Complement activation, classical pathway (Mus musculus)
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Cytoplasm
Prevents Complement Attack
antigen/antibody
complex
aggregated IgG,
IgM-antigen complex,
polyanions, RNA, DNA
lipopolysaccharides
C1 complex
Complex
Formation
Membrane
attack complex
Proteolytic Cleavage
Plasma
Membrane
Ions
C3
Masp1
C1qb
C1s
C4a
H2O
C2
C1r
Hc
C1qa
C7
C8a
Daf1
C4b
C6
C8b
C1qc
C9
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP545(r21826)
with a 64% conversion rate.
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Bibliography
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History
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Compare
Revision
Action
Time
User
Comment
117868
view
10:16, 23 May 2021
Eweitz
Modified title
106864
view
13:34, 17 September 2019
MaintBot
HMDB identifier normalization
72061
view
17:24, 24 October 2013
Mkutmon
updated annotation for C4a
69783
view
12:51, 11 July 2013
Mkutmon
fixed unconnected lines
69205
view
18:24, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67121
view
10:09, 26 June 2013
Christine Chichester
Ontology Term : 'classical complement pathway' added !
47967
view
13:21, 23 April 2012
MartijnVanIersel
font size
47966
view
13:19, 23 April 2012
MartijnVanIersel
41395
view
00:29, 2 March 2011
MaintBot
Removed redundant pathway information and comments
32694
view
23:38, 31 August 2009
Khanspers
Added xrefs
32361
view
13:42, 15 August 2009
MaintBot
Fixed text labels
31996
view
13:15, 14 August 2009
MaintBot
Fixed group labels
31408
view
20:52, 13 August 2009
MaintBot
Fixed text labels
30820
view
23:57, 29 July 2009
MaintBot
Converted from Homo sapiens
21101
view
11:30, 14 November 2008
MaintBot
[[Pathway:Mus musculus:Complement Activation Classical]] moved to [[Pathway:WP200]]: Moved to stable identifier
7968
view
13:46, 7 January 2008
MaintBot
[[Pathway:Mouse:Complement Activation Classical]] moved to [[Pathway:Mus musculus:Complement Activation Classical]]: Renaming species
7608
view
16:03, 18 December 2007
MaintBot
fixed category names
7465
view
12:42, 4 November 2007
MaintBot
Added categories to GPML
6427
view
22:18, 22 May 2007
Nsalomonis
gpml file for [[Mouse:Complement_Activation_Classical]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
C1qa
GeneProduct
12259 (Entrez Gene)
update: C1QA HUMAN
C1qb
GeneProduct
12260 (Entrez Gene)
C1qc
GeneProduct
12262 (Entrez Gene)
update C1QC HUMAN
C1r
GeneProduct
50909 (Entrez Gene)
C1s
GeneProduct
50908 (Entrez Gene)
C2
GeneProduct
12263 (Entrez Gene)
C3
GeneProduct
12266 (Entrez Gene)
C4a
GeneProduct
ENSMUSG00000015451 (Ensembl)
C4b
GeneProduct
12268 (Entrez Gene)
C6
GeneProduct
12274 (Entrez Gene)
C7
GeneProduct
109828 (Entrez Gene)
C8a
GeneProduct
230558 (Entrez Gene)
C8b
GeneProduct
110382 (Entrez Gene)
C9
GeneProduct
12279 (Entrez Gene)
Daf1
GeneProduct
13136 (Entrez Gene)
H2O
Metabolite
HMDB0002111 (HMDB)
Hc
GeneProduct
15139 (Entrez Gene)
Masp1
GeneProduct
17174 (Entrez Gene)
Annotated Interactions
No annotated interactions
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View approved pathways at the new wikipathways.org.Quality Tags
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DataNodes
Annotated Interactions
No annotated interactions