Mevalonate arm of cholesterol biosynthesis pathway with inhibitors (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Mevalonate arm of cholesterol biosynthesis pathway with inhibitors" Version="20171213" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">An analysis of the mevalonate branch of the cholesterol biosynthesis pathway, and a set of inhibitors directed against targets in this pathway. Inhibitors which have been found for Homo Sapiens are coloured red, those found for Rattus norvegicus orange. View more details on where these reactions in the cell take place at [https://www.wikipathways.org/index.php/Pathway:WP4190]. View the broader scope of cholesterol metabolism at [https://www.wikipathways.org/index.php/Pathway:WP430].</Comment> <BiopaxRef>c95</BiopaxRef> <Graphics BoardWidth="1237.8719211844407" BoardHeight="922.6554467659107"/> <DataNode TextLabel="(+)-Zaragozic acid" GraphId="a2217" Type="Metabolite" GroupRef="ef715"> <Graphics CenterX="757.9399981735988" CenterY="732.1345325366594" Width="107.99943924203603" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="ChEBI" ID="CHEBI:83934"/> </DataNode> <DataNode TextLabel="dimethylallyl-PP" GraphId="aaf7c" Type="Metabolite"> <Graphics CenterX="693.3425925925927" CenterY="489.58333333333337" Width="104.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q417398"/> </DataNode> <DataNode TextLabel="6-fluoromevalonate 5-diphosphate" GraphId="add09" Type="Metabolite" GroupRef="cff62"> <Graphics CenterX="129.58240828245556" CenterY="519.6098285405699" Width="187.60288065843616" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27074009"/> </DataNode> <DataNode TextLabel="L-659699" GraphId="b069e" Type="Protein"> <Comment>Only found for Rattus norvegicus. L-659699 is a.k.a. (E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecadienenoic acid</Comment> <Graphics CenterX="910.8796296296298" CenterY="152.77777777777777" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="ff6600"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="FDFT1" GraphId="bf9be" Type="Protein"> <Graphics CenterX="771.8036242614683" CenterY="816.3428778574211" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Wikidata" ID="Q21108578"/> </DataNode> <DataNode TextLabel="rosuvastatin" GraphId="bff2e" Type="Metabolite" GroupRef="ba1ce"> <Graphics CenterX="917.8240740740744" CenterY="215.2807377456917" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q415159"/> </DataNode> <DataNode TextLabel="Cinnamic acid" GraphId="c1027" Type="Metabolite" GroupRef="c81ce"> <Comment>Only found for Rattus norvegicus.</Comment> <Graphics CenterX="86.29629629629643" CenterY="384.2592592592593" Width="84.35185185185154" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="HMDB" ID="HMDB00567"/> </DataNode> <DataNode TextLabel="2-fluoromevalonate 5-diphosphate" GraphId="c64f0" Type="Metabolite" GroupRef="dfa72"> <Comment>Only found for Rattus norvegicus.</Comment> <Graphics CenterX="179.20109356014518" CenterY="453.2199270959901" Width="205.38882138517596" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="ff6600"/> <Xref Database="Wikidata" ID="Q27071897"/> </DataNode> <DataNode TextLabel="Acetyl-CoA" GraphId="d08e4" Type="Metabolite"> <Graphics CenterX="431.34259259259255" CenterY="99.58333333333333" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15351"/> </DataNode> <DataNode TextLabel="zoledronic acid" GraphId="d4356" Type="Metabolite" GroupRef="b536a"> <Graphics CenterX="932.4894514767959" CenterY="330.5203938115324" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q28852343"/> </DataNode> <DataNode TextLabel="BPH-628" GraphId="e22b1" Type="Metabolite" GroupRef="ecf9d"> <Graphics CenterX="898.7341772151893" CenterY="535.8649789029537" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27075447"/> </DataNode> <DataNode TextLabel="HMGCS1" GraphId="ed3ae" Type="Protein"> <Graphics CenterX="711.3425925925927" CenterY="153.58333333333331" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Wikidata" ID="Q21118293"/> </DataNode> <DataNode TextLabel="HMGCR" GraphId="ed8b1" Type="Protein"> <Graphics CenterX="711.3425925925927" CenterY="252.58333333333331" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P04035"/> </DataNode> <DataNode