SUMOylation of RNA binding proteins (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="SUMOylation of RNA binding proteins" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">SUMOylation of RNA-binding proteins (Li et al. 2004, reviewed in Filosa et al. 2013) alters their interactions with nucleic acids and with proteins. Whereas SUMOylation of HNRNPC decreases its affinity for nucleic acid (ssDNA), SUMOylation of NOP58 is required for binding of snoRNAs. SUMOylation of HNRNPK is required for its coactivation of TP53-dependent transcription. View original pathway at:[http://www.reactome.org/PathwayBrowser/#DIAGRAM=4570464 Reactome].</Comment> <Comment Source="Reactome-Converter">Pathway is converted from Reactome ID: 4570464</Comment> <Comment Source="Reactome-version">Reactome version: 66</Comment> <Comment Source="Reactome Author">Reactome Author: May, Bruce</Comment> <BiopaxRef>a47</BiopaxRef> <BiopaxRef>f2c</BiopaxRef> <Attribute Key="reactome_id" Value="4570464" /> <Graphics BoardWidth="656.0" BoardHeight="1337.0" /> <DataNode TextLabel="UBE2I" GraphId="a1d3e" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="261.0" CenterY="196.5" Width="72.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P63279" /> </DataNode> <DataNode TextLabel="PRC1 complex" GraphId="a445c" Type="Complex"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="541.5" CenterY="141.5" Width="113.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-389114" /> </DataNode> <DataNode TextLabel="NOP58" GraphId="a5067" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="353.0" CenterY="270.5" Width="66.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2X3" /> </DataNode> <DataNode TextLabel="RAE1 " GraphId="a52ca" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="507" /> <Graphics CenterX="100.0" CenterY="1157.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P78406" /> </DataNode> <DataNode TextLabel="TPR " GraphId="a6ef2" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="522" /> <Graphics CenterX="100.0" CenterY="1177.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P12270" /> </DataNode> <DataNode TextLabel="2SUMO1:NOP58" GraphId="a75e9" Type="Complex"> <BiopaxRef>c9c</BiopaxRef> <BiopaxRef>f80</BiopaxRef> <BiopaxRef>ecf</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="194.5" CenterY="421.5" Width="119.0" Height="27.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-4570540" /> </DataNode> <DataNode TextLabel="SUMO1-K250-HNRNPC " GraphId="abf4e" Type="Protein" GroupRef="cb744"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-4570453" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="617.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P07910" /> </DataNode> <DataNode TextLabel="NUP214 " GraphId="ac6a9" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="315" /> <Graphics CenterX="100.0" CenterY="997.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P35658" /> </DataNode> <DataNode TextLabel="NUPL2 " GraphId="af4b2" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="248" /> <Graphics CenterX="100.0" CenterY="897.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15504" /> </DataNode> <DataNode TextLabel="UBE2I-G93-SUMO2 " GraphId="b2644" Type="Protein" GroupRef="efad0"> <BiopaxRef>b1b</BiopaxRef> <BiopaxRef>dbd</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-2993778" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1157.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P61956" /> </DataNode> <DataNode TextLabel="UBE2I" GraphId="b3043" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="522.0" CenterY="201.5" Width="72.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P63279" /> </DataNode> <DataNode TextLabel="Nup45 " GraphId="b36cf" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="211" /> <Graphics CenterX="100.0" CenterY="837.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BVL2-2" /> </DataNode> <DataNode TextLabel="NUP37 " GraphId="b43ed" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="84" /> <Graphics CenterX="100.0" CenterY="757.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NFH4" /> </DataNode> <DataNode TextLabel="SUMO1-K467,K497-NOP58 " GraphId="b4cde" Type="Protein" GroupRef="e2ecf"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-4570540" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="997.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2X3" /> </DataNode> <DataNode TextLabel="PHC3 " GraphId="b4d52" Type="Protein" GroupRef="d3dfe"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-389114" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="737.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NDX5" /> </DataNode> <DataNode TextLabel="NUP155 " GraphId="b66cf" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="286" /> <Graphics CenterX="100.0" CenterY="937.