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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Glucose transport Cell growth differentiation Metabolic regulation GYG PFKM GYS1 PFKL GYS2 PPP1R3A LIPE Modulators of insulin action PTPRF IKBKB SOCS3 PRKCH PRKCD PTEN TRIB3 XBP1 PRKCB1 ENPP1 PRKCZ PRKCQ PRKAA2 PTPN1 MAPK8 INPPL1 INPP4A PTPN11 SOCS1 PRKCI PRKAA1 PRKCA Ras-MAPK signaling RAC1 GRB2 SOS1 RAC2 RRAD GRB14 SOS2 RAF1 HRAS GRB10 MEK/MAP kinases MINK1 MAP4K4 MAP3K2 MAPK12 MAP3K5 MAPK10 MAP3K3 MAP4K1 MAPK3 MAP2K7 MAPK13 MAP3K1 MAP4K3 MAP2K6 MAP3K8 MAP3K12 MAP2K4 MAPK7 MAPK14 MAP3K11 MAP3K7 MAPK11 MAPK9 MAPK6 MAP3K13 MAP2K3 MAPK4 MAP4K2 MAP2K5 MAP3K10 MAPK1 MAP2K1 MAP3K6 MAP3K4 MAP3K9 MAP4K5 MAP2K2 MAPK8 MAP3K14 Transcriptional regulators & immediate early genes SRF ELK1 FOXO1A FOS JUN FOXO3A EGR1 PDK/Akt signaling GSK3B AKT2 AKT1 SGKL SGK GSK3A PDPK1 SGK2 Translation regulation EIF4EBP1 EIF4E PI 3-kinase isoforms PIK3CD PIK3C3 PIK3R3 PIK3R1 PIK3C2G PIK3R2 PIK3CG PIK3CB PIK3R4 PIK3C2A PIK3CA p70 S6 kinases RPS6KB2 RPS6KB1 p90 Rsk kinases RPS6KA4 RPS6KA3 RPS6KA6 RPS6KA5 RPS6KA1 RPS6KA2 Vesicular trafficking STXBP2 PSCD3 KIF5B EHD2 ARF6 RAB4A CAP1 STXBP1 CRK STXBP4 TBC1D4 APS EHD1 SNX26 STX4A SNAP25 RHOQ SNAP23 CBLB STXBP3 CBL FLOT2 CBLC MYO1C RHOJ SORBS1 ARF1 RAPGEF1 VAMP2 FLOT1 KIF3A Insulin receptor substrates SHC3 IRS1 IRS2 SHC1 IRS4 SHC2 GAB1 Tor signaling TSC2 TSC1 PTP SLC2A1 RHEB INSR SLC2A4 IGF1R FRAP1 IRS1/2 PIK3 Name: Insulin signaling Organism: Homo sapiens
Description
Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentiation.
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](
https://assays.cancer.gov/available_assays?wp_id=WP481 )
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Quality Tags
Approved version The current version of this pathway was approved for data analysis by Egon Willighagen .
Ontology Terms
Bibliography
Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991 PubMed Europe PMC Scholia Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed Europe PMC Scholia Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed Europe PMC Scholia History
External references
DataNodes
Annotated Interactions
No annotated interactions
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