Proteasome degradation (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Ubiquitin / proteinDeubiquitinates proteinsProteins to be degradedUnfolds and degradesintact proteinsAMP ubiquitin / E1 complexOxidatively damagedcytosolic proteinsp45 ATPase subunitDegrades only peptidesE3 / proteinUbiquitin / E2 complexBeta subunits20S proteasome catalytic core (p45)Alpha subunitsPSMA2PSMB1PSMA5PSMB4PSMB2PSMA3PSMA7PSMA1PSMB6PSMA6PSMB5PSMA4PSMB7PSMB326S proteasome (PA700) (ATP dependent)PSMD12PSMD9PSMC5PSMD7PSMD11PSMC3PSMD10PSMD3PSMD13PSMD6PSMC1PSMD5PSMC6PSMC4PSMD4PSMD1PSMC2PSMD2PSMD8Activators of20S complexPSME1PSME3PSME2Lid subunitsRPN1RPN2Presentation by MHC class 1HLA-GHLA-EHLA-HHLA-AHLA-JHLA-FHLA-CHLA-BUbiquitinIFNGATPNEDD4PSMC5UCHL3UCHL1HIST1H2ABH2AFZH2AFXUBE1UBE1LPSMB10PSMB8PSMB9UBCUBBUBE2BUBE2D3UBE2D2UBE2D1Name: Proteasome degradationOrganism: Homo sapiens


Description

Degradation by proteasomes is part of the mechanism by which cells regulate the concentration of proteins and degrade misfolded proteins. Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Proteins are tagged for degradation by proteasomes by the addition of ubiquitin, by ubiquitin ligases.

Description adapted from [Wikipedia](https://en.wikipedia.org/wiki/Proteasome).

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP183)

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

  1. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W; ''Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.''; Proc Natl Acad Sci U S A, 2012 PubMed Europe PMC Scholia
  2. Hershko A, Ciechanover A, Varshavsky A; ''Basic Medical Research Award. The ubiquitin system.''; Nat Med, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137331
Approved
view19:08, 1 March 2025EweitzIncrease font size
137230view10:08, 1 March 2025EgonwModified description
128354view13:45, 2 February 2024EweitzUse conventional proteasome names
128353view13:44, 2 February 2024EweitzRemove empty node, standardize case
117060view14:22, 16 May 2021EweitzModified title
106528view23:49, 5 September 2019KhanspersModified description
105795view22:45, 15 August 2019KhanspersModified description
98547view20:58, 14 September 2018KhanspersModified description
97820view15:05, 9 June 2018EgonwUndo revision 97736 by [[Special:Contributions/Mick Eikelhof|Mick Eikelhof]] ([[User talk:Mick Eikelhof|Talk]]) Text cannot be copied from other websites.
97736view13:00, 7 June 2018Mick EikelhofModified description
95110view14:43, 16 November 2017Mkutmonfixed layout, removed nested groups
81161view12:00, 29 July 2015EgonwUpdated the outdated Uniprot ID. HT to @jervenbolleman for nothing the backpage header!
71712view20:04, 17 October 2013MaintBotUpdated UniProt/TrEMBL data source
70098view18:44, 12 July 2013MaintBotupdated to 2013 schema
62695view21:39, 1 May 2013MaintBotupdated uniprot data source
59174view18:40, 22 February 2013MaintBotUpdated Ensembl data source
49661view21:09, 23 July 2012EveloAdded general reference
49654view20:03, 23 July 2012EveloAdded reference for sructure of 26S subunit
45274view18:53, 7 October 2011KhanspersOntology Term : 'ubiquitin/proteasome degradation pathway' added !
41129view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
38856view18:07, 24 September 2010Khanspers
34481view18:38, 10 December 2009MaintBotAutomatic update of empty xrefs
32358view13:41, 15 August 2009MaintBotFixed text labels
31990view13:14, 14 August 2009MaintBotFixed group labels
29614view12:13, 23 May 2009MartijnVanIerselUpdated ensembl references
21063view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Proteasome Degradation]] moved to [[Pathway:WP183]]: Moved to stable identifier
14049view08:35, 21 May 2008Thomasadded groups and connected lines
13111view11:16, 17 May 2008MaintBotautomated metabolite conversion
12987view10:59, 17 May 2008MaintBotSticky edges patch by Sjoerd
11404view10:45, 27 March 2008Fdennissenedit deubiquitination proteins
11400view10:42, 27 March 2008FdennissenDeubiquitination
11399view10:37, 27 March 2008FdennissenPeriodical save, work in progress
11394view10:27, 27 March 2008FdennissenPeriodical save, work in progress
11384view10:17, 27 March 2008FdennissenPeriodical save, work in progress
8348view13:46, 7 January 2008MaintBot[[Pathway:Human:Proteasome Degradation]] moved to [[Pathway:Homo sapiens:Proteasome Degradation]]: Renaming species
7792view16:17, 18 December 2007MaintBotfixed category names
7485view12:42, 4 November 2007MaintBotAdded categories to GPML
6364view22:18, 22 May 2007Nsalomonisgpml file for [[Human:Proteasome_Degradation]]

