TGF-beta receptor signaling pathway (Rattus norvegicus)

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PMNUNucleusECGOTranslocationCYDeubiquitinationNUCYGlycosylation(Protein-protein interaction)CYNUMethylationReaction through unknown mechanisms/moleculesCYActivationNUNUMolecule in the pathwayNUInhibitionERNUNUCYReceptorCYSumoylationLigandProteins in a complex interactionPalmitoylationMitochondriaEndosomeNUCYCYCYAcetylationCYCYNUNUAccession Number: NetPath 7; cellmap:7MTNUCYGolgi apparatusENNU -> CYCYPlasma membraneDephosphorylationCYNUMolecular associationGlycosylationNUCYNUExtracellularNUNUCYNUNUNUNUCYEndoplasmic reticulumDemethylationPhosphorylationCYCYCYNUControlCYCYCYNU -> CYCytoplasmNUNUDeacetylationCYCYAutophosphorylationRecruitmentCYEnzyme complexNUProteolytic cleavageCYNUNUUbiquitinationDDesumoylationSUMO1Tgfbr2E2f5Pias1StrapMap2k6Kpnb1MEF2AAxin1Ube2d2Camk2dEsr1Atf3PrkcdZeb2Tgfbr2Smad6UBE2D3Cul1Gipc1Eid2NfycZfyve9SKP1ASnx1Cdc27Tgfb3Smad7Cdc25aCamk2bTgfbr1Smad3Snx2Map2k3CtcfFosbRunx2Dvl1Tgfbr3HgsAnapc7Smurf2Smad3E2F4Camk2aTgfb3E2F4JunCdk4Sdc2Rb1Hdac1Anapc10Cdc16PrkcbStrapAnapc1Smad4Pard3Tgfb2Tgfbr2Snx6PCAFRGD1309707FosBtrcUbe2d1Smad4Tgfbr2Rbl1Ap2b1Snx6Snip1Rbl1Rock1JundTgfbr3Tgfbr2ERBB2IPMef2cCops5Tfdp2Rbl1Foxg1Smad7Rbl2Cdc16Anapc2Tgfb3MycRBX1Snw1CDC23Smad4Cd44Tgif1Tgfbr3Smad3Smad2RBX1Rbl1Nup214CDC23Axin2Dab2E2f5Tgfbr1Anapc4JunbNfybSmad4Anapc2Anapc4Camk2gTgfbr3Lef1DaxxSmad4E2f5Tgfbr1Arrb2Tp73Cav1Sp1Kpnb1ArTgfbr2Smad3Tgfb2Cul1E2f5ENGSmad3Prkar2aSTAMBPL1Mapk8Smurf2Dcp1aTgfbr1Ppp2r2aCited1Tgfb1Rbl1Ets1Tgfb2VdrAnapc5Tgfbr3Foxo3Pik3r1Ccnb2Hspa8Tfdp2Snx4Ncoa1FntaEIF3S2Cul1Smad2Zeb1Cdk6Esr1Smad3Hoxa9SkilFoxo1Rb1BtrcMapk8Cdkn1aMap3k7Smad2E2f5Tp53MAP3K7IP1Stk11ipSmad3Ctnnb1Cdc27E2F4Mapk14Smad7Gene SymbolTFDP1Rock1Tgfbr3Tgfbr2Smad3Rbl2RBX1Trap1RGD1309707SparcRb1Tgfb3Tgfbr2Fzr1Anapc5Acvrl1TFDP1YAP1Anapc7Smad4Dcp1aPik3r2Cdk2Tgfb1Smad2Ep300Ccnd1Hnf4aXpo1Nup153Mapk14Anapc1CrebbpAtf2Anapc10TFDP1Stk11NfyaTfdp2Tgfb1E2F4Cdc2E2f5Pias2Tgfbr2SKP1AFkbp1aE2F4Prkar1bSmad3SKITgfb1Foxo4Tgfbr2Cdc27E2F4PrkcgFoxh1Ccne1


Description

No description

Comments

GenMAPP notes 
NetPath 7; cellmap:7 - TGF-beta Receptor Signaling Pathway

The TGF-beta Receptor Signaling pathway was kindly reviewed by Van Le Hong, Wei He and other members of Joan Massague’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP366(r21445) with a 88% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
118014view11:33, 23 May 2021EweitzModified title
69402view19:00, 8 July 2013MaintBotUpdated to 2013 gpml schema
67696view11:50, 26 June 2013DdiglesOntology Term : 'transforming growth factor-beta superfamily mediated signaling pathway' added !
41723view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
34099view19:19, 9 December 2009MaintBotAutomatic update of empty xrefs
31441view21:06, 13 August 2009MaintBotFixed text labels
30987view00:55, 30 July 2009MaintBotConverted from Homo sapiens
21437view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:TGF-beta-Receptor NetPath 7]] moved to [[Pathway:WP362]]: Moved to stable identifier
8438view13:46, 7 January 2008MaintBot[[Pathway:Rat:TGF-beta-Receptor NetPath 7]] moved to [[Pathway:Rattus norvegicus:TGF-beta-Receptor NetPath 7]]: Renaming species
7835view16:21, 18 December 2007MaintBotfixed category names
7306view12:42, 4 November 2007MaintBotAdded categories to GPML
6601view22:20, 22 May 2007A.Pandeygpml file for [[Rat:TGF-beta-Receptor_NetPath_7]]

External references

DataNodes

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NameTypeDatabase referenceComment
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EIF3S2GeneProduct
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Gene SymbolGeneProduct
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RBX1GeneProduct300084 (Entrez Gene)
RGD1309707GeneProduct690516 (Entrez Gene)
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SKIGeneProduct
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TFDP1GeneProduct
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Tp53GeneProduct24842 (Entrez Gene)
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UBE2D3GeneProduct81920 (Entrez Gene)
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Zfyve9GeneProduct313477 (Entrez Gene)

Annotated Interactions

No annotated interactions
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