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75694" /> </DataNode> <DataNode TextLabel="NUP153 " GraphId="b73ad" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="255" /> <Graphics CenterX="100.0" CenterY="917.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P49790" /> </DataNode> <DataNode TextLabel="NUP93 " GraphId="b7cc3" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="460" /> <Graphics CenterX="100.0" CenterY="1137.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N1F7" /> </DataNode> <DataNode TextLabel="NUP43 " GraphId="b9adc" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="352" /> <Graphics CenterX="100.0" CenterY="1057.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NFH3" /> </DataNode> <DataNode TextLabel="SCMH1-2 " GraphId="baa59" Type="Protein" GroupRef="d3dfe"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-389114" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="637.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96GD3-2" /> </DataNode> <DataNode TextLabel="NUP54 " GraphId="bab92" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="180" /> <Graphics CenterX="100.0" CenterY="817.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q7Z3B4" /> </DataNode> <DataNode TextLabel="HNRNPC" GraphId="bb87e" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="144.0" CenterY="58.5" Width="74.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P07910" /> </DataNode> <DataNode TextLabel="POM121 " GraphId="bbe03" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="1610" /> <Graphics CenterX="100.0" CenterY="1257.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96HA1" /> </DataNode> <DataNode TextLabel="RING1 " GraphId="bd44a" Type="Protein" GroupRef="d3dfe"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-389114" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="757.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q06587" /> </DataNode> <DataNode TextLabel="NUP98-4 " GraphId="bd581" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="544" /> <Graphics CenterX="100.0" CenterY="1217.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P52948-4" /> </DataNode> <DataNode TextLabel="SUMO2:UBE2I" GraphId="bf547" Type="Complex"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="521.5" CenterY="270.5" Width="109.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-2993778" /> </DataNode> <DataNode TextLabel="NUP98-5 " GraphId="c33fc" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="69" /> <Graphics CenterX="100.0" CenterY="737.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P52948-5" /> </DataNode> <DataNode TextLabel="Nuclear Pore Complex&#xA;(NPC)" GraphId="c5a02" Type="Complex"> <BiopaxRef>bcc</BiopaxRef> <BiopaxRef>c66</BiopaxRef> <BiopaxRef>cc0</BiopaxRef> <BiopaxRef>e20</BiopaxRef> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Graphics CenterX="54.5" CenterY="126.5" Width="101.0" Height="37.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-157689" /> </DataNode> <DataNode TextLabel="SUMO1-C93-UBE2I " GraphId="c7895" Type="Protein" GroupRef="ab109"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-2993783" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="517.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P63279" /> </DataNode> <DataNode TextLabel="SUMO1:C93-UBE2I" GraphId="ca270" Type="Complex"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="196.5" CenterY="263.5" Width="123.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-2993783" /> </DataNode> <DataNode TextLabel="K467-NOP58-G97-SUMO1 " GraphId="cac87" Type="Protein" GroupRef="e2ecf"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-4570540" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="917.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P63165" /> </DataNode> <DataNode TextLabel="NUP62 " GraphId="cd593" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="99" /> <Graphics CenterX="100.0" CenterY="777.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P37198" /> </DataNode> <DataNode TextLabel="NUP210 " GraphId="cd90f" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="233" /> <Graphics CenterX="100.0" CenterY="877.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8TEM1" /> </DataNode> <DataNode TextLabel="CBX2 " GraphId="d16f4" Type="Protein" GroupRef="d3dfe"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-389114" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="797.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14781" /> </DataNode> <DataNode TextLabel="NUP35 " GraphId="d1e68" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="330" /> <Graphics CenterX="100.0" CenterY="1017.