Focal adhesion (Mus musculus)

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1-17Cell survivalDNAPIP2+p+pFA turnover+pPIP3+p+pECM-receptor interactionsPKC+pITGA+pIntegrin betaWnt signalingFilopodia lamellipodia formation+p+p+pDNAMEK+pIntegrin alpha+pRegulation of actin cytoskeletonActin polymerization+pCell motility+p+p+p+p-p+p+pStress fiber / FA formation+pCytokine-cytokine receptor interactionsERKReceptor tyrosine kinases+pCell cycleRAF-p+p+pCell proliferation+p-pPhosphatidylinositiolsignaling system+pApoptosisITGB+p+pSpp1Pik3r1PxnKdrPpp1r12aCcnd1MylkItgb8Map2k2Pak2Pik3r2JunThbs4IbspCcnd3Pdpk1Map2k5Itga2bCcnd2Lamb3Rap1bThbs1ArafItgaePgfVegfcPak7Col4a1Col6a2Mapk1Pip5k1cItga6Birc4Map2k1Itga4ItgalVclPtk6Grb2Actg1Ptk2Tnk2Col4a4Flt1TnrIgf1rFgrVav1Tesk2Shc1MetTncBirc2Itgb3Birc3Rap1aRock2FlnaItgb6ItgavActbCol1a1ParvbPdgfaTln1Lamc3Pik3caTxkItgb5Col11a2CavRhobVegfbPik3cdItgb2Gsk3bIlkLama4SrmsRac3BrafCrk1LOC235580Col4a6PdgfrbMapk6Erbb2Col4a2Pak1ItgamLama1Bcl2Elk1Rock1ItgadItgb1Actn1Itgb7Tnk1Styk1Thbs2Itgb4Pik3cgEgfRac1Pik3r4Lama3ChadItga9Sos1Lamc1Mapk12VwfBlkLama5FigfMap2k6Thbs3Mylk2Mapk8Pak4Mapk4Arhgap5Cav2Itga11Myl6SrcHa-RasPak6Pik3cbPdgfcCav3Akt1Itga2Capn1Itga10RelnRapgef1VtnBrafLama2FynItga5Shc3Pik3r5PdgfdHckDock1Itga7Sepp1Pak3Mapk9Raf1Akt3Mapk7HgfPtenCol3a1Bcar1BadLamc2VegfaRhoaEgfrCompPeloCol1a2Rac2Itga3Itga8Cdc42TnnTnxbZyxCatnbFarp2Col5a2VaspFn1CrkPdgfraCol2a1PdgfbLamb1-1ItgaxCol11a1Col5a3Igf1Map2k3Lamb2Akt2Diap1Col5a1


Description

Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signaling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signaling.

