Phase I biotransformations, non-P450 (Homo sapiens)

From WikiPathways

Jump to: navigation, search
1HydrolysisOHOHOHOHcarboxylic acid estersESDamidesamidesLIPAPON1Phosphoric acid estersCES1thio estersthio estersPON2CES2Phosphoric acid esterscarboxylic acid estersCES7PON3


Description

This pathway lists several phase 1 biotransformations and their related enzymes.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Klaassen, C.D., Watkins III, J.B.; ''Casarett & Doull's Essentials of Toxicology''; ISNB 0071389148, 2003

History

View all...
CompareRevisionActionTimeUserComment
135337view20:53, 23 August 2024Khanspersupdated lit ref
128192view00:34, 29 January 2024EweitzModified title
118346view13:27, 27 May 2021Marvin M2added ref link
107116view14:19, 17 September 2019MaintBotChEBI identifier normalization
106543view00:08, 6 September 2019KhanspersModified description
105784view19:45, 15 August 2019KhanspersModified description
95126view15:16, 16 November 2017Mkutmonremove nested groups
80005view10:14, 30 April 2015ZariCorrected Ensembl ID for CES1 genes
73509view23:17, 29 January 2014KhanspersModified title
69015view17:47, 8 July 2013MaintBotUpdated to 2013 gpml schema
68058view13:18, 29 June 2013EgonwAdded ChEBI identifiers for compound classes.
61693view22:57, 16 April 2013MaintBotModified description
59200view19:14, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
56211view17:55, 4 January 2013EveloOntology Term : 'PW:0000375' removed !
56210view17:55, 4 January 2013EveloOntology Term : 'cytochrome P450-independent phase I biotransformation pathway' added !
45252view18:38, 7 October 2011KhanspersOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
41188view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
31942view12:58, 14 August 2009MaintBotFixed group labels
29886view11:13, 9 June 2009Thomasupdated ensembl references
20967view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Phase I - non P450 biotransformations]] moved to [[Pathway:WP136]]: Moved to stable identifier
14590view06:31, 23 May 2008Thomasadded metabolite boxes + links
11463view11:12, 1 April 2008ThomasModified categories
11073view14:31, 11 March 2008Thomas[[Pathway:Homo sapiens:Phase I, non P450 biotransformations]] moved to [[Pathway:Homo sapiens:Phase I - non P450 biotransformations]]: invalid character
11034view10:20, 4 March 2008Evelo[[Pathway:Homo sapiens:Phase I biotransformations]] moved to [[Pathway:Homo sapiens:Phase I, non P450 biotransformations]]: We also have a P450 pathway, which belongs to Phase 1
11033view10:20, 4 March 2008Evelorenamed
11019view12:14, 3 March 2008Thomasadded bibliography
11018view12:12, 3 March 2008ThomasModified description
11014view12:10, 3 March 2008Thomasadded gene annotations, translated labels
11011view11:52, 3 March 2008Thomas[[Pathway:Homo sapiens:Phase I]] moved to [[Pathway:Homo sapiens:Phase I biotransformations]]
10971view11:26, 28 February 2008RollieCreated PhaseI pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CES1GeneProductENSG00000198848 (Ensembl)
CES2GeneProductENSG00000172831 (Ensembl)
CES7GeneProductENSG00000159398 (Ensembl)
ESDGeneProductENSG00000139684 (Ensembl)
LIPAGeneProductENSG00000107798 (Ensembl)
PON1GeneProductENSG00000005421 (Ensembl)
PON2GeneProductENSG00000105854 (Ensembl)
PON3GeneProductENSG00000105852 (Ensembl)
Phosphoric acid estersMetaboliteCHEBI:37734 (ChEBI)
amidesMetaboliteCHEBI:32988 (ChEBI)
carboxylic acid estersMetaboliteCHEBI:33308 (ChEBI)
thio estersMetaboliteCHEBI:51277 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP136"
Personal tools