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NFH5" /> </DataNode> <DataNode TextLabel="CBX4 " GraphId="d5513" Type="Protein" GroupRef="d3dfe"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-389114" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="817.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O00257" /> </DataNode> <DataNode TextLabel="NUP50 " GraphId="d7d3a" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="383" /> <Graphics CenterX="100.0" CenterY="1077.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UKX7" /> </DataNode> <DataNode TextLabel="SUMO2-C93-UBE2I " GraphId="d9d1c" Type="Protein" GroupRef="efad0"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-2993778" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="1137.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P63279" /> </DataNode> <DataNode TextLabel="UBE2I-G97-SUMO1 " GraphId="da1e2" Type="Protein" GroupRef="ab109"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-2993783" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="537.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P63165" /> </DataNode> <DataNode TextLabel="NUP85 " GraphId="da307" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="398" /> <Graphics CenterX="100.0" CenterY="1097.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BW27" /> </DataNode> <DataNode TextLabel="NUP98-3 " GraphId="dd057" Type="Protein" GroupRef="f22f0"> <BiopaxRef>f43</BiopaxRef> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="1603" /> <Graphics CenterX="100.0" CenterY="1237.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P52948-3" /> </DataNode> <DataNode TextLabel="RANBP2 " GraphId="dea7d" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="337" /> <Graphics CenterX="100.0" CenterY="1037.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P49792" /> </DataNode> <DataNode TextLabel="UBE2I-G93-SUMO2 " GraphId="e012e" Type="Protein" GroupRef="d811e"> <BiopaxRef>b1b</BiopaxRef> <BiopaxRef>dbd</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-2993778" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="577.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P61956" /> </DataNode> <DataNode TextLabel="NUP188 " GraphId="e2221" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="293" /> <Graphics CenterX="100.0" CenterY="957.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5SRE5" /> </DataNode> <DataNode TextLabel="NUP88 " GraphId="e2b99" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="429" /> <Graphics CenterX="100.0" CenterY="1117.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99567" /> </DataNode> <DataNode TextLabel="NUP205 " GraphId="e3b1e" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="308" /> <Graphics CenterX="100.0" CenterY="977.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92621" /> </DataNode> <DataNode TextLabel="AAAS " GraphId="e5d2d" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="218" /> <Graphics CenterX="100.0" CenterY="857.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NRG9" /> </DataNode> <DataNode TextLabel="SEH1L-2 " GraphId="e7d9f" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="537" /> <Graphics CenterX="100.0" CenterY="1197.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96EE3-2" /> </DataNode> <DataNode TextLabel="POM121C " GraphId="e99d4" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="1617" /> <Graphics CenterX="100.0" CenterY="1277.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="A8CG34" /> </DataNode> <DataNode TextLabel="SUMO2-C93-UBE2I " GraphId="ea495" Type="Protein" GroupRef="d811e"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-2993778" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="557.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P63279" /> </DataNode> <DataNode TextLabel="SUMO1-C93-UBE2I " GraphId="eb059" Type="Protein" GroupRef="b701b"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-2993783" /> <Attribute 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Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="54" /> <Graphics CenterX="100.0" CenterY="717.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P57740" /> </DataNode> <DataNode TextLabel="SUMO1:HNRNPC" GraphId="f9d3d" Type="Complex"> <BiopaxRef>bc3</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="151.0" CenterY="192.5" Width="114.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-4570453" /> </DataNode> <DataNode TextLabel="SUMO1:C93-UBE2I" GraphId="fa3c9" Type="Complex"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="258.0" CenterY="62.5" Width="122.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-2993783" /> </DataNode> <DataNode TextLabel="CBX8 " GraphId="fc27a" Type="Protein" GroupRef="d3dfe"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-389114" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="837.