Activation of kainate receptors upon glutamate binding (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Activation of kainate receptors upon glutamate binding" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Kainate receptors are found both in the presynaptc terminals and the postsynaptic neurons. &lt;br&gt;Kainate receptor activation could lead to either ionotropic activity (influx of Ca2+ or Na+ and K+) in the postsynaptic neuron or coupling of the receptor with G proteins in the presynaptic and the postsynaptic neurons. &lt;br&gt;Kainate receptors are tetramers made from subunits GRIK1-5 or GluR5-7 and KA1-2. Activation of kainate receptors made from GRIK1 or KA2 release Ca2+ from the intracellular stores in a G protein-dependent manner. The G protein involved in this process is sensitive to pertussis toxin. View original pathway at:[http://www.reactome.org/PathwayBrowser/#DIAGRAM=451326 Reactome].</Comment> <Comment Source="Reactome-Converter">Pathway is converted from Reactome ID: 451326</Comment> <Comment Source="Reactome-version">Reactome version: 66</Comment> <Comment Source="Reactome Author">Reactome Author: Mahajan, SS</Comment> <BiopaxRef>a89</BiopaxRef> <Attribute Key="reactome_id" Value="451326"/> <Graphics BoardWidth="1504.0" BoardHeight="1401.0"/> <DataNode TextLabel="GNG2 " GraphId="a0c40" Type="Protein" GroupRef="c8591"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="1"/> <Graphics CenterX="240.0" CenterY="801.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P59768"/> </DataNode> <DataNode TextLabel="GNG12 " GraphId="a1123" Type="Protein" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="433"/> <Graphics CenterX="380.0" CenterY="801.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9UBI6"/> </DataNode> <DataNode TextLabel="Edited GRIK2 (GluR6) " GraphId="a2980" Type="Protein" GroupRef="dc3a3"> <Comment Source="Reactome">GRIK2 is edited at the Q/R site at 621 where the glutamine is edited to arginine. GRIK2 is also edited at 571 (Y/C) where a tyrosine residue is changed to cysteine and 567 (I/V) where an isoleucine is changed to valine. All three sites are edited postranscriptionally. A fully edited GRIK2 at all three sites is totally impermeable to calcium ions.</Comment> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-451279"/> <Attribute Key="copies_num" Value="11"/> <Graphics CenterX="100.0" CenterY="641.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q13002"/> </DataNode> <DataNode TextLabel="Cl- " GraphId="a3e4e" Type="Metabolite" GroupRef="dc3a3"> <Attribute Key="cellular_location" Value="extracellular region"/> <Attribute Key="complex_id" Value="R-HSA-451279"/> <Attribute Key="copies_num" Value="16"/> <Graphics CenterX="100.0" CenterY="661.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17996"/> </DataNode> <DataNode TextLabel="GNB1 " GraphId="a4251" Type="Protein" GroupRef="c8591"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="518"/> <Graphics CenterX="240.0" CenterY="1041.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P62873"/> </DataNode> <DataNode TextLabel="GNG4 " GraphId="a6f1f" Type="Protein" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="97"/> <Graphics CenterX="380.0" CenterY="661.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P50150"/> </DataNode> <DataNode TextLabel="Edited Kainate&#10;receptors" GraphId="a8335" Type="Complex"> <Comment Source="Reactome">Kainate receptors are formed by the assembly of four subunits. GluR5-7 (GRIK, glutamate receptor, ionotropic Kainate 1-3) form functional homomers whereas, KA1 and KA2 or GRIK4,5 form functional heteromers with GRIK1/2/3. Kainate receptor subunits bind Cl- ion in the anion binding site in the ligand binding domain. The dimer is stabilized by the presence of one Cl- ion which binds within the dimer interface.</Comment> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="324.5" CenterY="87.0" Width="97.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a"/> <Xref Database="Reactome" ID="R-HSA-451279"/> </DataNode> <DataNode TextLabel="GNG8 " GraphId="a92b1" Type="Protein" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="241"/> <Graphics CenterX="380.0" CenterY="721.