Focal adhesion (Homo sapiens)

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MYL5PMYLPFP1-17NucleusCytokine-cytokine receptor interactionsFA turnoverStress fiber-FA formationFilopodia / lamellipodia formationPI3K-Aktsignaling pathwayCell proliferationCell survivalCell motilityActin polymerizationExtracellular matrix - receptor interactionsCell cycleReceptor tyrosine kinasesLAMC3AKT1ITGA8PAK3ARHGAP5FGRITGA6AKT3COMPTNXBRAPGEF1ITGA1ITGA4ROCK2BUB1B-PAK6ITGB5ITGA2BRELNMAP2K1TNNITGB8LAMC1ITGA7TXKXIAPPAK6RHOAPGFITGA2ACTG1RAC1VEGFVASPPIK3CDLAMA3BIRC3IBSPCAV1RAC2ZYXITGAVCOL1A1FIGFSRCSTYK1PAK2LAMB3ACTN4COL6A2PAK4PDGFCPIP5K1CTHBS3ITGA10PIK3CBCOL4A4CTNNB1PARVBFLNAPDGFDTNK2SRMSTNK1ERBB2COL5A2TLN1ITGA3COL4A1GRB2TESK2CAV2RAP1AAKT2ITGB1PIK3R1PhosphatidylinositolsignalingPIK3R3RASGRF1PIK3CAPDGFRBMAPK3COL5A3IGF1Wnt signalingpathwayTHBS2EGFPTK6ITGB6GSK3BCCND1MAPK1TNCILKMYLKHGFVAV1VTNPDPK1PIP2DOCK1ITGB4THBS4FN1LAMA4IGF1RSPP1LAMB1THBS1KDRCRKLVCLFLT1RAC3LAMB2EGFRRAP1BACTBBADBCL2METSHC1VEGFBRAF1MAPK9VWFTNRDIAPH1HCKCAPN2ITGA9CRKPDGFRARegulation of actin cytoskeletonSHC3LAMA2ITGA5ITGB7CCND2PDGFBITGB3PTK2COL1A2COL4A6PIP3CCND3ITGA11PAK1LAMC2SOS1ELK1BLKCAV3HRASPPP1R12APDGFACHADBRAFPXNCDC42ROCK1LAMA5LAMA1EMP2PIK3R2BCAR1JUNMYLK2PTENCOL4A2FYNVEGFCCOL2A1BIRC2MAPK8PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPSHC2SHC4PPPRKCAPRKCBPRKCGARHGAP35PPPP1R12BPPP1R12CPPP1CAPPP1CBPPP1CCPPP1CCMYL7MYL10PPMYL12AMYL12BPMYL2PMYL9PPMYLK3MYLK4PPACTN1PARVAPARVGFLNBFLNCTLN2MAPK10PVAV2VAV3


Description

Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Bibliography

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  1. Turner CE; ''Paxillin and focal adhesion signalling.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
  2. Parsons JT; ''Focal adhesion kinase: the first ten years.''; J Cell Sci, 2003 PubMed Europe PMC Scholia
  3. Mitra SK, Hanson DA, Schlaepfer DD; ''Focal adhesion kinase: in command and control of cell motility.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  4. Stupack DG, Cheresh DA; ''Get a ligand, get a life: integrins, signaling and cell survival.''; J Cell Sci, 2002 PubMed Europe PMC Scholia
  5. Schlaepfer DD, Mitra SK; ''Multiple connections link FAK to cell motility and invasion.''; Curr Opin Genet Dev, 2004 PubMed Europe PMC Scholia
  6. Schmitz AA, Govek EE, Bأƒآ¶ttner B, Van Aelst L; ''Rho GTPases: signaling, migration, and invasion.''; Exp Cell Res, 2000 PubMed Europe PMC Scholia
  7. Berman AE, Kozlova NI, Morozevich GE; ''Integrins: structure and signaling.''; Biochemistry (Mosc), 2003 PubMed Europe PMC Scholia
  8. Danen EH, Yamada KM; ''Fibronectin, integrins, and growth control.''; J Cell Physiol, 2001 PubMed Europe PMC Scholia
  9. Lee JW, Juliano R; ''Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.''; Mol Cells, 2004 PubMed Europe PMC Scholia
  10. Guo W, Giancotti FG; ''Integrin signalling during tumour progression.''; Nat Rev Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  11. Oloumi A, McPhee T, Dedhar S; ''Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.''; Biochim Biophys Acta, 2004 PubMed Europe PMC Scholia
  12. Hlobilkovأƒآ، A, Knillovأƒآ، J, Bأƒآ،rtek J, Lukأƒآ،s J, Kolأƒآ،r Z; ''The mechanism of action of the tumour suppressor gene PTEN.''; Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2003 PubMed Europe PMC Scholia
  13. Nicholson KM, Anderson NG; ''The protein kinase B/Akt signalling pathway in human malignancy.''; Cell Signal, 2002 PubMed Europe PMC Scholia
  14. Burridge K, Wennerberg K; ''Rho and Rac take center stage.''; Cell, 2004 PubMed Europe PMC Scholia
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  16. Comoglio PM, Boccaccio C, Trusolino L; ''Interactions between growth factor receptors and adhesion molecules: breaking the rules.''; Curr Opin Cell Biol, 2003 PubMed Europe PMC Scholia
