Ovarian infertility (Mus musculus)

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CytoplasmGranulosa CellNucleusOoplasmOocyteNucleusInhaTbpCdk4Zp3Cdkn1bSmad3Fig-alphaNcor1AtmVdrZp2Cyp19a1Ccnd2Gja4DazlNr5a1Nrip1Gdf9Zp3Esr2PrlrEgr1Msh5Mlh1Gja4Bmpr1bPtger2PgrLhcgrSyne2CebpbSmpd1Dmc1FshrSmpd1


Description

Ovarian ’bottleneck’ genes associated with infertility 

A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility phenotypes. The individual gene pages in the OKdb (Ovarian Kaleidoscope Database: http://ovary.stanford.edu) contain information on associated fertility phenotypes sorted by ovarian and nonovarian defects and by subfertility or infertility. If one searches for null mutations (under ’mutation type’) causing infertility (’infertile - ovarian defect’, under ’female fertility status’) in mice (under ’species’), 44 gene entries are found. The expression of these infertility genes in the oocyte and granulosa cells together with their cellular localization is presented in Ovarian Infertility gene map. The theca cell genes are not presented because most publications emphasize granulosa cell studies.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP34(r20749) with a 91% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118921view10:30, 4 June 2021Mkutmonupdate metadata
118920view10:30, 4 June 2021Mkutmonupdate metadata
116558view12:56, 7 May 2021EweitzModified title
88257view14:29, 1 August 2016FehrhartOntology Term : 'oocyte' added !
88256view14:28, 1 August 2016FehrhartOntology Term : 'granulosa cell' added !
88255view14:28, 1 August 2016FehrhartOntology Term : 'infertility' added !
88254view14:28, 1 August 2016FehrhartOntology Term : 'urogenital disease pathway' added !
71724view20:16, 17 October 2013MaintBotAutomated update of data sources
69813view14:32, 11 July 2013Mkutmonfixing unconnected lines
69097view18:11, 8 July 2013MaintBotUpdated to 2013 gpml schema
41282view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
32715view23:04, 2 September 2009MaintBotAdded xref
32714view23:01, 2 September 2009MaintBotadded xref
32023view13:24, 14 August 2009MaintBotFixed group labels
30844view00:05, 30 July 2009MaintBotConverted from Homo sapiens
21253view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:Ovarian Infertility Genes]] moved to [[Pathway:WP273]]: Moved to stable identifier
8314view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Ovarian Infertility Genes]] moved to [[Pathway:Mus musculus:Ovarian Infertility Genes]]: Renaming species
7775view16:17, 18 December 2007MaintBotfixed category names
7284view12:41, 4 November 2007MaintBotAdded categories to GPML
19529view22:19, 22 May 2007A.Hsuehgpml file for [[Mouse:Ovarian_Infertility_Genes]]
6483view22:19, 22 May 2007I.BenShlomogpml file for [[Mouse:Ovarian_Infertility_Genes]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AtmGeneProduct11920 (Entrez Gene)
Bmpr1bGeneProduct12167 (Entrez Gene)
Ccnd2GeneProduct12444 (Entrez Gene)
Cdk4GeneProduct12567 (Entrez Gene)
Cdkn1bGeneProduct12576 (Entrez Gene)
CebpbGeneProduct12608 (Entrez Gene)
Cyp19a1GeneProduct13075 (Entrez Gene)
DazlGeneProduct13164 (Entrez Gene)
Dmc1GeneProduct13404 (Entrez Gene)
Egr1GeneProduct13653 (Entrez Gene)
Esr2GeneProduct13983 (Entrez Gene)
Fig-alphaGeneProduct
FshrGeneProduct14309 (Entrez Gene)
Gdf9GeneProduct14566 (Entrez Gene)
Gja4GeneProduct14612 (Entrez Gene)
InhaGeneProduct16322 (Entrez Gene)
LhcgrGeneProduct16867 (Entrez Gene)
Mlh1GeneProduct17350 (Entrez Gene)
Msh5GeneProduct17687 (Entrez Gene)
Ncor1GeneProduct20185 (Entrez Gene)
Nr5a1GeneProduct26423 (Entrez Gene)
Nrip1GeneProduct268903 (Entrez Gene)
PgrGeneProduct18667 (Entrez Gene)
PrlrGeneProduct19116 (Entrez Gene)
Ptger2GeneProduct19217 (Entrez Gene)
Smad3GeneProduct17127 (Entrez Gene)
Smpd1GeneProduct20597 (Entrez Gene)
Syne2GeneProduct319565 (Entrez Gene)
TbpGeneProduct21374 (Entrez Gene)
VdrGeneProduct22337 (Entrez Gene)
Zp2GeneProduct22787 (Entrez Gene)
Zp3GeneProduct22788 (Entrez Gene)

Annotated Interactions

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