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ATPMetabolite1927-31-7 (CAS)
H2AFXGeneProduct3014 (Entrez Gene)
H2AFZGeneProduct3015 (Entrez Gene)
HIST1H2ABGeneProduct8335 (Entrez Gene)
HLA-AGeneProduct3105 (Entrez Gene)
HLA-BGeneProduct3106 (Entrez Gene)
HLA-CGeneProduct3107 (Entrez Gene)
HLA-EGeneProduct3133 (Entrez Gene)
HLA-FGeneProduct3134 (Entrez Gene)
HLA-GGeneProduct3135 (Entrez Gene)
HLA-HGeneProduct3136 (Entrez Gene)
HLA-JGeneProduct3137 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
NEDD4GeneProduct4734 (Entrez Gene)
PSMA1GeneProduct5682 (Entrez Gene)
PSMA2GeneProduct5683 (Entrez Gene)
PSMA3GeneProduct5684 (Entrez Gene)
PSMA4GeneProduct5685 (Entrez Gene)
PSMA5GeneProduct5686 (Entrez Gene)
PSMA6GeneProduct5687 (Entrez Gene)
PSMA7GeneProduct5688 (Entrez Gene)
PSMB10GeneProduct5699 (Entrez Gene)
PSMB1GeneProduct5689 (Entrez Gene)
PSMB2GeneProduct5690 (Entrez Gene)
PSMB3GeneProduct5691 (Entrez Gene)
PSMB4GeneProduct5692 (Entrez Gene)
PSMB5GeneProduct5693 (Entrez Gene)
PSMB6GeneProduct5694 (Entrez Gene) U13393
PSMB7GeneProduct5695 (Entrez Gene)
PSMB8GeneProduct5696 (Entrez Gene)
PSMB9GeneProduct5698 (Entrez Gene)
PSMC1GeneProduct5700 (Entrez Gene)
PSMC2GeneProduct5701 (Entrez Gene)
PSMC3GeneProduct5702 (Entrez Gene)
PSMC4GeneProduct5704 (Entrez Gene) PRS6 HUMAN
PSMC5GeneProduct5705 (Entrez Gene)
PSMC6GeneProduct5706 (Entrez Gene)
PSMD10GeneProduct5716 (Entrez Gene)
PSMD11GeneProduct5717 (Entrez Gene)
PSMD12GeneProduct5718 (Entrez Gene)
PSMD13GeneProduct5719 (Entrez Gene)
PSMD1GeneProduct5707 (Entrez Gene)
PSMD2GeneProduct5708 (Entrez Gene)
PSMD3GeneProduct5709 (Entrez Gene)
PSMD4GeneProduct5710 (Entrez Gene)
PSMD5GeneProduct5711 (Entrez Gene)
PSMD6GeneProduct9861 (Entrez Gene)
PSMD7GeneProduct5713 (Entrez Gene)
PSMD8GeneProduct5714 (Entrez Gene)
PSMD9GeneProduct5715 (Entrez Gene)
PSME1GeneProduct5720 (Entrez Gene)
PSME2GeneProduct5721 (Entrez Gene)
PSME3GeneProduct10197 (Entrez Gene)
RPN1GeneProduct6184 (Entrez Gene)
RPN2GeneProduct6185 (Entrez Gene)
UBBGeneProductENSG00000170315 (Ensembl)
UBCGeneProduct7316 (Entrez Gene)
UBE1GeneProduct7317 (Entrez Gene)
UBE1LGeneProduct7318 (Entrez Gene)
UBE2BGeneProduct7320 (Entrez Gene)
UBE2D1GeneProduct7321 (Entrez Gene)
UBE2D2GeneProduct7322 (Entrez Gene)
UBE2D3GeneProduct7323 (Entrez Gene)
UCHL1GeneProductENSG00000154277 (Ensembl)
UCHL3GeneProductENSG00000118939 (Ensembl)
UbiquitinProteinP0CG48 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP183"
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