  17. Petit V, Thiery JP; ''Focal adhesions: structure and dynamics.''; Biol Cell, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135112view11:51, 6 August 2024EweitzEconomize layout
135111view11:45, 6 August 2024EweitzRestore state positions
135110view11:41, 6 August 2024EweitzEconomize layout
135109view11:38, 6 August 2024EweitzRestore state positions
135104view23:12, 5 August 2024EweitzEconomize layout
135103view23:11, 5 August 2024EweitzRestore state positions
135102view23:06, 5 August 2024EweitzEconomize layout
130801view12:29, 30 May 2024EweitzStandardize case
127184view17:57, 9 August 2023Khanspersupdated ptms
127171view06:16, 9 August 2023Fehrhartgave pathway nodes boxes
127170view23:33, 8 August 2023Khansperslayout and pathway identifier
127169view22:48, 8 August 2023Khanspersupdated ptms
127168view20:33, 8 August 2023Khansperswork in progress
116784view09:54, 14 May 2021EweitzModified title
106731view13:21, 17 September 2019MaintBotHMDB identifier normalization
106421view22:01, 28 August 2019KhanspersModified description
105598view04:49, 10 August 2019KhanspersModified description
105008view04:59, 28 June 2019KhanspersModified description
97459view19:25, 21 May 2018Khansperswork in progress
95135view01:02, 17 November 2017AriuttaConnected ILK to group
94849view21:23, 9 October 2017Khanspersconnected interactions, added nucleus
94846view17:59, 6 October 2017Khanspersoverhaul
94845view17:42, 6 October 2017Khanspersoverhaul in progress
92678view11:09, 28 June 2017MirellaKalafatiMetabolite was marked as gene, plant identifier instead of human
80308view20:15, 3 June 2015DtruongModified title
80207view20:58, 22 May 2015KhanspersReverted to version '20:41, 28 April 2015' by Khanspers
80193view22:52, 19 May 2015Khanspersupdated mir29c target interactions
80191view22:28, 19 May 2015KhanspersAdded mir29c interaction
80037view00:21, 2 May 2015KhanspersAdded MIR34C
79971view20:41, 28 April 2015Zariannotated Ha-Ras , Catnb and Diap1 genes
79698view12:28, 5 April 2015EgonwReplaced two non-numeric Entrez identifiers with numeric ones.
78800view18:41, 30 January 2015EgonwFixed an Entrez identifier: BIRC4 = 331.
71714view20:06, 17 October 2013MaintBotremoved data source from nodes without identifier
69965view21:06, 11 July 2013MaintBotupdating to 2013 schema
45270view18:49, 7 October 2011AlexanderPico
45269view18:49, 7 October 2011AlexanderPicoOntology Term : 'cell adhesion signaling pathway' added !
41071view23:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35287view22:50, 11 February 2010KhanspersAdded lit refs
35280view22:39, 11 February 2010KhanspersLit refs
35272view20:40, 11 February 2010KhanspersModified description
32638view14:51, 21 August 2009MaintBotautoconversion of Entrez symbols to IDs
32393view16:59, 15 August 2009MaintBotFixed text labels
32041view13:29, 14 August 2009MaintBotFixed group labels
21323view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Focal adhesion KEGG]] moved to [[Pathway:WP306]]: Moved to stable identifier
13963view11:11, 20 May 2008Thomasadded connectors / groups
13899view14:12, 19 May 2008ThomasWIP on connectors
13897view13:53, 19 May 2008ThomasWIP on connectors
13895view13:37, 19 May 2008ThomasPeriodical save, work in progress
13012view11:05, 17 May 2008MaintBotSticky edges patch by Sjoerd
8058view13:46, 7 January 2008MaintBot[[Pathway:Human:Focal adhesion KEGG]] moved to [[Pathway:Homo sapiens:Focal adhesion KEGG]]: Renaming species

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTBGeneProduct60 (Entrez Gene)
ACTG1GeneProduct71 (Entrez Gene)
ACTN1GeneProduct87 (Entrez Gene)
ACTN4GeneProductENSG00000130402 (Ensembl)
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
ARHGAP35GeneProductENSG00000160007 (Ensembl)