TextLabel="IDI1" GraphId="f1c29" Type="Protein" GroupRef="b2a67"> <Graphics CenterX="771.1000347094617" CenterY="377.6759463432561" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Wikidata" ID="Q21151146"/> </DataNode> <DataNode TextLabel="MVK" GraphId="f537e" Type="Protein"> <Graphics CenterX="430.240056760178" CenterY="337.6858691657479" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Wikidata" ID="Q424031"/> </DataNode> <DataNode TextLabel="cholesterol synthesis" GraphId="f718f" Type="Pathway"> <Graphics CenterX="784.7699969185783" CenterY="880.1554467659107" Width="139.44762954796022" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e"/> <Xref Database="WikiPathways" ID="WP197"/> </DataNode> <DataNode TextLabel="3-hydroxy-3-methylglutaryl-CoA" GraphId="f9983" Type="Metabolite"> <Graphics CenterX="551.3425925925926" CenterY="189.58333333333331" Width="190.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q27108899"/> </DataNode> <DataNode TextLabel="FDPS" GraphId="f9d3e" Type="Protein"> <Graphics CenterX="999.1670647343232" CenterY="472.1994814605571" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Wikidata" ID="Q21107439"/> </DataNode> <DataNode TextLabel="acetoacetyl-CoA" GraphId="fb00b" Type="Metabolite"> <Graphics CenterX="685.3425925925927" CenterY="99.58333333333333" Width="110.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q2639429"/> </DataNode> <DataNode TextLabel="farnesyl thiodiphosphate" GraphId="fba9b" Type="Metabolite"> <Graphics CenterX="200.74074074074073" CenterY="336.8055555555555" Width="142.22222222222223" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27077283"/> </DataNode> <DataNode TextLabel="mevaldyl-CoA" GraphId="dfef9" Type="Metabolite"> <Graphics CenterX="551.3425925925926" CenterY="253.58333333333331" Width="90.0" Height="25.0" ZOrder="32769" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="mevalonate" GraphId="b7977" Type="Metabolite"> <Graphics CenterX="551.3425925925926" CenterY="311.5833333333333" Width="90.0" Height="25.0" ZOrder="32770" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q27109878"/> </DataNode> <DataNode TextLabel="mevalonate-P" GraphId="df3ad" Type="Metabolite"> <Graphics CenterX="551.3425925925926" CenterY="369.5833333333333" Width="90.0" Height="25.0" ZOrder="32771" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q45414671"/> </DataNode> <DataNode TextLabel="mevalonate-PP" GraphId="f89b9" Type="Metabolite"> <Graphics CenterX="551.3425925925926" CenterY="429.5833333333333" Width="90.0" Height="25.0" ZOrder="32772" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q45415198"/> </DataNode> <DataNode TextLabel="isopenthyl-PP" GraphId="aa64f" Type="Metabolite"> <Graphics CenterX="551.3425925925926" CenterY="489.5833333333333" Width="90.0" Height="25.0" ZOrder="32773" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q417403"/> </DataNode> <DataNode TextLabel="PMVK" GraphId="bd1ff" Type="Protein"> <Graphics CenterX="431.34259259259255" CenterY="396.3782616685042" Width="90.0" Height="25.0" ZOrder="32775" FontSize="12" Valign="Middle"/> <Xref Database="Wikidata" ID="Q22676988"/> </DataNode> <DataNode TextLabel="MVD" GraphId="ed464" Type="Protein"> <Graphics CenterX="431.34259259259255" CenterY="456.3782616685042" Width="90.0" Height="25.0" ZOrder="32776" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P53602"/> </DataNode> <DataNode TextLabel="geranyl-PP" GraphId="f2c6d" Type="Metabolite"> <Graphics CenterX="610.3425925925927" CenterY="635.5177376171354" Width="90.0" Height="25.0" ZOrder="32779" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q418125"/> </DataNode> <DataNode TextLabel="famesyl-PP" GraphId="dc94f" Type="Metabolite"> <Graphics CenterX="610.3425925925926" CenterY="752.5148734472778" Width="90.0" Height="25.0" ZOrder="32780" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q45416123"/> </DataNode> <DataNode TextLabel="geranylgeranyl-PP" GraphId="bb9d6" Type="Metabolite"> <Graphics CenterX="413.5461821445991" CenterY="752.5148734472778" Width="127.0" Height="25.0" ZOrder="32781" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q774795"/> </DataNode> <DataNode TextLabel="presqualene-PP" GraphId="aaecf" Type="Metabolite"> <Graphics