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9UK08"/> </DataNode> <DataNode TextLabel="PLCB3 " GraphId="a9f42" Type="Protein" GroupRef="c8591"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" 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TextLabel="L-Glu " GraphId="ad8cf" Type="Metabolite" GroupRef="cba27"> <Attribute Key="cellular_location" Value="extracellular region"/> <Attribute Key="complex_id" Value="R-HSA-500705"/> <Attribute Key="copies_num" Value="5"/> <Graphics CenterX="240.0" CenterY="741.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:29985"/> </DataNode> <DataNode TextLabel="GNGT2 " GraphId="ae2f1" Type="Protein" GroupRef="c8591"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="283"/> <Graphics CenterX="240.0" CenterY="921.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O14610"/> </DataNode> <DataNode TextLabel="Cl- " GraphId="ae692" Type="Metabolite" GroupRef="fb8f2"> <Attribute Key="cellular_location" Value="extracellular region"/> <Attribute Key="complex_id" Value="R-HSA-450885"/> <Attribute Key="copies_num" Value="40"/> <Graphics CenterX="100.0" CenterY="1001.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17996"/> </DataNode> <DataNode TextLabel="GNB4 " GraphId="ae9a0" Type="Protein" GroupRef="c8591"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="656"/> <Graphics CenterX="240.0" CenterY="1101.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9HAV0"/> </DataNode> <DataNode TextLabel="L-Glu " GraphId="b0687" Type="Metabolite" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="extracellular region"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="721"/> <Graphics CenterX="380.0" CenterY="1061.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:29985"/> </DataNode> <DataNode TextLabel="GNG13 " GraphId="b1f1b" Type="Protein" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="481"/> <Graphics CenterX="380.0" CenterY="821.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9P2W3"/> </DataNode> <DataNode TextLabel="Cl- " GraphId="b2807" Type="Metabolite" GroupRef="a8e53"> <Attribute Key="cellular_location" Value="extracellular region"/> <Attribute Key="complex_id" Value="R-HSA-450196"/> <Attribute Key="copies_num" Value="5"/> <Graphics CenterX="240.0" CenterY="641.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17996"/> </DataNode> <DataNode TextLabel="Kainate&#10;receptor-glutamate&#10;complex" GraphId="b2fae" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="630.5" CenterY="160.0" Width="119.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a"/> <Xref Database="Reactome" ID="R-HSA-451281"/> </DataNode> <DataNode TextLabel="NCALD " GraphId="b4ba7" Type="Protein" GroupRef="d33a3"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-451281"/> <Attribute Key="copies_num" Value="13"/> <Graphics CenterX="100.0" CenterY="1161.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P61601"/> </DataNode> <DataNode TextLabel="GRIK 3 homomer" GraphId="b5e14" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="356.0" CenterY="218.0" Width="108.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a"/> <Xref Database="Reactome" ID="R-HSA-450196"/> </DataNode> <DataNode TextLabel="Kainate Receptors" GraphId="b669e" Type="Complex"> <Comment Source="Reactome">Kainate receptors are formed by the assembly of four subunits. GluR5-7 (GRIK, glutamate receptor, ionotropic Kainate 1-3) form functional homomers whereas, KA1 and KA2 or GRIK4,5 form functional heteromers with GRIK1/2/3. Kainate receptor subunits bind Cl- ion in the anion binding site in the ligand binding domain. The dimer is stabilized by the presence of one Cl- ion which binds within the dimer interface.</Comment> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="322.0" CenterY="159.0" Width="114.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a"/> <Xref Database="Reactome" ID="R-HSA-450885"/> </DataNode> <DataNode TextLabel="GNG11 " GraphId="b7e3a" Type="Protein" GroupRef="c8591"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="377"/> <Graphics CenterX="240.0" CenterY="961.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P61952"/> </DataNode> <DataNode TextLabel="GNB3 " GraphId="b858f" Type="Protein" GroupRef="c8591"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" 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</DataNode> <DataNode TextLabel="GNGT1 " GraphId="baffd" Type="Protein" GroupRef="c8591"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="518"/> <Graphics CenterX="240.0" CenterY="1021.