From WikiPathways
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Opioid Bombesin Somatostatin Thyrotropin-releasing hormone and Secretagogue (Rhod)opsin Rhodopsin Vertebrate Interleukin-8 Lutropin-choriogonadotropic hormone Neuropeptide Y / peptide YY Melanocortin Class A Orphan/other Platelet ADP & KI01 receptors Adrenomedullin (G10D) Other Chemokine Receptors Adrenoceptors Alpha Adrenoceptors Olfactory APJ like Fmet-leu-phe Hormone protein Follicle stimulating hormone CCK Mas proto-oncogene ORPH LGR like (hormone receptors) Purinoceptor type Y Rhodopsin Other Orexin & neuropeptide FF Purinoceptors C5a anaphylatoxin Nucleotide-like Adenosine Beta Adrenoceptors Cannabis Vasopressin-like GP40 like BONZO receptors (CXC6R) Chemokine receptor-like Chemokine C-C Chemokine Neuropeptide Y Amine Acetylcholine (muscarinic) Endothelin Platelet activating factor Class A Orphans Olfactory Other SREB Thrombin Neuromedin U C-X-C Chemokine GPR45 like CX3CR1 P2RY2 Dopamine Bradykinin F2R PTAFR Prostaglandin LHCGR Melatonin FSHR Serotonin AGTRL1 Angiotensin II BDKRB1 BDKRB2 Histamine IL8RB IL8RA Group object OR12D3 OR5U1 OR2T1 OR2AG1 Group object GPR32 CMKLR1 GPR44 GPR30 Group object P2RY13 P2RY14 GPR87 P2RY12 Group object OR1E2 OR3A3 OR10H3 OR7C1 OR5V1 OR7C2 OR8B8 OR7A17 OR2S2 OR2J2 OR1G1 OR10A4 OR7A10 OR2B6 OR2W1 OR2B3 OR2H2 OR5F1 OR1D2 OR1F1 OR1D5 OR10A5 OR6A2 OR1C1 OR2F2 OR2B2 OR10H1 OR8D2 OR3A1 OR2A4 OR10J1 OR1A1 OR2J3 OR5I1 OR2D2 OR7A5 OR10H2 OR2J1 OR2N1P OR3A2 OR1D4 OR1A2 OR2F1 OR1Q1 Q9UDD9 OR11A1 OR1E1 OR2C1 OR6B1 OR2H1 OR1I1 OR3A4 Group object NTSR2 NTSR1 GPR83 Group object AGTR1 AGTR2 Group object NMUR2 NMUR1 Group object PTGER1 PTGER4 PTGFR PTGER2 PTGER3 PTGIR TBXA2R PTGDR Group object MLNR TRHR GHSR Group object NMBR GRPR BRS3 Group object XCR1 CCRL1 CCR10 CCR7 Group object RRH Rgr OPN4 OPN3 Group object ADORA1 ADORA2A ADORA3 ADORA2B Group object MC1R MC2R MC3R MC4R MC5R Group object ADRA2A ADRA2C ADRA1B ADRA1A ADRA1D ADRA2B Group object CCKBR CCKAR Group object GPR42 GPR41 GPR40 GPR43 Group object MTNR1B MTNR1A GPR50 Group object GPR85 GPR173 GPR27 Group object GPR52 GPR17 GPR8 GPR15 GPR6 GPR19 GPR22 GPR31 GPR24 GPR1 GPR63 GPR7 GPR10 GPR3 GPR21 GPR4 GPR20 GPR12 GPR25 Group object HRH3 HRH1 HRH2 Group object ADRB1 ADRB3 ADRB2 Group object DRD2 DRD4 DRD3 DRD5 DRD1 Group object EDNRA EDNRB Group object CYSLTR2 GPR45 CYSLTR1 Group object SSTR5 SSTR4 SSTR2 SSTR1 SSTR3 Group object CHRM2 CHRM4 CHRM3 CHRM1 CHRM5 Group object CMKOR1 MAS1 Group object HTR2B HTR1F HTR4 HTR1B HTR5A HTR6 HTR1E HTR1A HTR2A HTR7 HTR2C HTR1D Group object OPN1MW RHO OPN1SW OPN1LW Group object CCR4 CCR8 CCR3 CCRL2 CCR6 CCBP2 CCR2 CCR1 CCR5 CCR9 Group object GPR37L1 GPR37 Group object FPR1 FPRL1 FPRL2 Group object F2RL1 GALR2 F2RL3 GALR1 OXTR AVPR1B F2RL2 GALR3 AVPR2 AVPR1A Group object GPR77 C3AR1 Group object HCRTR1 HCRTR2 GPR74 GPR147 Group object P2RY10 P2RY4 P2RY6 GPR92 P2RY1 LTB4R GPR35 GPR174 P2RY11 GPR23 P2RY5 SUCNR1 Group object NPY6R NPY1R NPY5R PPYR1 NPY2R Group object MAS1L GPR39 GPR161 GPR34 GPR68 GPR65 GPR109B GPR81 GPR171 GPR18 GPR75 Group object OPRM1 OPRL1 OPRK1 OPRD1 Group object BLR1 CXCR3 CXCR4 Group object CNR1 CNR2 Group object Name: GPCRs, class A rhodopsin-like Organism: Homo sapiens
Description
This pathway was created using the GPCRDB (Horn et al., 1998),
http://www.gpcr.org/7tm/ (originally at
http://www.cmbi.kun.nl/7tm/ ). The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](
https://assays.cancer.gov/available_assays?wp_id=WP455 )
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Quality Tags
Annotated lists Annotated lists of gene products are considered useful for analysis and for stimulating future pathway curation.
Approved version The current version of this pathway was approved for data analysis by Egon Willighagen .
Ontology Terms
Bibliography
Karchin R, Karplus K, Haussler D; ''Classifying G-protein coupled receptors with support vector machines.''; Bioinformatics, 2002 PubMed Europe PMC Scholia Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, Edvardsen O, Campagne F, Vriend G; ''GPCRDB: an information system for G protein-coupled receptors.''; Nucleic Acids Res, 1998 PubMed Europe PMC Scholia History
External references
DataNodes
Annotated Interactions
No annotated interactions
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