Focal adhesion (Rattus norvegicus)

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1-17-p+pECM-receptor interactions+p+pLamellipodiaApoptosis+pRAF+pITGB+pPhosphatidylinositiolactin cytoskeletonERKMEK+pCytokine-cytokine receptor interactionsWnt SignalingPKCITGA+p+p-p+pReceptor Tyrosine KinasesFilopodiaCell SurvivalIntegrin betaActin+p-p+pRegulation ofDNA+p+pIntegrin alpha+pDNAPIP2+pFA turnover+p+p+pPolymerizationformationformation+pCell CyclePIP3+p+p+p+p+psignaling system+pCell Motility+pStress Fiber/FACell ProliferationCol4a4Elk1LOC235580ItgaxBadItgb3BlkActg1Sepp1Birc2ItgadCol11a2Grb2FynBcar1Birc4Lama1ParvbMapk9MetItgb6Lamc2RhobItga3Col5a2Shc3PdgfraEgfrCav3ChadPdgfaFlt1ActbRock2Col11a1Rock1Pik3r5Shc1VegfbItgavCdc42Ptk2EgfRapgef1HckVwfItga8Thbs4Diap1Sos1RelnLama3Birc3PtenTnrIgf1rItga11Thbs3Arhgap5VaspCol1a2Pik3r2PdgfbMapk12FgrAkt1Itgb7Itgb1Pik3r4Rap1aLamb1Lama4Rac2Ccnd1FlnaPip5k1cRac3FigfIlkThbs1Lamc1Actn1Map2k6TncVav1HgfRap1bCol4a2VclItgalPik3cbPdgfdItga10Mylk2CavPak7Ha-RasCcnd2Col6a2TnnTnk1Pak4Erbb2Rac1Itga6BrafMap2k1Lama5Raf1SrcIgf1Akt3Ptk6RhoaPik3r1PdgfrbMapk6Itga9VegfaLamb2Ctnnb1Itga2Col5a1Ccnd3Pak2JunPdgfcMapk7IbspLamc3PxnCol3a1Tnk2Col4a6Styk1Itgb8TnxbPdpk1ItgaeMap2k3Lama2Col2a1Pak3Mapk8Map2k2Itgb2BrafItgb5Thbs2Spp1Itgb4Col1a1Itga2bFarp2SrmsPak6Pak1VegfcPik3cgPeloCapn1Fn1ItgamMapk1VtnDock1Tesk2Myl6Col4a1Map2k5Tln1ArafMylkItga7KdrPgfPpp1r12aBcl2CompMapk4Pik3caAkt2Gsk3bItga4Crk1ZyxCav2Col5a3Lamb3CrkPik3cdItga5Txk


Description

Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.

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Bibliography

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  1. Turner CE; ''Paxillin and focal adhesion signalling.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
  2. Lee JW, Juliano R; ''Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.''; Mol Cells, 2004 PubMed Europe PMC Scholia
  3. Schmitz AA, Govek EE, Böttner B, Van Aelst L; ''Rho GTPases: signaling, migration, and invasion.''; Exp Cell Res, 2000 PubMed Europe PMC Scholia
  4. Schlaepfer DD, Mitra SK; ''Multiple connections link FAK to cell motility and invasion.''; Curr Opin Genet Dev, 2004 PubMed Europe PMC Scholia
  5. Nicholson KM, Anderson NG; ''The protein kinase B/Akt signalling pathway in human malignancy.''; Cell Signal, 2002 PubMed Europe PMC Scholia
  6. Comoglio PM, Boccaccio C, Trusolino L; ''Interactions between growth factor receptors and adhesion molecules: breaking the rules.''; Curr Opin Cell Biol, 2003 PubMed Europe PMC Scholia
  7. Stupack DG, Cheresh DA; ''Get a ligand, get a life: integrins, signaling and cell survival.''; J Cell Sci, 2002 PubMed Europe PMC Scholia
  8. Guo W, Giancotti FG; ''Integrin signalling during tumour progression.''; Nat Rev Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  9. Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z; ''The mechanism of action of the tumour suppressor gene PTEN.''; Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2003 PubMed Europe PMC Scholia
  10. Burridge K, Wennerberg K; ''Rho and Rac take center stage.''; Cell, 2004 PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
116964view10:24, 16 May 2021EweitzModified title
104997view04:48, 28 June 2019Khanspersremoved KEGG comments
104996view04:47, 28 June 2019KhanspersModified description
82988view00:44, 17 November 2015Mkutmonfixed special characters in literature references
82978view23:50, 16 November 2015Mkutmonfixed outdated identifiers
79682view13:00, 4 April 2015EgonwAdded a mssing Entrez identifier.
