Alanine and aspartate metabolism (Homo sapiens)
From WikiPathways
Description
Converted from rat to human using ortholog information, originally from KEGG. Originally edited by Sebastien Burel.
This pathway describes the metabolism of amino acids alanine and aspartate. Alanine is broken down by oxidative deamination, the inverse reaction of the reductive amination biosynthesis, catalyzed by the same enzymes.
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Bibliography
- Wu G; ''Intestinal mucosal amino acid catabolism.''; J Nutr, 1998 PubMed Europe PMC Scholia
- Curien G, Bastien O, Robert-Genthon M, Cornish-Bowden A, Cárdenas ML, Dumas R; ''Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters.''; Mol Syst Biol, 2009 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
1.2.1.18 | GeneProduct | 1.2.1.18 (Enzyme Nomenclature) | |
1.4.3.1 | GeneProduct | 1.4.3.1 (Enzyme Nomenclature) | |
1.4.3.15 | GeneProduct | 1.4.3.15 (Enzyme Nomenclature) | |
1.4.3.16 | GeneProduct | 1.4.3.16 (Enzyme Nomenclature) | |
1.4.3.2 | GeneProduct | 1.4.3.2 (Enzyme Nomenclature) | |
2-Oxoglutarate | Metabolite | C00026 (KEGG Compound) | |
2-Oxosuccinamate | Metabolite | CHEBI:57735 (ChEBI) | |
2.1.3.2 | GeneProduct | 2.1.3.2 (Enzyme Nomenclature) | |
2.3.1.7 | GeneProduct | 2.3.1.7 (Enzyme Nomenclature) | |
2.6.1.12 | GeneProduct | 2.6.1.12 (Enzyme Nomenclature) | |
2.6.1.14 | GeneProduct | 2.6.1.14 (Enzyme Nomenclature) | |
2.6.1.18 | GeneProduct | 2.6.1.18 (Enzyme Nomenclature) | |
3.4.13.3 | GeneProduct | 3.4.13.3 (Enzyme Nomenclature) | |
3.5.1.1 | GeneProduct | 3.5.1.1 (Enzyme Nomenclature) | |
3.5.1.3 | GeneProduct | 3.5.1.3 (Enzyme Nomenclature) | |
3.5.1.38 | GeneProduct | 3.5.1.38 (Enzyme Nomenclature) | |
3.5.1.7 | GeneProduct | 3.5.1.7 (Enzyme Nomenclature) | |
4.1.1.11 | GeneProduct | 4.1.1.11 (Enzyme Nomenclature) | |
4.1.1.12 | GeneProduct | 4.1.1.12 (Enzyme Nomenclature) | |
4.3.1.1 | GeneProduct | 4.3.1.1 (Enzyme Nomenclature) | |
4.3.2.2 | GeneProduct | 4.3.2.2 (Enzyme Nomenclature) | |
5.1.1.13 | GeneProduct | 5.1.1.13 (Enzyme Nomenclature) | |
5.1.1.1 | GeneProduct | 5.1.1.1 (Enzyme Nomenclature) | |
6.1.1.22 | GeneProduct | 6.1.1.22 (Enzyme Nomenclature) | |
6.1.1.7 | GeneProduct | 6.1.1.7 (Enzyme Nomenclature) | |
6.3.1.1 | GeneProduct | 6.3.1.1 (Enzyme Nomenclature) | |
6.3.2.11 | GeneProduct | 6.3.2.11 (Enzyme Nomenclature) | |
6.3.4.4 | GeneProduct | 6.3.4.4 (Enzyme Nomenclature) | |
6.3.5.4 | GeneProduct | 6.3.5.4 (Enzyme Nomenclature) | |
6.3.5.6 | GeneProduct | 6.3.5.6 (Enzyme Nomenclature) | |
ABAT | GeneProduct | 18 (Entrez Gene) | |
AGXT | GeneProduct | 189 (Entrez Gene) | |
ASL | GeneProduct | 435 (Entrez Gene) | |
ASPA | GeneProduct | 443 (Entrez Gene) | |
ASS | GeneProduct | 445 (Entrez Gene) | |
Acetyl-CoA | Metabolite | 72-89-9 (CAS) | Acetyl-CoA |
Adenylosuccinate | Metabolite | CHEBI:15919 (ChEBI) | |
Arginine and Proline metabolism | Pathway | ||
Carnosine | Metabolite | 305-84-0 (CAS) | Carnosine |
Citric acid | Metabolite | HMDB0000094 (HMDB) | |
Cyanoamino acid metabolism | Pathway | ||
D-Ala metabolism | Pathway | ||
D-Alanine | Metabolite | 338-69-2 (CAS) | D-Alanine |
D-aspartate | Metabolite | C00402 (KEGG Compound) | |
DARS | GeneProduct | 1615 (Entrez Gene) | |
Fatty acid metabolism | Pathway | WP143 (WikiPathways) | |
Fumarate | Metabolite | C00122 (KEGG Compound) | |
GAD1 | GeneProduct | 2571 (Entrez Gene) | |
GAD2 | GeneProduct | 2572 (Entrez Gene) | |
GOT1 | GeneProduct | 2805 (Entrez Gene) | |
GOT2 | GeneProduct | 2806 (Entrez Gene) | |
GPT | GeneProduct | 2875 (Entrez Gene) | |
Glycine, serine and threonine metabolism | Pathway | ||
Glycolysis & gluconeogenesis | Pathway | WP534 (WikiPathways) | |
Histidine metabolism | Pathway | ||
L-Alanine | Metabolite | CHEBI:16977 (ChEBI) | |
L-Argininosuccinate | Metabolite | CHEBI:15682 (ChEBI) | |
L-Asparagine acid | Metabolite | 70-47-3 (CAS) | |
L-Asparagine | Metabolite | 70-47-3 (CAS) | L-Asparagine |
L-Aspartic acid | Metabolite | C00049 (KEGG Compound) | |
L-aspartate | Metabolite | C00049 (KEGG Compound) | |
Lysine biosynthesis | Pathway | ||
Malate | Metabolite | 6915-15-7 (CAS) | (S)-Malate |
Malonate semialdehyde | Metabolite | CHEBI:33190 (ChEBI) | |
N-Acetyl-L-aspartate | Metabolite | Q28000013 (Wikidata) | |
N-Carbamoyl-L-aspartate | Metabolite | CHEBI:15859 (ChEBI) | |
Nicotinate and nicotinamide metabolism | Pathway | ||
O-Acetylcarnitine | Metabolite | 3040-38-8 (CAS) | |
Oxaloacetate | Metabolite | C00036 (KEGG Compound) | |
PC | GeneProduct | 5091 (Entrez Gene) | |
Pantothenate and CoA biosynthesis | Pathway | ||
Pyrimidine metabolism | Pathway | WP4022 (WikiPathways) | |
Pyruvate | Metabolite | CHEBI:32816 (ChEBI) | |
Reductive carboxylate cycle (CO2 fixation) | Pathway | ||
Selenoamino acid metabolism | Pathway | ||
Succinate | Metabolite | C00042 (KEGG Compound) | |
Urea cycle and metabolism of amino groups | Pathway | WP497 (WikiPathways) | |
b-Alanine | Metabolite | 16958 (ChEBI) | beta-alanine |
beta-Alanine metabolism | Pathway | ||
tRNA (Asn) | GeneProduct | ||
tRNA(Asp) | GeneProduct |
Annotated Interactions
No annotated interactions