Proteasome degradation (Rattus norvegicus)

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1E3/ProteinUbiquitin/ProteinUbiquitin/E2 ComplexAMP Ubiquitin/E1 ComplexPresentation by MHC class 1Degrades only PeptidesActivators of20S ComplexLid subunitsUnfolds and DegradesIntact ProteinsBeta subunitsProteasome 20SCatalytic Core (p45)Alpha subunitsProteasome 26 S(PA700) (ATP dependent)p45 ATPase SubunitDeubiquitinates proteinsOxidatively DamagedCytosolic ProteinsProteins to be Degraded2Psmd6Psmc4Psmb1Psmc1RT1-M6-1Psmc6Ube2d3Psma2Psmd9H2AFZPsmc5RT1-M6-1Uba1Psmb10Psmb4HIST1H2ABUbe2d1Psme1RT1-M6-1Psmd4HLA-HPsmd12Psma4RT1-M6-1PSMA1Psma3Psmb9Psmb8Psmd8PSMD10Psmd3Psmd11Nedd4Psma7RT1-M6-1Psmd7Rpn1Rpn2ATPPsmb7IfngLOC100360846UBBUBCUchl1PSMB3Ube2bH2afxPsmd13AABR07045621.1Psmb5Ube2d2Psmd5Psmb2Psme3HLA-JPsme2Psmd2Uchl3Psmc5Uba7Psma5Psmc3Psmc2RT1-M6-1UbiquitinPsmd1


Description

No description

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP183 (r95110) with a 86.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hershko A, Ciechanover A, Varshavsky A; ''Basic Medical Research Award. The ubiquitin system.''; Nat Med, 2000 PubMed Europe PMC Scholia
  2. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W; ''Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.''; Proc Natl Acad Sci U S A, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117012view11:22, 16 May 2021EweitzModified title
95795view14:41, 19 January 2018MkutmonHomology conversion update
72157view11:58, 25 October 2013EgonwAdded a metabolite ID.
71801view20:34, 17 October 2013MaintBotAutomated update of data sources
71306view16:59, 17 October 2013MaintBotAutomated update of data sources
69432view19:04, 8 July 2013MaintBotUpdated to 2013 gpml schema
67613view11:33, 26 June 2013DdiglesOntology Term : 'ubiquitin/proteasome degradation pathway' added !
62852view05:06, 3 May 2013MaintBotUpdated UniProt data source
58967view18:39, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41756view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
34126view19:28, 9 December 2009MaintBotAutomatic update of empty xrefs
32391view16:59, 15 August 2009MaintBotFixed text labels
32039view13:28, 14 August 2009MaintBotFixed group labels
31426view21:00, 13 August 2009MaintBotFixed text labels
31020view01:08, 30 July 2009MaintBotConverted from Homo sapiens
21315view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Proteasome Degradation]] moved to [[Pathway:WP302]]: Moved to stable identifier
8352view13:46, 7 January 2008MaintBot[[Pathway:Rat:Proteasome Degradation]] moved to [[Pathway:Rattus norvegicus:Proteasome Degradation]]: Renaming species
7794view16:18, 18 December 2007MaintBotfixed category names
7487view12:42, 4 November 2007MaintBotAdded categories to GPML
6588view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:Proteasome_Degradation]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AABR07045621.1GeneProductENSRNOG00000049150 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5687
ATPMetabolite1927-31-7 (CAS)
H2AFZGeneProductENSRNOG00000031564 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3015
H2afxGeneProductENSRNOG00000010386 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3014
HIST1H2ABGeneProductNo homologues found for original id L:8335
HLA-HGeneProduct
HLA-JGeneProduct
IfngGeneProductENSRNOG00000007468 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3458
LOC100360846GeneProductENSRNOG00000011827 (Ensembl)
  • U13393
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5694
Nedd4GeneProductENSRNOG00000058898 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4734
PSMA1GeneProductNo homologues found for original id L:5682
PSMB3GeneProductNo homologues found for original id L:5691
PSMD10GeneProductNo homologues found for original id L:5716
Psma2GeneProductENSRNOG00000049920 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5683
Psma3GeneProductENSRNOG00000007851 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5684
Psma4GeneProductENSRNOG00000013493 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5685
Psma5GeneProductENSRNOG00000019868 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5686
Psma7GeneProductENSRNOG00000056853 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5688
Psmb10GeneProductENSRNOG00000019494 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5699
Psmb1GeneProductENSRNOG00000001488 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5689
Psmb2GeneProductENSRNOG00000011463 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5690
Psmb4GeneProductENSRNOG00000020979 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5692
Psmb5GeneProductENSRNOG00000013386 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5693
Psmb7GeneProductENSRNOG00000011732 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5695
Psmb8GeneProductENSRNOG00000000456 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5696
Psmb9GeneProductENSRNOG00000000459 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5698
Psmc1GeneProductENSRNOG00000003951 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5700
Psmc2GeneProductENSRNOG00000012026 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5701
Psmc3GeneProductENSRNOG00000011414 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5702
Psmc4GeneProductENSRNOG00000018994 (Ensembl)
  • PRS6 HUMAN
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5704
Psmc5GeneProductENSRNOG00000010038 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5705
Psmc6GeneProductENSRNOG00000007203 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5706
Psmd11GeneProductENSRNOG00000005538 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5717
Psmd12GeneProductENSRNOG00000003117 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5718
Psmd13GeneProductENSRNOG00000014109 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5719
Psmd1GeneProductENSRNOG00000017730 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5707
Psmd2GeneProductENSRNOG00000001719 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5708
Psmd3GeneProductENSRNOG00000028103 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5709
Psmd4GeneProductENSRNOG00000021042 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5710
Psmd5GeneProductENSRNOG00000018809 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5711
Psmd6GeneProductENSRNOG00000006751 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9861
Psmd7GeneProductENSRNOG00000014097 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5713
Psmd8GeneProductENSRNOG00000037580 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5714
Psmd9GeneProductENSRNOG00000001339 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5715
Psme1GeneProductENSRNOG00000019041 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5720
Psme2GeneProductENSRNOG00000019246 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5721
Psme3GeneProductENSRNOG00000051344 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10197
RT1-M6-1GeneProductENSRNOG00000022107 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3106
Rpn1GeneProductENSRNOG00000046345 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6184
Rpn2GeneProductENSRNOG00000007492 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6185
UBBGeneProductNo homologues found for original id En:ENSG00000170315
UBCGeneProductNo homologues found for original id L:7316
Uba1GeneProductENSRNOG00000019164 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7317
Uba7GeneProductENSRNOG00000029195 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7318
Ube2bGeneProductENSRNOG00000059348 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7320
Ube2d1GeneProductENSRNOG00000000611 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7321
Ube2d2GeneProductENSRNOG00000042523 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7322
Ube2d3GeneProductENSRNOG00000013741 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7323
UbiquitinProteinNo homologues found for original id S:P0CG48
Uchl1GeneProductENSRNOG00000002343 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000154277
Uchl3GeneProductENSRNOG00000009530 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000118939

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP302"
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