CenterX="610.3425925925927" CenterY="812.5148734472778" Width="106.0" Height="25.0" ZOrder="32782" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q27088444"/> </DataNode> <DataNode TextLabel="squalene" GraphId="f9414" Type="Metabolite"> <Graphics CenterX="610.3425925925926" CenterY="880.1554467659107" Width="90.0" Height="25.0" ZOrder="32783" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q407560"/> </DataNode> <DataNode TextLabel="protein prenylation" GraphId="c8400" Type="Pathway"> <Graphics CenterX="413.5461821445991" CenterY="832.5148734472778" Width="127.0" Height="25.0" ZOrder="32784" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="GGPS1" GraphId="cb5cc" Type="Protein"> <Graphics CenterX="419.46828167748583" CenterY="646.4515854671906" Width="90.0" Height="25.0" ZOrder="32785" FontSize="12" Valign="Middle"/> <Xref Database="Wikidata" ID="Q21106540"/> </DataNode> <DataNode TextLabel="IDI2" GraphId="c128e" Type="Protein" GroupRef="b2a67"> <Graphics CenterX="771.1000347094617" CenterY="402.6759463432561" Width="90.0" Height="25.0" ZOrder="32786" FontSize="12" Valign="Middle"/> <Xref Database="Wikidata" ID="Q21132842"/> </DataNode> <DataNode TextLabel="GGPS1" GraphId="b1566" Type="Protein"> <Graphics CenterX="746.2118831192022" CenterY="585.3280224911223" Width="90.0" Height="25.0" ZOrder="32787" FontSize="12" Valign="Middle"/> <Xref Database="Wikidata" ID="Q21106540"/> </DataNode> <DataNode TextLabel="cerivastatin" GraphId="a9802" Type="Metabolite" GroupRef="ba1ce"> <Graphics CenterX="917.8240740740744" CenterY="240.2807377456917" Width="90.0" Height="25.0" ZOrder="32789" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q423439"/> </DataNode> <DataNode TextLabel="atorvastatin" GraphId="f7b59" Type="Metabolite" GroupRef="ba1ce"> <Graphics CenterX="917.8240740740744" CenterY="265.28073774569197" Width="90.0" Height="25.0" ZOrder="32790" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q668093"/> </DataNode> <DataNode TextLabel="lovastatin" GraphId="b50d7" Type="Metabolite" GroupRef="ba1ce"> <Graphics CenterX="917.8240740740744" CenterY="290.280737745692" Width="90.0" Height="25.0" ZOrder="32791" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q417740"/> </DataNode> <DataNode TextLabel="simvastatin" GraphId="be7c9" Type="Metabolite" GroupRef="ba1ce"> <Graphics CenterX="1006.5277777777787" CenterY="215.5585155234696" Width="90.0" Height="25.0" ZOrder="32792" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q670131"/> </DataNode> <DataNode TextLabel="CHEMBL39312" GraphId="f960f" Type="Metabolite" GroupRef="ba1ce"> <Graphics CenterX="1006.5277777777787" CenterY="240.55851552346954" Width="90.0" Height="25.0" ZOrder="32793" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="ChEMBL compound" ID="CHEMBL39312"/> </DataNode> <DataNode TextLabel="CHEMBL39102" GraphId="ba6b7" Type="Metabolite" GroupRef="ba1ce"> <Graphics CenterX="1006.5277777777787" CenterY="265.55851552346957" Width="90.0" Height="25.0" ZOrder="32794" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="ChEMBL compound" ID="CHEMBL39102"/> </DataNode> <DataNode TextLabel="Fluvastatin" GraphId="d9fa1" Type="Metabolite" GroupRef="ba1ce"> <Graphics CenterX="1006.5277777777787" CenterY="290.5585155234697" Width="90.0" Height="25.0" ZOrder="32795" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q417942"/> </DataNode> <DataNode TextLabel="3-hydroxy-3-methyl-6-phosphohexanoic acid" GraphId="a23c8" Type="Metabolite" GroupRef="c81ce"> <Comment>Only found for Rattus norvegicus.</Comment> <Graphics CenterX="175.9259259259259" CenterY="409.30555555555605" Width="263.88888888888886" Height="25.0" ZOrder="32796" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27073729"/> </DataNode> <DataNode TextLabel="isoferulic acid" GraphId="fcab7" Type="Metabolite" GroupRef="c81ce"> <Comment>Only found for Rattus norvegicus.</Comment> <Graphics CenterX="170.20833333333314" CenterY="384.2592592592593" Width="83.4722222222219" Height="25.0" ZOrder="32797" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27096447"/> </DataNode> <DataNode TextLabel="p-coumaric acid" GraphId="bfe8d" Type="Metabolite" GroupRef="c81ce"> <Comment>Only found for Rattus norvegicus.