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HC52" /> </DataNode> <DataNode TextLabel="SUMO2-K467,K497-NOP58" GraphId="fc9d6" Type="Protein"> <BiopaxRef>c9c</BiopaxRef> <BiopaxRef>a97</BiopaxRef> <BiopaxRef>f80</BiopaxRef> <BiopaxRef>ecf</BiopaxRef> <BiopaxRef>ace</BiopaxRef> <BiopaxRef>a53</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="503.5" CenterY="425.0" Width="129.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y2X3" /> </DataNode> <DataNode TextLabel="SUMO2-K422-HNRNPK" GraphId="fd68e" Type="Protein"> <BiopaxRef>ace</BiopaxRef> <BiopaxRef>ecf</BiopaxRef> <BiopaxRef>a53</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="395.0" CenterY="201.5" Width="112.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P61978" /> </DataNode> <DataNode TextLabel="NUP160 " GraphId="fdfc5" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="100.0" CenterY="677.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q12769" /> </DataNode> <DataNode TextLabel="NDC1 " GraphId="fe01c" Type="Protein" GroupRef="f22f0"> <Attribute Key="cellular_location" Value="nuclear envelope" /> <Attribute Key="complex_id" Value="R-HSA-157689" /> <Attribute Key="copies_num" Value="1640" /> <Graphics CenterX="100.0" CenterY="1297.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BTX1" /> </DataNode> <DataNode TextLabel="K497-NOP58-G97-SUMO1 " GraphId="ffc36" Type="Protein" GroupRef="e2ecf"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-4570540" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="957.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P63165" /> </DataNode> <Interaction GraphId="a005a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="485.0" Y="141.0" GraphRef="a445c" RelX="-1.0" RelY="-0.04" /> <Point X="455.0" Y="140.0" GraphRef="ba520" RelX="0.5" RelY="4.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570499" /> </Interaction> <Interaction GraphId="a289f"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="266.0" Y="387.0" GraphRef="ac3aa" RelX="0.009999999999990905" RelY="0.8100000000000023" /> <Point X="315.0" Y="425.0" GraphRef="f2f71" RelX="-1.0" RelY="-0.04" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570467" /> </Interaction> <Interaction GraphId="a4851"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="266.0" Y="387.0" GraphRef="ac3aa" RelX="0.009999999999990905" RelY="0.8100000000000023" /> <Point X="253.0" Y="421.0" GraphRef="a75e9" RelX="0.9831932773109243" RelY="-0.037037037037037035" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570467" /> </Interaction> <Interaction GraphId="a6987"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="104.0" Y="126.0" GraphRef="c5a02" RelX="0.9801980198019802" RelY="-0.02702702702702703" /> <Point X="198.0" Y="126.0" GraphRef="d4821" RelX="0.5" RelY="-3.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570493" /> </Interaction> <Interaction GraphId="a8420"> <Comment Source="Reactome">NOP58 (NOP5) is SUMOylated at lysine-467 and lysine-497 with SUMO2 (Matic et al. 2010, Westman et al. 2010, Westman and Lamond 2011, Hendriks et al. 2014, Impens et al. 2014, Tammsalu et al. 2014). (Two molecules of SUMO2 are shown for each modification in order to represent the oligomeric chains of SUMO2 that are attached to a target protein.) SUMOylation of NOP58 is required for high affinity binding of snoRNAs by NOP58</Comment> <BiopaxRef>c9c</BiopaxRef> <BiopaxRef>a97</BiopaxRef> <BiopaxRef>f80</BiopaxRef> <BiopaxRef>ecf</BiopaxRef> <BiopaxRef>ace</BiopaxRef> <BiopaxRef>a53</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="436.0" Y="301.0" /> <Point X="435.0" Y="388.0" /> <Anchor Position="0.0" Shape="None" GraphId="fdfaf" /> <Anchor Position="0.99" Shape="None" GraphId="c9bd5" /> <Anchor Position="0.5" Shape="None" GraphId="c6d07" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570489" /> </Interaction> <Interaction GraphId="a969b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="257.0" Y="263.0" GraphRef="ca270" RelX="0.983739837398374" RelY="-0.034482758620689655" /> <Point X="265.0" Y="306.0" GraphRef="de4c9" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570467" /> </Interaction> <Interaction GraphId="ae9f8"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="257.0" Y="263.0" GraphRef="ca270" RelX="0.983739837398374" RelY="-0.034482758620689655" /> <Point X="265.0" Y="353.0" GraphRef="e2071" RelX="-0.5" RelY="6.