GPCRs, other (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none GPR84RLN3R1TAAR3TAAR2GPR77GPR55GPR145GPR88GPR62GPR135GPRTAAR5VN1R1HRH4CCR5OR7E24CELSR3GNRHRP47889OR8G2OR8G1FSHRF2RADORA2AEDG1OR10A5NTSR1LGR6HSA8HSA3HSA12HSA10HSA1HTR1FHTR2AIL8RBIL8RAQ9UEB1OR10A2UTS2RGPR143LTB4R2GPR61GPR56GPR116P2RY13GPR132GPR73L1GPR133GPR18OR10A1CCR2ADRA1DADORA3ADRB2OR7E18POR7E19POR7E35PHTR7LGR7OR2M4OR5-85OR5D3POR5E1POR3A4OR2A20POR2B6OR1F1OR2A9POR1N1OR1E1OR1G1OR1E3POR1R1POR2F1OR3A1OR2H1OR2A5OR5D3OR3A3GPR17CELSR2CELSR1O60411OR51A1PGRM8OR2A4Q9BYT4Q9H2C7GRPROR1J5CNR1CHRM3CHRM2CCKBRCXCR3GHRHRGRCAGPR83GRM1DRD3DRD4EMR2EBI2EDNRAEMR3FYALG6P2RY11MASS1LPHN3LPHN2PTGFRSSTR2SMOName: GPCRs, otherLast Modified: 10/15/2013Organism: Homo sapiens


Description

This pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP117)

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Quality Tags

Image:NonTypical.pngAnnotated lists
Image:Curated.pngApproved version

Ontology Terms

Bibliography

  1. Karchin R, Karplus K, Haussler D; ''Classifying G-protein coupled receptors with support vector machines.''; Bioinformatics, 2002 PubMed Europe PMC Scholia
  2. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, Edvardsen O, Campagne F, Vriend G; ''GPCRDB: an information system for G protein-coupled receptors.''; Nucleic Acids Res, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137227
Approved
view10:06, 1 March 2025EgonwModified description
117743view12:45, 22 May 2021EweitzModified title
107421view12:49, 6 October 2019EgonwReplaced a deprecated UniProt identifiers with the current one.
106427view23:20, 28 August 2019KhanspersModified description
106381view11:53, 24 August 2019EgonwRemoved three more deleted UniProt identifiers.
106380view09:31, 24 August 2019EgonwRemoved a no longer existing protein sequence and no clear replacement.
105603view04:51, 10 August 2019KhanspersModified description
82985view00:19, 17 November 2015Mkutmonspecial character issue in literature references fixed
82862view15:26, 10 November 2015Mkutmoncorrect outdated identifiers
80021view20:30, 30 April 2015Zari
79718view08:49, 6 April 2015EgonwAdded the two references cited in the Description.
79711view08:33, 6 April 2015EgonwModified description
79657view17:46, 1 April 2015Khansperschanged non-numeric Entrez id
71231view23:38, 15 October 2013MaintBotAutomated update of data sources
63206view20:56, 8 May 2013MaintBotUpdating gpml version
62692view21:35, 1 May 2013MaintBotupdated uniprot data source
45343view20:24, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway' added !
45105view22:26, 6 October 2011AlexanderPicofixed uniprot refs
41044view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
38915view20:52, 24 September 2010Khanspers
34573view22:04, 21 December 2009KhanspersModified description
34545view20:00, 21 December 2009KhanspersModified description
34544view19:59, 21 December 2009KhanspersChanged xrefs
34543view19:33, 21 December 2009KhanspersModified description
20929view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:GPCRDB Other]] moved to [[Pathway:WP117]]: Moved to stable identifier
8120view13:46, 7 January 2008MaintBot[[Pathway:Human:GPCRDB Other]] moved to [[Pathway:Homo sapiens:GPCRDB Other]]: Renaming species
7681view16:09, 18 December 2007MaintBotfixed category names
7425view12:42, 4 November 2007MaintBotAdded categories to GPML
19491view22:17, 22 May 2007BruceConklingpml file for [[Human:GPCRDB_Other]]
6324view22:17, 22 May 2007Nsalomonisgpml file for [[Human:GPCRDB_Other]]

