Oxidative stress response (Rattus norvegicus)
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Stress-regulated MAP kinase
Activation
TF activation
Repression of ROS-
producing systems
Repression
Induction of
antioxidant genes
Inhibition of oxidases
Reactive Oxygen Species
Immediate-early
gene induction
Adaptive response
TF inhibition
Txnrd2
Junb
Sp1
Nfkb1
Xdh
Cyp1a1
Sod2
Nfix
Ugt1a6
Maoa
Mapk14
Mapk10
Cyba
Nrf2
MT1X
Sod3
Gpx1
Nqo1
Sod1
Hmox1
Gclc
Mgst1
Txn2
Cat
Fos
Gsr
GSTT2
Txnrd1
Gpx3
Description
No description
Comments
GenMAPP notes
Adapted from Biochem J 1999 Sep 15;342 Pt 3:481-96 Morel Y, Barouki R. Repression of gene expression by oxidative stress. Biochem J 1999 Sep 15;342 Pt 3:481-96
GenMAPP remarks
Adapted from rat by GenMAPP.org
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP408(r21540)
with a 89% conversion rate.
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Bibliography
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History
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Compare
Revision
Action
Time
User
Comment
116998
view
10:57, 16 May 2021
Eweitz
Modified title
71778
view
20:31, 17 October 2013
MaintBot
Automated update of data sources
69354
view
18:53, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67563
view
11:26, 26 June 2013
Ddigles
Ontology Term : 'oxidative stress response pathways' added !
41666
view
02:35, 2 March 2011
MaintBot
Removed redundant pathway information and comments
34061
view
19:06, 9 December 2009
MaintBot
Automatic update of empty xrefs
32355
view
13:39, 15 August 2009
MaintBot
Fixed text labels
31985
view
13:12, 14 August 2009
MaintBot
Fixed group labels
31404
view
20:50, 13 August 2009
MaintBot
Fixed text labels
30993
view
00:57, 30 July 2009
MaintBot
Converted from Homo sapiens
21043
view
11:30, 14 November 2008
MaintBot
[[Pathway:Rattus norvegicus:Oxidative Stress]] moved to [[Pathway:WP173]]: Moved to stable identifier
8322
view
13:46, 7 January 2008
MaintBot
[[Pathway:Rat:Oxidative Stress]] moved to [[Pathway:Rattus norvegicus:Oxidative Stress]]: Renaming species
7779
view
16:17, 18 December 2007
MaintBot
fixed category names
7484
view
12:42, 4 November 2007
MaintBot
Added categories to GPML
19533
view
22:20, 22 May 2007
I.Reyes
gpml file for [[Rat:Oxidative_Stress]]
6584
view
22:20, 22 May 2007
N.Reyes
gpml file for [[Rat:Oxidative_Stress]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
Cat
GeneProduct
24248 (Entrez Gene)
Cyba
GeneProduct
79129 (Entrez Gene)
Probe set ID: u18729
Cyp1a1
GeneProduct
24296 (Entrez Gene)
Fos
GeneProduct
314322 (Entrez Gene)
GSTT2
GeneProduct
29487 (Entrez Gene)
Gclc
GeneProduct
25283 (Entrez Gene)
Gpx1
GeneProduct
24404 (Entrez Gene)
Gpx3
GeneProduct
64317 (Entrez Gene)
Gsr
GeneProduct
116686 (Entrez Gene)
Hmox1
GeneProduct
24451 (Entrez Gene)
Junb
GeneProduct
24517 (Entrez Gene)
MT1X
GeneProduct
Maoa
GeneProduct
29253 (Entrez Gene)
Mapk10
GeneProduct
25272 (Entrez Gene)
Mapk14
GeneProduct
81649 (Entrez Gene)
Mgst1
GeneProduct
171341 (Entrez Gene)
Nfix
GeneProduct
81524 (Entrez Gene)
Nfkb1
GeneProduct
81736 (Entrez Gene)
Nqo1
GeneProduct
24314 (Entrez Gene)
Nrf2
GeneProduct
Sod1
GeneProduct
24786 (Entrez Gene)
Sod2
GeneProduct
24787 (Entrez Gene)
Sod3
GeneProduct
25352 (Entrez Gene)
Sp1
GeneProduct
24790 (Entrez Gene)
Txn2
GeneProduct
79462 (Entrez Gene)
Txnrd1
GeneProduct
58819 (Entrez Gene)
Txnrd2
GeneProduct
50551 (Entrez Gene)
Ugt1a6
GeneProduct
113992 (Entrez Gene)
Xdh
GeneProduct
497811 (Entrez Gene)
Annotated Interactions
No annotated interactions
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