79470view11:26, 23 March 2015FehrhartReplaced a batch of gene names with their Entrez gene IDs
79468view10:28, 23 March 2015Fehrhart
79467view10:15, 23 March 2015Fehrhart
79466view09:53, 23 March 2015Fehrhart
79254view16:22, 17 March 2015MaintBotReplaced a batch of gene names with their Entrez gene IDs.
71837view19:43, 18 October 2013MaintBotremoved data source from nodes without identifier
69967view21:08, 11 July 2013MaintBotupdating to 2013 schema
67251view10:26, 26 June 2013Christine ChichesterOntology Term : 'cell adhesion signaling pathway' added !
41718view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
35639view20:22, 12 February 2010KhanspersAdded lit refs
34096view19:18, 9 December 2009MaintBotAutomatic update of empty xrefs
21075view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Focal adhesion KEGG]] moved to [[Pathway:WP188]]: Moved to stable identifier
8062view13:46, 7 January 2008MaintBot[[Pathway:Rat:Focal adhesion KEGG]] moved to [[Pathway:Rattus norvegicus:Focal adhesion KEGG]]: Renaming species
7653view16:07, 18 December 2007MaintBotfixed category names
7224view12:41, 4 November 2007MaintBotAdded categories to GPML
6542view22:20, 22 May 2007169.230.77.174gpml file for [[Rat:Focal_adhesion_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ActbGeneProduct81822 (Entrez Gene) actin, beta
Actg1GeneProduct287876 (Entrez Gene) actin, gamma 1
Actn1GeneProduct81634 (Entrez Gene) actinin, alpha 1
Akt1GeneProduct24185 (Entrez Gene) v-akt murine thymoma viral oncogene homolog 1
Akt2GeneProduct25233 (Entrez Gene) v-akt murine thymoma viral oncogene homolog 2
Akt3GeneProduct29414 (Entrez Gene) v-akt murine thymoma viral oncogene homolog 3
ArafGeneProduct64363 (Entrez Gene) ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
Arhgap5GeneProduct299012 (Entrez Gene) Rho GTPase activating protein 5
BadGeneProduct64639 (Entrez Gene) BCL2-associated agonist of cell death
Bcar1GeneProduct25414 (Entrez Gene) breast cancer anti-estrogen resistance 1
Bcl2GeneProduct24224 (Entrez Gene) B-cell CLL/lymphoma 2
Birc2GeneProduct60371 (Entrez Gene) baculoviral IAP repeat-containing 2
Birc3GeneProduct78971 (Entrez Gene) baculoviral IAP repeat-containing 3
Birc4GeneProduct63879 (Entrez Gene) X-linked inhibitor of apoptosis, also known as Birc4, Api3, riap3
BlkGeneProduct364403 (Entrez Gene) BLK proto-oncogene, Src family tyrosine kinase
BrafGeneProductENSRNOG00000010957 (Ensembl) B-Raf proto-oncogene, serine/threonine kinase
Capn1GeneProduct29153 (Entrez Gene) calpain 1, (mu/I) large subunit
Cav2GeneProduct363425 (Entrez Gene) CAV2; caveolin 2
CavGeneProduct25404 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
Cav3GeneProduct29161 (Entrez Gene) CAV3; caveolin 3
Ccnd1GeneProduct58919 (Entrez Gene) cyclin D1
Ccnd2GeneProduct64033 (Entrez Gene) cyclin D2
Ccnd3GeneProduct25193 (Entrez Gene) cyclin D3
Cdc42GeneProduct64465 (Entrez Gene) cell division cycle 42
ChadGeneProduct29195 (Entrez Gene) chondroadherin
Col11a1GeneProduct25654 (Entrez Gene) collagen, type XI, alpha 1
Col11a2GeneProduct294279 (Entrez Gene)
Col1a1GeneProduct29393 (Entrez Gene) collagen, type I, alpha 1
Col1a2GeneProduct84352 (Entrez Gene)
Col2a1GeneProduct25412 (Entrez Gene) collagen, type II, alpha 1
Col3a1GeneProduct84032 (Entrez Gene) collagen, type III, alpha 1