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Bibliography

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  1. Mitra SK, Hanson DA, Schlaepfer DD; ''Focal adhesion kinase: in command and control of cell motility.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  2. Guo W, Giancotti FG; ''Integrin signalling during tumour progression.''; Nat Rev Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  3. Parsons JT; ''Focal adhesion kinase: the first ten years.''; J Cell Sci, 2003 PubMed Europe PMC Scholia
  4. Comoglio PM, Boccaccio C, Trusolino L; ''Interactions between growth factor receptors and adhesion molecules: breaking the rules.''; Curr Opin Cell Biol, 2003 PubMed Europe PMC Scholia
  5. Vanhaesebroeck B, Alessi DR; ''The PI3K-PDK1 connection: more than just a road to PKB.''; Biochem J, 2000 PubMed Europe PMC Scholia
  6. Oloumi A, McPhee T, Dedhar S; ''Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.''; Biochim Biophys Acta, 2004 PubMed Europe PMC Scholia
  7. Danen EH, Yamada KM; ''Fibronectin, integrins, and growth control.''; J Cell Physiol, 2001 PubMed Europe PMC Scholia
  8. Stupack DG, Cheresh DA; ''Get a ligand, get a life: integrins, signaling and cell survival.''; J Cell Sci, 2002 PubMed Europe PMC Scholia
  9. Lee JW, Juliano R; ''Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.''; Mol Cells, 2004 PubMed Europe PMC Scholia
  10. Schlaepfer DD, Mitra SK; ''Multiple connections link FAK to cell motility and invasion.''; Curr Opin Genet Dev, 2004 PubMed Europe PMC Scholia
  11. Petit V, Thiery JP; ''Focal adhesions: structure and dynamics.''; Biol Cell, 2000 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
128042view22:50, 21 January 2024EweitzStandardize case
116710view09:41, 11 May 2021EweitzModified title
114017view15:06, 17 December 2020NhungPConnecting lines
109380view15:25, 16 March 2020L DupuisFixed interactions
104992view04:23, 28 June 2019KhanspersModified description
104991view04:22, 28 June 2019Khanspersremoved KEGG comments
94410view23:05, 6 September 2017Khansperstest
94409view22:57, 6 September 2017Khanspersconnected interactions
82887view12:45, 11 November 2015JmeliusCorrect outdated id
78289view11:32, 22 December 2014EgonwFixed the character encoding of an author in the reference list.
78288view11:31, 22 December 2014EgonwRemoved invalid Entrez identifiers.
69966view21:07, 11 July 2013MaintBotupdating to 2013 schema
67252view10:27, 26 June 2013Christine ChichesterOntology Term : 'cell adhesion signaling pathway' added !
59067view21:19, 21 February 2013MaintBotUpdated Ensembl data source
41365view00:27, 2 March 2011MaintBotRemoved redundant pathway information and comments
35638view20:19, 12 February 2010KhanspersAdded lit refs
35635view19:38, 12 February 2010KhanspersModified description
35634view19:36, 12 February 2010KhanspersModified description
33519view15:20, 30 November 2009MaintBotRemoved group label
32978view23:16, 29 September 2009MaintBotChanged xrefs from symbol to ID
32977view23:09, 29 September 2009MaintBotPeriodical save, work in progress
32976view22:48, 29 September 2009MaintBotPeriodical save, work in progress
32975view22:35, 29 September 2009MaintBotPeriodical save, work in progress
32952view18:59, 28 September 2009MaintBotconnected edges
32951view18:58, 28 September 2009MaintBotPeriodical save, work in progress
32950view18:48, 28 September 2009MaintBotPeriodical save, work in progress
32949view18:37, 28 September 2009MaintBotPeriodical save, work in progress
20859view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:Focal adhesion KEGG]] moved to [[Pathway:WP85]]: Moved to stable identifier
8060view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Focal adhesion KEGG]] moved to [[Pathway:Mus musculus:Focal adhesion KEGG]]: Renaming species
7652view16:07, 18 December 2007MaintBotfixed category names
7223view12:41, 4 November 2007MaintBotAdded categories to GPML
6443view22:18, 22 May 2007169.230.77.174gpml file for [[Mouse:Focal_adhesion_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ActbGeneProduct11461 (Entrez Gene)