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P63211"/> </DataNode> <DataNode TextLabel="CALM1 " GraphId="be515" Type="Protein" GroupRef="d33a3"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-451281"/> <Attribute Key="copies_num" Value="29"/> <Graphics CenterX="100.0" CenterY="1241.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P0DP23"/> </DataNode> <DataNode TextLabel="Na+" GraphId="bede9" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol"/> <Graphics CenterX="827.5" CenterY="341.5" Width="43.0" 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</DataNode> <DataNode TextLabel="GNG10 " GraphId="d3541" Type="Protein" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="337"/> <Graphics CenterX="380.0" CenterY="761.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P50151"/> </DataNode> <DataNode TextLabel="Edited GRIK 1 (GluR5) " GraphId="d4960" Type="Protein" GroupRef="dc3a3"> <Comment Source="Reactome">Glutamine at position 636 is replaced by arginine in an editing step which occurs posttranscriptionally.</Comment> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-451279"/> <Attribute Key="copies_num" Value="6"/> <Graphics CenterX="100.0" CenterY="601.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P39086"/> </DataNode> <DataNode 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Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q00722"/> </DataNode> <DataNode TextLabel="DLG3 " GraphId="db30a" Type="Protein" GroupRef="fb8f2"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-450885"/> <Attribute Key="copies_num" Value="26"/> <Graphics CenterX="100.0" CenterY="961.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q92796"/> </DataNode> <DataNode TextLabel="PLCB1 " GraphId="dbb58" Type="Protein" GroupRef="c8591"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="702"/> <Graphics CenterX="240.0" CenterY="1141.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9NQ66"/> </DataNode> <DataNode TextLabel="GNB5 " GraphId="dbdd4" Type="Protein" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="717"/> <Graphics CenterX="380.0" CenterY="941.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O14775"/> </DataNode> <DataNode TextLabel="GNG7 " GraphId="dc130" Type="Protein" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="193"/> <Graphics CenterX="380.0" CenterY="701.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O60262"/> </DataNode> <DataNode TextLabel="GRIK3 " GraphId="dd0ac" Type="Protein" GroupRef="cba27"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-500705"/> <Attribute Key="copies_num" Value="4"/> <Graphics CenterX="240.0" CenterY="701.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q13003"/> </DataNode> <DataNode TextLabel="DLG4 " GraphId="ddf99" Type="Protein" GroupRef="fb8f2"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-450885"/> <Attribute Key="copies_num" Value="21"/> <Graphics CenterX="100.0" CenterY="941.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P78352"/> </DataNode> <DataNode TextLabel="GNB1 " GraphId="e2609" Type="Protein" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="529"/> <Graphics CenterX="380.0" CenterY="861.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P62873"/> </DataNode> <DataNode TextLabel="GRIK4 " GraphId="e49d2" 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Type="Protein" GroupRef="c8591"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="142"/> <Graphics CenterX="240.0" CenterY="861.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P63218"/> </DataNode> <DataNode TextLabel="DLG4 " GraphId="f1728" Type="Protein" GroupRef="d33a3"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-451281"/> <Attribute Key="copies_num" Value="21"/> <Graphics CenterX="100.0" CenterY="1201.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P78352"/> </DataNode> <DataNode TextLabel="GNG10 " GraphId="f481e" Type="Protein" GroupRef="c8591"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="330"/> <Graphics CenterX="240.0" CenterY="941.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P50151"/> </DataNode> <DataNode TextLabel="GRIK3 homomer&#10;glutamate complex" GraphId="f4a4d" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="640.5" CenterY="219.0" Width="119.