</Comment> <Graphics CenterX="260.20833333333314" CenterY="384.25925925925924" Width="96.5277777777781" Height="25.0" ZOrder="32798" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q99374"/> </DataNode> <DataNode TextLabel="diphosphoglycolyl proline" GraphId="efe0e" Type="Metabolite" GroupRef="cff62"> <Graphics CenterX="122.18014490796992" CenterY="544.6098285405707" Width="172.31481481481478" Height="25.0" ZOrder="32799" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27077077"/> </DataNode> <DataNode TextLabel="CHEMBL1160330" GraphId="f2ced" Type="Metabolite" GroupRef="cff62"> <Graphics CenterX="266.78662638945116" CenterY="544.1468655776081" Width="119.21296296296276" Height="25.0" ZOrder="32800" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="ChEMBL compound" ID="CHEMBL1160330"/> </DataNode> <DataNode TextLabel="CHEMBL1160328" GraphId="debc0" Type="Metabolite" GroupRef="cff62"> <Graphics CenterX="274.84989799438995" CenterY="519.6098285405699" Width="102.93209876543213" Height="25.0" ZOrder="32801" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="ChEMBL compound" ID="CHEMBL1160328"/> </DataNode> <DataNode TextLabel="P'-geranyl 2-fluoromevalonate 5-diphosphate" GraphId="cd316" Type="Metabolite" GroupRef="cff62"> <Graphics CenterX="181.1693424388343" CenterY="568.6839026146453" Width="290.29320987654296" Height="25.0" ZOrder="32802" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27088347"/> </DataNode> <DataNode TextLabel="P′-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate" GraphId="e4b7f" Type="Metabolite" GroupRef="dfa72"> <Comment>Only found for Rattus norvegicus.</Comment> <Graphics CenterX="179.2010935601453" CenterY="478.21992709599016" Width="334.42284325637905" Height="25.0" ZOrder="32803" FontSize="12" Valign="Middle" Color="ff6600"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="NE97220" GraphId="dbb8c" Type="Metabolite" GroupRef="b536a"> <Graphics CenterX="932.4894514767959" CenterY="405.5203938115326" Width="90.0" Height="25.0" ZOrder="32804" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27087890"/> </DataNode> <DataNode TextLabel="Risedronate" GraphId="f24d6" Type="Metabolite" GroupRef="b536a"> <Graphics CenterX="932.4894514767959" CenterY="355.5203938115324" Width="90.0" Height="25.0" ZOrder="32805" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="HMDB" ID="HMDB15022"/> </DataNode> <DataNode TextLabel="NE58062" GraphId="a3864" 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Height="25.0" ZOrder="32809" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27075451"/> </DataNode> <DataNode TextLabel="BPH-629" GraphId="d367a" Type="Metabolite" GroupRef="ecf9d"> <Graphics CenterX="898.7341772151893" CenterY="610.8649789029536" Width="90.0" Height="25.0" ZOrder="32810" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27075449"/> </DataNode> <DataNode TextLabel="BPH-676" GraphId="c69ae" Type="Metabolite" GroupRef="ecf9d"> <Graphics CenterX="898.7341772151893" CenterY="635.8649789029536" Width="90.0" Height="25.0" ZOrder="32811" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27075453"/> </DataNode> <DataNode TextLabel="BPH-628" GraphId="cdde5" Type="Metabolite" GroupRef="ded8a"> <Graphics CenterX="249.0998593530233" CenterY="614.7819971870604" Width="90.0" Height="25.0" ZOrder="32813" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27075447"/> </DataNode> <DataNode TextLabel="BPH-608" GraphId="d16c1" Type="Metabolite" GroupRef="ded8a"> <Graphics CenterX="249.0998593530233" CenterY="639.7819971870603" Width="90.0" Height="25.0" ZOrder="32814" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27075443"/> </DataNode> <DataNode TextLabel="BPH-675" GraphId="c0453" Type="Metabolite" GroupRef="ded8a"> <Graphics CenterX="249.0998593530233" CenterY="664.7819971870603" Width="90.0" Height="25.0" ZOrder="32815" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27075451"/> </DataNode> <DataNode TextLabel="BPH-629" GraphId="de14d" Type="Metabolite" GroupRef="ded8a"> <Graphics CenterX="249.0998593530233" CenterY="688.3755274261601" Width="90.0" Height="25.0" ZOrder="32816" FontSize="12" Valign="Middle" Color="ff0000"/> <Xref Database="Wikidata" ID="Q27075449"/> </DataNode> <DataNode TextLabel="BPH-676" GraphId="e35dd" Type="Metabolite" GroupRef="ded8a"> <Graphics 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