Actg1GeneProduct11465 (Entrez Gene)
Actn1GeneProduct109711 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Akt2GeneProduct11652 (Entrez Gene)
Akt3GeneProduct23797 (Entrez Gene)
ArafGeneProduct11836 (Entrez Gene) ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
Arhgap5GeneProduct11855 (Entrez Gene)
BadGeneProduct12015 (Entrez Gene)
Bcar1GeneProduct12927 (Entrez Gene)
Bcl2GeneProduct12043 (Entrez Gene)
Birc2GeneProduct11797 (Entrez Gene)
Birc3GeneProduct11796 (Entrez Gene)
Birc4GeneProduct
BlkGeneProduct12143 (Entrez Gene)
BrafGeneProduct109880 (Entrez Gene)
Capn1GeneProduct12333 (Entrez Gene)
CatnbGeneProduct
CavGeneProduct12389 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
Cav2GeneProduct12390 (Entrez Gene) CAV2; caveolin 2
Cav3GeneProduct12391 (Entrez Gene) CAV3; caveolin 3
Ccnd1GeneProduct12443 (Entrez Gene)
Ccnd2GeneProduct12444 (Entrez Gene)
Ccnd3GeneProduct12445 (Entrez Gene)
Cdc42GeneProduct12540 (Entrez Gene)
ChadGeneProduct12643 (Entrez Gene)
Col11a1GeneProduct12814 (Entrez Gene)
Col11a2GeneProduct12815 (Entrez Gene)
Col1a1GeneProduct12842 (Entrez Gene)
Col1a2GeneProduct12843 (Entrez Gene)
Col2a1GeneProduct12824 (Entrez Gene)
Col3a1GeneProduct12825 (Entrez Gene)
Col4a1GeneProduct12826 (Entrez Gene)
Col4a2GeneProduct12827 (Entrez Gene)
Col4a4GeneProduct12829 (Entrez Gene)
Col4a6GeneProduct94216 (Entrez Gene)
Col5a1GeneProduct12831 (Entrez Gene)
Col5a2GeneProduct12832 (Entrez Gene)
Col5a3GeneProduct53867 (Entrez Gene)
Col6a2GeneProduct12834 (Entrez Gene)
CompGeneProduct
Crk1GeneProduct12929 (Entrez Gene)
CrkGeneProduct12928 (Entrez Gene)
Diap1GeneProduct13367 (Entrez Gene)
Dock1GeneProductMGI:2429765 (MGI) DOCK1; dedicator of cyto-kinesis
EgfGeneProduct13645 (Entrez Gene)
EgfrGeneProduct13649 (Entrez Gene)
Elk1GeneProduct13712 (Entrez Gene)
Erbb2GeneProduct13866 (Entrez Gene)
Farp2GeneProduct227377 (Entrez Gene)
FgrGeneProduct14191 (Entrez Gene)
FigfGeneProduct14205 (Entrez Gene)
FlnaGeneProduct192176 (Entrez Gene)
Flt1GeneProduct14254 (Entrez Gene)
Fn1GeneProduct14268 (Entrez Gene)
FynGeneProduct14360 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
Grb2GeneProduct14784 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
Gsk3bGeneProduct56637 (Entrez Gene)
Ha-RasGeneProduct
HckGeneProduct15162 (Entrez Gene)
HgfGeneProduct15234 (Entrez Gene)
IbspGeneProduct15891 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Igf1rGeneProduct
IlkGeneProduct16202 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
Itga10GeneProductENSMUSG00000090210 (Ensembl)
Itga11GeneProduct319480 (Entrez Gene)
Itga2GeneProduct16398 (Entrez Gene)
Itga2bGeneProduct16399 (Entrez Gene)
Itga3GeneProduct16400 (Entrez Gene)
Itga4GeneProduct16401 (Entrez Gene)
Itga5GeneProduct16402 (Entrez Gene)
Itga6GeneProduct16403 (Entrez Gene)
Itga7GeneProduct16404 (Entrez Gene)
Itga8GeneProduct241226 (Entrez Gene)
Itga9GeneProduct104099 (Entrez Gene)
ItgadGeneProduct381924 (Entrez Gene)
ItgaeGeneProduct16407 (Entrez Gene)
ItgalGeneProduct16408 (Entrez Gene)
ItgamGeneProduct16409 (Entrez Gene)
ItgavGeneProductMGI:96608 (MGI)
ItgaxGeneProduct16411 (Entrez Gene)
Itgb1GeneProduct16412 (Entrez Gene)
Itgb2GeneProduct16414 (Entrez Gene)
Itgb3GeneProduct16416 (Entrez Gene)
Itgb4GeneProduct192897 (Entrez Gene)
Itgb5GeneProduct16419 (Entrez Gene)
Itgb6GeneProduct16420 (Entrez Gene)
Itgb7GeneProduct16421 (Entrez Gene)
Itgb8GeneProduct320910 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
KdrGeneProduct
LOC235580GeneProduct
Lama1GeneProduct16772 (Entrez Gene)
Lama2GeneProduct16773 (Entrez Gene)
Lama3GeneProductENSMUSG00000024421 (Ensembl)
Lama4GeneProduct16775 (Entrez Gene)
Lama5GeneProduct16776 (Entrez Gene)
Lamb1-1GeneProduct16777 (Entrez Gene)
Lamb2GeneProduct16779 (Entrez Gene)
Lamb3GeneProduct16780 (Entrez Gene)
Lamc1GeneProduct226519 (Entrez Gene)
Lamc2GeneProduct16782 (Entrez Gene)
Lamc3GeneProduct23928 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