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a"/> <Xref Database="Reactome" ID="R-HSA-500705"/> </DataNode> <DataNode TextLabel="GNG3 " GraphId="f530a" Type="Protein" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="49"/> <Graphics CenterX="380.0" CenterY="641.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P63215"/> </DataNode> <DataNode TextLabel="GNGT2 " GraphId="f54b7" Type="Protein" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="289"/> <Graphics CenterX="380.0" CenterY="741.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O14610"/> </DataNode> <DataNode TextLabel="GRIK3 " GraphId="f7761" Type="Protein" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="720"/> <Graphics CenterX="380.0" CenterY="1021.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q13003"/> </DataNode> <DataNode TextLabel="GRIK2 " GraphId="f83fb" Type="Protein" GroupRef="fb8f2"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-450885"/> <Attribute Key="copies_num" Value="10"/> <Graphics CenterX="100.0" CenterY="881.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q13002"/> </DataNode> <DataNode TextLabel="GRIK3 " GraphId="f8b54" Type="Protein" GroupRef="a8e53"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-450196"/> <Attribute Key="copies_num" Value="4"/> <Graphics CenterX="240.0" CenterY="621.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q13003"/> </DataNode> <DataNode TextLabel="L-Glu" GraphId="f8df6" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region"/> <Graphics CenterX="366.5" CenterY="19.0" Width="49.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:29985"/> </DataNode> <DataNode TextLabel="Edited Kainate&#10;Receptor-glutamate&#10;complex" GraphId="f95f3" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="620.5" CenterY="83.0" Width="129.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a"/> <Xref Database="Reactome" ID="R-HSA-451304"/> </DataNode> <DataNode TextLabel="Cl- " GraphId="f9cb9" Type="Metabolite" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="extracellular region"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="721"/> <Graphics CenterX="380.0" CenterY="1041.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17996"/> </DataNode> <DataNode TextLabel="GNB2 " GraphId="fa922" Type="Protein" GroupRef="ba8f5"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-500703"/> <Attribute Key="copies_num" Value="576"/> <Graphics CenterX="380.0" CenterY="881.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P62879"/> </DataNode> <DataNode TextLabel="GRIK1 " GraphId="fac39" Type="Protein" GroupRef="d33a3"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-451281"/> <Attribute Key="copies_num" Value="56"/> <Graphics CenterX="100.0" CenterY="1301.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P39086"/> </DataNode> <DataNode TextLabel="Edited GRIK2 (GluR6) " GraphId="fc7c9" Type="Protein" GroupRef="f0356"> <Comment Source="Reactome">GRIK2 is edited at the Q/R site at 621 where the glutamine is edited to arginine. GRIK2 is also edited at 571 (Y/C) where a tyrosine residue is changed to cysteine and 567 (I/V) where an isoleucine is changed to valine. All three sites are edited postranscriptionally. 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<BiopaxRef>f43</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="773.0" Y="46.0"/> <Point X="824.0" Y="326.0"/> <Anchor Position="0.0" Shape="None" GraphId="f0a66"/> <Anchor Position="0.99" Shape="None" GraphId="cb1b3"/> <Anchor Position="0.5" Shape="None" GraphId="ab751"/> </Graphics> <Xref Database="Reactome" ID="R-HSA-451310"/> </Interaction> <Interaction GraphId="b0556"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="366.0" Y="34.0" GraphRef="f8df6" RelX="-0.02040816326530612" RelY="1.0"/> <Point X="443.0" Y="218.0" GraphRef="cc69b" RelX="0.0" RelY="0.0"/> </Graphics> <Xref Database="Reactome" ID="R-HSA-500708"/> </Interaction> <Interaction GraphId="b52cc"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="824.0" Y="326.0" GraphRef="cb1b3" RelX="0.5099999999999909" RelY="2.8000000000000114"/> <Point X="827.0" Y="329.0" GraphRef="bede9" RelX="-0.023255813953488372" 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