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570467" /> </Interaction> <Interaction GraphId="b3588"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="432.0" Y="67.0" GraphRef="ebccb" RelX="0.971830985915493" RelY="0.0" /> <Point X="454.0" Y="100.0" GraphRef="eb2c4" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570499" /> </Interaction> <Interaction GraphId="b4819"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="320.0" Y="270.0" GraphRef="a5067" RelX="-1.0" RelY="-0.034482758620689655" /> <Point X="265.0" Y="306.0" GraphRef="de4c9" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570467" /> </Interaction> <Interaction GraphId="bcd6a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="467.0" Y="270.0" GraphRef="bf547" RelX="-1.0" RelY="-0.034482758620689655" /> <Point X="436.0" Y="301.0" GraphRef="fdfaf" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570489" /> </Interaction> <Interaction GraphId="c0d71"> <Comment Source="Reactome">NOP58 (NOP5) is SUMOylated at lysine-467 and lysine-497 with SUMO1 (Matafora et al. 2009, Westman et al. 2010, Westman and Lamond 2011,Impens et al. 2014). SUMOylation is required for binding of snoRNAs by NOP58.</Comment> <BiopaxRef>c9c</BiopaxRef> <BiopaxRef>f80</BiopaxRef> <BiopaxRef>ecf</BiopaxRef> <BiopaxRef>c66</BiopaxRef> <BiopaxRef>fb0</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="265.0" Y="306.0" /> <Point X="266.0" Y="387.0" /> <Anchor Position="0.0" Shape="None" GraphId="de4c9" /> <Anchor Position="0.99" Shape="None" GraphId="ac3aa" /> <Anchor Position="0.5" Shape="None" GraphId="e2071" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570467" /> </Interaction> <Interaction GraphId="c20e0"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="466.0" Y="67.0" GraphRef="f4a76" RelX="-1.0" RelY="0.0" /> <Point X="454.0" Y="100.0" GraphRef="eb2c4" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570499" /> </Interaction> <Interaction GraphId="c9307"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="181.0" Y="58.0" GraphRef="bb87e" RelX="1.0" RelY="-0.04" /> <Point X="198.0" Y="97.0" GraphRef="d66ac" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570493" /> </Interaction> <Interaction GraphId="cb01a"> <Comment Source="Reactome">CBX4 (Pc2) SUMOylates HNRNPK at lysine-422 with SUMO2 (Li et al. 2004, Lee et al. 2012, Pelisch et al. 2012, Hendriks et al. 2014, Impens et al. 2014, Tammsalu et al. 2014). (Two molecules of SUMO2 are shown in the reaction in order to represent the oligomeric chains of SUMO2 that are attached to a target protein.) PIAS3 also SUMOylates HNRNPK predominantly with SUMO1 (Lee et al. 2012). HNRNPK is SUMOylated in response to DNA damage and SUMOylation is regulated by HIPK2 and CBX4. SUMOylation of HNRNPK is required for coactivation of TP53 (p53) activated transcription. 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SUMOylation decreases the interaction of HNRNPC with single-stranded DNA.</Comment> <BiopaxRef>bc3</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="198.0" Y="97.0" /> <Point X="197.0" Y="161.0" /> <Anchor Position="0.0" Shape="None" GraphId="d66ac" /> <Anchor Position="0.99" Shape="None" GraphId="a53d4" /> <Anchor Position="0.5" Shape="None" GraphId="d4821" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570493" /> </Interaction> <Interaction GraphId="f99b6"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="455.0" Y="172.0" GraphRef="e03ae" RelX="0.009999999999990905" RelY="0.7199999999999989" /> <Point X="486.0" Y="201.0" GraphRef="b3043" RelX="-1.0" RelY="-0.04" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-4570499" /> </Interaction> <Interaction GraphId="ffb53"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="467.0" Y="270.0" GraphRef="bf547" 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rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Impens F, Radoshevich L, Cossart P, Ribet D.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a53"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">24782567</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Proteome-wide identification of SUMO2 modification sites.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tammsalu T, Matic I, Jaffray EG, Ibrahim AFM, Tatham MH, Hay RT.</bp:AUTHORS> </bp:PublicationXref> 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signaling networks in a site-specific manner.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f43"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10087256</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fontoura BM, Blobel G, Matunis MJ.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" 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rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a47"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">23979992</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Proteomics strategies to identify SUMO targets and acceptor sites: a survey of RNA-binding proteins SUMOylation.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Filosa G, Barabino SM, Bachi A.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bcc"> <bp:ID 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