ARHGAP5GeneProduct394 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
BIRC2GeneProduct329 (Entrez Gene)
BIRC3GeneProduct330 (Entrez Gene)
BLKGeneProduct640 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
BUB1B-PAK6GeneProductENSG00000259288 (Ensembl)
CAPN2GeneProductENSG00000162909 (Ensembl)
CAV1GeneProduct857 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
CAV2GeneProduct858 (Entrez Gene) CAV2; caveolin 2
CAV3GeneProduct859 (Entrez Gene) CAV3; caveolin 3
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene)
CHADGeneProduct1101 (Entrez Gene)
COL1A1GeneProduct1277 (Entrez Gene)
COL1A2GeneProduct1278 (Entrez Gene)
COL2A1GeneProduct1280 (Entrez Gene)
COL4A1GeneProduct1282 (Entrez Gene)
COL4A2GeneProduct1284 (Entrez Gene)
COL4A4GeneProduct1286 (Entrez Gene)
COL4A6GeneProduct1288 (Entrez Gene)
COL5A2GeneProduct1290 (Entrez Gene)
COL5A3GeneProduct50509 (Entrez Gene)
COL6A2GeneProduct1292 (Entrez Gene)
COMPGeneProduct1311 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProductENSG00000099942 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
Cell cyclePathwayWP179 (WikiPathways)
Cell motilityPathway
DIAPH1GeneProductENSG00000131504 (Ensembl)
DOCK1GeneProduct1793 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
EMP2GeneProduct2013 (Entrez Gene)
ERBB2GeneProduct2064 (Entrez Gene)
FGRGeneProduct2268 (Entrez Gene)
FIGFGeneProduct2277 (Entrez Gene)
FLNAGeneProduct2316 (Entrez Gene)
FLNBGeneProductENSG00000136068 (Ensembl)
FLNCGeneProductENSG00000128591 (Ensembl)
FLT1GeneProduct2321 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
GRB2GeneProduct2885 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
GSK3BGeneProduct2932 (Entrez Gene)
HCKGeneProduct3055 (Entrez Gene)
HGFGeneProduct3082 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
IBSPGeneProduct3381 (Entrez Gene)
IGF1GeneProduct3479 (Entrez Gene)
IGF1RGeneProduct3480 (Entrez Gene)
ILKGeneProduct3611 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
ITGA10GeneProduct8515 (Entrez Gene)
ITGA11GeneProduct22801 (Entrez Gene)
ITGA1GeneProductENSG00000213949 (Ensembl)
ITGA2GeneProduct3673 (Entrez Gene)
ITGA2BGeneProduct3674 (Entrez Gene)
ITGA3GeneProduct3675 (Entrez Gene)
ITGA4GeneProduct3676 (Entrez Gene)
ITGA5GeneProduct3678 (Entrez Gene)
ITGA6GeneProduct3655 (Entrez Gene)
ITGA7GeneProduct3679 (Entrez Gene)
ITGA8GeneProduct8516 (Entrez Gene)
ITGA9GeneProduct3680 (Entrez Gene)
ITGAVGeneProduct3685 (Entrez Gene)
ITGB1GeneProduct3688 (Entrez Gene)
ITGB3GeneProduct3690 (Entrez Gene)
ITGB4GeneProduct3691 (Entrez Gene)
ITGB5GeneProduct3693 (Entrez Gene)
ITGB6GeneProduct3694 (Entrez Gene)
ITGB7GeneProduct3695 (Entrez Gene)
ITGB8GeneProduct3696 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
KDRGeneProduct3791 (Entrez Gene)
LAMA1GeneProduct284217 (Entrez Gene)
LAMA2GeneProduct3908 (Entrez Gene)
LAMA3GeneProduct3909 (Entrez Gene)
LAMA4GeneProduct3910 (Entrez Gene)
LAMA5GeneProduct3911 (Entrez Gene)
LAMB1GeneProduct3912 (Entrez Gene)
LAMB2GeneProduct3913 (Entrez Gene)
LAMB3GeneProduct3914 (Entrez Gene)
LAMC1GeneProduct3915 (Entrez Gene)
LAMC2GeneProduct3918 (Entrez Gene)
LAMC3GeneProduct10319 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK1GeneProduct5594 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK3GeneProductENSG00000102882 (Ensembl) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
METGeneProduct4233 (Entrez Gene)
MYL10GeneProductENSG00000106436 (Ensembl)
MYL12AGeneProductENSG00000101608 (Ensembl)
MYL12BGeneProductENSG00000118680 (Ensembl)
MYL2GeneProductENSG00000111245 (Ensembl)
MYL5GeneProductENSG00000215375 (Ensembl)
MYL7GeneProductENSG00000106631 (Ensembl)
MYL9GeneProductENSG00000101335 (Ensembl)
MYLK2GeneProduct85366 (Entrez Gene)
MYLK3GeneProductENSG00000140795 (Ensembl)
