One-carbon metabolism (Mus musculus)

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DNAvitamin B6DNA 5-methylcytosineMethylated histoneThymidylate Synthesis and DNA repairHistoneMthfd1Aldh1l15-Formiminotetrahydrofolic acid5-Methyl Tetrahydrofolate10-Formyl TetrahydrofolatedTMPDhfrTymsMthfd2Dhfr5,10-Methenyl TetrahydrofolateMthfd1FtcdPolyglutamateAhcy5,10-Methylene TetrahydrofolateEhmt1FtcdCobalaminS-Adenosylmethionine5-FormyltetrahydrofolateMatiaGartdUMPTcn IIDnmt1HomocysteineAticMthfd1MthfrDhfrS-AdenosylhomocysteineMthfd2Shmt1MthfsMat2bDnmt3aMthfd1lAmtMthfd1lL-MethionineEhmt2BetaineL-SerineAmtDnmt3bShmt2MtrrBhmtMtfmtDihydrofolateMethylcobalaminMthfd1lGartGlycineTetrahydrofolateFolh1MtrKiaa0828Riboflavin/Vitamin B2EthanolMonoglutamate1


Description

This one-carbon metabolism pathway is centered around folate. Folate is the primary methyl-group donor for processes such as DNA methylation reactions, nucleotide synthesis and DNA repair mechanisms. An important pathway for any study related to folate or DNA methylation.

Differential methylation (e.g. hypermethylation of tumor suppressors) as well as disturbances in nucleotide synthesis and repair, are associated with several forms of cancer. There are also indications that hypermethylation is involved in the progression of adenomas to cancer.