External references

DataNodes

View all...
Name  â†“Type  â†“Database reference  â†“Comment  â†“
ADORA2AGeneProduct135 (Entrez Gene)
ADORA3GeneProduct140 (Entrez Gene)
ADRA1DGeneProduct146 (Entrez Gene)
ADRB2GeneProduct154 (Entrez Gene)
ALG6GeneProduct29929 (Entrez Gene)
CCKBRGeneProduct887 (Entrez Gene)
CCR2GeneProduct1231 (Entrez Gene)
CCR5GeneProduct1234 (Entrez Gene)
CELSR1GeneProduct9620 (Entrez Gene)
CELSR2GeneProduct1952 (Entrez Gene)
CELSR3GeneProduct1951 (Entrez Gene)
CHRM2GeneProduct1129 (Entrez Gene)
CHRM3GeneProduct1131 (Entrez Gene)
CNR1GeneProduct1268 (Entrez Gene)
CXCR3GeneProduct2833 (Entrez Gene)
DRD3GeneProduct1814 (Entrez Gene)
DRD4GeneProduct1815 (Entrez Gene)
EBI2GeneProduct1880 (Entrez Gene)
EDG1GeneProduct1901 (Entrez Gene)
EDNRAGeneProduct1909 (Entrez Gene)
EMR2GeneProduct30817 (Entrez Gene)
EMR3GeneProduct84658 (Entrez Gene)
F2RGeneProduct2149 (Entrez Gene)
FSHRGeneProduct2492 (Entrez Gene)
FYGeneProduct2532 (Entrez Gene)
GHRHRGeneProduct2692 (Entrez Gene)
GNRHRGeneProduct2798 (Entrez Gene)
GPRGeneProduct11245 (Entrez Gene)
GPR116GeneProduct221395 (Entrez Gene)
GPR132GeneProduct29933 (Entrez Gene)
GPR133GeneProduct283383 (Entrez Gene)
GPR135GeneProduct64582 (Entrez Gene)
GPR143GeneProduct4935 (Entrez Gene)
GPR145GeneProduct84539 (Entrez Gene)
GPR17GeneProduct2840 (Entrez Gene)
GPR18GeneProduct2841 (Entrez Gene)
GPR55GeneProduct9290 (Entrez Gene)
GPR56GeneProduct9289 (Entrez Gene)
GPR61GeneProduct83873 (Entrez Gene)
GPR62GeneProduct118442 (Entrez Gene)
GPR73L1GeneProduct128674 (Entrez Gene)
GPR77GeneProduct27202 (Entrez Gene)
GPR83GeneProduct10888 (Entrez Gene)
GPR84GeneProduct53831 (Entrez Gene)
GPR88GeneProduct54112 (Entrez Gene)
GRCAGeneProduct27239 (Entrez Gene)
GRM1GeneProduct2911 (Entrez Gene)
GRM8GeneProduct2918 (Entrez Gene)
GRPRGeneProduct2925 (Entrez Gene)
HRH4GeneProduct59340 (Entrez Gene)
HSA10GeneProductQ9NZP4 (Uniprot-TrEMBL)
HSA12GeneProductQ9NZP3 (Uniprot-TrEMBL)
HSA1GeneProductQ9NZP5 (Uniprot-TrEMBL)
HSA3GeneProductQ9NZP2 (Uniprot-TrEMBL)
HSA8GeneProductQ9NZP0 (Uniprot-TrEMBL)
HTR1FGeneProduct3355 (Entrez Gene)
HTR2AGeneProduct3356 (Entrez Gene)
HTR7GeneProduct3363 (Entrez Gene)
IL8RAGeneProduct3577 (Entrez Gene)
IL8RBGeneProduct3579 (Entrez Gene)
LGR6GeneProduct59352 (Entrez Gene)
LGR7GeneProduct59350 (Entrez Gene)
LPHN2GeneProduct23266 (Entrez Gene)
LPHN3GeneProduct23284 (Entrez Gene)
LTB4R2GeneProduct56413 (Entrez Gene)
MASS1GeneProduct84059 (Entrez Gene)
NTSR1GeneProduct4923 (Entrez Gene)
O60411GeneProductO60411 (Uniprot-TrEMBL)
OR10A1GeneProduct144124 (Entrez Gene)
OR10A2GeneProduct341276 (Entrez Gene)
OR10A5GeneProduct144124 (Entrez Gene)
OR1E1GeneProduct8387 (Entrez Gene)
OR1E3PGeneProduct8389 (Entrez Gene)
OR1F1GeneProduct4992 (Entrez Gene)
OR1G1GeneProduct8390 (Entrez Gene)
OR1J5GeneProduct81370 (Entrez Gene)
OR1N1GeneProduct138883 (Entrez Gene)
OR1R1PGeneProduct9596 (Entrez Gene)
OR2A20PGeneProduct401428 (Entrez Gene)
OR2A4GeneProduct79541 (Entrez Gene)
OR2A5GeneProduct393046 (Entrez Gene)
OR2A9PGeneProductENSG00000228960 (Ensembl)
OR2B6GeneProduct26212 (Entrez Gene)
OR2F1GeneProduct26211 (Entrez Gene)
OR2H1GeneProduct26716 (Entrez Gene)
OR2M4GeneProduct26245 (Entrez Gene)
OR3A1GeneProduct4994 (Entrez Gene)
OR3A3GeneProduct8392 (Entrez Gene)
OR3A4GeneProductENSG00000180068 (Ensembl)
OR5-85GeneProductP30953 (Uniprot-TrEMBL)
OR51A1PGeneProduct26537 (Entrez Gene)
OR5D3GeneProductO95220 (Uniprot-TrEMBL)
OR5D3PGeneProduct8594 (Entrez Gene)
OR5E1PGeneProductENSG00000170688 (Ensembl)
OR7E18PGeneProduct390885 (Entrez Gene)
OR7E19PGeneProduct26651 (Entrez Gene)
OR7E24GeneProduct26648 (Entrez Gene)
OR7E35PGeneProduct391632 (Entrez Gene)
OR8G1GeneProduct26494 (Entrez Gene)
OR8G2GeneProduct26492 (Entrez Gene)
P2RY11GeneProduct5032 (Entrez Gene)
P2RY13GeneProduct53829 (Entrez Gene)
P47889GeneProductP47889 (Uniprot-TrEMBL)
PTGFRGeneProduct5737 (Entrez Gene)
Q9BYT4GeneProductQ9BYT4 (Uniprot-TrEMBL)
Q9H2C7GeneProductQ9H2C7 (Uniprot-TrEMBL)
Q9UEB1GeneProductENSG00000185385 (Ensembl)
RLN3R1GeneProduct51289 (Entrez Gene)
SMOGeneProduct6608 (Entrez Gene)
SSTR2GeneProduct6752 (Entrez Gene)
TAAR2GeneProduct9287 (Entrez Gene)
TAAR3GeneProduct9288 (Entrez Gene)
TAAR5GeneProduct9038 (Entrez Gene)
UTS2RGeneProduct2837 (Entrez Gene)
VN1R1GeneProduct57191 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP117"
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