Oxidation by cytochrome P450 (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Cytochrome P450 genesCYP26A1CYP4F11CYP2C8CYP2B6CYP4F22CYP4Z1CYP4F8CYP1B1CYP2C18CYP4A22CYP11B1CYP27B1CYP2A6CYP4F3CYP26C1CYP51A1CYP4A11CYP2A7CYP7B1CYP19A1CYP21A2CYP3A43CYP26B1CYP7A1CYP3A4CYP2W1CYP8B1CYP2S1CYP39A1CYP2R1CYP46A1CYP4B1CYP1A2CYP4V2CYP2U1CYP2J2CYP2G1PCYP4X1CYP51A1CYP2E1CYP11A1CYP20A1CYP17A1CYP4F2CYP3A5CYP27A1CYP2A13CYP2F1CYP2C19CYP27C1CYP11B2CYP24A1CYP2C9CYP4F12CYP1A1CYP2D6CYP3A7NADPHO2H2OSubstrate-OHNADP+PORSubstrateNADHNAD+CYB5ACYB5BFe3+CYPFe2+SubstrateCYPO2SubstrateFe2+Fe3+CYPactivated O2CYPSubstrateFe2+CYB5BFe3+CYB5ACYB5BFe2+CYB5ACYPFe3+SubstrateCYB5R1CYB5R4CYB5R2CYB5R3Name: Oxidation by cytochrome P450Last Modified: 2/22/2013Organism: Homo sapiens


Description

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP43)

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Quality Tags

Ontology Terms

 

