Fas ligand pathway and stress induction of heat shock proteins (Homo sapiens)
From WikiPathways
Description
This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress.
More info: BioCarta.
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Bibliography
- Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000 PubMed Europe PMC Scholia
- Ji Q, Hao X, Meng Y, Zhang M, Desano J, Fan D, Xu L; ''Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres.''; BMC Cancer, 2008 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ACTA1 | GeneProduct | 58 (Entrez Gene) | |
ACTB | GeneProduct | 60 (Entrez Gene) | |
ACTG1 | GeneProduct | 71 (Entrez Gene) | |
APAF1 | GeneProduct | 317 (Entrez Gene) | |
ARHGDIB | GeneProduct | 397 (Entrez Gene) | Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted) |
Apoptosis | Pathway | WP254 (WikiPathways) | |
BCL2 | GeneProduct | 596 (Entrez Gene) | |
CASP10 | GeneProduct | 843 (Entrez Gene) | |
CASP3 | GeneProduct | 836 (Entrez Gene) | |
CASP6 | GeneProduct | 839 (Entrez Gene) | |
CASP7 | GeneProduct | 840 (Entrez Gene) | |
CASP8 | GeneProduct | 841 (Entrez Gene) | |
CASP9 | GeneProduct | 842 (Entrez Gene) | |
CFLAR | GeneProduct | 8837 (Entrez Gene) | |
CYCS | GeneProduct | 54205 (Entrez Gene) | |
Ceramide | Metabolite | 104404-17-3 (CAS) | |
DAXX | GeneProduct | 1616 (Entrez Gene) | |
DFFA | GeneProduct | 1676 (Entrez Gene) | |
DFFB | GeneProduct | 1677 (Entrez Gene) | |
FADD | GeneProduct | 8772 (Entrez Gene) | |
FAF1 | GeneProduct | 11124 (Entrez Gene) | |
FAP1 | GeneProduct | 4799 (Entrez Gene) | |
FAS | GeneProduct | 355 (Entrez Gene) | |
FASLG | GeneProduct | 356 (Entrez Gene) | |
Glutathione | Metabolite | HMDB0000125 (HMDB) | |
HSPB1 | GeneProduct | 3315 (Entrez Gene) | |
IL1A | GeneProduct | 3552 (Entrez Gene) | |
JUN | GeneProduct | 3725 (Entrez Gene) | |
LMNA | GeneProduct | 4000 (Entrez Gene) | |
LMNB1 | GeneProduct | 4001 (Entrez Gene) | |
LMNB2 | GeneProduct | 84823 (Entrez Gene) | |
MAP2K4 | GeneProduct | 6416 (Entrez Gene) | |
MAP3K1 | GeneProduct | 4214 (Entrez Gene) | |
MAP3K7 | GeneProduct | 6885 (Entrez Gene) | |
MAPK8 | GeneProduct | 5599 (Entrez Gene) | |
MAPKAPK2 | GeneProduct | 9261 (Entrez Gene) | |
MAPKAPK3 | GeneProduct | 7867 (Entrez Gene) | |
MIR34C | Rna | ENSG00000207562 (Ensembl) | |
PAK1 | GeneProduct | 5058 (Entrez Gene) | |
PAK2 | GeneProduct | 5062 (Entrez Gene) | |
PARP1 | GeneProduct | 142 (Entrez Gene) | |
PRKDC | GeneProduct | 5591 (Entrez Gene) | |
Phosphate | Metabolite | HMDB0001429 (HMDB) | |
RB1 | GeneProduct | 5925 (Entrez Gene) | |
RIPK2 | GeneProduct | 8767 (Entrez Gene) | receptor (TNFRSF)-interacting serine-threonine kinase 2 |
SPTAN1 | GeneProduct | 6709 (Entrez Gene) | Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted) |
TNF | GeneProduct | 7124 (Entrez Gene) |
Annotated Interactions
No annotated interactions