD1 TWIST1 GADD45B GADD45A PCK1 SERPINE1 BMP1 NCOA2 E2F1 TRIB3 RBL2 STAT6 SMAD3 CYP26B1 RB1 LIF EPAS1 STAT3 FRZB LIFR KLF5 IL6ST CUGBP1 BMP3 CYP26A1 CDKN1A SCD STAT1 E2F4 Name: Adipogenesis Organism: Homo sapiens
Description
The different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from preadipocytes to adipocytes (fat cells). Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP236 )
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Quality Tags
Annotated lists Annotated lists of gene products are considered useful for analysis and for stimulating future pathway curation.
Approved version The current version of this pathway was approved for data analysis by Eric Weitz .
Ontology Terms
Bibliography
Rosen ED, Spiegelman BM; ''Molecular regulation of adipogenesis.''; Annu Rev Cell Dev Biol, 2000 PubMed Europe PMC Scholia History
External references
DataNodes
Annotated Interactions
No annotated interactions
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