Col4a1GeneProduct290905 (Entrez Gene) collagen, type IV, alpha 1
Col4a2GeneProduct306628 (Entrez Gene)
Col4a4GeneProduct301562 (Entrez Gene) collagen, type IV, alpha 4
Col4a6GeneProduct363458 (Entrez Gene) collagen, type IV, alpha 6
Col5a1GeneProduct85490 (Entrez Gene) collagen, type V, alpha 1
Col5a2GeneProduct85250 (Entrez Gene) collagen, type V, alpha 2
Col5a3GeneProduct60379 (Entrez Gene)
Col6a2GeneProduct361821 (Entrez Gene) collagen, type VI, alpha 2
CompGeneProduct25304 (Entrez Gene)
Crk1GeneProduct81649 (Entrez Gene) mitogen activated protein kinase 14, synonym: Mapk14, RK; Hog; p38; CRK1; CSBP; Exip; Mxi2; CSPB1; Csbp1; Csbp2; Prkm14; Prkm15; Sapk2A; p38Hog; p38alpha
CrkGeneProduct54245 (Entrez Gene) v-crk avian sarcoma virus CT10 oncogene homolog
Ctnnb1GeneProduct84353 (Entrez Gene)
Diap1GeneProduct307483 (Entrez Gene)
Dock1GeneProduct309081 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
EgfGeneProduct25313 (Entrez Gene)
EgfrGeneProduct24329 (Entrez Gene) epidermal growth factor receptor
Elk1GeneProduct314436 (Entrez Gene) ELK1, member of ETS oncogene family
Erbb2GeneProduct24337 (Entrez Gene) v-erb-b2 avian erythroblastic leukemia viral oncogene 2
Farp2GeneProduct316639 (Entrez Gene)
FgrGeneProduct79113 (Entrez Gene) FGR proto-oncogene, Src family tyrosine kinase
FigfGeneProduct360457 (Entrez Gene)
FlnaGeneProduct293860 (Entrez Gene) filamin A, alpha
Flt1GeneProduct54251 (Entrez Gene) FMS-related tyrosine kinase 1
Fn1GeneProduct25661 (Entrez Gene) fibronectin 1
FynGeneProduct25150 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
Grb2GeneProduct81504 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
Gsk3bGeneProduct84027 (Entrez Gene) glycogen synthase kinase 3 beta
Ha-RasGeneProduct293621 (Entrez Gene) Harvey rat sarcoma virus oncogene, also known as H-ras, HRAS1, c-H-ras
HckGeneProduct25734 (Entrez Gene) hemopoietic cell kinase
HgfGeneProduct24446 (Entrez Gene)
IbspGeneProduct24477 (Entrez Gene) integrin-binding sialoprotein
Igf1GeneProduct24482 (Entrez Gene)
Igf1rGeneProduct25718 (Entrez Gene) insulin-like growth factor 1 receptor
IlkGeneProduct170922 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
Itga10GeneProduct310683 (Entrez Gene)
Itga11GeneProduct315744 (Entrez Gene)
Itga2GeneProduct685269 (Entrez Gene) integrin, alpha 2B
Itga2bGeneProduct685269 (Entrez Gene) integrin, alpha 2B
Itga3GeneProduct360606 (Entrez Gene)
Itga4GeneProduct311144 (Entrez Gene)
Itga5GeneProduct315346 (Entrez Gene)
Itga6GeneProduct114517 (Entrez Gene) integrin, alpha 6
Itga7GeneProduct81008 (Entrez Gene) integrin, alpha 7
Itga8GeneProduct364786 (Entrez Gene) integrin, alpha 8
Itga9GeneProduct685004 (Entrez Gene) integrin, alpha 9
ItgadGeneProduct64350 (Entrez Gene) integrin, alpha D
ItgaeGeneProduct83577 (Entrez Gene) integrin, alpha E
ItgalGeneProduct308995 (Entrez Gene) integrin, alpha L
ItgamGeneProduct25021 (Entrez Gene) integrin, alpha M
ItgavGeneProduct296456 (Entrez Gene) integrin, alpha V
ItgaxGeneProduct499271 (Entrez Gene)
Itgb1GeneProduct24511 (Entrez Gene) integrin, beta 1
Itgb2GeneProduct309684 (Entrez Gene) integrin, beta 2
Itgb3GeneProduct29302 (Entrez Gene) integrin, beta 3
Itgb4GeneProduct3691 (Entrez Gene)
Itgb5GeneProductENSRNOG00000001795 (Ensembl) integrin, beta 5
Itgb6GeneProduct311061 (Entrez Gene) integrin, beta 6
Itgb7GeneProduct25713 (Entrez Gene) integrin, beta 7