Inferred from human one-carbon metabolism pathway.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hazra A, Wu K, Kraft P, Fuchs CS, Giovannucci EL, Hunter DJ; ''Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study''; Carcinogenesis 2007 Jul; 28(7) 1510-9., 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116571view11:03, 8 May 2021EweitzModified title
107207view14:29, 17 September 2019MaintBotChEBI identifier normalization
106895view13:37, 17 September 2019MaintBotHMDB identifier normalization
98059view07:06, 13 July 2018Fehrhartapplied HGNC nomenclature for mouse gene/products
98058view07:00, 13 July 2018Fehrhartadded IDs for dTMP and dUMP
89673view08:16, 24 September 2016EgonwReplaced the CAS for polyglutamate with the ChEBI ID for this metabolite.
71889view09:59, 22 October 2013Mkutmonchanged Unknown datanodes to GeneProduct datanodes
69057view18:07, 8 July 2013MaintBotUpdated to 2013 gpml schema
67551view11:24, 26 June 2013DdiglesOntology Term : 'folate mediated one-carbon metabolic pathway' added !
42576view23:31, 5 April 2011AlexanderPicotrying to fix glitch
41239view00:19, 2 March 2011MaintBotRemoved redundant pathway information and comments
34970view00:42, 9 February 2010KhanspersReverted to version '22:41, 9 December 2009' by Khanspers
34969view00:40, 9 February 2010KhanspersPeriodical save, work in progress
34369view22:41, 9 December 2009MaintBotAutomatic update of empty xrefs
32996view19:11, 30 September 2009MaintBotadded some connectors
32097view13:44, 14 August 2009MaintBotFixed group labels
29220view11:29, 15 April 2009EveloSpecify description
29219view11:27, 15 April 2009Eveloongoing work
29189view22:14, 9 April 2009EveloSmall updates
29188view21:55, 9 April 2009EveloPeriodical save, work in progress
29180view15:49, 9 April 2009EveloWork in progress
29179view15:44, 9 April 2009EveloPeriodical save, work in progress
29178view15:23, 9 April 2009EveloMore metabolites annotated
29177view15:14, 9 April 2009EveloPeriodical save, work in progress
29176view14:38, 9 April 2009EveloWork in progress
29175view14:35, 9 April 2009EveloMetabolite annotations
29172view14:18, 9 April 2009EveloPeriodical save, work in progress
21596view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:One-carbon metabolism]] moved to [[Pathway:WP435]]: Moved to stable identifier
10150view21:10, 14 January 2008AlexanderPicoadded category
10149view20:04, 14 January 2008KhanspersAdded author, maintained by and email info
8310view13:46, 7 January 2008MaintBot[[Pathway:Mouse:One-carbon metabolism]] moved to [[Pathway:Mus musculus:One-carbon metabolism]]: Renaming species
7558view09:02, 18 December 2007MichielSpecify description
7557view09:02, 18 December 2007MichielSpecify description
7556view09:00, 18 December 2007MichielSpecify description
7555view08:57, 18 December 2007MichielAdded description
7552view23:02, 17 December 2007KhanspersAdded author, email and maintained by info
7535view12:48, 19 November 2007Michiel
7531view12:37, 19 November 2007MichielAdded Histone methyl transferases
7530view10:12, 19 November 2007MichielCorrected FOLH1
7524view17:24, 17 November 2007MichielConverted from Human pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
10-Formyl TetrahydrofolateMetabolite2800-34-2 (CAS)
5,10-Methenyl TetrahydrofolateMetaboliteHMDB0001354 (HMDB)
5,10-Methylene TetrahydrofolateMetaboliteCHEBI:12071 (ChEBI)
5-Formiminotetrahydrofolic acidMetaboliteHMDB0001534 (HMDB)
5-FormyltetrahydrofolateMetaboliteHMDB0001562 (HMDB)
5-Methyl TetrahydrofolateMetabolite134-35-0 (CAS)
AhcyGeneProduct269378 (Entrez Gene)
Aldh1l1GeneProduct107747 (Entrez Gene)
AmtGeneProduct434437 (Entrez Gene)
AticGeneProduct108147 (Entrez Gene)
BetaineMetaboliteHMDB0000043 (HMDB)
BhmtGeneProduct12116 (Entrez Gene)
CobalaminMetaboliteHMDB0002174 (HMDB)
DhfrGeneProduct13361 (Entrez Gene)
DihydrofolateMetabolite4033-27-6 (CAS)
Dnmt1GeneProduct13433 (Entrez Gene)
Dnmt3aGeneProduct13435 (Entrez Gene)
Dnmt3bGeneProduct13436 (Entrez Gene)
Ehmt1GeneProduct77683 (Entrez Gene)
Ehmt2GeneProduct110147 (Entrez Gene)
EthanolMetaboliteHMDB0000108 (HMDB)
Folh1GeneProduct53320 (Entrez Gene)
FtcdGeneProduct14317 (Entrez Gene)
GartGeneProduct14450 (Entrez Gene)
GlycineMetaboliteHMDB0000123 (HMDB)
HomocysteineMetaboliteHMDB0000742 (HMDB)
Kiaa0828GeneProduct74340 (Entrez Gene)
L-MethionineMetaboliteHMDB0000696 (HMDB)
L-SerineMetaboliteHMDB0000187 (HMDB)
Mat2bGeneProduct108645 (Entrez Gene)
MatiaGeneProduct11720 (Entrez Gene)
MethylcobalaminMetaboliteHMDB0002274 (HMDB)
MonoglutamateMetabolite59-30-3 (CAS)
MtfmtGeneProduct69606 (Entrez Gene)
Mthfd1GeneProduct108156 (Entrez Gene)
Mthfd1lGeneProduct270685 (Entrez Gene)
Mthfd2GeneProduct17768 (Entrez Gene)
MthfrGeneProduct17769 (Entrez Gene)
MthfsGeneProduct107885 (Entrez Gene)
MtrGeneProduct238505 (Entrez Gene)
MtrrGeneProduct210009 (Entrez Gene)
PolyglutamateMetabolite25513-46-6 (CAS)
Riboflavin/Vitamin B2MetaboliteHMDB0000244 (HMDB)
S-AdenosylhomocysteineMetaboliteHMDB0000939 (HMDB)
S-AdenosylmethionineMetaboliteCHEBI:15414 (ChEBI)
Shmt1GeneProduct20425 (Entrez Gene)
Shmt2GeneProduct108037 (Entrez Gene)
Tcn IIGeneProduct21452 (Entrez Gene)
TetrahydrofolateMetabolite135-16-0 (CAS)
TymsGeneProduct22171 (Entrez Gene)
dTMPMetaboliteCHEBI:17013 (ChEBI)
dUMPMetaboliteCHEBI:17622 (ChEBI)

Annotated Interactions

No annotated interactions

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