p38 MAPK signaling (Homo sapiens)
From WikiPathways
Description
p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.
Quality Tags
Ontology Terms
Bibliography
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- Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia
- Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC Scholia
- Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC Scholia
- Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC Scholia
- Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC Scholia
- Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC Scholia
- Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC Scholia
- Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ATF2 | GeneProduct | 1386 (Entrez Gene) | |
Apoptosis | Pathway | WP254 (WikiPathways) | |
CDC42 | GeneProduct | 998 (Entrez Gene) | |
CREB1 | GeneProduct | 1385 (Entrez Gene) | |
DAXX | GeneProduct | 1616 (Entrez Gene) | |
DDIT3 | GeneProduct | 1649 (Entrez Gene) | |
ELK1 | GeneProduct | 2002 (Entrez Gene) | |
GRB2 | GeneProduct | 2885 (Entrez Gene) | |
HMGN1 | GeneProduct | 3150 (Entrez Gene) | |
HRAS | GeneProduct | 3265 (Entrez Gene) | |
HSPB1 | GeneProduct | 3315 (Entrez Gene) | |
MAP2K4 | GeneProduct | 6416 (Entrez Gene) | |
MAP2K6 | GeneProduct | 5608 (Entrez Gene) | |
MAP3K1 | GeneProduct | 4214 (Entrez Gene) | |
MAP3K5 | GeneProduct | 4217 (Entrez Gene) | |
MAP3K7 | GeneProduct | 6885 (Entrez Gene) | |
MAP3K9 | GeneProduct | 4293 (Entrez Gene) | |
MAPK14 | GeneProduct | 1432 (Entrez Gene) | |
MAPKAPK2 | GeneProduct | 9261 (Entrez Gene) | |
MAPKAPK5 | GeneProduct | 8550 (Entrez Gene) | |
MAX | GeneProduct | 4149 (Entrez Gene) | |
MEF2D | GeneProduct | 4209 (Entrez Gene) | |
MKNK1 | GeneProduct | 8569 (Entrez Gene) | |
MYC | GeneProduct | 4609 (Entrez Gene) | |
PLA2G4A | GeneProduct | 5321 (Entrez Gene) | |
RAC1 | GeneProduct | 5879 (Entrez Gene) | |
RASGRF1 | GeneProduct | 5923 (Entrez Gene) | PDZ domain containing guanine nucleotide exchange |
RIPK1 | GeneProduct | 8737 (Entrez Gene) | receptor (TNFRSF)-interacting serine-threonine kinase 1 |
RPS6KA5 | GeneProduct | 9252 (Entrez Gene) | |
SHC1 | GeneProduct | 6464 (Entrez Gene) | |
STAT1 | GeneProduct | 6772 (Entrez Gene) | |
TGFB2 | GeneProduct | 7042 (Entrez Gene) | |
TGFBR1 | GeneProduct | 7046 (Entrez Gene) | |
TRADD | GeneProduct | 8717 (Entrez Gene) | |
TRAF2 | GeneProduct | 7186 (Entrez Gene) |
Annotated Interactions
No annotated interactions