IL7 signaling (Homo sapiens)
From WikiPathways
Description
Please access this pathway at NetSlim database.
If you use this pathway, please cite following paper: Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Bibliography
- Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AKT1 | Protein | 207 (Entrez Gene) | |
BAD | Protein | 572 (Entrez Gene) | |
BCL2L1 | Rna | 598 (Entrez Gene) | |
CCND1 | Rna | 595 (Entrez Gene) | |
CDKN1B | Rna | 1027 (Entrez Gene) | |
FYN | Protein | 2534 (Entrez Gene) | |
GSK3B | Protein | 2932 (Entrez Gene) | |
IL2RA | Rna | 3559 (Entrez Gene) | |
IL2RG | Protein | 3561 (Entrez Gene) | |
IL7 | Protein | 3574 (Entrez Gene) | |
IL7R | Protein | 3575 (Entrez Gene) | The common gamma chain augments IL-7 binding affinity and internalization of IL-7, which may explain the defects in X-linked severe combined immunodeficiency. |
JAK1 | Protein | 3716 (Entrez Gene) | IL-7 stimulation induces tyrosine phosphorylation of the kinase JAK1 in human thymocytes |
JAK3 | Protein | 3718 (Entrez Gene) | IL7 stimulation induces increased phosphorylation of JAK3 in normal human chondrocytes and thymocytes. |
MAP2K1 | Protein | 5604 (Entrez Gene) | |
MAP2K2 | Protein | 5605 (Entrez Gene) | |
MAPK1 | Protein | 5594 (Entrez Gene) | |
MAPK3 | Protein | 5595 (Entrez Gene) | |
MYC | Rna | 4609 (Entrez Gene) | |
PIK3R1 | Protein | 5295 (Entrez Gene) | |
PIK3R2 | Protein | 5296 (Entrez Gene) | |
PTK2B | Protein | 2185 (Entrez Gene) | IL-7 stimulation induces the phosphorylation of PTK2B in human chondrocytes. |
STAT1 | Protein | 6772 (Entrez Gene) | IL-7 stimulation leads to tyrosine phosphorylation of STAT1 in human CD4 T cells and murine YT-5 cells |
STAT3 | Protein | 6774 (Entrez Gene) | IL7 stimulation induces increased phosphorylation of STAT3 in normal human chondrocytes and T lymphoblasts. |
STAT5A | Protein | 6776 (Entrez Gene) | |
STAT5B | Protein | 6777 (Entrez Gene) |
Annotated Interactions
No annotated interactions