Bibliography

  1. Niesink, R.J.M, Vries, de, J., Hollinger, M.A.; ''Toxicology; Principles and Applications''; , 1996

History

View all...
CompareRevisionActionTimeUserComment
137241view12:14, 1 March 2025EgonwModified description
122562view09:37, 16 April 2022EgonwTyped a datanode
119227view18:40, 22 June 2021FinterlyAdded ISBN for book citation
117814view14:46, 22 May 2021EweitzModified title
110684view13:25, 28 May 2020EgonwAdded missing @Type annotation
107400view16:19, 5 October 2019EgonwUndo revision 107385. Use BridgeDb to map old and new identifiers, please.
107385view18:23, 3 October 2019Zhangx888Reverted to version '21:15, 6 September 2019' by Zhangx888
107167view14:25, 17 September 2019MaintBotChEBI identifier normalization
106796view13:27, 17 September 2019MaintBotHMDB identifier normalization
106569view21:15, 6 September 2019KhanspersModified description
105770view19:38, 15 August 2019KhanspersModified description
101940view06:18, 19 November 2018EgonwReplaced Wikipedia with Wikidata identifiers.
94176view13:29, 25 August 2017Mkutmonadd missing metabolite identifier
84102view12:30, 14 January 2016EgonwCleaned up the layout of the complexes.
84101view12:26, 14 January 2016EgonwVisually represent the complexes as such.
79993view20:20, 29 April 2015Zariannotated CYP
79585view09:17, 26 March 2015Zarichanged ID for CYP2A6 and CYP2G1 genes
73490view23:02, 29 January 2014KhanspersModified title
73489view23:01, 29 January 2014KhanspersModified title
70584view13:57, 15 August 2013EgonwWell, Substrate-OH is not necessarily an alcohol, so marked it as a WP "Product (biology)".
70583view13:54, 15 August 2013EgonwAdded Wikpedia's "Enzyme substrate" entry as identifier for "Substrate".
70582view13:49, 15 August 2013EgonwLinked CYP to the matching Wikipedia page.
67127view10:10, 26 June 2013Christine ChichesterOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
64829view21:29, 3 June 2013MaintBotModified title
63172view20:28, 8 May 2013MaintBotUpdating gpml version
59223view20:14, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
48222view05:29, 17 May 2012MaintBotAutomatic update of PubChem xrefs
44998view14:44, 6 October 2011MartijnVanIerselReverted to version '20:11, 4 June 2011' by MartijnVanIersel
43619view09:34, 10 July 2011MohhafezPeriodical save, work in progress
43178view20:11, 4 June 2011EveloOntology Term : 'xenobiotics biodegradation pathway' added !
43177view20:10, 4 June 2011EveloOntology Term : 'hepatocyte' added !
41235view23:46, 1 March 2011MaintBotRemoved redundant pathway information and comments
34480view18:38, 10 December 2009MaintBotAutomatic update of empty xrefs
32093view13:43, 14 August 2009MaintBotFixed group labels
29608view11:45, 23 May 2009MartijnVanIerselConverted to new Ensembl references
20767view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:cytochrome P450]] moved to [[Pathway:WP43]]: Moved to stable identifier
14331view13:22, 22 May 2008SusanGrouping and connecting
11032view10:15, 4 March 2008EveloChanged name
11029view10:06, 4 March 2008Evelo[[Pathway:Homo sapiens:cytochrome 450]] moved to [[Pathway:Homo sapiens:cytochrome P450]]
11010view11:48, 3 March 2008ThomasModified categories
11009view11:47, 3 March 2008ThomasModified description
11008view11:44, 3 March 2008Thomasadded bibliography
11006view10:59, 3 March 2008Thomasadded more detailled reactions
11005view09:37, 3 March 2008Thomasadded CYP isoforms
10992view20:06, 2 March 2008MartijnVanIerseltranslated labels to english
10975view11:31, 28 February 2008Arikcytochrome P450 pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CYB5AGeneProductENSG00000166347 (Ensembl)
CYB5BGeneProductENSG00000103018 (Ensembl)
CYB5R1GeneProductENSG00000159348 (Ensembl)
CYB5R2GeneProductENSG00000166394 (Ensembl)
CYB5R3GeneProductENSG00000100243 (Ensembl)
CYB5R4GeneProductENSG00000065615 (Ensembl)
CYP11A1GeneProductENSG00000140459 (Ensembl)
CYP11B1GeneProductENSG00000160882 (Ensembl)
CYP11B2GeneProductENSG00000179142 (Ensembl)
CYPGeneProduct1559 (Entrez Gene)
CYP17A1GeneProductENSG00000148795 (Ensembl)
CYP19A1GeneProductENSG00000137869 (Ensembl)
CYP1A1GeneProductENSG00000140465 (Ensembl)
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP1B1GeneProductENSG00000138061 (Ensembl)
CYP20A1GeneProductENSG00000119004 (Ensembl)
CYP21A2GeneProductENSG00000198457 (Ensembl)
CYP24A1GeneProductENSG00000019186 (Ensembl)
CYP26A1GeneProductENSG00000095596 (Ensembl)
CYP26B1GeneProductENSG00000003137 (Ensembl)
CYP26C1GeneProductENSG00000187553 (Ensembl)
CYP27A1GeneProductENSG00000135929 (Ensembl)
CYP27B1GeneProductENSG00000111012 (Ensembl)
CYP27C1GeneProductENSG00000186684 (Ensembl)
CYP2A13GeneProductENSG00000197838 (Ensembl)
CYP2A6GeneProductENSG00000255974 (Ensembl)
CYP2A7GeneProductENSG00000198077 (Ensembl)
CYP2B6GeneProductENSG00000197408 (Ensembl)
CYP2C18GeneProductENSG00000108242 (Ensembl)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C8GeneProductENSG00000138115 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP2D6GeneProductENSG00000100197 (Ensembl)
CYP2E1GeneProductENSG00000130649 (Ensembl)
CYP2F1GeneProductENSG00000197446 (Ensembl)
CYP2G1PGeneProductENSG00000130612 (Ensembl)
CYP2J2GeneProductENSG00000134716 (Ensembl)
CYP2R1GeneProductENSG00000186104 (Ensembl)
CYP2S1GeneProductENSG00000167600 (Ensembl)
CYP2U1GeneProductENSG00000155016 (Ensembl)
CYP2W1GeneProductENSG00000073067 (Ensembl)
CYP39A1GeneProductENSG00000146233 (Ensembl)
CYP3A43GeneProductENSG00000021461 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
CYP3A5GeneProductENSG00000106258 (Ensembl)
CYP3A7GeneProductENSG00000160870 (Ensembl)
CYP46A1GeneProductENSG00000036530 (Ensembl)
CYP4A11GeneProductENSG00000187048 (Ensembl)
CYP4A22GeneProductENSG00000162365 (Ensembl)
CYP4B1GeneProductENSG00000142973 (Ensembl)
CYP4F11GeneProductENSG00000171903 (Ensembl)
CYP4F12GeneProductENSG00000186204 (Ensembl)
CYP4F22GeneProductENSG00000171954 (Ensembl)
CYP4F2GeneProductENSG00000186115 (Ensembl)
CYP4F3GeneProductENSG00000186529 (Ensembl)
CYP4F8GeneProductENSG00000186526 (Ensembl)
CYP4V2GeneProductENSG00000145476 (Ensembl)
CYP4X1GeneProductENSG00000186377 (Ensembl)
CYP4Z1GeneProductENSG00000186160 (Ensembl)
CYP51A1GeneProductENSG00000001630 (Ensembl)
CYP7A1GeneProductENSG00000167910 (Ensembl)
CYP7B1GeneProductENSG00000172817 (Ensembl)
CYP8B1GeneProductENSG00000180432 (Ensembl)
Fe2+MetaboliteCHEBI:29033 (ChEBI)
Fe3+MetaboliteCHEBI:29034 (ChEBI)
H2OMetaboliteHMDB0002111 (HMDB)
NAD+MetaboliteCHEBI:15846 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
O2MetaboliteHMDB0001377 (HMDB)
PORGeneProductENSG00000127948 (Ensembl)
Substrate-OHMetaboliteQ542929 (Wikidata)
SubstrateMetaboliteQ12119506 (Wikidata)
activated O2MetaboliteHMDB0001377 (HMDB)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP43"
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