MYLKGeneProduct4638 (Entrez Gene)
MYLK4GeneProductENSG00000145949 (Ensembl)
MYLPFGeneProductENSG00000180209 (Ensembl)
PAK1GeneProduct5058 (Entrez Gene)
PAK2GeneProduct5062 (Entrez Gene)
PAK3GeneProduct5063 (Entrez Gene)
PAK4GeneProduct10298 (Entrez Gene)
PAK6GeneProduct56924 (Entrez Gene)
PARVAGeneProductENSG00000197702 (Ensembl)
PARVBGeneProduct29780 (Entrez Gene)
PARVGGeneProductENSG00000138964 (Ensembl)
PDGFAGeneProduct5154 (Entrez Gene)
PDGFBGeneProduct5155 (Entrez Gene)
PDGFCGeneProduct56034 (Entrez Gene)
PDGFDGeneProduct80310 (Entrez Gene)
PDGFRAGeneProduct5156 (Entrez Gene)
PDGFRBGeneProduct5159 (Entrez Gene)
PDPK1GeneProduct5170 (Entrez Gene)
PGFGeneProduct5228 (Entrez Gene)
PI3K-Akt signaling pathwayPathwayWP4172 (WikiPathways)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteHMDB0004249 (HMDB)
PIP5K1CGeneProduct23396 (Entrez Gene)
PPP1CAGeneProductENSG00000172531 (Ensembl)
PPP1CBGeneProductENSG00000213639 (Ensembl)
PPP1CCGeneProductENSG00000186298 (Ensembl)
PPP1R12AGeneProduct4659 (Entrez Gene)
PPP1R12BGeneProductENSG00000077157 (Ensembl)
PPP1R12CGeneProductENSG00000125503 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
PRKCBGeneProductENSG00000166501 (Ensembl) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
PRKCGGeneProductENSG00000126583 (Ensembl) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
PTENGeneProduct5728 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
PTK6GeneProduct5753 (Entrez Gene)
PXNGeneProduct5829 (Entrez Gene)
Phosphatidylinositol signalingPathway
RAC1GeneProduct5879 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
RAC3GeneProduct5881 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
RAP1AGeneProduct5906 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
RAP1BGeneProduct5908 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
RAPGEF1GeneProduct2889 (Entrez Gene)
RASGRF1GeneProductENSG00000058335 (Ensembl)
RELNGeneProduct5649 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
ROCK1GeneProduct6093 (Entrez Gene)
ROCK2GeneProduct9475 (Entrez Gene)
Regulation of actin cytoskeletonPathwayWP51 (WikiPathways)
SHC1GeneProduct6464 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC2GeneProductENSG00000129946 (Ensembl) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC3GeneProduct53358 (Entrez Gene) SHC3; neuronal Sh
SHC4GeneProductENSG00000185634 (Ensembl) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SOS1GeneProduct6654 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
SPP1GeneProduct6696 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
SRMSGeneProduct6725 (Entrez Gene)
STYK1GeneProduct55359 (Entrez Gene)
TESK2GeneProduct10420 (Entrez Gene)
THBS1GeneProduct7057 (Entrez Gene)
THBS2GeneProduct7058 (Entrez Gene)
THBS3GeneProduct7059 (Entrez Gene)
THBS4GeneProduct7060 (Entrez Gene)
TLN1GeneProduct7094 (Entrez Gene)
TLN2GeneProductENSG00000171914 (Ensembl)
TNCGeneProduct3371 (Entrez Gene)
TNK1GeneProduct8711 (Entrez Gene)
TNK2GeneProduct10188 (Entrez Gene)
TNNGeneProduct63923 (Entrez Gene)
TNRGeneProduct7143 (Entrez Gene)
TNXBGeneProduct7148 (Entrez Gene)
TXKGeneProduct7294 (Entrez Gene)
VASPGeneProduct7408 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
VAV1GeneProduct7409 (Entrez Gene)
VAV2GeneProductENSG00000160293 (Ensembl)
VAV3GeneProductENSG00000134215 (Ensembl)
VCLGeneProduct7414 (Entrez Gene) VCL; vinculin
VEGFGeneProduct7422 (Entrez Gene)
VEGFBGeneProduct7423 (Entrez Gene)
VEGFCGeneProduct7424 (Entrez Gene)
VTNGeneProduct7448 (Entrez Gene)
VWFGeneProduct7450 (Entrez Gene)
Wnt signaling pathwayPathwayWP428 (WikiPathways)
XIAPGeneProductENSG00000101966 (Ensembl)
ZYXGeneProduct7791 (Entrez Gene) ZYX; zyxin

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP306"
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