Itgb8GeneProduct362800 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene) jun proto-oncogene
KdrGeneProduct25589 (Entrez Gene) kinase insert domain receptor
LOC235580GeneProductunknown gene product, LOC235580 was replaced by Col6a4 collagen, type VI, alpha 4 (M. musculus), Gene ID: 68553, updated on 17-Mar-2015
Lama1GeneProduct316758 (Entrez Gene)
Lama2GeneProductENSRNOG00000011134 (Ensembl)
Lama3GeneProduct307582 (Entrez Gene) laminin, alpha 3
Lama4GeneProduct309816 (Entrez Gene) laminin, alpha 4
Lama5GeneProduct140433 (Entrez Gene) laminin, alpha 5
Lamb1GeneProduct298941 (Entrez Gene)
Lamb2GeneProduct25473 (Entrez Gene) laminin, beta 2
Lamb3GeneProduct305078 (Entrez Gene) laminin, beta 3
Lamc1GeneProduct117036 (Entrez Gene)
Lamc2GeneProduct192362 (Entrez Gene) laminin, gamma 2
Lamc3GeneProduct311862 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
Map2k2GeneProduct58960 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
Map2k3GeneProduct303200 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
Map2k5GeneProduct29568 (Entrez Gene) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
Map2k6GeneProduct114495 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
Mapk1GeneProduct116590 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
Mapk12GeneProduct60352 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
Mapk4GeneProduct54268 (Entrez Gene) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
Mapk6GeneProduct58840 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
Mapk7GeneProduct114509 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
Mapk8GeneProduct116554 (Entrez Gene) mitogen-activated protein kinase 8
Mapk9GeneProduct50658 (Entrez Gene) mitogen-activated protein kinase 9
MetGeneProduct24553 (Entrez Gene) MET proto-oncogene, receptor tyrosine kinase
Myl6GeneProduct362816 (Entrez Gene)
Mylk2GeneProduct117558 (Entrez Gene) myosin light chain kinase 2
MylkGeneProduct288057 (Entrez Gene)
Pak1GeneProduct29431 (Entrez Gene) p21 protein (Cdc42/Rac)-activated kinase 1
Pak2GeneProduct29432 (Entrez Gene) p21 protein (Cdc42/Rac)-activated kinase 2
Pak3GeneProduct29433 (Entrez Gene) p21 protein (Cdc42/Rac)-activated kinase 3
Pak4GeneProduct292756 (Entrez Gene)
Pak6GeneProduct296078 (Entrez Gene)
Pak7GeneProduct311450 (Entrez Gene)
ParvbGeneProduct362973 (Entrez Gene)
PdgfaGeneProduct25266 (Entrez Gene)
PdgfbGeneProduct24628 (Entrez Gene) platelet-derived growth factor beta polypeptide
PdgfcGeneProduct79429 (Entrez Gene) platelet derived growth factor C
PdgfdGeneProduct66018 (Entrez Gene) platelet derived growth factor D
PdgfraGeneProduct25267 (Entrez Gene) platelet derived growth factor receptor, alpha polypeptide
PdgfrbGeneProduct24629 (Entrez Gene) platelet derived growth factor receptor, beta polypeptide
Pdpk1GeneProduct81745 (Entrez Gene) 3-phosphoinositide dependent protein kinase-1
PeloGeneProduct294754 (Entrez Gene)
PgfGeneProduct94203 (Entrez Gene)
Pik3caGeneProduct170911 (Entrez Gene) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Pik3cbGeneProduct85243 (Entrez Gene) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Pik3cdGeneProduct366508 (Entrez Gene)
Pik3cgGeneProduct298947 (Entrez Gene)
Pik3r1GeneProduct25513 (Entrez Gene) phosphoinositide-3-kinase, regulatory subunit 1
