De novo biosynthesis of pyrimidine ribonucleotides (Saccharomyces cerevisiae)

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Description

Purine and pyrimidine nucleotides have many diverse and essential roles in the cell. They are precursors to DNA, RNA, and many important metabolites (for example CDP-diacylglycerol). Nucleotides can also be used as an energy source (primarily as ATP), signaling molecules, and cofactor components (for example coenzyme A).

In yeast, the initial steps of de novo pyrimidine biosynthesis are catalyzed by the bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase Ura2p. In the first step, Ura2p catalyzes the synthesis of carbamoylphosphate from CO2, ATP, and glutamine. In the second, Ura2p condenses carbamoylphosphate with aspartate to yield ureidosuccinate/carbamoyl-L-aspartate. Third, dihydroorotase (Ura4p) catalyzes closure of the pyrimidine ring of ureidosuccinate to form dihydroorotate (DHO). DHO, in turn, is oxidized to orotic acid (OA), condensed with phosphoribosyl pyrophosphate to form orotidine 5-monophosphate, and finally decarboxylated to yield UMP. These three steps are catalyzed by Ura1p, Ura5p/Ura10p, and Ura3p, respectively. UMP may then undergo further processing to form other pyrimidines.

Source: https://pathway.yeastgenome.org/

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Bibliography

  1. Wagner R, de Montigny J, de Wergifosse P, Souciet JL, Potier S; ''The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease.''; FEMS Microbiol Lett, 1998 PubMed Europe PMC Scholia
  2. ''de novo biosynthesis of pyrimidine ribonucleotides''; YeastPathways,

History

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CompareRevisionActionTimeUserComment
135633view04:22, 8 October 2024Khanspersboard size
135632view04:21, 8 October 2024Khanspersupdated reference
135631view04:19, 8 October 2024Khanspersoverhaul
135621view21:49, 7 October 2024KhanspersOntology Term : 'classic metabolic pathway' added !
135620view21:44, 7 October 2024Khanspersremoved GenMAPP comments
135619view21:42, 7 October 2024KhanspersModified description
117290view11:02, 20 May 2021EweitzModified title
107032view13:48, 17 September 2019MaintBotHMDB identifier normalization
102792view13:45, 24 January 2019EgonwBetter PubChem ID.
87230view14:47, 19 July 2016SusanOntology Term : 'de novo pyrimidine biosynthetic pathway' added !
87229view14:47, 19 July 2016SusanOntology Term : 'PW:0000861' removed !
87226view14:44, 19 July 2016SusanOntology Term : 'pyrimidine biosynthetic pathway' added !
71184view15:09, 11 October 2013EgonwFixed a metabolite label and added its identifier.
71183view15:01, 11 October 2013EgonwAdded missing metabolite identifiers.
71182view14:48, 11 October 2013EgonwPeriodical save, work in progress
70996view15:30, 22 September 2013EgonwAdded metabolite identifiers.
70248view21:36, 15 July 2013MaintBotupdated to 2013 schema
70053view06:01, 12 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69729view08:03, 11 July 2013EgonwGive water HMDB ids.
54773view07:18, 9 December 2012EgonwReplaced multiple general nodes by Metabolite DataNode's.
54772view07:14, 9 December 2012EgonwConnecting dots
41915view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
36648view22:38, 9 April 2010MaintBotDescription and bibliography added from SGD
20875view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:De Novo Biosynthesis of Pyrimidine Ribonucleotides]] moved to [[Pathway:WP92]]: Moved to stable identifier
12686view07:58, 17 May 2008MaintBotautomated metabolite conversion
8690view14:06, 7 January 2008MaintBotAdded to category $category
8688view14:06, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2 ADPMetabolite58-64-0 (CAS)
2 ATPMetabolite1927-31-7 (CAS)
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
CO2Metabolite274 (Chemspider)
CTPMetabolite6176 (PubChem-compound)
EC 2.7.4.6GeneProductEC 2.7.4.6 (Enzyme Nomenclature)
H+Metabolite1010 (Chemspider)
H2OMetaboliteHMDB0002111 (HMDB)
HCO3-Metabolite749 (Chemspider)
L-aspartateMetaboliteCHEBI:29991 (ChEBI)
L-glutamateMetabolite56-86-0 (CAS)
L-glutamineMetabolite56-85-9 (CAS)
PRPPMetabolite97-55-2 (CAS)
UDPMetabolite1158 (PubChem-compound)
UMPMetabolite6030 (PubChem-compound)
URA10GeneProductS000004884 (SGD)
URA1GeneProductS000001699 (SGD)
URA2GeneProductS000003666 (SGD)
URA3GeneProductS000000747 (SGD)
URA4GeneProductS000004412 (SGD)
URA5GeneProductS000004574 (SGD)
URA6GeneProductS000001507 (SGD)
URA7GeneProductS000000135 (SGD)
URA8GeneProductS000003864 (SGD)
UTPMetabolite6133 (PubChem-compound)
carbamoyl-L-aspartateMetabolite279 (PubChem-compound)
carbamoyl-phosphateMetabolite3423467 (PubChem-compound)
dihydroorotateMetabolite1232048 (Chemspider)
diphosphateMetabolite29888 (ChEBI)
orotateMetabolite942 (Chemspider)
orotidine-5'-phosphateMetabolite160617 (PubChem-compound)
phosphateMetabolite14265-44-2 (CAS)

Annotated Interactions

No annotated interactions

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