Map2k2GeneProduct26396 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
Map2k3GeneProduct26397 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
Map2k5GeneProduct23938 (Entrez Gene) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
Map2k6GeneProduct26399 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
Mapk12GeneProduct29857 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
Mapk1GeneProduct26413 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
Mapk4GeneProduct225724 (Entrez Gene) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
Mapk6GeneProduct50772 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
Mapk7GeneProduct23939 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
Mapk8GeneProduct26419 (Entrez Gene)
Mapk9GeneProduct26420 (Entrez Gene)
MetGeneProduct17295 (Entrez Gene)
Myl6GeneProduct17904 (Entrez Gene)
MylkGeneProduct107589 (Entrez Gene)
Mylk2GeneProduct228785 (Entrez Gene)
Pak1GeneProduct18479 (Entrez Gene)
Pak2GeneProduct224105 (Entrez Gene)
Pak3GeneProduct18481 (Entrez Gene)
Pak4GeneProduct70584 (Entrez Gene)
Pak6GeneProduct214230 (Entrez Gene)
Pak7GeneProduct241656 (Entrez Gene)
ParvbGeneProduct170736 (Entrez Gene)
PdgfaGeneProduct18590 (Entrez Gene)
PdgfbGeneProduct18591 (Entrez Gene)
PdgfcGeneProduct54635 (Entrez Gene)
PdgfdGeneProduct71785 (Entrez Gene)
PdgfraGeneProduct18595 (Entrez Gene)
PdgfrbGeneProduct18596 (Entrez Gene)
Pdpk1GeneProduct18607 (Entrez Gene)
PeloGeneProduct105083 (Entrez Gene)
PgfGeneProduct18654 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
Pik3cbGeneProduct74769 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
Pik3cgGeneProduct30955 (Entrez Gene)
Pik3r1GeneProduct18708 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Pik3r4GeneProduct75669 (Entrez Gene)
Pik3r5GeneProduct320207 (Entrez Gene)
Pip5k1cGeneProduct18717 (Entrez Gene)
Ppp1r12aGeneProduct17931 (Entrez Gene)
PtenGeneProduct19211 (Entrez Gene)
Ptk2GeneProduct14083 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
Ptk6GeneProduct20459 (Entrez Gene)
PxnGeneProduct19303 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Rac2GeneProduct19354 (Entrez Gene)
Rac3GeneProduct170758 (Entrez Gene)
Raf1GeneProductMGI:97847 (MGI) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
Rap1aGeneProduct109905 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
Rap1bGeneProduct215449 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
Rapgef1GeneProduct107746 (Entrez Gene)
RelnGeneProduct19699 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
RhobGeneProduct11852 (Entrez Gene)
Rock1GeneProduct19877 (Entrez Gene)
Rock2GeneProduct19878 (Entrez Gene)
Sepp1GeneProduct20363 (Entrez Gene) SEPP1; selenoprotein P plasma
Shc1GeneProduct20416 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
Shc3GeneProduct20418 (Entrez Gene) SHC3; neuronal Sh
Sos1GeneProduct20662 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
Spp1GeneProduct20750 (Entrez Gene)
SrcGeneProduct20779 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
SrmsGeneProduct20811 (Entrez Gene)
Styk1GeneProduct243659 (Entrez Gene)
Tesk2GeneProduct230661 (Entrez Gene)
Thbs1GeneProduct21825 (Entrez Gene)
Thbs2GeneProduct21826 (Entrez Gene)
Thbs3GeneProduct21827 (Entrez Gene)
Thbs4GeneProduct21828 (Entrez Gene)
Tln1GeneProduct21894 (Entrez Gene)
TncGeneProduct21923 (Entrez Gene)
Tnk1GeneProduct83813 (Entrez Gene)
Tnk2GeneProduct51789 (Entrez Gene)
TnnGeneProduct329278 (Entrez Gene)
TnrGeneProduct21960 (Entrez Gene)
TnxbGeneProduct81877 (Entrez Gene)
TxkGeneProduct22165 (Entrez Gene)
VaspGeneProduct22323 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
Vav1GeneProduct22324 (Entrez Gene)
VclGeneProduct22330 (Entrez Gene) VCL; vinculin
VegfaGeneProduct22339 (Entrez Gene)
VegfbGeneProduct22340 (Entrez Gene)
VegfcGeneProduct22341 (Entrez Gene)
VtnGeneProduct22370 (Entrez Gene)
VwfGeneProduct22371 (Entrez Gene)
ZyxGeneProduct22793 (Entrez Gene) ZYX; zyxin

Annotated Interactions

No annotated interactions

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