Pik3r2GeneProduct29741 (Entrez Gene) phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Pik3r4GeneProduct363131 (Entrez Gene)
Pik3r5GeneProduct497931 (Entrez Gene)
Pip5k1cGeneProduct314641 (Entrez Gene) phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
Ppp1r12aGeneProduct116670 (Entrez Gene) protein phosphatase 1, regulatory subunit 12A
PtenGeneProduct50557 (Entrez Gene) phosphatase and tensin homolog
Ptk2GeneProduct25614 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
Ptk6GeneProduct366275 (Entrez Gene)
PxnGeneProduct360820 (Entrez Gene) paxillin
Rac1GeneProduct363875 (Entrez Gene) ras-related C3 botulinum toxin substrate 1
Rac2GeneProduct366957 (Entrez Gene) ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Rac3GeneProductENSRNOG00000048172 (Ensembl) also known as LOC688319, ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
Raf1GeneProduct24703 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
Rap1aGeneProduct295347 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
Rap1bGeneProduct171337 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
Rapgef1GeneProduct63881 (Entrez Gene) Rap guanine nucleotide exchange factor
RelnGeneProduct24718 (Entrez Gene) reelin
RhoaGeneProduct117273 (Entrez Gene) ras homolog family member A
RhobGeneProduct64373 (Entrez Gene) ras homolog family member B
Rock1GeneProduct81762 (Entrez Gene) Rho-associated coiled-coil containing protein kinase 1
Rock2GeneProduct25537 (Entrez Gene) Rho-associated coiled-coil containing protein kinase 2
Sepp1GeneProduct29360 (Entrez Gene) SEPP1; selenoprotein P plasma
Shc1GeneProduct85385 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
Shc3GeneProduct114858 (Entrez Gene) SHC3; neuronal Sh
Sos1GeneProduct313845 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
Spp1GeneProduct25353 (Entrez Gene) secreted phosphoprotein 1
SrcGeneProduct83805 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
SrmsGeneProduct296472 (Entrez Gene) src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Styk1GeneProduct500340 (Entrez Gene)
Tesk2GeneProduct170908 (Entrez Gene) testis-specific kinase 2
Thbs1GeneProduct445442 (Entrez Gene) thrombospondin 1
Thbs2GeneProduct292406 (Entrez Gene) thrombospondin 2
Thbs3GeneProduct681309 (Entrez Gene) thrombospondin 3
Thbs4GeneProduct29220 (Entrez Gene)
Tln1GeneProduct313494 (Entrez Gene) talin 1
TncGeneProduct116640 (Entrez Gene) tenascin C
Tnk1GeneProduct303247 (Entrez Gene)
Tnk2GeneProduct303882 (Entrez Gene) tyrosine kinase, non-receptor, 2
TnnGeneProduct304913 (Entrez Gene)
TnrGeneProduct25567 (Entrez Gene) tenascin R
TnxbGeneProduct415089 (Entrez Gene) tenascin XB
TxkGeneProduct305311 (Entrez Gene) TXK tyrosine kinase
VaspGeneProduct361517 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
Vav1GeneProduct25156 (Entrez Gene) vav 1 guanine nucleotide exchange factor
VclGeneProduct305679 (Entrez Gene) VCL; vinculin
VegfaGeneProduct83785 (Entrez Gene) vascular endothelial growth factor A
VegfbGeneProduct89811 (Entrez Gene) vascular endothelial growth factor B
VegfcGeneProduct114111 (Entrez Gene) vascular endothelial growth factor C
VtnGeneProduct29169 (Entrez Gene) vitronectin
VwfGeneProduct116669 (Entrez Gene)
ZyxGeneProduct114636 (Entrez Gene) ZYX; zyxin

Annotated Interactions

No annotated interactions

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