Arginine degradation (Saccharomyces cerevisiae)

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Description

Under conditions where optimal sources of nitrogen are unavailable, S. cerevisiae is able to utilize arginine as its sole nitrogen source. Arginine catabolism occurs in the cytosol with the hydrolysis of arginine to proline, releasing three nitrogen atoms that can be used by the cell. In the absence of oxygen, the proline ring is unable to be further degraded. The utilization of arginine as a nitrogen source is repressed if better nitrogen compounds such as ammonia, asparagine or glutamine are present. This is known as nitrogen catabolite repression (NCR). The CAR1 gene is subject to the effect of this repression which is mediated by the negative regulator Ure2p. In the presence of arginine and the absence of a preferred nitrogen source, NCR is released by the GATA transcriptional activators Gln3p and Gat1p. Unrelated to NCR, the presence of arginine also induces CAR1 and CAR2 expression by the regulators Arg80p, Arg81p and Mcm1p. The CAR genes are also activated by the globally acting transcription factors Rap1p and Abf1p. Conversely, CAR1 and CAR2 expression is repressed by the Ume6p-Sin2p-Rpd3p complex. Additionally, CAR2 expression is induced by the two positive regulators Dal81p and Dal82p as well as allophanate, a degradation product of urea. Description from YeastPathways.

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Bibliography

  1. ''L-arginine degradation VI (arginase 2 pathway)''; https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=ARG-PRO-PWY,

History

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CompareRevisionActionTimeUserComment
135444view21:53, 5 September 2024KhanspersModified description
135443view21:45, 5 September 2024Khanspers
135442view21:43, 5 September 2024KhanspersModified description
135441view21:41, 5 September 2024Khanspersadded lit ref
135415view21:38, 4 September 2024Khanspersoverhaul
89653view16:21, 23 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
89534view11:06, 16 September 2016Mkutmonontology tag fix
70247view21:35, 15 July 2013MaintBotupdated to 2013 schema
69953view20:49, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
67060view10:01, 26 June 2013Christine ChichesterOntology Term : 'arginine degradation pathway' added !
53673view10:57, 11 November 2012EgonwUse the unicode ? instead of a regular 2.
45182view09:20, 7 October 2011Mkutmonconnected lines
41909view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
20791view11:29, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Arginine Degradation]] moved to [[Pathway:WP54]]: Moved to stable identifier
12658view07:56, 17 May 2008MaintBotautomated metabolite conversion
8648view14:05, 7 January 2008MaintBotAdded to category $category
8646view14:05, 7 January 2008J.HeckmanUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
CAR1GeneProductS000006032 (SGD)
CAR2GeneProductS000004430 (SGD)
H2OMetaboliteHMDB02111 (HMDB)
L-arginineMetabolite74-79-3 (CAS)
L-delta-1 pyrroline-5-carboxylateMetabolite17388 (ChEBI)
L-glutamateMetabolite56-86-0 (CAS)
L-ornithineMetabolite70-26-8 (CAS)
L-prolineMetabolite147-85-3 (CAS)
N-acetylglutamate semialdehydeMetabolite58066 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
NADPMetaboliteHMDB00217 (HMDB)
PRO3GeneProductS000000825 (SGD)
ureaMetabolite57-13-6 (CAS)

Annotated Interactions

No annotated interactions

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