TCA cycle - detailed (Saccharomyces cerevisiae)
From WikiPathways
Description
The tricarboxylic acid (TCA) cycle is a catabolic pathway that functions to generate energy and reduced cofactors from the oxidative decarboxylation of acetyl (C2) units. It occupies a central role in the metabolism of aerobic organisms, enabling the production of energy from carbohydrates, fatty acids, amino acids, and potentially any other molecule that can be converted or broken down to acetyl-CoA. In addition to its role in catabolism, the TCA cycle can also serve a biosynthetic role, as several intermediates in the pathway (e.g. oxaloacetate, succinate) provide carbon for the synthesis of amino acids or other biological compounds.
Source: https://pathway.yeastgenome.org/
Quality Tags
Ontology Terms
Bibliography
- ''TCA cycle, aerobic respiration ''; YeastPathways,
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
2-ketoglutarate dehydrogenase | GeneProduct | S000001387 (SGD) | |
2-oxoglutarate | Metabolite | 16810 (ChEBI) | |
ADP | Metabolite | 58-64-0 (CAS) | |
ATP | Metabolite | 1927-31-7 (CAS) | |
CHO3 | Metabolite | 17544 (ChEBI) | |
CO2 | Metabolite | 16526 (ChEBI) | |
Coenzyme A | Metabolite | 64885-97-8 (CAS) | |
D-threo-isocitrate | Metabolite | 15562 (ChEBI) | |
H+ | Metabolite | 15378 (ChEBI) | |
H2O | Metabolite | 15377 (ChEBI) | |
NAD+ | Metabolite | 57540 (ChEBI) | |
NADH | Metabolite | 53-84-9 (CAS) | |
acetyl-CoA | Metabolite | 72-89-9 (CAS) | |
aconitase | GeneProduct | S000004295 (SGD) | |
aconitate hydratase | GeneProduct | S000003736 (SGD) | |
cis-aconitate | Metabolite | 16383 (ChEBI) | |
citrate synthase 1 | GeneProduct | S000005284 (SGD) | |
citrate synthase 2 | GeneProduct | S000000598 (SGD) | |
citrate synthase 3 | GeneProduct | S000006205 (SGD) | |
citrate | Metabolite | 16947 (ChEBI) | |
cytoplasmic malate dehydrogenase | GeneProduct | S000005486 (SGD) | |
dihydrolipoamide dehydrogenase | GeneProduct | S000001876 (SGD) | |
dihydrolipoyl transsuccinylase | GeneProduct | S000002555 (SGD) | |
fumarate hydratase | GeneProduct | S000006183 (SGD) | |
fumarate | Metabolite | 29806 (ChEBI) | |
isocitrate dehydrogenase 1 | GeneProduct | S000004982 (SGD) | |
isocitrate dehydrogenase 2 | GeneProduct | S000005662 (SGD) | |
malate dehydrogenase | GeneProduct | S000002236 (SGD) | |
malate | Metabolite | 15589 (ChEBI) | |
mitochondrial malate dehydrogenase | GeneProduct | S000001568 (SGD) | |
oxaloacetic acid | Metabolite | HMDB0000223 (HMDB) | |
phosphate | Metabolite | 14265-44-2 (CAS) | |
pyruvate carboxylase 1 | GeneProduct | S000003030 (SGD) | |
pyruvate carboxylase 2 | GeneProduct | S000000422 (SGD) | |
pyruvate | Metabolite | HMDB0000243 (HMDB) | |
succinate dehydrogenase 1 | GeneProduct | S000001631 (SGD) | |
succinate dehydrogenase 2 | GeneProduct | S000003964 (SGD) | |
succinate dehydrogenase 3 | GeneProduct | S000001624 (SGD) | |
succinate dehydrogenase 4 | GeneProduct | S000002585 (SGD) | |
succinate | Metabolite | 30031 (ChEBI) | |
succinyl-CoA ligase 1 | GeneProduct | S000005668 (SGD) | |
succinyl-CoA ligase 2 | GeneProduct | S000003476 (SGD) | |
succinyl-CoA | Metabolite | 57292 (ChEBI) | |
ubiqionol | Metabolite | 17976 (ChEBI) | |
ubiquinone | Metabolite | 303-97-9 (CAS) |
Annotated Interactions
No annotated interactions