Estrogen signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none MAPKsERK 1/2JNKsMAPK14NucleusApoptotic switchAF1LegendInhibitionGene expression(Cyc D, IGFR1 etc.)Genomic function of ER (slow)ActivationGene expression(pS2, Complement 3 etc.)MitochondrionNon-genomic function of ER (fast)TranslocationCell proliferation and progressionMTOR signaling, etc.Gene expression(anti-apoptotic and proliferation)FOSSP1EREEstradiolESR1ESR1ELK1ESR1EstradiolGPER1GNGT1GNB1GNASJUNPI3KEstradiolGrowth factorsNFKBNon-EREBCL2GFRsCyclic AMPPKB/AktCREB1MAPKKKESR1MAPKKPRKACANFKBCREB1CHUKIKBKBIKBKGESR1TFIKK complexAF2Name: Estrogen signalingOrganism: Homo sapiens


Description

Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP712).

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Quality Tags

Image:Curated.pngApproved version
Image:Unconnected.pngFix interactions

Ontology Terms

Pathway Ontology : estrogen signaling pathway
 

Bibliography

  1. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  2. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC Scholia
  3. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138161
Approved
view00:34, 19 March 2025EweitzTailor node widths
138160view00:32, 19 March 2025EweitzFix truncated text, align nodes
138159view00:30, 19 March 2025EweitzIncrease font size
138158view00:23, 19 March 2025EweitzUse gene symbols
138157view00:18, 19 March 2025EweitzUse gene symbols
138156view00:15, 19 March 2025EweitzUse gene symbols
138155view00:09, 19 March 2025EweitzModified description
138154view00:06, 19 March 2025EweitzUse gene symbols
137457view14:44, 2 March 2025EgonwModified description
129716view01:32, 22 May 2024EweitzModified title
128693view21:08, 19 February 2024EweitzEconomize layout
128689view17:28, 19 February 2024EweitzUntangle interaction, simplify line type, economize layout
128688view17:20, 19 February 2024EweitzUpgrade mitochondrion, economize layout
128687view17:12, 19 February 2024EweitzEconomize layout
128686view16:57, 19 February 2024EweitzStraighten remaining lines, economize layout, standardize case
128685view16:14, 19 February 2024EweitzSimplify interaction line types
128684view16:08, 19 February 2024EweitzEconomize layout
126218view15:04, 16 April 2023EgonwLicense is CCZero
109450view10:10, 18 March 2020L DupuisConverted interactions to graphical lines in legend
106408view21:55, 28 August 2019KhanspersModified description
106173view12:07, 16 August 2019MaintBotHMDB identifier normalization
105588view04:44, 10 August 2019KhanspersModified description
78491view10:28, 7 January 2015MaintBotadded missing graphIds
77341view19:19, 22 August 2014AlexanderPicoModified description
77340view19:18, 22 August 2014AlexanderPicoLinked refs to pathway element
72117view23:15, 24 October 2013AlexanderPicoReplaced IKK node with actual complex of individual nodes
63186view20:45, 8 May 2013MaintBotUpdating gpml version
59090view22:08, 21 February 2013MaintBotUpdated Ensembl data source
48214view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45247view18:33, 7 October 2011AlexanderPicoOntology Term : 'estrogen signaling pathway' added !
41039view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
39752view06:49, 17 January 2011AlexanderPico
38812view08:50, 24 September 2010Jildaunucleus
34842view09:12, 27 January 2010Vtriver6Specify description
34841view09:10, 27 January 2010Vtriver6Specify description
34840view09:09, 27 January 2010Vtriver6Specify description
34839view09:06, 27 January 2010Vtriver6ER signaling
34838view07:51, 27 January 2010Vtriver6Periodical save, work in progress
33422view14:53, 30 November 2009MaintBotRemoved group label
29739view22:35, 1 June 2009KhanspersModified categories
29675view11:39, 26 May 2009LauravanzonSpecify description
29593view11:18, 20 May 2009LauravanzonSpecify description
29589view08:39, 19 May 2009LauravanzonSpecify description
29588view08:38, 19 May 2009LauravanzonSpecify description
29587view08:32, 19 May 2009LauravanzonModified description
29586view08:31, 19 May 2009LauravanzonSpecify description
29585view08:24, 19 May 2009LauravanzonSpecify description
29584view08:20, 19 May 2009LauravanzonPeriodical save, work in progress
29582view07:29, 19 May 2009LauravanzonSpecify description
29581view07:19, 19 May 2009LauravanzonSpecify description

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
BCL2GeneProduct596 (Entrez Gene) "BCL2 apoptotic switch" originally
CHUKGeneProduct1147 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene) "CREB" originally
Cyclic AMPMetaboliteHMDB0000058 (HMDB)
ELK1GeneProduct2002 (Entrez Gene) "ELK" originally
EREGeneProduct2099 (Entrez Gene)
ERK 1/2GeneProductENSG00000100030 (Ensembl)
ESR1GeneProduct2099 (Entrez Gene) "ER" originally
EstradiolMetaboliteHMDB0000151 (HMDB)
FOSGeneProduct2353 (Entrez Gene) "C-FOS" originally
GFRsGeneProduct2099 (Entrez Gene)
GNASGeneProduct2778 (Entrez Gene) "GSA" originally
GNB1GeneProduct2782 (Entrez Gene)
GNGT1GeneProduct2792 (Entrez Gene)
GPER1GeneProduct2852 (Entrez Gene) "GPR30" originally
Growth factorsMetaboliteHMDB0000151 (HMDB)
IKBKBGeneProduct3551 (Entrez Gene)
IKBKGGeneProduct8517 (Entrez Gene)
JNKsGeneProduct5601 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene) "c-Jun" originally
MAPK14GeneProduct1432 (Entrez Gene) "p38" originally
MAPKKGeneProductENSG00000169032 (Ensembl)
MAPKKKGeneProduct673 (Entrez Gene)
NFKBGeneProduct4790 (Entrez Gene)
Non-EREGeneProduct2099 (Entrez Gene)
PI3KGeneProduct5290 (Entrez Gene)
PKB/AktGeneProduct207 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene) "PKACA" originally
SP1GeneProduct6667 (Entrez Gene)
TFGeneProduct2099 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP712"
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