Nuclear receptors in lipid metabolism and toxicity (Homo sapiens)
From WikiPathways
Description
In addition to lipid metabolism, some members of the cytochrome P450 family genes are responsible for activation of procarcinogens, detoxification of environmental toxins and metabolism of drugs and xenobiotics. In particular, CAR, Nsil2 and recently identified VDR are important in up-regulation of these cytochromes. Of all the human cytochrome P450 genes, only a few CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4 account for most toxicity effects, specifically CYP3A is responsible for clearing approximately half of the clinically prescribed drugs. For instance, acetaminophen, one of the most commonly used drug, is toxic in high doses due to the activation of CAR and the drugs subsequent conversion to acetyl-p-benzoquinone imine (NAPQI) by CYP1A2, CYP2E1 and CYP3A.
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Bibliography
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History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
1,25-Dihydroxy-Vitamins D3 | Metabolite | CHEBI:17823 (ChEBI) | |
7-DehydroCholesterol | Metabolite | 434-16-2 (CAS) | |
ABCA1 | GeneProduct | 19 (Entrez Gene) | |
ABCB11 | GeneProduct | 8647 (Entrez Gene) | |
ABCB1 | GeneProduct | 5243 (Entrez Gene) | |
ABCB1a | GeneProduct | ||
ABCB4 | GeneProduct | 5244 (Entrez Gene) | |
ABCC2 | GeneProduct | 1244 (Entrez Gene) | |
ABCC3 | GeneProduct | 8714 (Entrez Gene) | |
ABCD2 | GeneProduct | 225 (Entrez Gene) | |
ABCD3 | GeneProduct | 5825 (Entrez Gene) | |
ABCG1 | GeneProduct | 9619 (Entrez Gene) | |
ABCG5 | GeneProduct | 64240 (Entrez Gene) | |
Acetyl CoA | Metabolite | 72-89-9 (CAS) | |
Bile Acids | Metabolite | CHEBI:3098 (ChEBI) | |
CYP1A2 | GeneProduct | 1544 (Entrez Gene) | |
CYP24A1 | GeneProduct | 1591 (Entrez Gene) | |
CYP26A1 | GeneProduct | 1592 (Entrez Gene) | |
CYP27B1 | GeneProduct | 1594 (Entrez Gene) | |
CYP2B6 | GeneProduct | 1555 (Entrez Gene) | |
CYP2C9 | GeneProduct | 1559 (Entrez Gene) | |
CYP2E1 | GeneProduct | 1571 (Entrez Gene) | |
CYP3A4 | GeneProduct | 1576 (Entrez Gene) | |
CYP4A11 | GeneProduct | 1579 (Entrez Gene) | |
CYP4B1 | GeneProduct | 1580 (Entrez Gene) | |
CYP7A1 | GeneProduct | 1581 (Entrez Gene) | |
CYP8B1 | GeneProduct | 1582 (Entrez Gene) | |
Cholesterol | Metabolite | 57-88-5 (CAS) | |
Fatty Acids | Metabolite | CHEBI:35366 (ChEBI) | |
Isoprenoids | Metabolite | CHEBI:24913 (ChEBI) | |
Lanosterol | Metabolite | CHEBI:16521 (ChEBI) | |
MIR33A | GeneProduct | ENSG00000207932 (Ensembl) | |
MIR33B | GeneProduct | ENSG00000207839 (Ensembl) | |
NR1H3 | GeneProduct | 10062 (Entrez Gene) | |
NR1H4 | GeneProduct | 9971 (Entrez Gene) | Farnesoid X-activated receptor |
NR1I2 | GeneProduct | 8856 (Entrez Gene) | |
NR1I3 | GeneProduct | 9970 (Entrez Gene) | |
Oxysterol | Metabolite | CHEBI:53030 (ChEBI) | |
PPARA | GeneProduct | 5465 (Entrez Gene) | |
PPARD | GeneProduct | 5467 (Entrez Gene) | |
PPARG | GeneProduct | 5468 (Entrez Gene) | |
RARA | GeneProduct | 5914 (Entrez Gene) | |
RARB | GeneProduct | 5915 (Entrez Gene) | |
RARG | GeneProduct | 5916 (Entrez Gene) | |
Retinoic acid | Metabolite | HMDB0001852 (HMDB) | |
Steroids | Metabolite | CHEBI:35341 (ChEBI) | |
VDR | GeneProduct | 7421 (Entrez Gene) | |
Xenobiotics | Metabolite | CHEBI:35703 (ChEBI) | |
abcg6 | GeneProduct |
Annotated Interactions
No annotated interactions